Department of Health and Human Services
Part 1. Overview Information
Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

National Cancer Institute (NCI)
National Human Genome Research Institute (NHGRI)
National Institute on Aging (NIA)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute on Drug Abuse (NIDA)
National Institute of Mental Health (NIMH)
National Institute of Nursing Research (NINR)
National Institute on Minority Health and Health Disparities (NIMHD)
National Center for Complementary and Integrative Health (NCCIH)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers.  The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Office of Strategic Coordination (Common Fund)

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

Division of Program Coordination, Planning and Strategic Initiatives, Office of AIDS Research (OAR)

Office of Research on Women's Health (ORWH))

Funding Opportunity Title

Administrative Supplements for Research on Sexual and Gender Minority (SGM) Populations (Admin Supp  Clinical Trial Optional)

Activity Code

Administrative Supplement

Additional funds may be awarded as supplements to parent awards using the following Activity Code(s):

Administrative supplement requests may be submitted electronically for the following activity codes:

C06 Research Facilities Construction Grant

D43 International Training Grants in Epidemiology

D71 International Training Program Planning Grant

DP1 NIH Director's Pioneer Award (NDPA)

DP2 NIH Director's New Innovator Awards

DP3 Type 1 Diabetes Targeted Research Award

DP4 NIH Director's Pathfinder Award- Multi-Yr Funding

DP5 Early Independence Award

DP7 NIH Director's Workforce Innovation Award

F05 International Research Fellowships

F30 Individual Predoctoral NRSA for MD/PhD Fellowships

F31 Predoctoral Individual National Research Service Grant Award

F32 Postdoctoral Individual National Research Service Award

F33 National Research Service Awards for Senior Fellows

F37 Medical Informatics Fellowships

F38 Applied Medical Informatics Fellowships

F99/K00 Pre-doc to Post-doc Transition Award/ Post-doctoral Transition Award

FI2 Intramural Postdoctoral Research Associate

G08 Resources Project Grant (NLM)

G11 Extramural Associate Research Development Award (EARDA)

G13 Health Sciences Publication Support Awards (NLM)

G20 Grants for Repair, Renovation and Modernization of Existing Research Facilities

K01 Research Scientist Development Award - Research & Training

K02 Research Scientist Development Award – Research

K05 Research Scientist Award

K06 Research Career Awards

K07 Academic/Teacher Award (ATA)

K08 Clinical Investigator Award (CIA)

K12 Physician Scientist Award (Program) (PSA)

K18 Career Enhancement Award

K22 Career Transition Award

K23 Mentored Patient-Oriented Research Career Development Award

K24 Midcareer Investigator Award in Patient-Oriented Research

K25 Mentored Quantitative Research Career Development Award

K26 Midcareer Investigator Award in Biomedical and Behavioral Research

K43 International Research Career Development Award

K76 Emerging Leaders Career Development Award

K99/R00 Career Transition Award/Research Transition Award

KL1 Linked Research Career Development Award

KL2 Mentored Career Development Award

KM1 Institutional Career Enhancement Awards

OT1 Pre-Application for another Transaction Award

OT2 Research Project - Other Transaction Award

RC2 High Impact Research and Research Infrastructure Programs

RC3 Biomedical Research, Development, and Growth to Spur the Acceleration of New Technologies (BRDG-SPAN) Program

RC4 High Impact Research and Research Infrastructure Programs – Multi-Yr Funding

RM1 Research Project with Complex Structure

R01 Research Project Grant

R03 Small Grant Program

R13 Support for Conferences and Scientific Meetings

R13/U13 Support for Conferences and Scientific Meetings

R15 Academic Research Enhancement Award (AREA)

