and Human Services (HHS)
EXPIRED
GENE/ENVIRONMENT INTERACTION IN NEURODEGENERATIVE DISEASE
RELEASE DATE: August 6, 2003
PA NUMBER: PAS-03-160 (Expiration date changed, see NOT-ES-06-006)
(see NOT-ES-04-009)
EXPIRATION DATE: March 2, 2006, unless reissued.
National Institute of Environmental Health Sciences (NIEHS)
(http://www.niehs.nih.gov)
CATALOG OF FEDERAL DOMESTIC ASSISTANCE NUMBER(S): 93.113, 93.115
THIS PA CONTAINS THE FOLLOWING INFORMATION
o Purpose of the PA
o Background
o Research Objectives
o Mechanism(s) of Support
o Funds Available
o Eligible Institutions
o Individuals Eligible to Become Principal Investigators
o Where to Send Inquiries
o Submitting an Application
o Peer Review Process
o Review Criteria
o Award Criteria
o Required Federal Citations
PURPOSE OF THIS PA
There is provocative evidence that environmental exposures to certain
neurotoxicants (heavy metals, pesticides and fungicides) may play a role in
the development of neurodegenerative movement disorders such as Parkinson's
disease (PD) and amyotrophic lateral sclerosis (ALS). Recent research in
these diseases has focused on both the underlying biological processes
critical to disease manifestation for the development of new treatments and
on the relative roles of environmental, endogenous neurochemical and genetic
factors in their etiologies. Much work, however, remains to be done to
clarify these fundamental processes.
The objective of this three-year Program Announcement (PA) is to stimulate
research on the relative roles of environmental, endogenous neurochemical and
genetic factors in the causation of neurodegenerative diseases. In previous
years, the NIEHS has focused its efforts on the expansion of research in
Parkinson's disease culminating in the establishment of Collaborative Centers
for Parkinson's Disease Environmental Research (See
http://www.niehs.nih.gov/dert/consorti.htm) This new initiative will
selectively shift its research focus each year to emphasize a different
neurodegenerative disease. In the current year, the special focus is to
mainly solicit research on gene-environment interactions as a risk factor in
ALS (a fatal disease of unknown etiology marked by the progressive
degeneration of motor neurons) in order to stimulate much needed research in
this area. In succeeding years, there will be an announcement indicating a
different neurodegenerative disease focus area.
Background
Several epidemiological studies have implicated gene/environment interactions
in the development of PD and ALS. Nevertheless, it is still not clear
whether differences in prevalence rates or clusters of these diseases in
various communities are due to the differential distribution of a
hypothetical environmental toxicant or are more frequent where a familial
heritable defect is more common. To date, analytic epidemiological studies
have varied in case and control selection methodology and venues (e.g.,
clinics, population bases, different countries) partly accounting for the
disparate conclusions reached by some investigators.
While a good deal of research has been devoted to the influence of the
environment in the susceptibility to PD, there has not been a similar effort
committed to ALS. In ALS the motor neurons of the brain and spinal cord are
primarily targeted to degenerate, leading to muscle atrophy and progressive
paralysis while cognitive function is usually unimpaired. No treatment is
currently available that will prevent, reverse, or otherwise alter the course
of the disease nor are the basic pathogenetic mechanisms of the disease
known. On a worldwide basis, ALS affects five to seven persons per 100,000,
striking about 1.2 times as many men as women. Around 30,000 Americans have
ALS. About 10 percent of all cases are believed to be familial, usually
inherited in an autosomal dominant pattern, and affecting roughly half of
family members. Prevalence studies indicate about 5,000 new cases of ALS in
the U.S. each year, 90 percent of which are sporadic. Familial and sporadic
ALS (SALS) appear to be clinically undistinguishable. The disease commonly
strikes in the fifth through seventh decades of life, although cases in young
adults and in the elderly are known. The average duration of life after
onset of symptoms of ALS is around three years, encompassing a progressive
course of increasing disability.
