GEOGRAPHIC-BASED RESEARCH IN CANCER CONTROL AND EPIDEMIOLOGY
Release Date: July 11, 2000
PA NUMBER: PAS-00-120
National Cancer Institute
Letter of Intent Date: October 9, 2000 and June 14, 2001
Application Receipt Date: November 13, 2000 and July 19, 2001
THIS PA USES THE "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. IT INCLUDES
DETAILED MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE USED
WHEN PREPARING APPLICATIONS IN RESPONSE TO THIS PA.
The recently published Atlas of Cancer Mortality in the United States, 1950-
1994(*1) displays the geographic patterns for various forms of cancer (see
http://www.nci.nih.gov/atlas). This PA encourages applicants to use this
exciting new resource as a catalyst for research in cancer etiology and
control. Further epidemiologic research is needed to identify the reasons
for the geographic variation of specific cancers including the clustering of
areas with high or low incidence and/or mortality rates. In addition,
Geographic Information Systems (GIS) provide new tools for the exploration of
such geographic patterns. GIS can be used for assessment of environmental
risk factors, identification of places and/or subpopulations where cancer
surveillance and control programs are needed, statistical analysis of spatial
patterns and presentation, and dissemination of information to the public.
The NCI wishes to stimulate research in three areas in order to encourage
researchers to use the Atlas to speed the process of scientific discovery and
application. The areas include: (1) epidemiologic research to study the
determinants of the geographic patterns uncovered by the Atlas, (2) use of
GIS for cancer research in response to the Atlas, and (3) methodologic GIS
research needed to accomplish such research.
This PA is for investigator-initiated R01 applications. A PA for smaller R03
applications is being advertised in parallel to this announcement
(http://grants.nih.gov/grants/guide/pa-files/PAS-00-121.html). This PA will
expire on July 20, 2001.
This PA will facilitate interdisciplinary collaborations among researchers to
foster appropriate use of the recently published Atlas of Cancer Mortality in
the United States, 1950-1994 to examine geographic variations in cancer and
to study the factors that may contribute to the variations. It also will
facilitate integration of new GIS tools for epidemiologic and behavioral
research, cancer surveillance and control research, promote development of
GIS methodology, and encourage researchers to integrate different types and
geographic levels of data in epidemiologic research and in planning,
implementation and evaluation of cancer-related programs.
The proposed mechanism is a Program Announcement, with a set-aside, to
encourage NIH grant-funded research in these three areas. It is a response
to the recently released Atlas, to technological advances in science and to
advisory group recommendations. Specifically, this PA responds to a
recommendation of the Surveillance Implementation Group (SIG) Report (March
1999) that the DCCPS Surveillance Research Program explore the feasibility
and utility of employing GISs for geocoding surveillance data and reporting
geographic relationships among screening measures, risk factors (including
environmental exposures), and improved cancer outcomes , as well as
increasing general interest in the use of GIS by public health researchers.
The new Atlas of Cancer Mortality in the United States shows the geographic
patterns of cancer death rates in over 3,000 counties across the country for
more than four decades. The Atlas uses 1950-94 mortality data from the
National Center for Health Statistics and population estimates from the
Census Bureau. Rates per 100,000 person-years, directly standardized using
the 1970 U.S. population, are calculated by race (whites, blacks) and sex for
40 forms of cancer. The Atlas includes more than 250 computerized color-
coded maps showing variations in cancer rates during 1970-94 and compares
them with corresponding maps for 1950-69. Summary tables and figures are
also presented. Maps, tables, and the underlying data from the new Atlas are
also available on the Web at http://www.nci.nih.gov/atlas. Another feature
of the atlas Web site is that the user can create customized maps to look at
cancer rates in any county.