R18 Research Demonstration and Disseminations Projects

R21 Exploratory/Developmental Research Grant Award

R21/R33 Phased Innovation Award

R24 Resource-Related Research Projects

R25 Education Projects

R28 Resource-Related Research Projects

R33 Exploratory/Developmental Grants Phase II

R34 Clinical Trial Planning Grant Program

R35 Outstanding Investigator Award

R36 Dissertation Award

R37 Method to Extend Research in Time (MERIT) Award

R41 Small Business Technology Transfer (STTR) Grant - Phase I only

R41/R42 Small Business Technology Transfer (STTR) Grant - Phase I, Phase II, and Fast-Track

R41/R42 Small Business Technology Transfer (STTR) Grant - Phase I and Phase II

R42 Small Business Technology Transfer (STTR) Grant - Phase II only

R43 Small Business Innovation Research (SBIR) Grant - Phase I only

R43/R44 Small Business Innovation Research (SBIR) Grant - Phase I, Phase II, and Fast-Track

R43/R44 Small Business Innovation Research (SBIR) Grant - Phase I and Phase II

R44 Small Business Innovation Research (SBIR) Grant - Phase II only

R50 Research Specialist Award

R61/R33 Exploratory/Developmental Phased Award

RC1 NIH Challenge Grants and Partnerships Program – Phase I

RC2 High Impact Research and Research Infrastructure Programs

RC3 Biomedical Research, Development, and Growth to Spur the Acceleration of New Technologies (BRDG-SPAN) Program

RC4 High Impact Research and Research Infrastructure Programs – Multi-Yr Funding

RF1 Multi-Year Funded Research Project Grant

RL1 Linked Research project Grant

RL2 Linked Exploratory/Development Grant

RL5 Linked Education Project

RL9 Linked Research Training Award

RM1 Research Project with Complex Structure

S07 Biomedical Research Support Grants

S10 Biomedical Research Support Shared Instrumentation Grants

S11 Minority Biomedical Research Support Thematic Project Grants

S21 Research and Institutional Resources Health Disparities Endowment Grants – Capacity Building

SB1 Commercialization Readiness Program

SC1 Research-Enhancement Award

SC2 Pilot Research Project

SC3 Research Continuance Award

T14 Conferences

T15 Continuing Education Training Grants

T32 Institutional National Research Service Award (NRSA)

T34 MARC Undergraduate NRSA Institutional Grants

T35 National Research Service Award (NRSA) Short -Term Research Training

T36 MARC Ancillary Training Activities Grant

T37 Minority International Research Training Grants

T42 Educational Resource Center Training Grants

T90/R90 Interdisciplinary Research Training Award/Interdisciplinary Regular Research Training Award

TL1 Linked Training Award

TL4 Undergraduate NRSA Institutional Research Training Grants

TU2 Institutional National Research Service Award with Involvement of NIH Intramural Faculty

U01 Research Project – Cooperative Agreements

U13 Conferences Cooperative Agreements

U18 Research Demonstration – Cooperative Agreements

U2R International Training Cooperative Agreement

U24 Resource-Related Research Projects – Cooperative Agreements U34 Clinical Planning Grant Cooperative Agreement

U44 Small Business Innovation Research (SBIR) Cooperative Agreements - Phase II

UA5 Academic Research Enhancement Award (AREA) Cooperative Agreements

UB1 Commercialization Readiness Program - Cooperative Agreement

UC4 High Impact Research and Research Infrastructure - Cooperative Agreement Programs

UFI Multi-Year Funded Research Project Cooperative Agreement UG1 Clinical Research Cooperative Agreements - Single Project

UG3/UH3 Exploratory/Developmental Phased Award Cooperative Agreement

UH2 Exploratory/Developmental Cooperative Agreement Phase I

UH2/UH3 Phase Innovation Awards Cooperative Agreement

UH3 Exploratory/Developmental Cooperative Agreement Phase II

UM1 Multi-Component Research Project Cooperative Agreements

UP5 Cooperative Agreement

Announcement Type

Reissue of PA-17-098

Related Notices
Funding Opportunity Announcement (FOA) Number

PA-18-713

Companion Funding Opportunity

None

Catalog of Federal Domestic Assistance (CFDA) Number(s)

