RESEARCH CAREER DEVELOPMENT IN MENTAL DISORDERS OF CHILDREN Release Date: November 18, 1998 RFA: MH-99-002 P.T. National Institute of Mental Health Letter of Intent Receipt Date: January 11, 1999 Application Receipt Date: February 11, 1999 THIS RFA USES THE "JUST-IN-TIME" CONCEPT. THIS RFA INCLUDES DETAILED MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE USED WHEN PREPARING AN APPLICATION IN RESPONSE TO THIS RFA. PURPOSE This Request for Applications (RFA) solicits Research Career Award applications from qualified applicants dedicated to pursuing research careers in areas relevant to child and adolescent mental disorders. Evidence from the World Health Organization indicates that the numbers of mental illnesses in children and adolescents will increase by 50 percent by the year 2020, exceeding other causes of illness such as childhood cancers and chronic diseases such as asthma and diabetes. Despite these expanding mental health needs, very little research has been done to identify the causes, consequences and effective treatments for these conditions. The principal reason for the relatively slow rate of progress has been the small number of well-trained investigators committed to research in child and adolescent mental disorders. The National Institute of Mental Health (NIMH) is committed to enhancing and sustaining a critical mass of well-trained clinically oriented researchers committed to conducting research on children and adolescents with mental and behavioral disorders. Although the NIMH encourages applications from individuals who are just entering into and have made a commitment to this area of research, the NIMH also wishes to encourage established investigators in other disciplines to broaden their research foci and to integrate their area of investigation with questions on child and adolescent mental disorders. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Research Career Awards in Mental Disorders in Children, is related to the priority areas of mental health and mental disorders. Potential applicants may obtain a copy of "Healthy People 2000" at ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic for-profit and nonprofit organizations, public and private organizations such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as principal investigators. Candidates for all the mechanisms described below must be U. S. Citizens, Non-citizens nationals, or lawfully admitted for permanent residence. Foreign institutions are not eligible. MECHANISM OF SUPPORT This RFA will use six different NIMH Research Career Development Programs. These include K01 [(Mentored Scientist Development Award (PA-95-049)], K01 [(Scientist Development Award for New Minority Faculty (PAR-95-040)], K02 [(Independent Scientist Award (PA 95-050)], K05 [(Senior Scientist Award (PA-95-051)], K08 [(Mentored Clinical Scientist Development Award (PA-95-053)], K23 [(Mentored Patient-Oriented Research Career Development Award (PA-98-052)], and the K24 [(Mid-career Investigator Award in Patient-Oriented Research (PA-98-053)]. Note: Candidates who are proposing to retool or broaden their research fields will find the K01 or K02 better suited for their purposes. Each K-mechanism applicable under this RFA is briefly described below to assist potential applicants in deciding which is more suitable for their interests. However, complete, specific K-announcements and revised NIMH policy on Career Awards should be consulted when applying. These may all be obtained electronically through the NIMH Extramural Career Development Page: Candidates for the Mentored Scientist Award (K01) should be research scientists who need an additional period of sponsored research experience. They should hold a doctoral degree, be able to demonstrate a capacity or potential for highly productive independent research, identify a mentor with extensive research experience and must devote 75 percent professional effort of a full time position during each 12 month period conducting research career development activities as described in the application. Current principal investigators on PHS research grants are not eligible. Past principal investigators are eligible provided the proposed research experience is a new field of study or there has been a hiatus in research career due to family or personal obligations or they are faculty members at institutions with substantial minority enrollment (see below). The project period is for 3, 4, or 5 years depending upon prior experience and the need for additional research development experience. Awards are not renewable. Candidates for the Scientist Development Award for Minority Faculty (K01) must be new, non-tenured minority faculty in their first faculty position who have earned a doctoral degree (Ph.D., M.D., D.Sc., etc.) by the time the award is made. (This represents special use of the NIH Mentored Career Development Award). Candidates must have the necessary time and assistance early in their academic careers to initiate a program of research and to become outstanding independent investigators. It is a five-year, non-renewable award. Candidates must devote 75 percent effort of a full-time appointment for each 12 month period to career development activities, research or research-related activities relevant to their career goals as described in the application. Candidates for the