The updated maps show that previously observed patterns of selected cancers
have persisted. For some tumors, the geographic clustering of areas with
elevated rates has become more pronounced in the recent time period. Follow-
up studies of geographic relations among cancer mortality rates demonstrated
in the first published cancer atlas have led to such notable findings as the
association of snuff dipping and oral cancer(*2) and the association of
shipyard asbestos exposure and lung cancer(*3). The updated geographic
patterns will provide direction in formulating etiologic and other
hypotheses, and in targeting high-risk populations for further epidemiologic
research and cancer control interventions.
One new method which allows the evaluation of the spatial distribution of
disease and disease risk is Geographic Information System (GIS). A GIS is a
computer system which carries out various data management and analytic tasks
on spatially referenced data. The basic elements of a GIS are geographic
data and a computer system for input, storage, processing, linkage, analysis,
modeling, and display (for more information, see
http://www.esri.com/gisforeveryone). A GIS produces a series of stacked
maps or data layers of georeferenced data linked to descriptive attribute
information. By processing multidimensional data at different geographic
levels and maintaining the spatial relationships among them, a GIS provides a
powerful tool for the analysis and presentation of spatial data. In
addition, a GIS is capable of integrating both spatial and temporal data.
This is important when studying diseases such as cancer for which the
relevant time period of exposure may have occurred many years prior to
diagnosis. The National Cancer Institute (NCI) has supported a variety of
modest efforts in this area through intramural research and extramural
contracts and has recently funded a large GIS project for breast cancer
research on Long Island.
A GIS is a unique tool for the analysis of the spatial structure of data,
because it has the capability to analyze associations among data collected at
virtually any geographic resolution. Ecologic analyses can be conducted at a
finer geographic resolution than previously possible. Therefore, researchers
may use GIS to develop hypotheses about cancer etiology and control. In the
past, important links between cancer mortality and risk factors have been
identified by astute observers who brought personal knowledge of local areas
to bear on cancer mortality maps. Now, a GIS can present layers of risk
factor data, providing a more systematic and efficient way to explore these
associations. The layering of information, such as water source, land use,
location of pollution sources and cancer screening facilities, and various
other environmental, demographic and lifestyle information, also offers
advantages in exposure assessment for both ecologic and analytic
epidemiologic studies. For individual-based exposure assessment, researchers
can analyze spatial and spatio-temporal relationships (e.g., proximity of a
study participant to a pollution source). More importantly, researchers can
incorporate information about the geophysical environment into the GIS, e.g.,
to ascertain the transport of a pollution source or to identify physical
barriers, such as distance, to screening facility utilization.
Applications of GIS in cancer research include both exploratory and
confirmatory spatial analysis of cancer incidence, mortality, survival,
and/or prevalence in local populations. Investigators can use a GIS to
monitor cancer patterns and their changes over both time and space, thus
serving as a tool for surveillance, planning and evaluation of cancer control
strategies as well as for implementation of culturally relevant cancer
prevention and intervention efforts in economically disadvantaged and
underserved communities. Investigators can develop hypotheses about the
relationships between cancer rates and community characteristics for the
purpose of focusing future etiologic studies and determining community
barriers to cancer screening and prevention programs. The latter type of
study will help target further research to analyze social factors, such as
socioeconomic status (SES), education, coping resources and support systems,
residential factors, cultural variables, institutional and political forces
such as racism and classism, familial factors, health access and health
outcomes and media influences. In etiologic studies, a GIS can aid in
evaluating patterns of community and individual characteristics such as
occupation, ethnicity and lifestyle factors that may be related to the cancer
rates in the area. A GIS is also a valuable tool for the evaluation of
environmental exposures which cannot be obtained by questionnaires or direct
measurements. GIS-based environmental exposure assessment will be useful in
understanding cancers with shorter latencies, e.g., childhood leukemias,
however, cancers with longer latencies can be studied when data are
available. A GIS has proven to be a valuable tool for the modeling of the
fate and transport of environmental contaminants. Examples of models that
lend themselves well to GIS-based technology include models of air
pollutants, ground water quality, and pesticide transport.
