***REVISED***

BIOENGINEERING RESEARCH PARTNERSHIPS

Release Date:  November 30, 1999 (Superceded by PA-01-024)
                                 (Supercedes October 15, 1999 version) 

PA NUMBER:  PAS-00-006

National Cancer Institute
National Center for Research Resources
National Eye Institute
National Human Genome Research Institute
National Heart, Lung, and Blood Institute
National Institute on Aging
National Institute of Allergy and Infectious Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Institute of Child Health and Human Development
National Institute on Drug Abuse
National Institute on Deafness and Other Communication Disorders
National Institute of Dental and Craniofacial Research
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Environmental Health Sciences
National Institute of General Medical Sciences
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
National Institute of Nursing Research
National Library of Medicine

Letter of Intent Receipt Dates:  December 15, 1999  and June 30, 2000  
Application Receipt Dates:  January 7, 2000  and August 10, 2000

PURPOSE

Participating Institutes and Centers (ICs) of the National Institutes of Health 
(NIH) invite applications for R01 awards to support Bioengineering Research 
Partnerships (BRPs) for basic bioengineering research addressing important 
biological or medical research problems.  A BRP is a multidisciplinary research 
team applying an integrative, systems approach to develop knowledge and/or 
methods to prevent, detect, diagnose, and treat disease and understand health 
and behavior.  The partnership must include bioengineering expertise in 
combination with basic and/or clinical investigators.  A BRP may propose design-
directed or hypotheses-driven research in universities, national laboratories, 
medical schools, private industry and other public and private entities. 

On October 29, 1998, NIH issued PAR-99-009 
(https://grants.nih.gov/grants/guide/pa-files/PAR-99-009.html for Bioengineering 
Research Grants (BRGs).  BRG applications are also funded as R01 awards.  They 
differ from the BRP applications in that the research is generally performed in 
a single laboratory or by a small number of investigators.

HEALTHY PEOPLE 2000

The Public Health Service (PHS) is committed to achieving the health promotion 
and disease prevention objectives of "Healthy People 2000," a PHS-led national 
activity for setting priority areas. This PA, Bioengineering Research 
Partnerships (BRP), is related to all priority areas.  Potential applicants may 
obtain a copy of "Healthy People 2000" (Full Report:  Stock No. 017-001-00474-0 
or Summary Report:  Stock No. 017-001-00473-1) through the Superintendent of 
Documents, Government Printing Office, Washington, DC 20402-9325 (Tel: 202-512-
1800)or at http://odphp.osophs.dhhs.gov/pubs/hp2000

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic for-profit and non-profit 
organizations, public and private, such as universities, colleges, hospitals, 
laboratories, units of State and local governments, and eligible agencies of the 
Federal government.  Foreign institutions are not eligible to apply, but BRP 
collaborative projects may include work at a foreign site when the expertise at 
the foreign site is not present in the United States.  Racial/ethnic minority 
individuals, women, and persons with disabilities are encouraged to apply as 
principal investigators.

MECHANISM OF SUPPORT

The mechanism of support will be the regular research grant (R01). 
Responsibility for the planning, direction, and execution of the proposed 
project will be solely that of the applicant.  The total requested project 
period may not exceed five years.

An applicant planning to submit an application for this PA requesting $500,000 
or more in direct costs for any year is advised that NIH policy requires an 
applicant to obtain agreement for acceptance of both any such new application 
and/or any subsequent amended application.  Refer to the NIH Guide for Grants 
and Contracts, March 20, 1998, which is available on the Internet at the 
following URL address:
https://grants.nih.gov/grants/guide/notice-files/not98-030.html.  

To obtain agreement, an applicant must contact IC program staff (listed under 
INQUIRIES) before submitting the application, i.e., as plans for the study are 
being developed.  Furthermore, the applicant must obtain written agreement from 
IC staff that the IC will accept the application for consideration for award. 

FUNDS AVAILABLE

The estimated total funds (direct and facilities and administrative costs) 
available in FY 2001 for the first year of support for awards under this PA will 
be approximately $12 million.  Because the nature and scope of the research 
proposed in response to this PA may vary, it is anticipated that the size of the 
awards will vary also.  For any grant, the maximum total costs to be awarded in 
any year is $2 million.  The number of awards and level of support will depend 
upon receipt of a sufficient number of applications of high scientific merit.  
Although this PA is provided for in the financial plans of the participating 
ICs, awards pursuant to this PA are contingent upon the availability of funds. 
Funding beyond the first and subsequent years of the grant will be 
contingent upon satisfactory progress during the preceding years and the 
availability of funds.  Applicants are encouraged to discuss budget requests 
with program staff listed under INQUIRIES prior to submission.  The initial 
period of support for a BRP award may be up to five years.  The award may be 
competitively renewed for a second period (up to five years) based on peer 
review of a renewal application.  NIH does not envision more than one renewal 
period.

