January 30, 2018
March 6, 2018
March 6, 2018
April 6, 2018, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on this date.
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
April 7, 2018
It is critical that applicants follow the Research (R) Instructions in the SF424 (R&R) Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.
Applications that do not comply with these instructions will not be reviewed
Part 1. Overview Information
Part 2. Full Text of the Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information
The NIH recognizes a unique and compelling need to promote diversity in the NIH-funded biomedical, behavioral, clinical, and social sciences workforce. The NIH Research Education Program (R25) supports research educational activities that complement other formal training programs in the mission areas of the NIH Institutes and Centers. The overarching goals of the NIH R25 program are to: (1) complement and/or enhance the training of a workforce to meet the nation's biomedical, behavioral and clinical research needs; (2) enhance the diversity of the biomedical, behavioral and clinical research workforce; (3) help recruit individuals with specific specialty or disciplinary backgrounds to research careers in biomedical, behavioral and clinical sciences; and (4) foster a better understanding of biomedical, behavioral and clinical research and its implications. The National Heart, Lung, and Blood Institute (NHLBI), part of the NIH, provides global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases, and sleep disorders and enhance the health of all individuals so that they can live longer and more fulfilling lives. The NHLBI expects efforts to diversify the workforce to lead to the recruitment of the most talented researchers from all groups, improve the quality of the educational and training environment, balance and broaden the perspective in setting research priorities, improve the ability to recruit subjects from diverse backgrounds into clinical research protocols, and improve the Nation's capacity to address and eliminate health disparities.
The overarching goal of this National Heart, Lung, and Blood Institute (NHLBI) R25 program is to support mentoring and research education activities that enhance the diversity of the biomedical, behavioral and clinical research workforce. The major goal of this R25 program is to establish long-term mentoring that will enable junior faculty who are underrepresented in the biomedical sciences, as defined by NOT-OD-18-122, to develop a research program and obtain NIH funding. This FOA specifically invites applications from senior faculty, established researchers, and experienced mentors to develop and direct the Summer Institutes for the Programs to Increase Diversity Among Individuals Engaged in Health-Related Research (PRIDE) program in order to mentor promising eligible junior faculty who have specific scientific interests in heart, lung, blood and sleep (HLBS) disorders research.
To accomplish the overarching goal, this FOA will support creative educational activities with a primary focus on Research Experiences and Mentoring Activities (described below).
Success of the PRIDE Summer Institute program will be evaluated using the following metrics: aggregate number and demographic characteristics of participants; career progress of participants, including participation in independent research; employment and promotion in a research or research-related field; authorship of scientific publications in a STEM field; and independent research grant support from NIH or another source subsequent to participation in the PRIDE Summer Institute program.
Despite of tremendous advancements in scientific research, educational and research opportunities are not equally available to all. Individuals from racial and ethnic groups and individuals with disabilities have been shown by the National Science Foundation to be underrepresented in health-related sciences on a national basis (see the National Center for Science and Engineering Statistics (NCSES) Publications and Data page and the report, Women, Minorities, and Persons with Disabilities in Science and Engineering.) The continued need for increasing representation of individuals from underrepresented groups in the scientific workforce is also documented by national scientific bodies, including The American Physiological Society's research report, Undergraduate Research and Professional Societies: Partners in Increasing STEM Diversity, and The Road to the STEM Professoriate for Underrepresented Minorities from the American Institutes For Research.
Research mentoring and research education experiences through summer programs have been identified as a valid means for increasing diversity in the workforce (see Weaving a Richer Tapestry in Biomedical Science and The National Academies Report, Expanding Underrepresented Minority Participation).
Purpose and Description of the Program
The primary goal of the Summer Institutes (SIs) of the PRIDE program is to establish long-term mentoring that will enable junior faculty who are underrepresented in the biomedical sciences to develop a research program and obtain NIH funding. Through active involvement in research education and mentorship activities, program participants will further develop their skills and gain experience in advanced methods and experimental approaches in the basic and applied sciences relevant to the NHLBI. Ultimately, the enhanced skills gained from participation in the PRIDE program will contribute to mentees' career development as faculty members and scientists. SI programs have demonstrated efficacy for furtherance of participants' research careers for this target population (see Ethnicity & Disease. 2017 Jul 20;27(3):249-256 and Ethnicity & Disease. 2016 Summer; 26(3): 379–386).
This FOA specifically invites applications from senior faculty, established researchers, and experienced mentors to develop and direct SIs that will provide opportunities for skills development, research experiences, and mentoring to promising junior faculty and transitioning postdoctoral scientists who have received a formal, full-time, faculty appointment letter in hand by the time the SI program to which they are recruited is convened. In this FOA 'applicant' refers to the Principal Investigator(s) of the SI program, and 'mentees' refers to the junior faculty.
To facilitate coordination of the research education and evaluation activities among and between SI awardees and the NHLBI, this FOA runs in parallel with a separate FOA soliciting applications for a Coordination Center (CC) for the PRIDE program (described in detail in RFA-HL-19-001). SI applicants may apply to the CC FOA (RFA-HL-19-001) and vice versa; however, the PD/PI for the SI application must be different than the PD/PI for the CC application.
Research Education Objectives
This FOA will support the development, organization, and implementation of NHLBI mission-focused SI programs. The SI programs must be open to individuals nationwide who are from backgrounds identified by the National Institutes of Health as nationally underrepresented in the biomedical research workforce. SI applications must focus on the targeted underrepresented groups with plans to support enhancement of mentees' skills through focused research education and mentoring activities in NHLBI mission-relevant areas. NHLBI's mission-oriented goals are at the center of the NHLBI Strategic Vision and are discussed on the Strategic Goals and Objectives web page. It is intended that the SIs will be structured to provide research education activities related to research design, methodologies, skills and strategies important to preparing NIH research grants, as well as to provide mentorship on strategies for success and tips for obtaining external research funding related to HLBS disorders.
Applications submitted in response to this FOA must propose to develop an NHLBI mission-focused research education and mentoring SI program during the last quarter of 2018 and early part of 2019, and to implement the proposed SI program during the summers of 2019, 2020, 2021, 2022 and 2023 with appropriate modifications or refinements following each of the prior years. The CC will support the SI program as detailed in RFA-HL-19-001 and will facilitate cross-site collaborative activities.
This FOA therefore intends to support applicants who offer mentoring and research education experiences in one of the NHLBI mission-relevant disease areas (i.e., heart, lung, blood, or sleep disorders), or cross-cutting HLBS areas such as health disparities or implementation science. Applications characterized by innovation, scholarship, and responsiveness to the priorities and/or changing needs of the NHLBI in meeting its objectives as described in its Strategic Vision are of high programmatic interest.
Examples of relevant topic areas include but are not limited to:
Applications must contain the following to be considered responsive to this FOA. Non-responsive applications will not proceed to review.
Summer Institutes (SIs)
While the specifics of the SI program will be left to the applicant, this FOA will support a four-component program consisting of two consecutive summers of research enhancement and skills development activities, supplemented by mentoring and relevant research experiences occurring throughout the intervening and follow-up academic year.