RESEARCH OBJECTIVES
Some progress has been made in recent years toward understanding the
biological bases of ALS. A number of pathological, biochemical, and
electrophysiological abnormalities are found in affected patients and are
seen in post-mortem nervous tissues. Markers for genes in familial ALS
(FALS), both dominant and recessive, have been identified, but they represent
only a portion of the possible gene loci. Fifteen to 20 percent of FALS have
a mutation of the copper/zinc superoxide dismutase (SOD1) gene on chromosome
21. However, the overwhelming majority of ALS patients do not have this
mutation. Genetic studies of ALS linked to other chromosomes are needed
especially of those genes easily influenced by neurotoxicants.
It is significant that the first descriptions of ALS coincided with the
industrial revolution. Therefore, it has been logical to consider whether
environmental contamination associated with increased levels of industrial
activity might be implicated in its pathogenesis. The possible role of
occupational exposures in ALS has also been investigated. Epidemiological
studies have implicated heavy metals and other environmental exposures as
risk factors for ALS but as yet have not provided a clear directional lead.
For example, various studies have looked at occupational exposure to lead,
mercury, selenium, manganese, aluminum, and iron exposure in assessing risk
factors for the disease. Calcium has also been studied because of
suggestions that excitotoxicity and calcium channel antibodies may be
implicated in its etiology. In addition, in some areas, agricultural workers
seem to have a higher risk of developing ALS, while studies on the exposure
to industrial solvents and chemicals have brought mixed results. No coherent
picture has emerged from these studies nor have many of them been correlated
with genetic studies. Therefore, much remains to be learned about the
mechanisms through which genetic mutations and other biological insults lead
to pathology. Consequently, research on the response to endogenous and
environmental toxicants, on the abnormal biology of the affected motor and
non-motor neurons, and on the identification of metabolic, endocrine, and
immunological abnormalities needs to be expanded.
The genetic defects identified in the familial form of ALS have lead to the
development of some useful animal models of the disease but more models are
needed to expand research on the abnormal biology of the affected motor
neuron and nonneuronal cells, on nervous system response to endogenous and
environmental toxins and toxicants, and on identification of metabolic,
endocrine, and immunological abnormalities.
Several meetings focused on ALS have categorized fruitful mechanistic
approaches to studying ALS. These are (1) the role of mitochondrial
oxidative stress, (2) the role of calcium/excitotoxicity, (3) the role of
proteosomal dysfunction and (4) the role of cytoskeletal dysfunction.
Additional research is also needed to understand the contribution of
environmental exposure, endogenous susceptibility factors, and increasing age
in the disease linkage. This will require a concurrent advancement and
refinement of methodologies and sciences. Of particular significance may be
those approaches that can be used across species from lower animals to
humans. Such approaches permit a precise characterization in animal models
of alterations arising from defined environmental exposures that can serve as
a cogent guide to underlying cellular and molecular mechanisms in humans.
This initiative will seek to solicit novel approaches to understanding ALS,
with emphasis on how gene-environment interactions may play in the above.
Examples of research goals that could be pursued, especially in appropriate
animal models and tissue culture, are listed below.
o Development of animal models of ALS especially nonmammalian models useful
for gene/environment research.
o Development of biomarkers of exposure/disease in animal models
(metabonomics, etc.)
o Research on modifier genes and environmental influences in animal models.
o Studies on the intersections/synergies between genetic susceptibilities and
environmental factors, as well as strategies for identifying putative
toxicants and other environmental factors involved in the etiology of ALS.
o Establishment of disease incidence and variation according to age, gender,
race/ethnicity, geography, exposure.
o Studies on potentially informative clusters (Western Pacific ALS/PDC,
Persian Gulf War ALS, Kelly Air Force, etc.)
o Studies on occupational/environmental exposures and non-occupational
exposures (evidence for role of metals, pesticides, solvents,
residential/avocational exposures, tobacco, alcohol, infectious agents.)
o Research on the potential role of dietary excitotoxins in Western Pacific
ALS-PDC-Dementia; analogies with other disorders.
o Research on the role of dietary intake of antioxidants, minerals (copper,
zinc, iron) and the association of fat and fiber intake with ALS.
o Research on factors targeting putative environmental toxicants specific to
motor neurons and surrounding cells including muscle cells.
o Research on disease mechanisms on cellular/subcellular level (oxidative
stress, excitotoxicity, apoptosis) from neurotoxic exposures.
o Evaluation of retrograde axonal transport of toxins to the spinal motor
neurons and their response (access and possible uptake of toxic substances at
the neuromuscular junction.)