RESEARCH OBJECTIVES

Background

Many of today"s biological problems are too complex to be solved by biologists 
alone, partners are needed in many disciplines, including physics, mathematics, 
chemistry, computer sciences, and engineering.  Bioengineering integrates 
principles from a diversity of fields.  The creativity of interdisciplinary 
teams is resulting in new basic understanding, novel products, and innovative 
technologies.  Bioengineering also crosses the boundaries of academia, science, 
medicine, and industry.

Recognizing the increasing importance of bioengineering in public health, the 
NIH established the Bioengineering Consortium (BECON) as a central focus for NIH 
bioengineering research.  BECON held a two-day Bioengineering Symposium on 
February 27-28, 1998.  A summary of the presentations and the conclusions of the 
panels are included in the full report which is available on the Internet at the 
following URL: (http://www.nibib.nih.gov/)  

The discussions and recommendations of symposium participants aided in the 
formulation of the BRP and BRG  PAs.   For example, both the BRP and BRG  PAs 
recognize that applications for bioengineering projects are often focused on 
technology development rather than on proving or disproving a scientific 
hypothesis.  Therefore, the NIH review criteria for bioengineering applications 
submitted in response to these PAs have been modified to ensure that these 
applications are evaluated appropriately and fairly.

Objective and Scope

The objective of this program announcement is to encourage research in selected 
basic bioengineering areas.  Bioengineering is defined as follows: 
Bioengineering integrates physical, chemical, or mathematical sciences and 
engineering principles for the study of biology, medicine, behavior, or health.  
It advances fundamental concepts, creates knowledge from the molecular to the 
organ systems level, and develops innovative biologics, materials, processes, 
implants, devices, and informatics approaches for the prevention, diagnosis, and 
treatment of disease, for patient rehabilitation, and for improving health.

Each BRP should bring together the necessary engineering, basic science, and/or 
clinical expertise to focus on a significant area of bioengineering research 
within the mission of the NIH. A BRP can vary in size and exhibit diverse forms 
of organization, participation, and operation.  No single type of BRP fits the 
needs of every area.  Rather, the size, structure, and operation of a BRP are 
determined by the proposed research.

Areas of Bioengineering Research for a BRP.

Applications for BRP awards should focus on an area of bioengineering research 
where progress is likely to make a significant contribution to improving human 
health.  It is likely that these areas will be of interest to many ICs.  For 
example, materials science may be relevant to the ultimate development of 
artificial organs or novel medical implants, thus a research initiative in 
materials science would be of interest to many ICs, even though it is not clear 
at the outset which organ or which IC will benefit from advances in the field.  
Similarly, bioinformatics may provide analysis and modeling tools for large sets 
of biological data, may facilitate home-based devices, and may create 
networks to help manage chronic diseases.  Imaging may be applied to the 
monitoring of cellular processes, elucidation of developmental processes in the 
organism, identification and localization of disease or its progression, 
development of virtual reality training tools, and monitoring of therapeutic 
interventions.  Micro- and nano- fabrication and fluidics may be applied to 
creating in vivo sensors, biochemical analysis systems, imaging systems, and 
surgical devices.

Bioengineering areas of particular relevance to the mission of ICs are 
identified below.  The topics listed are not intended to be exclusive.

Bioengineering Research Areas

o  Biomechanics
o  Bioprocessing
o  Bioelectrics, Ion Channels, and Organ Function
o  Clinical Medicine, Therapeutics & Drug Delivery
o  Combinatorial Approaches to Chemistry, Materials, Genes, and Therapeutics
o  Functional Genomics including Microarray Technology, Integrated Systems, and 
Analysis Tools
o  Imaging
o  Nanotechnology
o  Informatics and Computational Methods
o  Medical Implants, Biomembranes, Sensors and Devices
o  Complex Biological Systems
o  Organ Culture Systems and Organogenesis
o  Rehabilitation, Prostheses
o  Cell and Tissue Engineering and Biomaterials
o  Tissue Regeneration
o  Integrative Physiology
o  Drug Bioavailability

Organizational Structure

An organizational structure which clearly defines the partnership and 
relationships among the various components must exist.

BRP Leadership and Management

The BRP Principal Investigator (PI) is responsible for management, staffing, and 
resource allocation and for administering the award in accordance with NIH 
policies.  The PI has both the responsibility and authority to use BRP funds in 
the most productive way to achieve the goals proposed in the application.  To 
accomplish this task, the PI should adjust BRP funding among BRP participants to 
support new Partners or to reduce support to old Partners as needed.  The PI"s 
administrative structure will depend upon the size and scope of the proposed 
research.  For example, there may be less involvement of a clinical component in 
the early stages of a BRP and far more when the issue of clinical application is 
more salient.