93.121, 93.172, 93.173, 93.213, 93.393, 93.394, 93.395, 93.396, 93.399, 93.846, 93.847, 93.855, 93.866, 93.279, 93.847, 93.855

Funding Opportunity Purpose

 The National Institutes of Health (NIH) Office of the Director announces the availability of administrative supplements to expand existing research to focus on Sexual and Gender Minority (SGM) health.  Program Directors/Principal Investigators holding specific types of NIH research grants, listed in this Funding Opportunity Announcement (FOA) are notified that funds may be available for administrative supplements to meet increased costs that are within the scope of the approved award, but that were unforeseen when the new or renewal application or grant progress report for non-competing continuation support was submitted. 

Applications for administrative supplements are considered prior approval requests (as described in Section 8.1.2.11 of the NIH Grants Policy Statement) and will be routed directly to the Grants Management Officer of the parent award. Although requests for administrative supplements may be submitted through this FOA, there is no guarantee that funds are available from the awarding IC or for any specific grant. All applicants are encouraged to discuss potential requests with the awarding IC.

SGM populations include, but are not limited to, lesbian, gay, bisexual, and transgender people, and individuals with differences or disorders of sexual development (sometimes referred to as "intersex" or as specific diagnoses). This trans-NIH effort, which involves multiple Institutes, Centers and Offices from across NIH, is intended to encourage investigation in this growing, field of research. To increase our collective understanding of the broad range of research needed to address the unique health issues of SGM populations, the supplement will focus on areas of research interest, including, but not limited to: studies on increased disease risk; mental, behavioral and social health; approaches to personalized medicine; access to care; reproductive and sexual development; neurological and cognitive development; and resilience.   

Key Dates

 

Posted Date

March 15, 2018

Open Date (Earliest Submission Date)

March 15, 2018

Letter of Intent Due Date(s)

Not Applicable

Application Due Date(s)

May 7, 2018, by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s)

Not Applicable

Scientific Merit Review

Not Applicable

Advisory Council Review

Not Applicable

Earliest Start Date

June 2018

Expiration Date

May 8, 2018

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the instructions in the Application Guide (SF424 (R&R) Application Guide, eRA Commons Administrative Supplement User Guide, as appropriate) except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.


There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

  1. Use the NIH ASSIST system to prepare, submit and track your application online.
  2. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and eRA Commons to track your application. Check with your institutional officials regarding availability.

  3. Use Grants.gov Workspace to prepare and submit your application and eRA Commons to track your application.
  4. Table of Contents

    Part 1. Overview Information
    Part 2. Full Text of the Announcement
    Section I. Funding Opportunity Description
    Section II. Award Information
    Section III. Eligibility Information
    Section IV. Application and Submission Information
    Section V. Application Review Information
    Section VI. Award Administration Information
    Section VII. Agency Contacts
    Section VIII. Other Information


    Part 2. Full Text of Announcement
    Section I. Funding Opportunity Description
     Purpose

    The mission of the NIH is to seek fundamental knowledge about the nature and behavior of living systems, and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The NIH is committed to supporting research that will increase scientific understanding of the health and wellbeing of various population and subpopulation groups and study the effectiveness of evidence-based health interventions and services for individuals within those groups.  NIH places high priority on research with populations that appear to have distinctive health risk profiles but have received insufficient attention from investigators.  This Supplement provides administrative support to expanding existing research to focus on sexual and gender minority (SGM) populations, which include (but are not limited to) lesbian, gay, bisexual, and transgender people, and individuals with differences or disorders of sex development (DSD) (sometimes referred to as "intersex"). Basic, social, behavioral, clinical, translational, and health services research relevant to the missions of the sponsoring Institutes, Centers and Offices may be proposed. Potential applicants are also encouraged to review recent portfolio analyses of NIH-funded SGM research (found at https://dpcpsi.nih.gov/sgmro/reports) to identify gaps in research that may be relevant to this Funding Opportunity Announcement (FOA).