The first component must be an initial summer session lasting from 10-28 days, which may be divided into more than one segment with mentees participating in multiple segments. The segments may involve classroom, laboratory, and/or field research activities. Topics for consideration may include instructional segments about the unique challenges related to conducting research and obtaining funding faced by researchers from underrepresented backgrounds, reviewing manuscripts, participating on grant review committees, research project management, and budgeting for research proposals.
The second component must consist of mentoring and networking activities that occur throughout the academic year following the first summer session. It is recommended that mentees and program mentors plan to commit at least 0.6 person months of their effort between the first and second year to mentoring and networking activities and research experiences. It is anticipated that, with the assistance of the CC, a mentorship committee tailored to the research pursuits of mentees will be developed for each individual mentee. The mentorship committee would ideally consist of experienced or senior faculty from the mentee's institution, from the SI, and/or other thought leaders, nationally. Applicants may want to consider how to leverage existing mentoring resources such as the NIH-funded National Research Mentoring Network or other similar resources to enhance the required mentoring committee. Mentoring plans can be designed for online, telephone, and/or in-person interactions. Mentoring activities may include assistance with career goal-setting, research design and statistical analysis, external funding, proposal development for submission, and mentored visits to the laboratory or research site of a mentor during the academic year.
It is anticipated that applications will propose at least one in-person mid-year mentoring meeting that can be held either during intervals between semesters, in conjunction with a conference, a three-day weekend during the winter, or at another appropriate time and location. Additional mentoring activities that could occur during the mid-year meeting include identifying appropriate grant mechanisms and funding agencies, review and feedback on draft research concepts or unfunded applications, and progress on funded and ongoing research projects.
The third component is a follow-up session that will be held the following summer (Summer Session 2) as a continuation of the first component of the program. It may be of a different duration than the first summer session. This second summer session could be held either at one location for all mentors and mentees, or each mentee could attend a summer session at the laboratory of their mentor(s). Activities could include developing and writing a grant application, holding a mock study section meeting, additional coursework on relevant topic areas, focused mentoring, or research projects progress updates.
A fourth component has been added to provide support for mentee-proposed small research projects (SRPs) to facilitate transition to research independence and possibly lead to subsequent NIH research grant applications. The SRP may not be a clinical trial. All mentees will have access to SRP funds, but the amount of funds for individual projects will differ depending upon the number of mentees recruited to each program. This component will generally occur between Summers 1 and 2 for each cohort beginning in Year 1. Oversight of this component would occur throughout the intervening year between Summer 1 and Summer 2, and updates on projects could be provided at the mid-year meetings or at Summer Session 2. Mentees could also present their research progress and findings at the consortium-wide PRIDE Annual Meetings.
NOTE: An optional, informational webinar session will be held for applicants prior to application submission and a Notice will be published in the NIH Guide to Grants and Contracts.
Research education programs may complement ongoing research training and education occurring at the applicant institution, but the proposed educational experiences must be distinct from those training and education programs currently receiving Federal support. R25 programs may augment institutional research training programs (e.g., T32, T90) but cannot be used to replace or circumvent Ruth L. Kirschstein National Research Service Award (NRSA) programs.
See Section VIII. Other Information for award authorities and regulations.
Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.
The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types.
Not allowed: Only accepting applications that do not propose clinical trials.
Note: Appointed Participants (mentees) are permitted to obtain research experience in NIH-funded clinical trials led by a mentor or co-mentor.
NHLBI intends to commit $3.11 million per year from FY2019-FY2023 (Year 1-5) to fund up to nine awards for the SI programs. NHLBI also intends to commit 1.12 million per year from FY2019-FY2022 (Year 1-4) to support small research projects (SRPs) for the PRIDE mentees.
Although the size of SI award may vary with the scope of the research education program proposed, awards must not exceed the following budgetary limits:
Direct costs for each Summer Institute (SI) program may be up to $320,000 per year for each of the five years. Direct costs for the mentee small research project (SRP) component may be up to $115,000 per year for each of the four years allowed. Total direct costs for the SI Program plus the SRP component may not exceed $435,000 per year for years 1-4. Total direct costs for the SI program may not exceed $320,000 in Year 5 and should not include an SRP component. F&A is limited to 8% of direct costs.
The project period is 5 years.
Individuals designing, directing, and implementing the research education program may request salary and fringe benefits appropriate for the person months devoted to the program. Salaries requested may not exceed the levels commensurate with the institution's policy for similar positions and may not exceed the congressionally mandated cap. (If mentoring interactions and other activities with participants are considered a regular part of an individual's academic duties, then any costs associated with the mentoring and other interactions with participants are not allowable costs from grant funds).
Mentee costs must be justified as specifically required for the execution of the proposed activities of the program. Mentee costs must be itemized in the Research & Related Budget. Mentees in the program may receive funds to defray meals, lodging, and travel expenses. Tuition is not allowed and stipends are not allowed. SRP funds may not be used for tuition or coursework.
Because the R25 program is not intended as a substitute for an NRSA institutional training program (e.g., T32), costs to support full-time mentees (supported for 40 hours/week for a continuous, 12-month period) are not allowable.
Expenses for foreign travel are not allowed.
Individuals supported by NIH training and career development mechanisms except for those specified in NOT-OD-11-026 may receive, and indeed are encouraged to receive, educational experiences supported by an R25 program as mentees, but may not receive salary or stipend supplementation from a research education program.
Consultant costs, equipment, supplies, travel for key persons, and other program-related expenses may be included in the proposed budget. These expenses must be justified as specifically required by the proposed program and must not duplicate items generally available at the applicant institution. Costs to support mentor participation in the program may also be included in the proposed budget. Costs for administration of the small research projects (SRP) component may also be included in the proposed budget.
Indirect Costs (also known as Facilities & Administrative [F&A] Costs) are reimbursed at 8% of modified total direct costs (exclusive of tuition and fees and expenditures for equipment), rather than on the basis of a negotiated rate agreement.
NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this FOA.
Higher Education Institutions
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
sponsoring institution must assure support for the proposed program.
Appropriate institutional commitment to the program includes the provision of
adequate staff, facilities, letter of
support and educational resources that
can contribute to the planned program.
Institutions with existing Ruth L. Kirschstein National Research Service Award (NRSA) institutional training grants (e.g., T32) or other Federally funded training programs may apply for a research education grant provided that the proposed educational experiences are distinct from those training programs receiving federal support. In many cases, it is anticipated that the proposed research education program will complement ongoing research training occurring at the applicant institution.
Non-domestic (non-U.S.) Entities (Foreign Institutions) are
not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.
Program Directors/Principal Investigators (PD(s)/PI(s))
All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.
Any individual(s) with the skills, knowledge, and resources
necessary to carry out the proposed research as the Program Director(s)/Principal
Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to
develop an application for support. Individuals from diverse backgrounds,
including underrepresented racial and ethnic groups, individuals with
disabilities, and women are always encouraged to apply for NIH support.
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.
The PD/PI should be an established investigator in the scientific area in which the application is targeted and capable of providing both administrative and scientific leadership to the development and implementation of the proposed program. The PD/PI will be expected to monitor and assess the program and submit all documents and reports as required.