Annual BRP PI Meeting.

BRP PIs will meet annually to share substantive results, to ensure that the NIH 
has a coherent view of the advances in these fields, and to have an opportunity 
for collective problem solving among the BRPs.  The cost of participating in the 
BRP PI annual meeting should be built into the BRP budget.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups and their 
sub-populations must be included in all NIH supported medical and behavioral 
research projects involving human subjects, unless a clear and compelling 
rationale and justification are provided that inclusion is inappropriate with 
respect to the health of the subjects of the purpose of the research.  This 
policy results from the NIH Revitalization Act of 1993 (Section 492B of Public 
Law 103-43).

All investigators proposing research involving human subjects should read the 
"NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical 
Research," which have been published in the Federal Register of March 28, 1994 
(FR 59 14508-14513) and the NIH Guide for Grants and Contracts, Vol. 23, No. 11, 
March 18, 1994, which is available on the Internet at the following URL address:
(https://grants.nih.gov/grants/guide/notice-files/not94-100.html).

Investigators may obtain copies from these sources or from the program staff 
listed under INQUIRIES.  Program staff may also provide additional relevant 
information concerning the policy.

INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21) 
must be included in all human subjects research, conducted or supported by the 
NIH, unless there are scientific and ethical reasons not to include them. This 
policy applies to all initial (Type 1) applications submitted for receipt dates 
after October 1, 1998.

All investigators proposing research involving human subjects should read the 
"NIH Policy and Guidelines on the Inclusion of Children as Participants in 
Research Involving Human Subjects" that was published in the NIH Guide for 
Grants and Contracts, March 6, 1998, and is available at the following URL 
address: (https://grants.nih.gov/grants/guide/notice-files/not98-024.html)

Investigators may obtain copies from these sources or from the Program Contact 
person listed under INQUIRIES who may also provide additional relevant 
information concerning the policy.

LETTER OF INTENT

Prospective applicants are asked to submit by December 15, 1999, a letter of 
intent that includes a descriptive title of the overall proposed research, the 
name, address, and telephone number of the Principal Investigator, the 
identities of other key personnel and participating institutions, and the number 
and title of the PA in response to which the application may be submitted.  
Although the letter of intent is not required, is not binding, and does not 
enter into the review of a subsequent application, the information it contains 
allows NIH staff to estimate the potential review workload and avoid conflict of 
interest in the review.

The letter of intent is to be sent via email to [email protected].  An 
acknowledgement of receipt will be provided. 

APPLICATION PROCEDURES

Applicants are strongly advised to contact IC program staff listed under 
INQUIRIES to discuss the responsiveness of their plans before developing a 
detailed research application.  Applicants are reminded that Institute or Center 
approval must be obtained for submission of applications whose annual direct 
costs exceed $500,000 in any year.  Since a BRP award may include funds from a 
single IC or from several NIH ICs, applicants may be directed to contact IC 
program staff in more than one IC.  The use of email for such communication is 
strongly recommended. 

Applications will be accepted on the receipt dates of January 7, 2000 and August 
10, 2000.

Electronic Submission of Applications for the August 10, 2000 Receipt Date:

Directions for submitting electronically will be posted in the NIH Guide and the 
BECON website well in advance of the August receipt date.  Applications for the 
January receipt date should use the PHS 398 application in the usual paper 
format.

Submission of Applications

Applications should be submitted on the grant application form 
PHS 398 (rev. 4/98). Application kits are available at most institutional 
offices of sponsored research and may be obtained from the Division of 
Extramural Outreach and Information Resources, National Institutes of Health, 
6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, Telephone: (301) 710-0267, Email: [email protected].  Application kits are also available on the 
Internet at URL address: (https://grants.nih.gov/grants/funding/funding.htm).

Application Instructions 

Follow the PHS 398 instructions for "Preparing Your Application" with 
modifications and additions as described in the sections below.

Page limitations.  Page limitations have been increased from the normal 25 page 
limit for sections A-D of the "Research Plan" of an application. For 
applications in response to this program announcement, the page limitation is a 
maximum of 40 pages for sections A-D.  This 40 page limit is an absolute maximum 
and applicants are encouraged to be concise and use fewer pages.

Title and Abstract. Identify the institution leading the BRP and any other 
participating institutions. The abstract should provide clear descriptions of 
the area of bioengineering research that will be the focus of the BRP, the 
planned multidisciplinary approach, and the specific milestones to be achieved 
and timelines for achievement for the first year and additional years of the 
grant.