    Background

    The Institute of Medicine (IOM), (now the National Academy of Medicine) report issued in March 2011 (http://www.nationalacademies.org/hmd/Reports/2011/The-Health-of-Lesbian-Gay-Bisexual-and-Transgender-People.aspx stated, in reference to SGM health, that the "existing body of evidence is sparse, and that substantial research is needed." This situation has improved, but there is still a need for further research on a range of health-related issues.  NIH encourages potential applicants to read the IOM report, as a number of specific issues are raised and discussed therein; however, readers should note that this IOM report addresses most, but not all, of the populations within NIH's SGM definition.  Recent data from national health surveys and targeted studies suggest that prevalence rates for some health conditions are significantly higher among SGM populations than for the general population.

    "Sexual and gender minority" is an umbrella phrase that encompasses lesbian, gay, bisexual, and transgender populations as well as those whose sexual orientation, gender identity and expressions, or reproductive development varies from traditional, societal, cultural, or physiological norms.

    NIH uses the term SGM for these populations as well as for individuals within them. However, applicants may study subpopulations, and/or adopt other classification frameworks and terminologies as appropriate for proposed research in such understudied populations.

    Specific Areas of Research Interest

    This FOA calls for research that will enrich scientific understanding of how sexual orientation, gender identity, and/or being born with DSD/Intersex conditions relate to health and health risks, perceptions and expectations about health, health behaviors, and barriers and access to health-related services.

    Appropriate topics/studies for these supplements include, but are not limited to, those listed below:

    • Addition of SGM individuals to a study which either originally excluded them or has not enrolled enough SGM participants to make any meaningful comparisons between groups; studies need to have sufficient power to allow for meaningful comparisons
    • Expansion of an ongoing SGM study focused on one group to add another; sample sizes need to be powered to allow for meaningful comparisons
    • Expansion of questionnaires administered in any setting where it is relevant to address issues of sexual attraction, sexual behavior, sexual orientation, gender identity, and/or gender expression
    • Assessment of reliability and validity of measures relevant to sexual attraction, sexual behavior, sexual orientation, gender identity, and/or gender expression
    • Methodological innovations to improve the recruitment and retention of SGM individuals in any research initiative
    • Ethical, legal, or social science research on the implications of genetic and other research findings on SGM populations.
    Scope of Support

    Administrative supplements can be used to meet increased costs that are within the scope of the approved award, but that were unforeseen when the new or renewal application or grant progress report for non-competing continuation support was submitted.  Applicants should propose research that, if successful, would contribute to a greater understanding of the health and wellbeing of sexual and gender minority communities.

    IC-Specific Considerations

    Applicants are strongly encouraged to discuss their proposed supplement project with the IC Program Official of the approved award prior to submission of a supplement application in order to ensure that the proposed activity fits with the scientific priorities of the IC and is within the scope of the approved award. Please note that NIDDK will only support applications that pertain to benign conditions of lower urinary tract or bladder in response to this FOA.  In addition to contact with the IC Program Official for the approved award, applicants are strongly encouraged to include the Scientific/Research Contact listed in Section VII. Agency Contacts in these communications.

    See Section VIII. Other Information for award authorities and regulations.

    Section II. Award Information
    Funding Instrument

    The funding instrument will be the same as the parent award. 

    Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

    Cooperative Agreement: A support mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI.2 for additional information about the substantial involvement for this FOA.

    Application Types Allowed

    Non-competing Administrative Supplements

    Clinical Trials

    Optional:

    Accepting applications that either propose or do not propose clinical trial(s)

    Need help determining whether you are doing a clinical trial?

    Funds Available and Anticipated Number of Awards

    The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

    The NIH Office of the Director and partner ICOs intend to commit up to $1 Million in FY 2018 to fund approximately 10 awards.