This FOA specifically invites applications from senior faculty, established researchers, and experienced mentors to direct the SIs of the PRIDE program and to provide research education and mentorship experiences for junior faculty who are underrepresented in the biomedical sciences as defined by NOT-OD-18-122. The PD/PI should be an established investigator in the HLBS scientific area to which the application is targeted and capable of providing both administrative and scientific leadership to the development and implementation of the PRIDE research education program, or of providing evidence of a team that has these capabilities. The PD/PI team should also have scientific leadership and background in HLBS topic areas, or expertise in specialized research techniques, methodologies or cross-cutting approaches relevant to HLBS scientific areas as evidenced by scientific publications and a record of peer-reviewed scientific support. The PD/PI or the PD/PI team must also have experience and leadership in mentoring and have a strong record of providing research education and mentorship experiences to individuals underrepresented in the biomedical sciences. A PD/PI with strong scientific experience and expertise could partner with a Program Administrator at their institution who has mentorship and leadership experience, or vice versa to fulfill the requirements for leadership of this program.
This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.
Applicant organizations may submit more than one application, provided that each application is scientifically distinct. Only one SI application per institution will be funded per DUNS number.
The NIH will not accept duplicate or highly overlapping applications under review at the same time. This means that the NIH will not accept:
Any qualified researcher can participate as a mentor. However, researchers from nationally underrepresented backgrounds, including racial and ethnic minorities, persons with disabilities, and women are particularly encouraged to participate as mentors. Mentors should have research expertise and experience relevant to NHLBI mission areas and the proposed SI program. Mentors must be committed to continuing their involvement throughout the total period of the mentee's participation in this program.
SI PD/PIs are expected to recruit mentors nationally who are experts in the HLBS program area targeted by their SI programs. Mentors may be from the mentees' institutions, the SI-sponsoring institution, and/or other institutions as necessary to complement the needed expertise for the mentees' career goals. SI faculty are expected to have significant prior mentoring and research educational/training experience.
Eligible mentees for the PRIDE program are those who are junior faculty and who meet the diversity eligibility requirements. Diversity programs support individuals from groups that have been identified as underrepresented in the biomedical, clinical, behavioral and social sciences, such as:
A. Individuals from racial and ethnic groups that have been shown by the National Science Foundation (NSF) to be underrepresented in health-related sciences on a national basis (see Publications and Data from the National Center for Science and Engineering Statistics and the report Women, Minorities, and Persons with Disabilities in Science and Engineering). The following racial and ethnic groups have been shown to be underrepresented in biomedical research: Blacks or African Americans, Hispanics or Latinos, American Indians or Alaska Natives, Native Hawaiians and other Pacific Islanders.
B. Individuals with disabilities, defined as those with a physical or mental impairment that substantially limits one or more major life activities as described in the Americans with Disabilities Act of 1990 as amended. See Data on Women, Minorities, and Persons with Disabilities in Science and Engineering from the NSF.
C. Individuals from disadvantaged backgrounds, defined as:
1. Individuals who come from a family with an annual income below established low-income thresholds. These thresholds are based on family size and are published by the U.S. Bureau of the Census; are adjusted annually for changes in the Consumer Price Index; and are adjusted by the Secretary for use in all health professions programs. The Secretary periodically publishes these income levels at http://aspe.hhs.gov/poverty/index.shtml.
2. Individuals who come from an educational environment such as that found in certain rural or inner-city environments that has demonstrably and directly inhibited the individual from obtaining the knowledge, skills, and abilities necessary to develop and participate in a research career.
The disadvantaged background category (C1 and C2) is applicable to programs focused on high school and undergraduate candidates. Since eligible mentees for this program must be junior faculty, individuals from Category C are not eligible for participation.
Literature shows that women from the above backgrounds (categories A, B, and C) face particular challenges at the graduate level and beyond in scientific fields (see Inside the Double Bind, A Synthesis of Empirical Research on Undergraduate and Graduate Women of Color in Science, Technology, Engineering, and Mathematics). Women have been shown to be underrepresented in doctorate-granting research institutions at senior faculty levels in most biomedical-relevant disciplines, and may also be underrepresented at other faculty levels in some scientific disciplines (see data from the National Center for Science and Engineering Statistics: Women, Minorities, and Persons with Disabilities in Science and Engineering special report, especially the table describing science, engineering, and health doctorate holders employed in universities and 4-year colleges, by broad occupation, sex, years since doctorate, and faculty rank (Table 9-23 of Special Report NSF 13-304 from 2013).
In planning their mentee pool, applicants to this FOA should note that potential mentees may not participate in this program if they are currently appointed to certain research education awards, or if they hold an individual fellowship or an NIH independent research award or equivalent. To be considered for matriculation into the PRIDE program, eligible mentees must submit a letter of support from their department chair or dean that includes a commitment to research time for the mentee; at least 0.6 person months for mentorship activities during the academic year and at least 0.6 person months during the summer to attend the SI sessions (see requirements under Letters of Support).
This research education program is to be used for the education of U.S. citizens and permanent residents who are from the identified targeted groups.
Buttons to access the online ASSIST system or to download application forms are available in Part 1 of this FOA. See your administrative office for instructions if you plan to use an institutional system-to-system solution.
It is critical that applicants follow the Research (R) Instructions in the SF424 (R&R) Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions will not be reviewed.
For information on Application Submission and Receipt, visit Frequently Asked Questions – Application Guide, Electronic Submission of Grant Applications.
Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.
By the date listed in Part 1. Overview Information, prospective applicants are asked to submit a letter of intent that includes the following information:
The letter of intent should be sent to:
Director, Office of Scientific Review
Division of Extramural Research Activities
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, Room 7214
Bethesda, MD 20892-7924 (Express zip 20817)
All page limitations described in the SF424 (R&R) Application Guide and the Table of Page Limits must be followed.
Instructions for Application Submission
The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this FOA.
Follow all instructions provided in the SF424 (R&R) Application Guide.
Follow all instructions provided in the SF424 (R&R) Application Guide. Note that if multiple sites are involved in the research education program, the applicant institution must be the primary site for the program.
Follow all instructions provided in the SF424 (R&R) Application Guide with the following additional modifications:
Facilities & Other Resources. Describe the educational environment, including the facilities, laboratories, participating departments, computer services, and any other resources to be used in the development and implementation of the proposed program. List all thematically related sources of support for research training and education following the format for Current and Pending Support.
Follow all instructions provided in the SF424 (R&R) Application Guide. NOTE: Key Personnel include the PD/PI (or multiple PDs/PIs, if applicable), as well as any other key persons (such as those involved in developing, implementing, directing, monitoring, evaluating, etc., who are integral to the proposed research education program) who will be participating in the research education program.