Partnership Organization.  An organization chart (OC) must be included in the 
application.  It should clearly define the partnership and relationships among 
its various components.  A program plan (PP) should accompany the OC and list 
major tasks with a timeline of expected milestones for the entire project 
period.  The OC and PP must not exceed one page each.

BRP BUDGET ITEMS

Proposed Budget Organization.  Include a separate budget for each Partner at a 
non-grantee institution, and when appropriate for clarity, for each Partner 
within the grantee institution.  Include a summary budget for all BRP 
participants with Partners at non-grantee institutions shown as consultants or 
consortium arrangements.

Maximum Request and Award Level. The NIH ICs will not provide annual 
support in excess of $2 million total cost in any year.  Direct cost 
inflationary increases following the first year may be included, but the total 
cost maximum request level of $2,000,000 must be adhered to.

Personnel.  Percent Effort - The PI is expected to devote a minimum of 25% 
effort to the BRP.  The percent effort requested for other personnel should be 
limited to time devoted specifically to BRP Partner activities and not to other 
research activities.  Information documenting the level of effort on BRP 
activities should be included in the application.  The need for all requested 
personnel costs should be thoroughly justified.  The percent effort of the BRP 
PI should be justified in the context of the PI"s other responsibilities. 
Administrative support (a secretary or an administrative assistant) may be 
requested for the BRP office only for matters directly pertaining to the BRP.

Travel.  BRP PI meeting(s) - There will be an annual BRP PI meeting at a 
location to be determined by NIH staff.  The PI meeting will be held at NIH, at 
a BRP site, or at the site of a scientific conference that many of the PIs plan 
to attend.  The BRP PI and at least one other BRP scientist should attend the 
annual meeting.  Additional BRP members are welcome.  Applicants should include 
travel funds specifically for these meetings in the BRP budget request.  For 
budget purposes, applicants may assume that total annual costs to the grant for 
the BRP PIs meeting will not exceed $2500.

Other Travel - Applicants may request and justify travel funds in addition to 
the funds required for the Annual PI Meeting.  Travel funds could be used to 
promote collaboration among BRP partners at different institutions or at a 
distant site, be used for travel of external advisors to the BRP site, and/or be 
used for BRP Partners to attend scientific meetings essential to the progress of 
the BRP and for which other funds are not available.

Other Expenses.  This category includes the costs necessary for the central 
administration and fiscal management of the BRP including relevant and 
reasonable costs for reprints, graphics, and publications.

Projected Funding by Source.  Some BRP applicants may anticipate or receive 
commitments for significant funding from other than NIH sources, e.g., from a 
collaborating company. When this is the case, applications should describe the 
source, annual amount, and use of the other funding.

OTHER SUPPORT 

Provide a complete listing of current and pending support for the Principal 
Investigator, Co-Investigator(s), and non Co-Investigator Senior Personnel only.

RESOURCES

Facilities and Equipment.  Describe the equipment and facilities available to 
the proposed BRP.

Institutional commitment.  If the BRP implies an institutional commitment of 
resources across boundaries in the institution or anticipates the provision of 
institutional resources, please include letters from relevant senior level 
individuals describing those commitments.

Shared Experimental Facilities.  Where appropriate, describe the shared 
facilities to be established, including specific major research instrumentation, 
and plans for the development of instrumentation.  Describe plans for 
maintaining and operating the facilities, including staffing, provisions for 
user fees, and plans for ensuring access to outside users.  Distinguish between 
existing facilities and those still to be developed.

RESEARCH PLAN

A.  Specific Aims.  Describe the specific aims in the selected area of 
bioengineering research and the goals for the first year and for the long term. 
Delineate the design principle(s) supporting the research or the hypothesis(-es) 
to be tested.  Describe the expected applications of the bioengineering research 
that will improve human health. One 
page is recommended.

B.  Background and Significance.  Briefly describe the area of bioengineering 
research that is the focus of the BRP.  Critically evaluate existing knowledge 
and approaches that have been or are being directed in the area, and 
specifically describe how the BRP approach will advance the field.  State 
concisely the importance and health relevance of the proposed research to the 
Specific Aims.

C.  Preliminary Studies and Rationale.  Preliminary studies are not required for 
BRP applications, but applicants with preliminary results should describe them. 
In the absence of preliminary results, applicants should describe the rationale 
and scientific and engineering bases for the proposal.