The above is not intended to be all-inclusive. Moreover, the NIEHS would
like to encourage multidisciplinary and interdisciplinary studies. What may
be especially useful are collaborations with ongoing research in other motor
disorder diseases that could be expanded to include ALS studies. We also
encourage the use of novel animal models such as drosophila, zebra fish and
C. elegans, as well as newly available technologies. Especially useful would
be collaborative pooling of resources to standardize epidemiological
instruments, microarray analyses, -omics technologies, etc, for meaningful
use among several laboratories.
MECHANISM(S) OF SUPPORT
This PA primarily will use the NIH Research Project Grant (R01) and
Exploratory/Developmental Grant (R21) award mechanisms (though, if
appropriate, competitive supplements may be considered if it is to accomplish
collaborations.) As an applicant, you will be solely responsible for
planning, directing, and executing the proposed project. This PA uses just-
in-time concepts. It also uses the modular as well as the non-modular
budgeting formats (see
http://grants.nih.gov/grants/funding/modular/modular.htm). Specifically, if
you are submitting an application with direct costs in each year of $250,000
or less, use the modular format. Otherwise follow the instructions for non-
modular research grant applications. This program does not require cost
sharing as defined in the current NIH Grants Policy Statement at
http://grants.nih.gov/grants/policy/nihgps_2001/part_i_1.htm.
FUNDS AVAILABLE
The NIEHS intends to commit approximately $2M in FY 2004 to fund 10-15 new
grants in response to this PA. An applicant may request a project period of
up to five years for R01s and up to two years for R21s. Direct costs for
R21s may not exceed $275,000. The characteristics, requirements,
preparation, and review criteria for R21 applications are described at
http://grants.nih.gov/grants/guide/pa-files/PA-03-107.html. Because the
nature and scope of the proposed research will vary from application to
application, it is anticipated that the size and duration of each award will
also vary. Although the financial plans of the NIEHS provide support for
this program, awards pursuant to this PA are contingent upon the availability
of funds and the receipt of a sufficient number of meritorious applications.
ELIGIBLE INSTITUTIONS
You may submit (an) application(s) if your institution has any of the
following characteristics:
o For-profit or non-profit organizations
o Public or private institutions, such as universities, colleges, hospitals,
and laboratories
o Units of State and local governments
o Eligible agencies of the Federal government
o Domestic or foreign
INDIVIDUALS ELIGIBLE TO BECOME PRINCIPAL INVESTIGATORS
Any individual with the skills, knowledge, and resources necessary to carry
out the proposed research is invited to work with their institution to
develop an application for support. Individuals from underrepresented racial
and ethnic groups as well as individuals with disabilities are always
encouraged to apply for NIH programs.
WHERE TO SEND INQUIRIES
We encourage your inquiries concerning this PA and welcome the opportunity to
answer questions from potential applicants. Inquiries may fall into two
areas: scientific/research and financial or grants management issues:
o Direct your questions about scientific/research issues to:
Annette Kirshner, Ph.D.
Program Administrator
Cellular, Organs and Systems Pathobiology Branch
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233, MD-23
Research Triangle Park, NC 27709
Telephone: (919) 541-0488
FAX: (919) 541-5064
Email: [email protected]
o Direct your questions about financial or grants management matters to:
Pamela Evans
Grants Management Specialist
Grants Management Branch
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233, MD-22
Research Triangle Park, NC 27709
Telephone: (919) 541-7629
FAX: (919) 541-2860
Email: [email protected]
SUBMITTING AN APPLICATION
Applications must be prepared using the PHS 398 research grant application
instructions and forms (rev. 5/2001). The PHS 398 is available at
http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive
format. For further assistance contact GrantsInfo, Telephone (301) 435-0714,
Email: [email protected].
APPLICATION RECEIPT DATES: Applications submitted in response to this program
announcement will be accepted at the standard application deadlines, which
are available at http://grants.nih.gov/grants/dates.htm. Application
deadlines are also indicated in the PHS 398 application kit.