Follow all instructions provided in the SF424 (R&R) Application Guide with the following additional modifications:
Include all personnel other than the PD(s)/PI(s) in the Other Personnel section, including clerical and administrative staff.
o SI programs are extended face-to-face meetings, and as such, applicants should budget for travel, lodging, and meals for all mentees from their home institutions to the site of the SI; for necessities of meeting logistics including meeting space; and should provide travel, lodging, and meals for mentors.
o SI mentees should also have one mid-year face-to-face meeting with a mentor. If mentees or mentors are anticipated to travel for this meeting, the application should include the cost for travel.
o SI applications should use the Other Program Related Expense section to request support for the SRP component. A budgeted line item labeled "Small Research Project" may request up to $115,000 per year in total direct costs plus F&A for this component. F&A costs for this component are capped at 8%. The total SRP funds will be provided directly to SI awardees as part of their annual award but will be designated exclusively for the support of SRPs for the SI mentees. The actual amounts to be disbursed for each SRP will depend on the project cost(s) and study aims but must not be less than $10,800 and not more than $54,000 including 8% F&A. The CC, SI, and NHLBI program office will work collaboratively to develop the review and selection process for meritorious SRPs eligible for support from each SI. In consultation with the NHLBI, the SIs will manage the disbursement of funds for the SRP projects and provide post-award scientific oversight.
It is expected that the PD/PI will provide a minimum of 1.8 person months during the academic year and 1.5 to 2.25 person months during the summer. It is expected that the Program Administrator will provide a minimum of 1.6 person months during the academic year and 2.25 to 3 person months during the summer.
Follow all instructions provided in the SF424 (R&R) Application Guide.
All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:
The Research Strategy section must be used to upload the Research Education Program Plan, which must include the following components described below:
Research Education Program Plan
Proposed Research Education Program. While the proposed research education program may complement ongoing research training and education occurring at the applicant institution, the proposed educational experiences must be distinct from those research training and research education programs currently receiving federal support. When research training programs are on-going in the same department, the applicant organization should clearly distinguish between the activities in the proposed research education program and the research training supported by the training program. The research education program plan description should include the educational and career level(s) of the planned mentees. Each SI applicant must propose to design, organize, and implement an SI program that targets junior faculty and transitioning postdoctoral scientists who are underrepresented in the biomedical sciences (as defined by NOT-OD-18-122)
and must be opened nationwide. Each awardee must hold two consecutive summer programs for four separate cohorts, as illustrated by the PRIDE timeline below.
Quarter 1 Fall/Winter
Quarter 2 Winter/Spring
Quarter 3 Spring
Quarter 4 Summer
Program Development/ Recruitment Cohort 1
Completion of Recruitment Cohort 1
SI program Implementation
Cohort 1 (Summer Session 1)
Recruitment of Cohort 2
Recruitment of Cohort 2
Completion of Recruitment of Cohort 2
SI program Implementation
Cohort 1 (Summer Session 2) and Cohort 2 (Summer Session 1)
Recruitment of Cohort 3
Recruitment of Cohort 3
Completion of Recruitment of Cohort 3
SI program Implementation
Cohort 2 (Summer Session 2) and Cohort 3 (Summer Session 1)
Recruitment of Cohort 4
Recruitment of Cohort 4
Completion of Recruitment of Cohort 4
SI program Implementation
Cohort 3 (Summer Session 2) and Cohort 4 (Summer Session 1)
Continuation of SI Activities
Continuation of SI Activities
Continuation of SI Activities
Cohort 4 (Summer Session 2) and Program Close Out
SI awardees will begin developing their program during the last quarter of 2018 and subsequently implement it during the summers of 2019, 2020, 2021, 2022, and 2023 with appropriate modifications or refinements following each of the prior years. The SI programs will run from fiscal year 2019 through fiscal year 2023. The SI awardees will collaborate with the CC (described in RFA-HL-19-001) to implement and execute the PRIDE program as a whole.
The specifics of the individual SI program will be left to the applicants, but NHLBI anticipates a program consisting of four components as described below:
Component One: An initial summer session lasting from 10-28 days, and
Component Three: A follow-up session (Summer Session 2) to be held the following summer as a continuation of the first component of the program (Summer Session I).
Component Four: A SI site-specific small research project (SRP) component plan that includes
For the SRP component, types of mentee research studies that can be supported by the SRP funds are limited to, a) ancillary studies to an NIH-funded and registered clinical trial (no independent, NIH-defined clinical trial can be supported), and b) independent, non-clinical trial research studies. These non-clinical trial resesarch studies do not have to be attached to an NIH-funded study and can be qualitative/formative studies such as focus groups, interviews, surveys etc., or basic science studies not involving humans. All studies must focus on an NHLBI mission interest area or cross-cutting methodological area in an NHLBI area of scientific focus. See Does your human subjects research study meet the NIH Definition of a clinical trial? and NOT-OD-15-015 for the NIH definition of clinical trials and clinical research studies.
Details of the SRP fund administration and how meritorious SRPs will be selected will be decided once the consortium of SIs and CC is convened. Briefly, the consortium of SIs will work collaboratively with NHLBI Program staff and the CC to develop the plan for soliciting mentees' proposals from the SI sites, and for reviewing and selecting meritorious projects. The SIs will then work with their mentees to submit competitive projects for consideration to the consortium (inclusive of SI, CC and NHLBI Program Office). Once meritorious projects are selected, the SIs will manage the distribution of the funds to their mentees' SRPs from their budgets. SIs must be able to subcontract to other institutions of higher education or must demonstrate intent to create appropriate subcontractual agreements as needed to support the mentee SRP awards from their institution. The CC and NHLBI Program Office will work collaboratively for the administrative management of this component.
In describing their program plan, applicants should indicate how the implementation of the proposed program will advance the objectives of this FOA and the mission of the NHLBI.
The SI programs are designed for junior faculty and transitioning postdoctoral scientists who are underrepresented in the biomedical sciences. Postdoctoral mentees must have received a formal, full-time faculty appointment letter in hand by the time the SI program to which they are recruited is convened.
Applications must describe the intended mentees, and/or specific educational background characteristics that are essential for participation in the proposed SI program. The applications must identify the career levels essential for participation in the planned program. All mentees in the PRIDE program are expected to be junior faculty or postdoctoral scientists transitioning to an academic research career with documented letters of appointment, and demonstrated commitment to heart, lung, blood or sleep disorders research. Mentees must also hold research doctoral degrees such as a PhD, MD, MBBS, DO, Ed.D., or equivalent.
Each year, PRIDE SI awardees are encouraged to enroll a cohort of up to 14 but no less than 8 eligible mentees in their programs. Each awardee will execute an SI program, consisting of the four program components described above, for four separate cohorts, as illustrated by the PRIDE timeline. The CC (described in RFA-HL-19-001) will work with the SI programs to facilitate recruitment and screening of candidates and achievement of recruitment goals.
SI awardees will begin developing their program during the last quarter of 2018 and will conclude it in the summer of 2023. The SI programs will run from fiscal year 2019 through fiscal year 2023. The SI awardees will collaborate with the CC to implement and administer the PRIDE program.
Applicants should describe how they will work with the CC to recruit and select eligible participants who have a demonstrated commitment to HLBS disorders research. Applicants should also describe plans to secure, as part of matriculation, a Letter of Support from the mentee's department chair or dean, in support for protected time to participate in the SI research education and mentoring activities. Expected commitment includes research time of at least 0.45 (for 9-month appointment) to 0.6 (for 12-month appointment) person months for mentorship activities during the academic year and at least 2.97 (for 9-month appointment) to 3.96 (for 12-month appointment) person months for SRP participants and to attend the SI sessions and mid-year meetings. If awarded an SRP grant, mentees' institutions must also include plans to secure a Letter of Support for protected research time for the conduct of the SRP. Applicants' institutions must also describe their commitment to provide oversight for the SRP component. For applications proposing joint institutional partnerships, applicants should delineate which of the required elements will be provided by each institution.