Substantial methodologic advances are needed before GIS can reach its full
potential in cancer research. For example, once a GIS database is compiled,
how may these data be used by researchers to identify areas with unusually
high rates and to examine the links between potential causal factors and
these geographic patterns. Issues of data availability, quality, and
confidentiality must be addressed, analytic methods must be enhanced, and
presentation methods improved. Risk factor, confounding factor and disease
data must be collected, measured and georeferenced in a standardized way for
all small areas and, where possible, for all minority and underserved groups
in the study region.
Once researchers identify suitable georeferenced data, they need analytic
methods to evaluate the spatial and spatio-temporal patterns of cancer
incidence, survival and death and the associations of these patterns with
those of relevant exposures. Current methods for exploratory data analysis
are limited to smoothing techniques with often untenable assumptions, e.g.,
kriging, or pairwise comparisons of disease and exposure maps. We must also
encourage the formal development of formal methods for evaluating the
magnitude of effects and mechanisms through which health may be influenced by
sociocultural factors. More advanced methods of visualizing multivariable
associations among geo-referenced data are needed. For confirmatory
analysis, statistical methods for the assessment of spatial or
spatio-temporal patterns of cancer and their association with potential risk
factors need to be expanded beyond current methods. Automated identification
of statistically meaningful cancer clusters is needed to objectively evaluate
apparent "hot spots" on cancer maps so as to better focus etiologic and
intervention studies and to allay fears of cancer in communities where
occasionally high cancer rates are likely due to chance variation over time.
The recently published Atlas of Cancer Mortality in the United States, 1950-
1994 displays the geographic patterns for various forms of cancer. This PA
encourages applicants to use this exciting new resource as a catalyst for
research in cancer etiology and control. Further epidemiologic research is
needed to identify the reasons for the geographic variation of specific
cancers including the clustering of areas with high or low incidence and/or
mortality rates. In addition, Geographic Information Systems (GIS) provide
new tools for the exploration of such geographic patterns. GIS can be used
for assessment of environmental risk factors, identification of places
and/or subpopulations where cancer surveillance and control programs are
needed, statistical analysis of spatial patterns and presentation, and
dissemination of information to the public. The NCI wishes to stimulate
research in three areas in order to encourage researchers to use the Atlas to
speed the process of scientific discovery and application. The areas
include: (1) epidemiologic research to study the determinants of the
geographic patterns uncovered by the Atlas, (2) use of GIS for cancer
research in response to the Atlas, and (3) methodologic GIS research needed
to accomplish such research.
Examples of Studies Sought
Applications in Epidemiologic Research
o Analytic epidemiologic studies, (e.g., case-control or cohort studies) to
identify risk factors such as occupation, lifestyle factors, environmental
contaminants for cancers showing interesting geographic and/or temporal
patterns and cancers, including but not limited to those for which GIS-based
analyses might be particularly useful. Small studies may complement ongoing
or existing studies.
o Ecologic studies of cancer patterns: generate hypotheses about etiologic
and prognostic factors responsible for geographic patterns of cancer and/or
changing patterns over time.
o Development of a GIS for specific ecologic or analytic epidemiologic
o Development of a GIS for exposure assessment to use in future, ongoing, or
existing epidemiologic studies.
Applications in Cancer Control
o Cancer and cancer control surveillance: monitor emerging trends in cancer-
related health behaviors, incidence, mortality, or treatment in a particular
o Sociocultural studies: Identify under-served or high-risk sub-populations
by examining the inter-relation of ethnicity, access to and use of health
services, SES, health behaviors and other cancer risk factors through the use
of GIS and/or the Cancer Atlas.