SPECIFIC INSTRUCTIONS FOR MODULAR GRANT APPLICATIONS: Applications
requesting up to $250,000 per year in direct costs must be submitted in a
modular grant format. The modular grant format simplifies the preparation of
the budget in these applications by limiting the level of budgetary detail.
Applicants request direct costs in $25,000 modules. Section C of the
research grant application instructions for the PHS 398 (rev. 5/2001) at
http://grants.nih.gov/grants/funding/phs398/phs398.html includes step-by-step
guidance for preparing modular grants. Additional information on modular
grants is available at
http://grants.nih.gov/grants/funding/modular/modular.htm.
SPECIFIC INSTRUCTIONS FOR APPLICATIONS REQUESTING $500,000 OR MORE PER YEAR:
Applications requesting $500,000 or more in direct costs for any year must
include a cover letter identifying the NIH staff member within one of NIH
institutes or centers who has agreed to accept assignment of the application.
Applicants requesting more than $500,000 must carry out the following steps:
1) Contact the IC program staff at least six weeks before submitting the
application, i.e., as you are developing plans for the study;
2) Obtain agreement from the IC staff that the IC will accept your
application for consideration for award; and,
3) Identify, in a cover letter sent with the application, the staff member
and IC who agreed to accept assignment of the application.
This policy applies to all investigator-initiated new (type 1), competing
continuation (type 2), competing supplement, or any amended or revised
version of these grant application types. Additional information on this
policy is available in the NIH Guide for Grants and Contracts, October 19,
2001 at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-004.html.
SENDING AN APPLICATION TO THE NIH: Submit a signed, typewritten original of
the application, including the checklist, and five signed photocopies in one
package to:
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710
Bethesda, MD 20817 (for express/courier service)
APPLICATION PROCESSING: Applications must be mailed on or before the receipt
dates described at
http://grants.nih.gov/grants/funding/submissionschedule.htm. The CSR will
not accept any application in response to this PA that is essentially the
same as one currently pending initial review unless the applicant withdraws
the pending application. The CSR will not accept any application that is
essentially the same as one already reviewed. This does not preclude the
submission of a substantial revision of an application already reviewed, but
such application must include an Introduction addressing the previous
critique.
Although there is no immediate acknowledgement of the receipt of an
application, applicants are generally notified of the review and funding
assignment within 8 weeks.
PEER REVIEW PROCESS
Applications submitted for this PA will be assigned on the basis of
established PHS referral guidelines. An appropriate scientific review group
convened in accordance with the standard NIH peer review procedures
(http://www.csr.nih.gov/refrev.htm) will evaluate applications for scientific
and technical merit.
As part of the initial merit review, all applications will:
o Receive a written critique
o Undergo a selection process in which only those applications deemed to have
the highest scientific merit, generally the top half of applications under
review, will be discussed and assigned a priority score
o Receive a second level review by the National Advisory Environmental Health
Sciences Council.
REVIEW CRITERIA
The goals of NIH-supported research are to advance our understanding of
biological systems, improve the control of disease, and enhance health. In
the written comments, reviewers will be asked to discuss the following
aspects of the application in order to judge the likelihood that the proposed
research will have a substantial impact on the pursuit of these goals:
o Significance
o Approach
o Innovation
o Investigator
o Environment
The scientific review group will address and consider each of these criteria
in assigning the application's overall score, weighting them as appropriate
for each application. The application does not need to be strong in all
categories to be judged likely to have major scientific impact and thus
deserve a high priority score. For example, an investigator may propose to
carry out important work that by its nature is not innovative but is
essential to move a field forward.
SIGNIFICANCE: Does this study address an important problem? If the aims of
the application are achieved, how will scientific knowledge be advanced? What
will be the effect of these studies on the concepts or methods that drive
this field?
APPROACH: Are the conceptual framework, design, methods, and analyses
adequately developed, well integrated, and appropriate to the aims of the
project? Does the applicant acknowledge potential problem areas and consider
alternative tactics?
INNOVATION: Does the project employ novel concepts, approaches or methods?
Are the aims original and innovative? Does the project challenge existing
paradigms or develop new methodologies or technologies?