Each SI must propose a robust evaluation protocol and describe plans to independently evaluate their own SI programs. The proposed evaluation protocol should include a timeline and specific and detailed plans for evaluation of both the program mentees and mentors. The evaluation plan must assess the effectiveness of the program in terms of the mentees' perceptions of the curriculum and conduct of the program, as well as the longer-term impact, as measured by mentees' success in receipt of external funding from NIH, other government agencies, or private foundations. The desired outcome of the PRIDE program is for each mentee to submit an NIH grant application within two years of completing the program. The evaluation plan should also include an assessment of the overall performance of the SRP component and must be ongoing to permit evidence-based modification of specific (e.g., recruitment strategies) or comprehensive program activities. The CC will work collaboratively with the SIs to coordinate common measures for the site-specific evaluation protocols and will facilitate ongoing follow-up and evaluation of the PRIDE program overall. Annual evaluation data must be provided with the non-competing continuation application and a summary of the final evaluation must be provided to the NHLBI as part of the final report.
After this 5-year program cycle, NHLBI will review the overall success of the entire PRIDE program to determine whether to continue funding it as currently configured. This review will be distinct from the individual reviews that take place under the auspices of the annual Progress Report. NHLBI will consider: a) the duration of the program, given programmatic goals and how long it may take for results or meeting outcomes to manifest; and whether to b) continue the program as currently configured after the sunset period and review; or c) continue the program with modifications after the sunset period and review, or d) discontinue the program after sunset and review period. Discontinuation of the program is a policy option that will be made at the discretion of NHLBI.
SI sessions are extended face-to-face meetings. Applicants should provide a detailed plan that includes a description of the structure of planned summer session meetings and the topic areas that will be covered during research education activities. Applicants should provide sample meeting itineraries that may include: anticipated topics of discussion; preliminary schedule and anticipated duration of each session; proposed mechanism(s) to garner attendee feedback on session impact and value; proposed mechanism(s)/metrics to evaluate meeting success. Without repeating information provided under the R&R budget, describe plans regarding expected logistics (i.e., appropriate budget to cover travel, lodging, and meals for all mentees and mentors from their home institutions to the site of the SI) and logistics related to the anticipated budget for mentees' mid-year face-to-face meetings with mentors, including travel expenses, if applicable.
In addition to the meeting during the SI sessions, SI Program Directors and staff, mentees, mentors, the CC Director and staff, and the NHLBI program staff will meet annually in the Washington, D.C. metro area. In all, there will be five (annual) in-person meetings across the five-year funding cycle. The first meeting will be a one-day face to face kick-off meeting involving SIs, CC, and NHLBI program staff. The remaining four meetings will be the 2-3-day program-wide annual meetings involving SIs, CC and NHLBI program staff, mentees and mentors. SI applicants should also plan for an additional one-day virtual meeting with their staff, mentors, the CC and the NHLBI program office staff annually.
At least one in-person mid-year meeting must be held for the mentees and mentors either during intervals between semesters, in conjunction with a conference, or a three-day weekend during the winter, or at another appropriate time and location. Applicants should provide a written description that includes planned activities that will be the focus of the mid-year meeting. Examples include:
Program Director/Principal Investigator
Describe arrangements for administration of the program. Provide evidence that the PD/PI is actively engaged in research and/or teaching in an area related to the mission of NIH, and can organize, administer, monitor, and evaluate the research education program. For programs proposing multiple PDs/PIs, describe the complementary and integrated expertise of the PDs/PIs, their leadership approach, and governance appropriate for the planned project. PDs/PIs or PD/PI teams should provide evidence of expertise in NHLBI scientific mission areas and evidence of complementary mentoring, teaching and administrative skills that will foster successful implementation of the proposed SI program.
Researchers from diverse backgrounds, including racial and ethnic minorities, persons with disabilities, and women are encouraged to participate as program faculty. Faculty should have research expertise and experience relevant to the proposed program and demonstrate a history of, or the potential for, their intended roles. Program faculty/mentors should have expertise in areas relevant to NHLBI scientific mission. Any qualified researcher can participate as a mentor. However, researchers from diverse backgrounds, including racial and ethnic minorities, persons with disabilities, and women are particularly encouraged to participate as mentors. Mentors must be committed to continue their involvement throughout the total period of the mentees' participation in the program. SI applicants are expected to work with the CC to identify and recruit mentors nationally who are experts in the NHLBI program focus areas described in their application. SI faculty are expected to have significant prior mentoring and educational/training experience as well.
Applications must describe the intended participants, and the eligibility criteria and/or specific educational background characteristics that are essential for participation in the proposed research education program. Identify the career levels for which the proposed program is planned. All mentees of the PRIDE program must meet the diversity eligibility requirements; be junior faculty or transitioning postdoctoral scientists who have received formal, full-time faculty appointment letter in hand by the time the SI program to which they are recruited is convened; and demonstrate primary commitment/interest to HLBS disorders research or relevant cross-cutting areas such as HLBS health disparities research or HLBS-focused implementation science research. Mentees without definite HLBS scientific focus are not eligible as participants for the NHLBI-funded PRIDE program.
Institutional Environment and Commitment
Describe the institutional environment, reiterating the availability of facilities and educational resources (described separately under "Facilities & Other Resources"), that can contribute to the planned Research Education Program. Evidence of institutional commitment to the research educational program is required. A letter of institutional commitment must be attached as part of Letters of Support (see below). Appropriate institutional commitment should include the provision of adequate staff, facilities, and educational resources that can contribute to the planned research education program. Because the major goal of this NHLBI R25 program is to enable junior faculty and transitioning postdoctoral scientists who are underrepresented in the biomedical sciences to enhance research skills, develop a research program, and obtain NIH funding, the application should describe the institutional commitment that will foster the ability of the participant to achieve this goal.
Recruitment Plan to Enhance Diversity: Fostering diversity in the scientific research workforce is a key component of the NIH strategy to identify, develop, support and maintain the quality of our scientific human capital (NOT-OD-18-122).
New applications must include a description of plans to enhance recruitment, including the strategies that will be used to enhance the recruitment of trainees from nationally underrepresented backgrounds and may wish to include data in support of past accomplishments.
Renewal applications must include a detailed account of experiences in recruiting individuals nationally from underrepresented groups during the previous funding period, including successful and unsuccessful recruitment strategies. Information should be included on how the proposed plan reflects the program's past experiences in recruiting individuals from underrepresented groups.
For those individuals who
participated in the research education program, the report should include
information about the duration of education and aggregate information on the
number of individuals who finished the program in good standing. Additional
information on the required Recruitment Plan to Enhance Diversity is available
at Frequently Asked Questions: Recruitment Plan to Enhance Diversity (Diversity
Applications lacking a diversity recruitment plan will not be reviewed.