D.  Research Design and Methods.  A BRP should focus on a systems approach in a 
significant area of bioengineering research.  Describe an overall research plan 
that is sufficiently long term (5-10 years) to justify a BRP organization and 
adaptable enough to permit change as the research proceeds.  Clearly indicate 
current activities, why a BRP is necessary, and what unique opportunities will 
be provided by the proposed BRP.  Explain the integrative-engineering approach 
and why such an approach is essential to the proposed research.  If the proposed 
BRP research is closely related to ongoing research or an existing Center, 
explain how the research activities of the BRP will complement but not overlap 
with existing research.  Describe the efforts of each Partner and how these 
will be integrated and organized to accomplish the specific aims of the project.  
Provide a tentative sequence or timetable for the project.  Include how the data 
will be collected, analyzed, and interpreted.  Describe how the data and 
technological advances will be disseminated to other investigators, and if 
relevant, how the technology information (intellectual property) will be 
transferred to the commercial sector for product development.

SUBMISSION OF APPLICATIONS

The title and number of this program announcement must be typed on line 2 of the 
face page of the application form and the YES box must be marked.  Submit a 
signed, typewritten original of the application, including the Checklist, and 
five signed photocopies in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

APPENDICES

Applicants are advised that the 40-page application itself should contain all 
relevant information.  Reviewers have no obligation to read appendices.  
Appendix materials should not be submitted with the application.  Applicants who 
wish to send appendices should wait until they receive notification that the 
application has been assigned to an Initial Review Group.  At that time they 
should contact the Scientific Review Administrator of the committee to which 
their application is assigned to receive further instructions.

The Center for Scientific Review (CSR) will not accept any application in 
response to this PA that is essentially the same as one currently pending 
initial review, unless the applicant withdraws the pending application.  The CSR 
will not accept any application that is essentially the same as one already 
reviewed.  This does not preclude the submission of substantial revisions of 
applications already reviewed, but such applications must include an 
introduction addressing the previous critique.

REVIEW CONSIDERATIONS

Upon receipt, applications will be reviewed for completeness by the NIH Center 
for Scientific Review (CSR), and for responsiveness by program staff of the IC 
to which an application is assigned.  Incomplete and/or non-responsive 
applications will be returned to the applicant without further consideration.  
Applications that are complete and responsive will be evaluated for scientific 
and technical merit by Scientific Review Groups (SRGs) of CSR.  As part of the 
initial merit review, all applications will receive a written critique and 
undergo a process in which only those applications deemed to have the highest 
scientific merit, generally the top half of applications under review, will be 
discussed, assigned a priority score, and receive a second level review by the 
appropriate national advisory council or board. 

Review Criteria

The NIH review criteria have been adapted to ensure that the BRP application is 
evaluated appropriately.  The score should reflect the overall impact that the 
BRP award could have on the selected area of bioengineering research based on 
consideration of the five criteria, with the emphasis on each criterion varying 
from one application to another, depending on the nature of the application and 
its relative strengths.  Note that an application need not be strong in all 
categories to be judged likely to have major scientific impact and thus deserve 
a high priority score.  For example, an investigator may propose to carry out 
important work that by its nature is not innovative but is essential to move a 
field forward.  The review criteria follow:

(1) Significance.  If the Specific Aims of the BRP are achieved, will they 
provide significant advances in the selected area of bioengineering research? Is 
the research likely to have a significant impact on other areas of research? 
Will the technological advances have a significant impact on human health?

(2) Approach.  Are the BRP engineering, scientific and clinical approaches and 
methods adequately developed, well integrated, and appropriate to the aims of 
the project?  Does the applicant acknowledge potential problem areas and 
consider alternative tactics?  Are the milestones and evaluation procedures 
appropriate?  Are the plans for information dissemination and technology 
transfer reasonable?

(3) Innovation.  Does the BRP propose new approaches or explore new research 
paradigms or new concepts that combine engineering, basic and clinical sciences?  
Are extant approaches or concepts applied to new scientific problems in novel 
ways?

(4) Investigators.  Is the PI capable of coordinating and managing the proposed 
BRP? Are the investigators (Partners) appropriately trained in their disciplines 
and well suited to carry out the proposed work?  Is there evidence that the 
Partners can work together effectively?  Do the advantages of a Partner at a 
distant site outweigh the disadvantages?

(5) Environment.  Does the scientific and technological environment in which the 
work will be done contribute to the probability of success?  Does the proposed 
research take advantage of unique features of the scientific environment or 
employ useful collaborative arrangements?  Is there evidence of institutional 
support?

In addition to these five review criteria, applicants must demonstrate adequate 
provisions for the protection of human and animal subjects, the safety of the 
research environment, and conformance with the "NIH Guidelines for the Inclusion 
of Women and Minorities as Subjects in Clinical Research," and "NIH Policy and 
Guidelines on the Inclusion of Children as Participants in Research Involving 
Human Subjects."