INVESTIGATOR: Is the investigator appropriately trained and well suited to
carry out this work? Is the work proposed appropriate to the experience level
of the principal investigator and other researchers (if any)?
ENVIRONMENT: Does the scientific environment in which the work will be done
contribute to the probability of success? Do the proposed experiments take
advantage of unique features of the scientific environment or employ useful
collaborative arrangements? Is there evidence of institutional support?
PROTECTION OF HUMAN SUBJECTS FROM RESEARCH RISK: The involvement of human
subjects and protections from research risk relating to their participation
in the proposed research will be assessed. (See criteria included in the
section on Federal Citations, below).
INCLUSION OF WOMEN, MINORITIES AND CHILDREN IN RESEARCH: The adequacy of
plans to include subjects from both genders, all racial and ethnic groups
(and subgroups), and children as appropriate for the scientific goals of the
research will be assessed. Plans for the recruitment and retention of
subjects will also be evaluated. (See Inclusion Criteria in the sections on
Federal Citations, below).
CARE AND USE OF VERTEBRATE ANIMALS IN RESEARCH: If vertebrate animals are to
be used in the project, the five items described under Section f of the PHS
398 research grant application instructions (rev. 5/2001) will be assessed.
ADDITIONAL CONSIDERATIONS
BUDGET: The reasonableness of the proposed budget and the requested period
of support in relation to the proposed research.
AWARD CRITERIA
Applications submitted in response to a PA will compete for available funds
with all other recommended applications. The following will be considered in
making funding decisions:
o Scientific merit of the proposed project as determined by peer review
o Availability of funds
o Relevance to program priorities
REQUIRED FEDERAL CITATIONS
HUMAN SUBJECTS PROTECTION: Federal regulations (45CFR46) require that
applications and proposals involving human subjects must be evaluated with
reference to the risks to the subjects, the adequacy of protection against
these risks, the potential benefits of the research to the subjects and
others, and the importance of the knowledge gained or to be gained.
http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm
INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH: It is the policy of
the NIH that women and members of minority groups and their sub-populations
must be included in all NIH-supported clinical research projects unless a
clear and compelling justification is provided indicating that inclusion is
inappropriate with respect to the health of the subjects or the purpose of
the research. This policy results from the NIH Revitalization Act of 1993
(Section 492B of Public Law 103-43).
All investigators proposing clinical research should read the "NIH Guidelines
for Inclusion of Women and Minorities as Subjects in Clinical Research -
Amended, October 2001," published in the NIH Guide for Grants and Contracts
on October 9, 2001
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-001.html);
a complete copy of the updated Guidelines are available at
http://grants.nih.gov/grants/funding/women_min/guidelines_amended_10_2001.htm.
The amended policy incorporates: the use of an NIH definition of clinical
research; updated racial and ethnic categories in compliance with the new OMB
standards; clarification of language governing NIH-defined Phase III clinical
trials consistent with the new PHS Form 398; and updated roles and
responsibilities of NIH staff and the extramural community. The policy
continues to require for all NIH-defined Phase III clinical trials that: a)
all applications or proposals and/or protocols must provide a description of
plans to conduct analyses, as appropriate, to address differences by
sex/gender and/or racial/ethnic groups, including subgroups if applicable;
and b) investigators must report annual accrual and progress in conducting
analyses, as appropriate, by sex/gender and/or racial/ethnic group
differences.
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS:
The NIH maintains a policy that children (i.e., individuals under the age of
21) must be included in all human subjects research, conducted or supported
by the NIH, unless there are scientific and ethical reasons not to include
them. This policy applies to all initial (Type 1) applications submitted for
receipt dates after October 1, 1998.
All investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines" on the inclusion of children as participants in
research involving human subjects that is available at
http://grants.nih.gov/grants/funding/children/children.htm
REQUIRED EDUCATION ON THE PROTECTION OF HUMAN SUBJECT PARTICIPANTS: NIH
policy requires education on the protection of human subject participants for
all investigators submitting NIH proposals for research involving human
subjects. You will find this policy announcement in the NIH Guide for Grants
and Contracts Announcement, dated June 5, 2000, at
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.