Plan for Instruction in the Responsible Conduct of Research. All applications must include a plan to fulfill NIH requirements for instruction in the Responsible Conduct of Research (RCR). The plan must address the five required instructional components outlined in the NIH policy: 1) Format - the required format of instruction, i.e., face-to-face lectures, coursework, and/or real-time discussion groups (a plan with only on-line instruction is not acceptable); 2) Subject Matter - the breadth of subject matter, e.g., conflict of interest, authorship, data management, human subjects and animal use, laboratory safety, research misconduct, research ethics; 3) Faculty Participation - the role of the program faculty in the instruction; 4) Duration of Instruction - the number of contact hours of instruction, taking into consideration the duration of the program; and 5) Frequency of Instruction – instruction must occur during each career stage and at least once every four years. See also NOT-OD-10-019. The plan should be appropriate and reasonable for the nature and duration of the proposed program. Renewal (Type 2) applications must, in addition, describe any changes in formal instruction over the past project period and plans to address any weaknesses in the current instruction plan. All participating faculty who served as course directors, speakers, lecturers, and/or discussion leaders during the past project period must be named in the application.
an application is received without the plan to fulfill NIH requirements for instruction in the
Responsible Conduct of Research (RCR), it will be considered non-responsive and will returned
Evaluation Plan. Each application must include a plan for evaluating the activities proposed for the SI including the mentees and mentors. The application must specify baseline metrics (e.g., numbers, educational levels, and demographic characteristics of mentees), as well as measures to gauge the short and long-term success of the research education award in achieving its objectives. Wherever appropriate, applicants are encouraged to obtain feedback from mentees to help identify weaknesses and to provide suggestions for improvements.
Other specific details to be addressed in the evaluation plan include: mentees' perceptions of the curriculum, conduct of the program, and longer-term impact as measured by mentees' success in receipt of external funding from government agencies or private foundations.
The primary desired outcome of the PRIDE program is for each mentee to submit an NIH grant application or equivalent which focuses on an HLBS disorder within two years of completing the program. To this end, mentees accepted into the program must demonstrate and evidence commitment to NHLBI scientific areas of interest and must maintain an NHLBI mission focus of research interest throughout their participation in the program as a key condition of selection into any of the SI programs. Other desired outcomes are that mentees will further the progress of their academic research careers as evidenced by peer-reviewed scientific publications, scientific presentations, research scholarship and service, or receipt of non-NIH grants and promotions. Thus, aside from maintaining focus on an NHLBI mission focused research area, the evaluation metrics for the program include the following: aggregate number and demographic characteristics of participants; career progress of participants, including participation in independent research, employment and promotion in a research or research-related field, authorship of scientific publications in a STEM field, and independent research grant support from NIH or another source subsequent to participation in the PRIDE program.
Evaluation must be ongoing to permit evidence-based modification of the program or specific activities of the program (e.g., changing recruitment strategies). Annual evaluation data must be provided with the non-competing continuation application and a summary of the final evaluations must be provided to the NHLBI as part of the final report. The CC will facilitate ongoing follow-up and evaluation of the overall program.
If an application is received without an evaluation plan, it will be considered non-responsive and will returned without review.
Dissemination Plan. A specific plan must be provided to disseminate nationally any findings resulting from or materials developed under the auspices of the research education program, e.g., sharing course curricula and related materials via web postings, presentations at scientific meetings, workshops.
Letters of Support
A letter of institutional commitment must be attached as part of Letters of Support (see section above: "Institutional Environment and Commitment)." The Letter of Support from the applicant institution must demonstrate the intent to host the SI program if awarded. The Letter of Support must include the provision that mentors and mentees will have access to facilities, such as classrooms, research laboratories, computers, dormitories, food service, and some leisure off-time activities as appropriate for the program being proposed. Include a justification for the use of any site(s) other than the applicant institution. Additionally, the letter must commit facilities as appropriate and include institutional acceptance to provide scientific oversight for the small research project component if the SI mentees are awarded funds. The Letter of Support should also indicate the institution's ability to subcontract, or describe its intent to develop appropriate subcontracting relationships with institutions of higher education from which mentees are recruited. Applicants must also describe how the PRIDE program complements but does not duplicate other ongoing training efforts at the institution and should evidence appropriate collaboration among participating programs, departments, and institutions as well as indicate institutional commitment to the proposed SI program. The Letter of Support must also indicate the plan to recruit and select junior faculty and transitioning postdoctoral scientists (with a formal, full-time faculty appointment letter in hand by the time the SI program is convened) from underrepresented backgrounds. If an application is received without the requested Letter(s) of Support, it will be considered non-responsive and will returned without review.
Resource Sharing Plans
Individuals are required to comply with the instructions for the Resource Sharing Plan as provided in the SF424 (R&R) Application Guide, with the following Guide modification:
When relevant, applications are expected to include a software dissemination plan if support for development, maintenance, or enhancement of software is requested in the application. There is no prescribed single license for software produced. However, the software dissemination plan should address, as appropriate, the following goals:
Only limited Appendix materials are allowed. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide.
When involving NIH-defined human subjects research, clinical research, and/or clinical trials (and when applicable, clinical trials research experience) follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the SF424 (R&R) Application Guide, with the following additional instructions:
If you answered "Yes" to the question "Are Human Subjects Involved?" on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or Delayed Onset Study record.
Study Record: PHS Human Subjects and Clinical Trials Information
All instructions in the SF424 (R&R) Application Guide must be followed with the following additional instructions:
Delayed Onset Study
All instructions in the SF424 (R&R) Application Guide must be followed.
All instructions in the SF424 (R&R) Application Guide must be followed.
See Part 1. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov
Part I. Overview Information contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.
Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH's electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Policy on Late Application Submission.
responsible for viewing their application before the due date in the eRA
Commons to ensure accurate and successful submission.
Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.
This initiative is not subject to intergovernmental review.
All NIH awards are subject to the terms and conditions, cost
principles, and other considerations described in the NIH
Grants Policy Statement.
Pre-award costs are allowable only as described in the NIH Grants Policy Statement.
SRP designated funds can only be used for mentees' research projects and not for any other program-related cost.
Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. Paper applications will not be accepted.
Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.
For assistance with your electronic application or for more information on the electronic submission process, visit Applying Electronically. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Guidelines for Applicants Experiencing System Issues. For assistance with application submission, contact the Application Submission Contacts in Section VII.
All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF424(R&R) Application Package. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.
The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization's profile in the eRA Commons and for the System for Award Management (SAM). Additional information may be found in the SF424 (R&R) Application Guide.
See more tips for avoiding common errors.
Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review and responsiveness by components of participating organizations, NIH. Applications that are incomplete, non-compliant and/or nonresponsive will not be reviewed.
Applicants are required to follow the instructions for post-submission materials, as described in the policy. Any instructions provided here are in addition to the instructions in the policy. Please see NOT-OD-17-066.
Only the review criteria described below will be considered in the review process. As part of the NIH mission, all applications submitted to the NIH in support of biomedical, behavioral, and clinical research are evaluated for scientific and technical merit through the NIH peer review system.