    Award Budget

    Application budgets are limited to no more than the amount of the current parent award and must reflect the actual needs of the proposed project but must not exceed $100,000 in total costs.

    The funding mechanism being used to support this program, administrative supplements, can be used to cover cost increases that are associated with achieving certain new research objectives, as long as the research objectives are within the original scope of the peer reviewed and approved project, or the cost increases are for unanticipated expenses within the original scope of the project. Any cost increases need to result from making modifications to the project that would increase or preserve the overall impact of the project consistent with its originally approved objectives and purposes.

    Award Project Period

    The project and budget periods must be within the currently approved project period for the existing parent award. All awards are for a one-year period.  

    NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this FOA.

    Section III. Eligibility Information
    1. Eligible Applicants
    Eligible Organizations

    All organizations administering an eligible parent award may apply for a supplement under this announcement.

    Higher Education Institutions

    • Public/State Controlled Institutions of Higher Education
    • Private Institutions of Higher Education

    The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

    o Hispanic-serving Institutions

    o Historically Black Colleges and Universities (HBCUs)

    o Tribally Controlled Colleges and Universities (TCCUs)

    o Alaska Native and Native Hawaiian Serving Institutions

    o Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

    Nonprofits Other Than Institutions of Higher Education

    • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
    • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

    For-Profit Organizations

    • Small Businesses
    • For-Profit Organizations (Other than Small Businesses)

    Governments

    • State Governments
    • County Governments
    • City or Township Governments
    • Special District Governments
    • Indian/Native American Tribal Governments (Federally Recognized)
    • Indian/Native American Tribal Governments (Other than Federally Recognized)
    • Eligible Agencies of the Federal Government
    • U.S. Territory or Possession

    Other

    • Independent School Districts
    • Public Housing Authorities/Indian Housing Authorities
    • Native American Tribal Organizations (other than Federally recognized tribal governments)
    • Faith-based or Community-based Organizations
    • Regional Organizations
    • Non-domestic (non-U.S.) Entities (Foreign Institutions)

    This announcement is for supplements to existing projects. To be eligible, the parent award must be active and the research proposed in the supplement must be accomplished within the competitive segment. The proposed supplement must be to provide for an increase in costs due to unforeseen circumstances. All additional costs must be within the scope of the peer reviewed and approved project.

    IMPORTANT: The research proposed by the NIH grantee in the supplement application must be within the original scope of the NIH-supported grant project.

    Foreign Institutions

    Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
    Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
    Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

    Required Registrations

    Applicant Organizations

    Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. Since administrative supplements are made against active grants and cooperative agreements, many of these registrations may already be in place. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

    • Dun and Bradstreet Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.
    • System for Award Management (SAM) (formerly CCR) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
    • NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. 
    • eRA Commons - Applicants must have an active DUNS number and SAM registration in order to complete the eRA Commons registration. Organizations can register with the eRA Commons as they are working through their SAM or Grants.gov registration. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
    • · Grants.gov – Applicants must have an active DUNS number and SAM registration in order to complete the Grants.gov registration. Grants.gov registration is only required if you plan to submit using the 'Electronic Application Submission through Grants.gov' option.

    Program Directors/Principal Investigators (PD(s)/PI(s))

    All PD(s)/PI(s) must have an eRA Commons account.  PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons.If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

    Eligible Individuals (Program Director/Principal Investigator)

    Individual(s) must hold an active grant or cooperative agreement, and the research proposed in the supplement must be accomplished within the competitive segment of the active award. Individuals are encouraged to work with their organizations to develop applications for support.

    For supplements to parent awards that include multiple PDs/PIs, the supplement may be requested by any or all of the PDs/PIs (in accordance with the existing leadership plan) and submitted by the awardee institution of the parent award. Do not use this administrative supplement application to add, delete, or change the PDs/PIs listed on the parent award. Visit the Multiple Program Director/Principal Investigator Policy in the SF424 (R&R) Application Guide for more information.