o Sociocultural studies: Improve methodologies for examining the
juxtaposition of culture and behavior in spatial terms by assessing the
influence of spatial relationships with cancer-related behaviors, e.g.,
examine spatial relationship of neighborhood crime, physical activity,
intake of fruits and vegetables and travel distance to purchase produce,
examine issues regarding barriers to health care by exploring the concept of
distance e.g. what do people consider a long way to go to the doctor? too
many buses? travel through unknown or dangerous neighborhoods?, etc., explore
the disproportionate placement of hazardous waste sites in low-income and
o Neighborhood and community research: Combine GIS analyses with
quantitative epidemiological analyses and survey methods to examine the
relationship of neighborhood conditions (e.g. poverty, environmental
pollution) to cancer-related behaviors and practices and/or indicators of
disparities in health outcomes. Measure relationship between cancer-related
behaviors of families/communities and neighborhood structural factors such as
impoverishment, geographic isolation, residential instability, economic
o Communication of cancer risk and/or rate information to the public using
the Atlas and/or GIS.
o Improve and/or develop methods related to geographic-based data, e.g.,
protecting data confidentiality, identifying specific locations of cancer
cases and exposure sources, geocoding, standardized methods for collecting
detailed data, i.e., occurrence, timing and sequencing of life events or
o Develop and validate GIS-based databases relevant to studies of cancer
epidemiology and control, e.g., environmental databases for exposure
assessment, model-based exposure estimates.
o Refine analytical methods for geographic and/or GIS-based cancer research,
e.g., statistical assessment of spatial or spatio-temporal cancer patterns or
a change in these trends, analysis of multivariate cancer and risk factor
data, automated identification of cancer clusters, small-area estimation of
cancer-related factors from larger-area survey data, methods for integrating
environmental models into epidemiologic studies.
o Examine issues related to the visualization and presentation of GIS data,
e.g., how to use-new technologies to improve the design of GIS maps and
usability of computer-user-interfaces, studies of GIS design and usability,
appropriate methods of conveying cancer risk information to the public
through a GIS.
o Develop extensions or software links to existing GIS software to add
analytic tools such as described above.
MECHANISM OF SUPPORT
This PA will use the National Institute of Health (NIH) research project
grant (R01). Responsibility for the planning, direction, and execution of
the proposed project will be solely that of the applicant. NIH Grants
policies apply to these awards.
Specific application instructions have been modified to reflect "MODULAR
GRANT" and "JUST-IN-TIME" streamlining efforts being examined by the NIH.
Complete and detailed instructions and information on Modular Grant
applications can be found at
The NCI has budgeted $3 million total costs (direct plus facilities and
administrative costs) for the first year of funding for each round of
applications received, subject to the availability of funds. This amount
includes those grants selected for funding for this PA as well as the
parallel PA for R03 submissions
(http://grants.nih.gov/grants/guide/pa-files/PAS-00-121.html). It is expected
that NCI will make a total of four to seven R01 awards for periods up to five
years. The number of awards and individual level of support are dependent on
the receipt of a sufficient number and diversity of applications with high
scientific merit. Program balance and diversity of topics will be factors in
selecting applications for
Budget requests should be justified and commensurate with the needs of the
project. Annual budgets for years two through four should not exceed the
first year budget plus a 3% yearly increase. Equipment needs, especially in
future years, must be well justified.
Applications may be submitted by foreign and domestic, for-profit and not-
for-profit organizations, public and private, such as universities, colleges,
hospitals, laboratories, units of State and local governments, and eligible
agencies of the Federal government. The total requested project period for an
application submitted in response to this PA may not exceed five years.
Foreign applications will receive no support for Facility and Administrative
(F&A) costs. Domestic applications may include international components but
these components will receive no support for F&A costs. Racial/ethnic
minority individuals, women, and persons with disabilities are encouraged to
apply as principal investigators.
Inquiries are encouraged. The opportunity to clarify any issues or questions
from potential applicants is welcome.
Direct inquiries regarding programmatic issues to:
Burdette (Bud) W. Erickson, Jr., M.Sc.