AWARD CRITERIA

BRP applications will compete for available funds with all other recommended 
applications. The following will be considered in making funding decisions:

o  Quality of the proposed research as determined by peer review
o  Availability of funds
o  Institute"s priority for area of proposed research

INQUIRIES

The opportunity to clarify any issues or questions regarding a BRP or a BRP 
application is welcome.  

General questions regarding the BRP may be directed to:

Richard Swaja, Ph.D., Senior Advisor for Bioengineering, Office of Extramural 
Research, Building 1, Room 152, Bethesda, MD 20892, telephone (301) 402-2725, 
email: [email protected]

Specific questions regarding BRP scientific issues, management issues, or issues 
on cores 
related to participating ICs may be directed to:

NCI - Carol Dahl, Ph.D., National Cancer Institute, Building 31, Room 11A03, MSC 
2590, Bethesda, MD  20892-2590, Telephone:  (301) 496-1550, FAX:  (301) 496-
7807, Email:  [email protected]

NCRR - Richard Dubois, Ph.D., Biomedical Technology, National Center for 
Research Resources, 6705 Rockledge Drive, Room 61060, MSC 7965, Bethesda, MD  
20892-7965, Telephone:  (301) 435-0755, FAX:  (301) 480-3659, Email:  
[email protected]

NEI - Lore Anne McNicol, Ph.D., National Eye Institute, 6120 Executive 
Boulevard, Suite 350, MSC 7164, Bethesda, MD  20892-7164, Telephone:  (301) 496-
5301, FAX: (301) 402-0528, Email:  [email protected]

NHGRI - Jeffery A. Schloss, Ph.D., Division of Extramural Research, National 
Human Genome Research Institute, Building 31, Room B2B07, MSC 2033,  Bethesda, 
MD  20892-2033, Telephone:  (301) 496-7531, FAX:  (301) 480-2770, Email:  
[email protected]

NHLBI - John T. Watson, Ph.D., Acting Deputy Director, National Heart, Lung, and 
Blood Institute, 9000 Rockville Pike, Room 5A49,  Bethesda, MD  20892, 
Telephone:  (301) 435-0513, FAX:  (301) 402-3686, Email:  [email protected]

NIA - Evan Hadley, M.D., Geriatrics, National Institute on Aging, Gateway 
Building, Suite 3E327, MSC 9205, Bethesda, MD  20892-9205, Telephone:  (301) 
435-3044, FAX: (301) 402-1784, Email:  [email protected]

NIAID - Vicki Seyfert, Ph.D., National Institute of Allergy and Infectious 
Diseases, 6003 Executive Boulevard, Room 4A21, Rockville, MD  20852, Telephone:  
(301) 496-7551, FAX:  (301) 402-2571, Email:  [email protected]

NIAMS - James S. Panagis, M.D., M.P.H., Musculoskeletal Diseases Branch, 
National Institute of Arthritis and Musculoskeletal and Skin Diseases, 6500 
Center Drive, Room 5AS-37K, Bethesda, MD  20892-6500, Telephone:  (301) 594-
5055, FAX:  (301) 480-4543, Email:  [email protected]

NICHD - Louis A. Quatrano, Ph.D., National Center for Medical Rehabilitation 
Research, National Institute of Child Health and Human Development, Building 
61E, Room 2A03, Bethesda, MD  20892-7510, Telephone:  (301) 402-2242, FAX:  
(301) 402-0832, Email:  [email protected]

NIDA - Thomas G. Aigner, Ph.D., Division of Basic Research, National Institute 
on Drug Abuse,  6001 Executive Boulevard, Room 4282, MSC 9555, Bethesda, MD 
20892-9555, Telephone:  (301) 443-6975, FAX:  (301) 594-6043, Email:  
[email protected]

NIDCD - Lynn E. Luethke, Ph.D., National Institute on Deafness and Other 
Communication Disorders, 6120 Executive Boulevard, MSC 7180, Bethesda, MD 
20892-7180, Telephone:  (301) 402-3458, FAX:  (301) 402-6251, Email:  
[email protected]

NIDDK - Joan T. Harmon, Ph.D., Division of Diabetes, Endocrinology, and 
Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney 
Diseases, 45 Center Drive, Room 5AN-18G, MSC 6600, Bethesda, MD 20892-6600, 
Telephone:  (301) 594-8808, FAX:  (301) 480-3503, Email:  
[email protected]