    2. Cost Sharing

    This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

    3. Additional Information on Eligibility
    Number of Applications

    Applicant organizations may submit more than one application, provided that each is sufficiently distinct from any other administrative supplement currently under consideration by the awarding NIH Institute or Center.  

     Since applications in response to this announcement will only receive administrative review by the awarding Institute or Center, and will not receive a peer review, the NIH policy on resubmissions will not apply.

    Only active awards with at least 18 months remaining at the time of submission will be considered.  Awards in no-cost extension periods are not allowed to submit an application in response to this FOA.

    The administrative funds are not to be used for constructions, renovations and alterations, purchase of research equipment and/or instrumentation for enhancement of laboratories or facilities.

     
    Section IV. Application and Submission Information
    1. Requesting an Application Package

    Applicants must prepare applications using current forms in accordance with the Application Guide.

    Buttons to access the online ASSIST system or to download application forms are available in Part 1 of this FOA. See your administrative office for instructions if you plan to use an institutional system-to-system solution.

    2. Content and Form of Application Submission

    All forms must be completed for the supplemental activities only and must not reflect funding or activities for the previously awarded parent award.

    It is critical that applicants follow the instructions for their submission option (SF424 (R&R) Application Guide, eRA Commons Administrative Supplement User Guide) including Supplemental Grant Application Instructions except where instructed in this funding opportunity announcement to do otherwise. Conformance to documented requirements is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

    For information on Application Submission and Receipt, visit Frequently Asked Questions – Application Guide, Electronic Submission of Grant Applications.

    Page Limitations

    All page limitations applicable to the parent award as described in the Application Guide and the Table of Page Limits must be followed, with the following exceptions or additional requirements:

    The Research Strategy section of the administrative supplement may not exceed 6 pages.

    Application Submission

    Administrative supplement requests for most single-project activity codes can be submitted using electronic submission processes. Administrative supplement requests for multi-project activity codes must be submitted using the paper submission process. See Activity Code section in Part 1 to determine if electronic submission is an option for your activity code.

    Instructions for Electronic Application Submission through Grants.gov

    Use the "Apply" button(s) in Part I of this announcement to access the application forms package posted at Grants.gov. If presented with more than one form package, use the Competition ID and Competition Titles provided to determine the most appropriate application forms package for your situation.

    Prepare applications using the SF424 (R&R) forms associated with the chosen package. Please note that some forms marked optional in the application package are required for submission of applications for this announcement. Follow all instructions in the SF424 (R&R) Application Guide to ensure you complete all appropriate required and optional forms, with the following additional guidance:

    • R&R Cover form:  Select "Revision" in the "Type of Application" field.
    • Research Plan form: At a minimum, the Research Strategy section should be completed and must include a summary or abstract of the funded parent award or project. Other sections should also be included if they are being changed by the proposed supplement activities.
    • Project/Performance Site Location form: Include the primary site where the proposed supplement activities will be performed. If a portion of the proposed supplement activities will be performed at any other site(s), identify the locations in the fields provided.
    • Sr/Key Personnel form: List the PD/PI as the first person (regardless of their role on the supplement activities). List any other Senior/Key Personnel who are being added through this supplement, or for whom additional funds are being requested through this supplement; include a biographical sketch for each.
    • Budget forms (e.g., R&R Budget, PHS 398 Training Budget): Only include funds requested for the additional supplement activities.
    • R&R Other Project Information form: If applicable, attach PDF documents in the "Other Attachments" field indicating that the proposed research experience was approved by the Institutional Animal Care and Use Committee (IACUC) or human subjects Institutional Review Board (IRB) at the grantee institution. Name the documents "IACUC Documentation.pdf" and/or "IRB Documentation.pdf". Adherence to the NIH policy for including women and minorities in clinical studies must also be ensured, if additional human subjects' involvement is planned for the supplement.
    • PHS Human Subjects and Clinical Trial Information: This form is optional. Given that the proposed supplement should not change the scope of the awarded parent project, it will typically not be needed. If new recruitment or use of an additional existing dataset or resource is proposed in the supplement application, Section 2.4 should be revised and new Inclusion Enrollment Reports created, as appropriate.