Independent Scientist Award (K02) should be newly independent scientists who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. This award is intended to foster the development of outstanding scientists and to enable them to expand their potential to make significant contributions to their field of research. This mechanism is recommended for those candidates, including senior scientists, who wish to "retool" or broaden their expertise in order to conduct research on child and adolescent mental disorders. Candidates should hold a doctoral degree and have peer-reviewed, independent research support or have work that is primarily theoretical in the absence of external research grant support. A mentor is required and candidates must devote a minimum of 75 percent effort of a full time appointment for each 12-month period to research during the award period. The project period is five years and is renewable once. The Senior Scientist Award (K05) provides support to outstanding scientists who have demonstrated a sustained, high level of productivity and whose expertise, research accomplishments and contributions to the field have been and will continue to be critical to the mission of the NIMH. The candidate must have peer-reviewed research support from NIMH at the time of the award. This mechanism is well-suited for candidates who wish to broaden their research foci in order to be able to conduct research on child and adolescent mental disorders. A minimum of 75 percent effort of a full time position during each 12-month period is required during this award. No mentor is required and the award is not renewable. The Mentored Clinical Scientist Development Award (K08) provides support to develop outstanding clinician research scientists. This award supports specialized study for clinical professionals who wish to develop into independent investigators. Candidates should hold a clinical doctoral degree and should have initiated postgraduate clinical training. The candidate must identify a mentor with extensive research experience and must devote 75 percent effort of a full- time position during each 12-month period to research career development activities as described in the application during the award period. Duration of the award is for 3, 4, or 5 years. Former principal investigators on PHS research grants are not eligible and a concurrent PHS award may not be held. The award is not renewable. The Mentored Patient-Oriented Research Career Development Award (K23) supports clinically trained professionals who have made a commitment to focus their research endeavors on patient-oriented research, and who have the potential to develop into productive investigators focusing on patient-oriented research. Duration of support is up to 5 years (minimum of 3) with 75 percent effort of a full time position during each 12-month period devoted to research as described in the application under the guidance of a mentor. The award is non-renewable. Patient-oriented research is defined as research conducted with human subjects (or on material of human origin such as tissues, specimens, and cognitive phenomena) for which an investigator directly interacts with human subjects. This area of research includes: 1) mechanism of human disease, 2) therapeutic interventions, 3) clinical trials, and (4) the development of new technologies. The Midcareer Investigator Award in Patient Oriented Research (K24) is designed for outstanding clinical scientists engaged in patient-oriented research, within 15 years of specialty training, who need a period of intensive research focus to enhance their clinical research careers, and who are committed to mentoring the next generation of clinical investigators focusing on patient-oriented research. Up to 50 percent effort (no less than 25 percent) of a full-time appointment for each 12-month budget period is expected for up to five years and is renewable for one time. No mentor is required. This RFA is a one-time solicitation. Future, unsolicited competing continuation applications for those eligible K mechanisms will compete with all investigator- initiated applications and be reviewed according to the customary peer review procedures. FUNDS AVAILABLE One million dollars will be set aside for this RFA. The earliest beginning date is expected to be September 30, 1999. It is anticipated that between eight and ten awards will be made as a result of this RFA. RESEARCH OBJECTIVES Background The Institute of Medicine, in its 1990 "A Report on Behavioral, Emotional, and Developmental Disorders in children and Adolescents," noted that the child mental health research field lagged the comparable area in adults by two or more decades. The principal reason for the relatively slow rate of progress has been the small number of well-trained investigators committed to research on child and adolescent mental disorders. The field of child and adolescent mental health needs a core group of investigators around which a more aggressive research effort can coalesce. Through this RFA, the NIMH hopes to enhance the cadre of outstanding investigators who can provide continuing leadership for vigorous research. Given the diversity of research needs and opportunities, no single specialty is sufficient to be the core, rather, that role needs to be shared among several disciplines that have distinct but overlapping