Division of Cancer Control and Population Sciences
National Cancer Institute
6130 Executive Blvd., Rm. 240H
Bethesda, MD 20892
Telephone: (301) 435-4913
FAX: (301) 402-4279
Direct inquiries regarding fiscal matters to:
Ms. Sara Stone
Grants Administration Branch
National Cancer Institute
6120 Executive Blvd., Rm. 243
Bethesda, MD 20892
Telephone: (301) 496-9927
FAX: (301) 496-8601
LETTER OF INTENT
Prospective applicants are asked to submit, by the date listed at the
beginning of this PA, a letter of intent that includes a descriptive title of
the proposed research, the name, address, and telephone number of the
Principal Investigator, the identities of other key personnel and
participating institutions, and the number and title of the PA in response to
which the application may be submitted. Although a letter of intent is not
required, is not binding, and does not enter into the review of a subsequent
application, the information that it contains allows IC staff to estimate the
potential review workload and to plan the review.
The letter of intent is to be sent to Mr. Burdette W. Erickson, Jr., listed
under INQUIRIES by the letter of intent receipt date listed in the heading of
Applications are to be submitted on the grant application form PHS 398 (rev.
4/98) and will be accepted on or before the receipt dates indicated on the
first page of this announcement. Application kits are available at most
institutional offices of sponsored research and may be obtained from the
Division of Extramural Outreach and Information Resources, National
Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-
7910, telephone 301/435-0714, E-mail: firstname.lastname@example.org. The title and
number of the program announcement must be typed on line 2 of the face page
of the application form and the YES box must be marked. For those applicants
with internet access, the 398 kit may be found at
Applicants planning to submit an application requesting $500,000 or more in
direct costs for any year are advised that he or she must contact the
Institute program staff before submitting the application, i.e. as plans for
the study are being developed. Furthermore, the applicant must obtain
agreement from the Institute staff that the Institute will accept the
application for consideration for award. Finally, the applicant must
identify, in a cover letter sent with the application, the staff member and
Institute who agreed to accept assignment of the application.
SPECIFIC INSTRUCTIONS FOR MODULAR GRANT APPLICATIONS
The title and number of the program announcement must be typed on line 2 of
the face page of the application form and the YES box must be marked.
Modular Grant applications will request direct costs in $25,000 modules, up
to a total direct cost request of $250,000 per year. (Applications that
request more than $250,000 direct costs in any year must follow the
traditional PHS 398 application instructions.) The total direct costs must be
requested in accordance with the program guidelines and the modifications
made to the standard PHS 398 application instructions described below:
o FACE PAGE: Items 7a and 7b should be completed, indicating Direct Costs
(in $25,000 increments) and Total Costs [Modular Total Direct plus Facilities
and Administrative (F&A) costs] for the initial budget period. Items 8a and
8b should be completed indicating the Direct and Total Costs for the entire
proposed period of support.
o DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD - Do not complete Form Page
4 of the PHS 398. It is not required and will not be accepted with the
o BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT - Do not complete the
categorical budget table on Form Page 5 of the PHS 398. It is not required
and will not be accepted with the application.
o NARRATIVE BUDGET JUSTIFICATION - Prepare a Modular Grant Budget Narrative
page (see http://grants.nih.gov/grants/funding/modular/modular.htm for sample
pages). At the top of the page, enter the total direct costs requested for
each year. This is not a form page.
o Under Personnel, list key project personnel, including their names,
percent of effort, and roles on the project. No individual salary information
should be provided. However, the applicant should use the NIH appropriation
language salary cap and the NIH policy for graduate student compensation in
developing the budget request.
For Consortium/Contractual costs, provide an estimate of total costs (direct
plus facilities and administrative) for each year, each rounded to the
nearest $1,000. List the individuals/organizations with whom consortium or
contractual arrangements have been made, the percent effort of key personnel,
and the role on the project. Indicate whether the collaborating institution
is domestic or foreign. The total cost for a consortium/contractual
arrangement is included in the overall requested modular direct cost amount.
Include the Letter of Intent to establish a consortium.