NIDCR - Eleni Kousvelari, D.D.S., D.Sc.,  Chief - Biomaterials, Biomimetics, and 
Tissue Engineering Branch, National Institute of Dental and Craniofacial 
Research, Natcher Building, Room 4AN 18A, MSC 6402, Bethesda, MD 20892-6402, 
Telephone:  (301) 594-2427, FAX:  (301) 480-8318, Email:  
[email protected]

NIEHS - Jose Velazquez, Ph.D., Division of Extramural Research Training, 
National Institute for Environmental Health Sciences, P.O. Box 12233, MSC EC-21, 
Research Triangle Park, NC  27709, Telephone:  (919) 541-4998, FAX:  (919) 541-
2860, Email:  [email protected]

NIGMS - Warren Jones, Ph.D., Division of Pharmacology, Physiology and Biological 
Chemistry, National Institute of General Medical Sciences, 45 Center Drive, Room 
2AS-43H, MSC 6200, Bethesda, MD  20892-6200, Telephone:  (301) 594-5938, FAX:  
(301) 480-2802, Email:  [email protected]

NIMH - Michael F. Huerta, Ph.D., Division of Neuroscience and Basic Behavioral 
Sciences,  National Institute of Mental Health, 6001 Executive Boulevard, Room 
7202, MSC 9645, Bethesda, MD  20892-9645, Telephone:  (301) 443-3563, FAX:  
(301) 443-1731, Email:  [email protected]

NINDS - William Heetderks, M.D., Ph.D., Division of Stroke, Trauma, and 
Neurodegenerative Disorders, National Institute of Neurological Disorders and 
Stroke, Neuroscience Center, Room 2207, Bethesda, MD  20892,  Telephone:  (301) 
496-1447, FAX:  (301) 480-1080,  Email:  [email protected]

NINR - Hilary D. Sigmon, Ph.D., RN,  Division of Extramural Activities, National 
Institute of Nursing Research, 45 Center Drive, Room 3AN12, MSC 6300, Bethesda, 
MD  20892-6300, Telephone:  (301) 594-5970, FAX:  (301) 480-8260, Email:  
[email protected]

NLM - Peter Clepper, Program Officer, National Library of Medicine, 6705 
Rockledge Drive, Suite 301, Bethesda, MD  20871, Telephone:  (301) 594-4882, 
FAX:  (301) 402-2952, Email:  [email protected]

Questions on review issues may be directed to:

CSR - Eileen Bradley, D.Sc.,  Chief - Surgery, Radiology, and Bioengineering, 
Center for Scientific Review, 6701 Rockledge Drive, Bethesda, MD  20892, 
Telephone:  (301) 435-1179, FAX:  (301) 480-2241, Email:  [email protected]

Questions on fiscal issues may be directed to:

NCI - Bill Wells, Grants Administration Branch, National Cancer Institute, 6120 
Executive Boulevard, Room 243, MSC 7150, Bethesda, MD  20892-7150, Telephone:  
(301) 496-7800, FAX:  (301) 496-8601, Email:  [email protected]

NCRR - Joellen Harper, Office of Grants Management, National Center for Research 
Resources, 6705 Rockledge Drive, Room 6086, MSC 7965, Bethesda, MD  20892-7965, 
Telephone:  (301) 435-0836, FAX:  (301) 402-1951, Email:  [email protected]

NEI - William Derby, Grants Management Officer, National Eye Institute, 6120 
Executive Boulevard, Suite 350, MSC 7164, Bethesda, MD  20892-7164, Telephone:  
(301) 496-5884, FAX:  (301) 402-0528 

NHGRI - Jean Cahill, Grants Management Officer, National Human Genome Research 
Institute, Building 31, Room B2B34,  31 Center Drive,  MSC 2030,  Bethesda, MD 
20892-2030, Telephone:  (301) 402-0733, FAX:  (301) 402-1951, Email:  
[email protected]

NHLBI -  Jane Davis, National Heart, Lung, and Blood Institute, 6701 Rockledge 
Drive, Room 7174, Bethesda, MD  20892, Telephone:  (301) 435-0166, FAX:  (301) 
480-3310, Email: [email protected]

NIA - Joseph Ellis, Grants and Contracts Management Officer, National Institute 
on Aging, Gateway Building, Suite 2N212, Bethesda, MD  20892, Telephone:  (301) 
496-1472, FAX:  (301) 402-3672, Email:  [email protected]

NIAID - Linda Shaw, Grants Management Branch, National Institute of Allergy and 
Infectious Diseases, 6003 Executive Boulevard, Room 4B-31, Rockville, MD  20850, 
Telephone:  (301) 402-6611, FAX:  (301) 480-3780, Email:  [email protected]