areas of interest. Academic clinical settings are especially suitable for leadership roles because they have both patient populations and research capacity. Given the small numbers of child psychiatrists and psychologists who have been able to be recruited into child mental disorders research, the NIMH is interested in increasing the numbers of investigators able to conduct integrated research on basic biological questions, such as brain development, with clinical questions in studies of child and adolescent psychopathology. This RFA is designed both to encourage qualified applicants already involved in mental health research on children and adolescent mental disorders to continue their career development in this area as well as encourage individuals in other relevant disciplines, such as adult psychiatrists, developmental neurobiologists, psychologists with developmental and clinical backgrounds, social workers, special educators, pediatricians, nurses and other health professionals not currently involved in this research area, to broaden their foci in order to be able to conduct research on child and adolescent mental disorders. Research Areas of Interest Well-trained investigators are needed who can address problems of classification, course and outcome of mental disorders that afflict children and adolescents. Historically, clinical researchers, often with special training in epidemiology, have been in the forefront of contributing knowledge in these areas. However, much more work needs to be done in defining and assessing these conditions, characterizing their natural history, identifying risk factors and delineating variables of prognostic importance. More researchers are needed who can focus on a) epidemiology, diagnosis, treatment and prevention of these disorders, b) clinical service delivery and the effectiveness, outcome and dissemination of validated services models, and c) basic neuroscience and other biological and behavioral factors that can clarify the origins of these disorders and suggest new avenues for overcoming them. Examples of research areas of interest are presented below. These are only meant to be illustrative and not restrictive. Applicants should choose areas which are of greatest interest to them, which build on their current professional discipline and level of training, and which are in line with their long-range research career development goals. Risk Factors, Disorder Onset, Course of Disorder and Outcomes, and Opportunities for Prevention Research of interest includes factors underlying cognitive, emotional, social and brain development in children and adolescents that underlie problematic behaviors, maladjustment, psychopathology and diagnosed psychiatric disorder. Support will be provided for research on the biological, individual and environmental risk factors that contribute to the developmental course of psychopathology, the manifestations, assessment, classification, diagnosis and prognosis of disorders, family genetics and behavioral genetics, and development and refinement of scientific methods and tools for studying developmental psychopathology. Studies in these areas are especially applicable to the understanding of prevention of disorder onset as well as the prevention of secondary comorbidities and adverse outcomes. Given the extensive modifiability and plasticity of brain development and functioning during childhood and adolescence, NIMH is particularly interested in studies that address brain development and the multiple factors, which effect this process such as genetic and environmental factors. Also of great importance is the need for research to improve strategies in assessment of childhood psychopathology. As in all aspects of training, multidisciplinary perspectives can lead to clearer understanding of the complex interactions among developmental processes, intrinsic features of the child and environmental influences. Likewise, efforts are greatly needed to refine, discard or expand current nosologic or typologic theories. Such work can provide a foundation for development of preventive interventions, treatment models and service delivery for children and adolescents with mental disorders. Examples of specific research areas of interest include: o Affective and Anxiety Disorders (e.g., suicide, phobias, OCD), o Disruptive Behavior Disorders (e.g., conduct disorder, serious aggression, psychopathology), o Developmental Disorders (e.g., autism, learning disorders, aphasia, mental retardation), o Family and Interpersonal Risk Processes (e.g., neighborhood risk), o Early Influences on Socio-emotional Development (e.g., attachment, temperament, dysregulation), o Assessment and Nosology, o Identification of Potent Risk Factors Amenable to Prevention, o Identification of Critical Windows of Time for Intervention, o Methods Development, o Neuropsychology (e.g., neuroimaging, psychobiology), o Trauma (effects of violence, PTSD, effects of sexual abuse, resiliency to exposure), o Tourette"s Syndrome and o Effects of child abuse (physical, emotional or sexual abuse and/or neglect) on development of psychopathology and behavioral problems: studies which can contribute to the development and testing of effective interventions and services for maltreated children. Services, Treatment and Prevention Studies Studies on the organization, financing, delivery, effectiveness