Provide an additional narrative budget justification for any variation in the
number of modules requested.
o BIOGRAPHICAL SKETCH - The Biographical Sketch provides information used by
reviewers in the assessment of each individual"s qualifications for a
specific role in the proposed project, as well as to evaluate the overall
qualifications of the research team. A biographical sketch is required for
all key personnel, following the instructions below. No more than three
pages may be used for each person. A sample biographical sketch may be
- Complete the educational block at the top of the form page,
- List position(s) and any honors,
- Provide information, including overall goals and responsibilities, on
research projects ongoing or completed during the last three years,
- List selected peer-reviewed publications, with full citations.
o CHECKLIST - This page should be completed and submitted with the
application. If the F&A rate agreement has been established, indicate the
type of agreement and the date. All appropriate exclusions must be applied in
the calculation of the F&A costs for the initial budget period and all future
The applicant should provide the name and phone number of the individual to
contact concerning fiscal and administrative issues if additional information
is necessary following the initial review.
Applications not conforming to these guidelines will be considered
unresponsive to this PA and will be returned without further review.
Submit a signed, typewritten original of the application, including the
checklist, and five signed, exact, single-sided photocopies, in one package
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive
Room 1040 - MSC 7710
Bethesda, MD 20892-7710
(20817 for express service)
Applications must be received by the receipt date on the front page of this
PA. If an application is received after that date, it will be returned to
the applicant without review. The Center for Scientific Review (CSR) will
not accept any application in response to this PA that is essentially the
same as one currently pending initial review, unless the applicant withdraws
the pending application. The CSR will not accept any application that is
essentially the same as one already reviewed. This does not preclude the
submission of substantial revisions of applications already reviewed, but
such applications must include an introduction addressing the previous
Upon receipt, applications will be reviewed for completeness by the Center
for Scientific Review (CSR). Incomplete applications will be returned to the
applicant without further consideration.
Applications that are complete will be evaluated for scientific and technical
merit by a special peer review group convened by CSR in accordance with the
standard NIH peer review procedures. As part of the initial merit review,
all applications will receive a written critique and undergo a process in
which only those applications deemed to have the highest scientific merit,
generally the top half of applications under review, will be discussed,
assigned a priority score, and receive a second level review by the National
Cancer Advisory Board.
The five criteria to be used in the evaluation of grant applications are
The goals of NIH-supported research are to advance our understanding of
biological systems, improve the control of disease, and enhance health. The
reviewers will comment on the following aspects of the application in their
written critiques in order to judge the likelihood that the proposed research
will have a substantial impact on the pursuit of these goals. Each of these
criteria will be addressed and considered by the reviewers in assigning the
overall score weighting them as appropriate for each application. Note that
the application does not need to be strong in all categories to be judged
likely to have a major scientific impact and thus deserve a high priority
score. For example, an investigator may propose to carry out important work
that by its nature is not innovative but is essential to move a field
1. Significance. Does this study address an important problem? If the aims
of the application are achieved, how will scientific knowledge be advanced?
What will be the effect of these studies on the concepts or methods that
drive this field?
2. Approach. Are the conceptual framework, design, methods, and analyses
adequately developed, well-integrated, and appropriate to the aims of the
project? Does the applicant acknowledge potential problem areas and consider
3. Innovation. Does the project employ novel concepts, approaches or
method? Are the aims original and innovative? Does the project challenge
existing paradigms or develop new methodologies or technologies?
4. Investigator. Is the investigator appropriately trained and well suited
to carry out this work? Is the work proposed appropriate to the experience
level of the principal investigator and other researchers (if any)?
5. Environment. Does the scientific environment in which the work will be
done contribute to the probability of success? Do the proposed experiments
take advantage of unique features of the scientific environment or employ
useful collaborative arrangements? Is there evidence of institutional
The initial review group will also examine: the appropriateness of proposed
project budget and duration, the adequacy of plans to include both genders
and minorities and their subgroups, and children as appropriate for the
scientific goals of the research and plans for the recruitment and retention
of subjects, the provisions for the protection of human and animal subjects,
and the safety of the research environment.