NIAMS - Sally A. Nichols, Grants Management Branch, National Institute of 
Arthritis and Musculoskeletal and Skin Diseases, 6500 Center Drive, Room 5AS-
49F, Bethesda, MD  20892-6500, Telephone:  (301) 594-3535, FAX:  (301) 480-5450, 
Email:  [email protected]

NICHD - Mary Ellen Colvin, Grants Management Branch, National Institute of Child 
Health and Human Development, Building 61E, Room 8A17, Bethesda, MD  20892-
7510, Telephone:  (301) 496-1303, FAX:  (301) 402-0915, Email:  [email protected]

NIDA - Gary Fleming, J.D., M.A., Grants Management Branch, National Institute on 
Drug Abuse, 6001 Executive Boulevard, Room 3131, MSC 9541, Bethesda, MD 20892-
9541, Telephone:  (301) 443-6710, FAX:  (301) 594-6847, Email:  [email protected]

NIDCD - Sharon Hunt, Grants Management Branch, National Institute on Deafness 
and Other Communication Disorders, 6120 Executive Boulevard, Room 400-C, MSC 
7180, Bethesda, MD  20892-7180, Telephone:  (301) 402-0909, FAX:  (301) 402-
1758, Email:  [email protected]

NIDDK - Nancy Dixon, Grants Management Officer, National Institute of Diabetes 
and Digestive and Kidney Diseases, 45 Center Drive, Room 6AS49K, MSC 6600, 
Bethesda, MD  20892-6600, Telephone:  (301) 594-8854, FAX:  (301) 480-4237, 
Email:  [email protected]

NIDCR - Kevin Crist, Division of Extramural Research, National Institute of 
Dental and Craniofacial Research, Natcher Building, Room 4AS 55, Bethesda, MD  
20892-6402, Telephone:  (301) 594-4800, FAX:  (301) 480-8301, Email:  
[email protected]

NIEHS - Dorothy Duke, Division of Extramural Research and Training, National 
Institute of Environmental Health Sciences, P.O. Box 12233, MSC EC-21, Research 
Triangle Park, NC  27709, Telephone:  (919) 541-1373, FAX:  (919) 541-2860, 
Email:  [email protected]

NIGMS - Antoinette Holland, Grants Management Specialist, National Institute of 
General Medical Sciences, 45 Center Drive, Room 2AN-50B, MSC 6200, Bethesda, MD  
20892-6200, Telephone:  (301) 594-5132, FAX:  (301) 480-2554, Email:  
[email protected]

NIMH -  Diana S. Trunnell, Grants Management Branch, National Institute of 
Mental Health, 6001 Executive Boulevard, Room 6115, MSC 9605, Bethesda, MD  
20892-9605, Telephone:  (301) 443-2805, FAX:  (301) 443-6885, Email:  
[email protected]

NINDS - Brenda Kibler, Grants Management Specialist, National Institute of 
Neurological Disorders and Stroke, Federal Building, Room 1004, Bethesda, MD  
20892, Telephone:  (301) 496-7441, FAX:  (301) 402-0219, Email:  [email protected]

NINR - Jeff Carow, Division of Extramural Activities, National Institute of 
Nursing Research, 45 Center Drive, Room 3AN12, MSC 6300, Bethesda, MD  20892-
6300, Telephone:  (301) 594-6869, FAX:  (301) 480-8260, Email:  
[email protected]

NLM - Dwight Mowery, Extramural Programs, National Library of Medicine, 6705 
Rockledge Drive, Suite 301, Bethesda, MD  20871, Telephone:  (301) 496-4221, 
FAX:  (301) 402-2952, Email:  [email protected]

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance Nos. 
93.394, 93.395, 93.396, 93.306, 93.867, 93.172, 93.837, 93.838, 93.839, 93.866, 
93.273, 93.855, 93.856, 93.846, 93.864, 93.865, 93.929, 93.279, 93.173, 93.121, 
93.847, 93.848, 93.849, 93.113, 93.821, 93.859, 93.862, 93.242, 93.853, 93.854, 
93.361, and 93.879.  Awards are made under authorization of the Public Health 
Service Act, Sec. 301, Title IV, Part A (Public Law 78-410, as amended by Public 
Law 99-158, 42 USC 241 and 285). Awards will be administered under PHS grants 
policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74 and Part 92. 
This program is not subject to the intergovernmental review requirements of 
Executive Order 12372 or Health Systems review.

The PHS strongly encourages all grant and contract recipients to provide a 
smoke-free workplace and promote the non-use of all tobacco products.  In 
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in 
certain facilities (or, in some cases, any portion of a facility) in which 
regular or routine education, library, day care, health care or early childhood 
development services are provided to children. This is consistent with the PHS 
mission to protect and advance the physical and mental health of the American 
people.

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)