and appropriateness of mental health care in everyday settings are important for improving the effectiveness, efficiency and equity of mental health services (including preventive services) in community and other settings. Studies on pharmacoeconomics, pharmacoepidemiology, and the distribution, determinants and course of mental illness in the context of various clinical settings are also encouraged. Interventions on pharmacologic approaches (individual and combination medications), behavioral and psychotherapeutic approaches are encouraged. Also encouraged is research on individual and combined approaches, including acute, continuation and maintenance studies and long-term symptomatic management and improvement of functional status. Studies to establish the short and long term efficacy of interventions, to assess the effectiveness/cost effectiveness of interventions in standard or usual practice settings, and to develop treatment algorithms/strategies for improvement of clinical care are especially needed. Preventive intervention studies that are designed to reduce the occurrence of mental disorders, dysfunctions and related problems within asymptomatic and subclinical populations and those related to treatment (e.g., prevention of relapse, recurrence, inappropriate resource use) or side effects (prevention/minimization of tardive dyskinesia, etc.) are encouraged. A specially designated programmatic focus is in the area of suicide prevention. Neurobiology A comprehensive understanding of how the brain develops and matures, and of the factors that can regulate these fundamental processes, is central to advancing our understanding of the causes of child and adolescent mental disorders as well as to the development of effective treatments for these complex psychopathologies. For example, the brain is the organ of cognition and controls behavior. These functions are a result of the activity of many groups of nerve cells, the specific interconnections between them, and their specialized roles. Studies in developmental neuroscience aim to elucidate how these vital relationships are formed. Although there has been significant research activity in developmental neuroscience, many basic conceptual issues concerning the development and maturation of multiple brain regions are poorly understood. This is especially true for higher brain areas involved in mentation, cognition, and the control of emotion and behavior. Some of the key questions include how nerve cell types are determined, how many cells are generated, how they are organized, and how precise connections are formed among neurons that will collectively form the functioning nervous system. There is also a significant lack of understanding about the relationship between the neurobiological maturation of the brain and the emergence of human cognitive, emotional, and behavioral states. Other examples of specific research topics include: o Identification of genes which are involved in the development of the nervous system, and the mechanisms through which these genes are regulated, o Elucidation of the cellular and molecular determinants which participate in cell phenotype determination, o Identification of factors which may mediate neuronal differentiation, growth, and function, o Isolation, purification, and elucidation of the mechanisms of action of neurotrophic agents as they relate to cell survival or alter subsequent neuronal development and function, o Studies on the formation, overproduction, elimination, and stabilization of synaptic connections and the factors which regulate these events, o Examination of the role of cell death in the formation of brain regionalization and in response to cell injury. Identification of intrinsic and extrinsic mechanisms governing cell survival and growth, o Studies on the role of gonadal steroid hormones and their receptors on brain development, cell survival, and cellular signaling pathways, o Studies of the development of brain regions associated with higher cognitive functions and regions associated with emotion such as the limbic system and paralimbic cortex, o Studies on the sexual dimorphism in the brain and the developmental events and mechanisms leading to these differences, o Development of normative databases on brain development through childhood and adolescence in humans and primates, including cytoarchitectonic, morphometric, and functional changes, o Studies of the effects of the postnatal environment (e.g. stress) on neural structure and function, o Studies of neurodevelopmental processes implicated in mental illnesses, particularly schizophrenia and autism, o Identification of structural and functional neuroanatomical changes associated with or that predict illness onset (e.g. longitudinal studies of high risk individuals) and o Studies of postnatal brain maturation, particularly during adolescence. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research," which was published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts, Volume 23, Number 11, March 18, 1994, available on the web at: Investigators also may obtain copies of the policy from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that children (i.e., individuals under the age of 21) must be included in all human subjects research, conducted or supported by the NIH, unless thee are scientific and ethical reasons not to include them. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines on the Inclusion of Children as Participants in Research Involving Human Subjects" that was published in the NIH Guide for Grants and Contracts, March 6, 1998, and is available at the following URL address: LETTER OF INTENT Prospective applicants are asked to submit, by January 11, 1999, a letter of intent that includes a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator, the identities of other key personnel and participating institutions, and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows NIMH to estimate the potential review workload and avoid conflict of interest in the review. The letter of intent is to be sent to: Carolyn Strete, Ph.D. Division of Mental Disorders, Behavior and AIDS National Institute of Mental Health 5600 Fishers Lane, Room 18C-06 Rockville, MD 20857 Telephone: (301) 443-5944 FAX: (301) 443-0954 Email: APPLICATION PROCEDURES The research grant application form, PHS 398 (rev. 5/95), is to be used in applying for these grants. These forms are available at most institutional offices of sponsored research and from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 67001 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone (301) 710-0267, FAX (301) 480-0525, Email: GrantsInfo@NIH.GOV. The application must address the specific factors outlined in the selected K- Award program announcement and revised NIMH Policy on Career Awards. These may be obtained electronically through the NIMH Extramural Career Development Page: In addition, since the K02, K05 and K24 mechanisms require applicants to have other active support, candidates for these awards should include in the body of the application, a description of "other funded research", including the source, percent effort and any similarities/overlap with the proposed research to be conducted under the K-mechanism. Applicants should consult the appropriate program announcement and revised NIMH K-award policy statement regarding allowable costs under each award mechanism. Budget requests must be provided according to the instructions in form PHS 398, modified as described below: BUDGET INSTRUCTIONS The total direct costs must be requested in accordance with the K program guidelines, following the budget instructions described below. o DETAILED BUDGET FOR INITIAL BUDGET PERIOD Do not complete Form Page 4 of the PHS 398 (rev. 5/95). It is not required nor will it be accepted at the time of application. In some cases it may be requested prior to award. o BUDGET FOR ENTIRE PROPOSED PERIOD OF SUPPORT Do not complete the categorical budget table on Form Page 5 in the PHS 398 (rev. 5/95). Only the requested total direct costs for each year and total direct costs for the entire proposed period of support should be shown. Begin the budget justification in the space provided, using continuation pages as needed. o BUDGET JUSTIFICATION - Budget Justifications should be provided under "Justifications" on Form Page 5 of the PHS 398. - List the name, role on project and percent effort for all project personnel (salaried or unsalaried) and provide a narrative justification for each person based on his/her role on the project and proposed level of effort. - Identify all consultants by name and organizational affiliation and describe the services to be performed. - Provide a narrative justification for any major budget items, other than personnel, that are requested for the conduct of the project that would be considered unusual for the scope of research. No specific costs for items or categories should be shown. - Indirect costs will be calculated at the time of the award using the institution"s actual indirect cost rate. Applicants will be asked to identify the indirect cost exclusions prior to award. o CONSORTIUM/CONTRACTUAL COSTS If consortium/contractual costs are requested, provide the percentage of the subcontract total costs (direct and indirect) relative to the total direct costs of the overall project. The subcontract budget justification should be prepared following the instructions provided above. o BIOGRAPHICAL SKETCH A biographical sketch is required for all key personnel, following the modified instructions below. Do not exceed the two-page limit for each person. - Complete the education block at the top of the form page, - List current position(s) and those previous positions directly relevant to the application, - List selected peer-reviewed publications directly relevant to the proposed project, with full citation, - Provide information on research projects completed and/or research grants participated in during the last five years that are relevant to the proposed project. Title, principal investigator, funding source, and role on project must be provided. o CHECKLIST Do not submit the checklist page. For amended and competing continuation applications, applicants must complete the block in the upper right corner of the face page to indicate the previous grant number. A completed checklist will be required prior to award. o OTHER SUPPORT - Do not complete the other support page (format page 7 of the PHS 398 (rev. 5/95)). Information on active support for key personnel will be requested prior to award. These additional instructions for this section apply only to the following Mentored Career Awards: o Mentored