Applications will compete for available funds with all other recommended
applications. The following will be considered in making funding decisions:
Quality of the proposed project as determined by peer review, availability of
funds, and program priority.
INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of the NIH that women and members of minority groups and
their subpopulations must be included in all NIH supported biomedical and
behavioral research projects involving human subjects, unless a clear and
compelling rationale and justification is provided that inclusion is
inappropriate with respect to the health of the subjects or the purpose of
the research. This policy results from the NIH Revitalization Act of 1993
(Section 492B of Public Law 103-43).
All investigators proposing research involving human subjects should read the
"NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical
Research," which have been published in the Federal Register of March 20,
1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts,
Volume 23, Number 11, March 18, 1994 available on the web at the following
URL address: http://grants.nih.gov/grants/guide/notice-files/not94-100.html.
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS.
It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by
the NIH, unless there are clear and compelling scientific and ethical reasons
not to include them. This policy applies to all initial (Type 1) applications
submitted for receipt dates after October 1, 1998.
All investigators proposing research involving human subjects should read the
NIH Policy and Guidelines on the Inclusion of Children as Participants in
Research Involving Human Subjects that was published in the NIH Guide for
Grants and Contracts, March 6, 1998, and is available at the following URL
Investigators also may obtain copies of the policy from the program staff
listed under INQUIRIES. Program staff may also provide additional relevant
information concerning the policy.
URLs IN NIH GRANT APPLICATIONS OR APPENDICES
All applications and proposals for NIH funding must be self-contained within
specified page limitations. Unless otherwise specified in an NIH
solicitation, internet addresses (URLs) should not be used to provide
information necessary to the review because reviewers are under no obligation
to view the Internet sites. Reviewers are cautioned that their anonymity may
be compromised when they directly access an Internet site (see
HEALTHY PEOPLE 2010
The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2010," a
PHS-led national activity for setting priority areas. This PA, Geographic-
based Research in Cancer Control And Epidemiology , is related to the
priority area of Cancer. Potential applicants may obtain a copy of "Healthy
People 2010" or at http://www.health.gov/healthypeople/.
AUTHORITY AND REGULATIONS
This program is described in the Catalog of Federal Domestic Assistance No.
93.399, Cancer Control Research. Awards are made under authorization of the
Sections 301 and 405 of the Public Health Service Act as amended ( 42 USC 241
and 284) and administered under NIH grants policies and Federal Regulations
42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the
intergovernmental review requirements of Executive Order 12372 or Health
Systems Agency review.
The PHS strongly encourages all grant and contract recipients to provide a
smoke-free workplace and promote the non-use of all tobacco products. In
addition, Public Law 103-227, the Pro- Children Act of 1994, prohibits
smoking in certain facilities (or in some cases, any portion of a facility)
in which regular or routine education, library, day care, health care or
early childhood development services are provided to children. This is
consistent with the PHS mission to protect and advance the physical and
mental health of the American people.
1. Devesa SS, Grauman DJ, Blot WJ, Pennello GA, Hoover RN, Fraumeni JF Jr.
Atlas of Cancer Mortality in the United States, 1950-94. NIH Publ. No. 99-
4564. Bethesda, MD: National Institutes of Health, 1999. See accompanying
web site: http://www-dceg.ims.nci.nih.gov/atlas/index.html
2.Winn DM, Blot WJ, Shy CM, Pickle LW, Toledo A, Fraumeni JF Jr. Snuff
dipping and oral cancer among women in the southern United States. N Eng J
Med 304:745-9, 1981.
3. Blot WJ, Morris LE, Stroube R, Tagnon I, Fraumeni JF Jr. Lung and
laryngeal cancers in relation to shipyard employment in coastal Virginia. J
Natl Cancer Inst 65:571-5, 1980.
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NIH Funding Opportunities and Notices