HUMAN EMBRYONIC STEM CELLS (hESC): Criteria for federal funding of research on
hESCs can be found at http://stemcells.nih.gov/index.asp and at
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-005.html. Only
research using hESC lines that are registered in the NIH Human Embryonic Stem
Cell Registry will be eligible for Federal funding (see http://escr.nih.gov).
It is the responsibility of the applicant to provide, in the project
description and elsewhere in the application as appropriate, the official NIH
identifier(s)for the hESC line(s)to be used in the proposed research.
Applications that do not provide this information will be returned without
review.
PUBLIC ACCESS TO RESEARCH DATA THROUGH THE FREEDOM OF INFORMATION ACT: The
Office of Management and Budget (OMB) Circular A-110 has been revised to
provide public access to research data through the Freedom of Information Act
(FOIA) under some circumstances. Data that are (1) first produced in a
project that is supported in whole or in part with Federal funds and (2)
cited publicly and officially by a Federal agency in support of an action
that has the force and effect of law (i.e., a regulation) may be accessed
through FOIA. It is important for applicants to understand the basic scope
of this amendment. NIH has provided guidance at
http://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm.
Applicants may wish to place data collected under this PA in a public
archive, which can provide protections for the data and manage the
distribution for an indefinite period of time. If so, the application should
include a description of the archiving plan in the study design and include
information about this in the budget justification section of the
application. In addition, applicants should think about how to structure
informed consent statements and other human subjects procedures given the
potential for wider use of data collected under this award.
STANDARDS FOR PRIVACY OF INDIVIDUALLY IDENTIFIABLE HEALTH INFORMATION: The
Department of Health and Human Services (DHHS) issued final modification to
the "Standards for Privacy of Individually Identifiable Health Information",
the "Privacy Rule," on August 14, 2002. The Privacy Rule is a federal
regulation under the Health Insurance Portability and Accountability Act
(HIPAA) of 1996 that governs the protection of individually identifiable
health information, and is administered and enforced by the DHHS Office for
Civil Rights (OCR). Those who must comply with the Privacy Rule (classified
under the Rule as "covered entities") must do so by April 14, 2003 (with the
exception of small health plans which have an extra year to comply).
Decisions about applicability and implementation of the Privacy Rule reside
with the researcher and his/her institution. The OCR website
(http://www.hhs.gov/ocr/) provides information on the Privacy Rule, including
a complete Regulation Text and a set of decision tools on "Am I a covered
entity?" Information on the impact of the HIPAA Privacy Rule on NIH
processes involving the review, funding, and progress monitoring of grants,
cooperative agreements, and research contracts can be found at
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-025.html.
URLs IN NIH GRANT APPLICATIONS OR APPENDICES: All applications and proposals
for NIH funding must be self-contained within specified page limitations.
Unless otherwise specified in an NIH solicitation, Internet addresses (URLs)
should not be used to provide information necessary to the review because
reviewers are under no obligation to view the Internet sites. Furthermore,
we caution reviewers that their anonymity may be compromised when they
directly access an Internet site.
HEALTHY PEOPLE 2010: The Public Health Service (PHS) is committed to
achieving the health promotion and disease prevention objectives of "Healthy
People 2010," a PHS-led national activity for setting priority areas. This
PA is related to one or more of the priority areas. Potential applicants may
obtain a copy of "Healthy People 2010" at
http://www.health.gov/healthypeople.
AUTHORITY AND REGULATIONS: This program is described in the Catalog of
Federal Domestic Assistance at http://www.cfda.gov and is not subject to the
intergovernmental review requirements of Executive Order 12372 or Health
Systems Agency review. Awards are made under the authorization of Sections
301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284)
and under Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. All
awards are subject to the terms and conditions, cost principles, and other
considerations described in the NIH Grants Policy Statement. The NIH Grants
Policy Statement can be found at
http://grants.nih.gov/grants/policy/policy.htm
The PHS strongly encourages all grant recipients to provide a smoke-free
workplace and discourage the use of all tobacco products. In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in
certain facilities (or in some cases, any portion of a facility) in which
regular or routine education, library, day care, health care, or early
childhood development services are provided to children. This is consistent
with the PHS mission to protect and advance the physical and mental health of
the American people.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
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