Research Scientist Development Award (K01) o Scientist Development Award for New Minority Faculty (K01) o Mentored Clinical Scientist Development Award (K08) o Mentored Patient-Oriented Research Career Development Award (K23) It is still necessary to provide information about the research activity of the sponsor and co-sponsor on mentored career awards. Information about the level and nature of the research support of the sponsor(s) will continue to be used by review committees to judge the strength of the research environment available to the candidate during the award period. Applicants are to provide information on the sponsor"s and cosponsor"s current and pending research support relevant to the candidate"s research plan in a table within the section titled "Statement by the Sponsor(s) Consultant(s), and Collaborator(s)" in Section II, Part 2 of the application. Within this table, the following information on all related research projects must be provided: the funding source, the title of the project, the name of the Principal Investigator, the dates of the approved or proposed project, the annual direct costs, and a brief description of the major goals. The RFA label available in the PHS 398 (rev. 5/95) application form must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for the review. In addition, the RFA title and number must be typed in section 2 of the face page of the application and the YES box must be marked. Submit a signed, typewritten original of the application, including the Checklist and three signed photocopies, in one package to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040-MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) At the time of submission, two additional copies of the application must be sent to: Henry Haigler, Ph.D. Division of Extramural Activities National Institute of Mental Health 5600 Fishers Lane, Room 9C-02 Bethesda, MD 20857 Applications must be received by February 11, 1999. If an application is received after that date, it will be returned to the applicant without review. The Center for Scientific Review (CSR) will not accept any application in response to this RFA that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. The CSR will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of the substantial revisions of applications already reviewed, but such applications must include an introduction addressing the previous critique. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for completeness by the CSR and for responsiveness by NIMH staff. Incomplete and/or non-responsive applications will be returned to the applicant without further consideration. Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by an appropriate peer review group convened by the NIMH in accordance with the review criteria stated below. As part of the initial merit review, all applications will receive a written critique and may undergo a process in which only those applications deemed to have the highest scientific merit will be discussed, assigned a priority score, and receive a second level review by the National Advisory Mental Health Council. Review Criteria The specific review criteria outlined in the selected K-award program announcement will be applied. Factors to be judged, and which are spelled out in each announcement, include the candidate, the career development plan, the research plan, the mentor(s) (when applicable), the institutional environment and commitment and adequacy of the proposed budget. AWARD CRITERIA The NIMH will notify the applicant of the National Advisory Mental Health Council"s action shortly after its meeting. Funding decisions will be made based on the recommendations of the initial review group and Council, the need for research personnel in the specified research area and the availability of funds. INQUIRIES Inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to the staff cited under each scientific area below. Carolyn Strete, Ph.D. Division of Mental Disorders, Behavior and AIDS 5600 Fishers Lane, Room 18C-06 Rockville, MD 20857 Telephone: (301) 443-5945 FAX: (301) 443-0954 Email: Benedetto Vitiello, M.D. Division of Services and Intervention Research 5600 Fishers Lane, Room 10C-09 Rockville, MD 20857 Telephone: (301) 443-4283 FAX: (301) 443-4045 Email: Douglas L. Meinecke, Ph.D. Division of Basic and Clinical Neuroscience Research 5600 Fishers Lane, Room 11C-06 Rockville, MD 20857 Telephone: (301) 443-5288 FAX: (301) 443-4822 Email: Direct Inquiries regarding fiscal matters to: Diana S. Trunnell Grants Management Branch National Institute of Mental Health 5600 Fishers Lane, Room 7C-08 Rockville, MD 20857 Telephone: (301) 443-2805 FAX: (301) 443-6885 Email: AUTHORITY AND REGULATIONS This program is described in the catalog of Federal Domestic Assistance No. 93.281. Awards are made under authorization of the Public Health Service Act, title IV, Part A (public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. Awards will be administered under PHS grants policy as stated in the NIH Grants Policy Statement (October 1, 1998) and the NIMH Supplemental Policy Information for "K" programs (August 14, 1998). PHS strongly encourages all grant recipients to provide a smoke-free workplace and promote the nonuse of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.

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