For this announcement, note the following:
The goal of this Research Education Program (R25) program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce. The major goal of this R25 program is to establish long-term mentoring that will enable junior faculty and transitioning postdoctoral scientists who are underrepresented in the biomedical sciences (as defined by NOT-OD-18-122) to develop a research program and obtain NIH funding. This FOA specifically invites applications from senior faculty, established researchers, and experienced mentors to develop and direct the SIs of the PRIDE program in order to mentor promising eligible junior faculty and transitioning postdoctoral scientists with a formal full-time faculty appointment letter in hand who have specific scientific interests in heart, lung, blood and sleep (HLBS) disorders research.
Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to strongly advance research education by fulfilling the goal of this R25 Education Program, in consideration of the following review criteria and additional review criteria, as applicable for the project proposed.
Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact.
Does the proposed program address a key audience and an important aspect or important need in research education? Is there convincing evidence in the application that the proposed program will significantly advance the stated goal of the program?
Specific to this FOA:
This FOA intends to support applications that propose to design, organize, and implement NHLBI-mission-focused SI programs that will be opened to individuals nationwide, who are from backgrounds identified by the National Institutes of Health as nationally underrepresented in the biomedical research workforce. How likely is implementation of the proposed program to advance the objectives of this FOA?
Is the PD/PI capable of providing both administrative and scientific leadership to the development and implementation of the proposed program? Is there evidence that an appropriate level of effort will be devoted by the program leadership to ensure the program's intended goal is accomplished? If applicable, is there evidence that the participating faculty have experience in mentoring students and teaching science? If applicable, is there evidence that the faculty are good role models for the participants by nature of their scientific accomplishments? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?
Specific to this FOA:
How well does the PD/PI team evidence complementary skills that will foster successful implementation of the proposed SI program?
Taking into consideration the nature of the proposed research education program, does the applicant make a compelling case for this program effectively reaching an audience in need of the program's offerings? Where appropriate, is the proposed program developing or utilizing innovative approaches and latest best practices to improve the knowledge and/or skills of the intended audience?
Specific to this FOA:
If described, what is the added value for the creation of this proposed SI given existing research education, training and/or career development activities currently supported at the applicant's institution?
Does the proposed program clearly state its goals and objectives, including the educational level of the audience to be reached, the content to be conveyed, and the intended outcome? Is there evidence that the program is based on a sound rationale, as well as sound educational concepts and principles? Is the plan for evaluation sound and likely to provide information on the effectiveness of the program? If the proposed program will recruit participants, are the planned recruitment, retention, and follow-up (if applicable) activities adequate to ensure a highly qualified participant pool?
Specific to this FOA:
How adequate is the plan for and description of each component of the program and each activity within the components? How adequate is the plan for providing mentees with appropriate mentoring experiences? Does the application contain adequate plans for recruiting experienced faculty/mentors with relevant scientific backgrounds? Is there an effective plan for program administration and coordination of faculty/mentors? Does the application contain adequate plans for recruitment, selection, and retention of candidates from diverse backgrounds? Does the application adequately document the host institutions', collaborating partners', and faculty/mentors' willingness to participate in the PRIDE program? Does the application adequately document the host institution's intent and ability to oversee the SRP program as required?
How robust is the proposed evaluation plan that will document the achievement of the program's objectives and demonstrate effectiveness and attainment of the program's goals? Are the evaluation plan and timeline adequate for assessing the effectiveness (process and outcome) of the program in achieving its goals and objectives? Is the proposed evaluation plan adequate for obtaining feedback from mentees to measure the quality and effectiveness of the research education program?
Will the scientific and educational environment of the proposed program contribute to its intended goals? Is there a plan to take advantage of this environment to enhance the educational value of the program? Is there tangible evidence of institutional commitment? Is there evidence that the faculty have sufficient institutional support to create a sound educational environment for the participants? Where appropriate, is there evidence of collaboration and buy-in among participating programs, departments, and institutions?
Specific to this FOA:
Is there evidence of appropriate collaboration among participating programs, departments, and institutions? Is the institutional commitment to the proposed program appropriate? Are the facilities, environment, and resources adequate and appropriate for the proposed research education program?
As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items.
For research that involves human subjects but does
not involve one of the six categories of research that are exempt under 45 CFR
Part 46, the committee will evaluate the justification for involvement of human
subjects and the proposed protections from research risk relating to their
participation according to the following five review criteria: (1) risk to
subjects, (2) adequacy of protection against risks, (3) potential benefits to
the subjects and others, (4) importance of the knowledge to be gained, and (5)
data and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: (1) the justification for the exemption, (2) human subjects involvement and characteristics, and (3) sources of materials. For additional information on review of the Human Subjects section, please refer to the Guidelines for the Review of Human Subjects.
When the proposed project involves human subjects and/or NIH-defined clinical research, the committee will evaluate the proposed plans for the inclusion (or exclusion) of individuals based on sex/gender, race, and ethnicity, as well as the inclusion (or exclusion) of children to determine if it is justified in terms of the scientific goals and research strategy proposed. For additional information on review of the Inclusion section, please refer to the Guidelines for the Review of Inclusion in Clinical Research.
The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following criteria: (1) description of proposed procedures involving animals, including species, strains, ages, sex, and total number to be used; (2) justifications for the use of animals versus alternative models and for the appropriateness of the species proposed; (3) interventions to minimize discomfort, distress, pain and injury; and (4) justification for euthanasia method if NOT consistent with the AVMA Guidelines for the Euthanasia of Animals. Reviewers will assess the use of chimpanzees as they would any other application proposing the use of vertebrate animals. For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Animal Section.
Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
For Renewals, the committee will consider the progress made in the last funding period, and the success of the program in attracting and retaining individuals from diverse populations underrepresented in biomedical, behavioral and clinical research on a national basis.
As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.
Peer reviewers will separately evaluate the recruitment plan to enhance diversity after the overall score has been determined. Reviewers will examine the strategies to be used in the recruitment of individuals from underrepresented groups. The review panel's evaluation will be included in the summary statement. Plans will be rated as acceptable or unacceptable, and the summary statement will provide the consensus of the review committee.
Taking into account the specific characteristics of the proposed research education program, the level of mentee experience, the reviewers will evaluate the adequacy of the proposed RCR training in relation to the following five required components: 1) Format - the required format of instruction, i.e., face-to-face lectures, coursework, and/or real-time discussion groups (a plan with only on-line instruction is not acceptable); 2) Subject Matter - the breadth of subject matter, e.g., conflict of interest, authorship, data management, human subjects and animal use, laboratory safety, research misconduct, research ethics; 3) Faculty Participation - the role of the program faculty in the instruction; 4) Duration of Instruction - the number of contact hours of instruction, taking into consideration the duration of the program; and 5) Frequency of Instruction – instruction must occur during each career stage and at least once every four years. See also: NOT-OD-10-019. The review panel's evaluation will be included in the summary statement. Plans will be rated as acceptable or unacceptable, and the summary statement will provide the consensus of the review committee.
Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.
Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: 1) Data Sharing Plan; 2) Sharing Model Organisms; and 3) Genomic Data Sharing Plan. If support for development, maintenance, or enhancement of software is requested in the application, the reviewers will comment on the proposed software dissemination plan.
Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.
Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by NHLBI, in accordance with NIH peer review policy and procedures, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons.
As part of the scientific peer review, all applications:
Appeals of initial peer review will not be accepted for applications submitted in response to this FOA.
Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications submitted in response to this FOA. Following initial peer review, recommended applications will receive a second level of review by the National Heart, Lung, and Blood Advisory Council. The following will be considered in making funding decisions:
After the peer review of the application is completed, the
PD/PI will be able to access his or her Summary Statement (written critique)
via the eRA
Commons. Refer to Part 1 for dates for peer review, advisory council
review, and earliest start date.
Information regarding the disposition of applications is available in the NIH Grants Policy Statement.
If the application is under consideration for funding, NIH will
request "just-in-time" information from the applicant as described in
Grants Policy Statement.
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee's business official.
Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.
Any application awarded in response to this FOA will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website. This includes any recent legislation and policy applicable to awards that is highlighted on this website.
By applying to this FOA, applicants indicate acceptance to work with the PRIDE CC (supported under RFA-HL-19-001) and all other PRIDE SIs awardees and the NHLBI program officers as part of the PRIDE consortium.
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.
Recipients of federal financial assistance (FFA) from HHS must administer their programs in compliance with federal civil rights law. This means that recipients of HHS funds must ensure equal access to their programs without regard to a person's race, color, national origin, disability, age and, in some circumstances, sex and religion. This includes ensuring your programs are accessible to persons with limited English proficiency. HHS recognizes that research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigator's scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research.
For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this FOA. HHS provides general guidance to recipients of FFA on meeting their legal obligation to take reasonable steps to provide meaningful access to their programs by persons with limited English proficiency. Please see http://www.hhs.gov/ocr/civilrights/resources/laws/revisedlep.html. The HHS Office for Civil Rights also provides guidance on complying with civil rights laws enforced by HHS. Please see http://www.hhs.gov/ocr/civilrights/understanding/section1557/index.html; and http://www.hhs.gov/ocr/civilrights/understanding/index.html. Recipients of FFA also have specific legal obligations for serving qualified individuals with disabilities. Please see http://www.hhs.gov/ocr/civilrights/understanding/disability/index.html. Please contact the HHS Office for Civil Rights for more information about obligations and prohibitions under federal civil rights laws at http://www.hhs.gov/ocr/office/about/rgn-hqaddresses.html or call 1-800-368-1019 or TDD 1-800-537-7697. Also note it is an HHS Departmental goal to ensure access to quality, culturally competent care, including long-term services and supports, for vulnerable populations. For further guidance on providing culturally and linguistically appropriate services, recipients should review the National Standards for Culturally and Linguistically Appropriate Services in Health and Health Care at http://minorityhealth.hhs.gov/omh/browse.aspx?lvl=2&lvlid=53.
In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Defense Authorization Act of Fiscal Year 2009 (Public Law 110-417), NIH awards will be subject to the Federal Awardee Performance and Integrity Information System (FAPIIS) requirements. FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award. An applicant, at its option, may review information in the designated integrity and performance systems accessible through FAPIIS and comment on any information about itself that a Federal agency previously entered and is currently in FAPIIS. The Federal awarding agency will consider any comments by the applicant, in addition to other information in FAPIIS, in making a judgement about the applicant's integrity, business ethics, and record of performance under Federal awards when completing the review of risk posed by applicants as described in 45 CFR Part 75.205 "Federal awarding agency review of risk posed by applicants." This provision will apply to all NIH grants and cooperative agreements except fellowships.
When multiple years are involved, awardees will be required to submit the Research Performance Progress Report (RPPR) annually. Continuation support will not be provided until the required forms are submitted and accepted. Programs that involve participants should report on education in the responsible conduct of research and complete a Training Diversity Report, in accordance with the RPPR Instruction Guide.
The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.
Failure by the grantee institution to submit required forms in a timely, complete, and accurate manner may result in an expenditure disallowance or a delay in any continuation funding for the award.
In accordance with the regulatory requirements provided at 45 CFR 75.113 and Appendix XII to 45 CFR Part 75, recipients that have currently active Federal grants, cooperative agreements, and procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 for any period of time during the period of performance of a Federal award, must report and maintain the currency of information reported in the System for Award Management (SAM) about civil, criminal, and administrative proceedings in connection with the award or performance of a Federal award that reached final disposition within the most recent five-year period. The recipient must also make semiannual disclosures regarding such proceedings. Proceedings information will be made publicly available in the designated integrity and performance system (currently FAPIIS). This is a statutory requirement under section 872 of Public Law 110-417, as amended (41 U.S.C. 2313). As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available. Full reporting requirements and procedures are found in Appendix XII to 45 CFR Part 75 – Award Term and Conditions for Recipient Integrity and Performance Matters.
A final RPPR and the expenditure data portion of the Federal Financial Report are required for closeout of an award as described in the NIH Grants Policy Statement.
In carrying out its stewardship of human resource-related programs, the NIH or its Institutes and Centers (ICs) will periodically evaluate their R25 research education programs, employing the measures identified below and may request information essential to an assessment of the effectiveness of this program from databases and/or from program mentees directly. Program mentees may be contacted directly after the completion of this award for periodic updates on various aspects of their employment history, publications, support from research grants or contracts, honors and awards, professional activities, and other information helpful in evaluating the impact of the program.
Where necessary, PDs/PIs may be contacted after the completion of a research education experience for periodic updates on mentees' subsequent educational or employment history and professional activities. Upon the completion of a program evaluation, NIH and its ICs will determine whether to (a) continue a program as currently configured, (b) continue a program with modifications, or (c) discontinue a program.
NHLBI plans to review the overall success of the entire PRIDE program after 5 years to determine whether to continue funding it as currently configured. This review will be distinct from the individual reviews that take place under the auspices of the annual Progress Report. NHLBI will consider: (a) the duration of the program, given programmatic goals and how long it may take for results or meeting outcomes to manifest; and whether to (b) continue the program as currently configured after the sunset period and review; or (c) continue the program with modifications after the sunset period and review, or (d) discontinue the program after sunset and review period. Discontinuation of the program is a policy option that will be made at the discretion of NHLBI.
In evaluating this research education program NHLBI expects to use the following evaluation measures:
For Courses for Skills Development:
For Research Experience and Mentoring Programs Involving the Following Groups:
Transitioning Postdoctoral Scientists and Junior Faculty (Early Career) Investigators:
o Subsequent participation in research
o Subsequent employment in a research or research-related field
o Subsequent authorship of scientific publications in a STEM field
o Subsequent independent research grant support from NIH or another source
We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.
eRA Service Desk (Questions regarding ASSIST, eRA Commons
registration, submitting and tracking an application, documenting system
problems that threaten submission by the due date, post submission issues)
Finding Help Online: http://grants.nih.gov/support/ (preferred method of contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)
GrantsInfo (Questions regarding application instructions and
process, finding NIH grant resources)
Email: GrantsInfo@nih.gov (preferred method of contact)
Josephine Boyington, Ph.D., M.P.H., CNS
National Heart, Lung, and Blood Institute (NHLBI)
Office of Scientific Review
Division of Extramural Research Activities
National Heart, Lung, and Blood Institute (NHLBI)
National Heart, Lung, and Blood Institute (NHLBI)
Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Part 75.
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