    Special Instructions for Streamlined Submissions using the eRA Commons for electronic-based submissions

    NIH offers a streamlined system through the eRA Commons for submitting administrative supplements. Login to the eRA Commons, identify the parent award, and prepare an administrative supplement request. A User's Guide for submitting through this system is available, with the following additional guidance:

    • udget information should be entered for the grantee institution in the tabs provided for each selected budget period.
    • Since there is no template or form available for subaward budget information, all subaward information must be included as a PDF attachment in the Subrecipient Budgets section showing the funds requested (by budget period) and using the same categories provided for the grantee institution. The attachment must also include any related budget justification information.
    • Use the "Add Other Attachments" function to include the following PDF documents:
    • Research Strategy including a summary or abstract of the funded parent award or project.
    • If applicable, attach documents indicating that the proposed research experience was approved by the Institutional Animal Care and Use Committee (IACUC) or human subjects Institutional Review Board (IRB) at the grantee institution. Adherence to the NIH policy for including women and minorities in clinical studies must also be ensured, if additional human subjects' involvement is planned for the supplement component.
    • PHS Human Subjects and Clinical Trial Information: This form is optional. Given that the proposed supplement should not change the scope of the awarded parent project, it will typically not be needed. If new recruitment or use of an additional existing dataset or resource is proposed in the supplement application, Section 2.4 should be revised and new Inclusion Enrollment Reports created, as appropriate.
    Foreign Institutions

    Foreign (non-U.S.) institutions must follow policies described in the NIH Grants Policy Statement, and procedures for foreign institutions described throughout the Application Guide.

    3. Unique Entity Identifier and System for Award Management (SAM)

    See Part 1. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov.

    4. Submission Dates and Times

    Part I. Overview Information contains information about Key Dates and Times. Applicants are encouraged to submit electronic applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.

    Applicants are responsible for viewing their electronic application before the due date in the eRA Commons to ensure accurate and successful submission.

    For electronic application submission, information on the submission process and a definition of on-time submission are provided in the SF424(R&R) Application Guide.

    Information on the process of receipt and determining if your application is considered on-time is described in detail in the PHS 398 Application Guide.

    5. Intergovernmental Review (E.O. 12372)

    This initiative is not subject to intergovernmental review.

    6. Funding Restrictions

    All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

    Pre-award costs are allowable only as described in the NIH Grants Policy Statement.

    7. Other Submission Requirements and Information

    Applications must be submitted using the instructions specified above.

    Applicants must complete all required registrations prior to submission. Section III. Eligibility Information contains information about registration.

    For assistance with your electronic application or for more information on the electronic submission process, visit Applying Electronically. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Guidelines for Applicants Experiencing System Issues. For assistance with application submission contact the Application Submission Contacts in Section VII.

    Important reminders:
    For applications submitted electronically on the SF424 (R&R) Application forms, all PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form of the SF 424(R&R) Application Package. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.

    The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization's profile in the eRA Commons and for the (SAM). Additional information may be found in the Application Guide.

    See more tips for avoiding common errors.

    Post Submission Materials

    Not Applicable

    Section V. Application Review Information
    1. Criteria

    Administrative Supplements do not receive peer review. Instead, the administrative criteria described below will be considered in the administrative evaluation process.

    The staff of the NIH awarding component will evaluate requests for a supplement to determine its overall merit. The following general criteria will be used:

    Budget and Period of Support

    NIH staff will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.

    Overall Impact

    NIH staff will consider the ability of the proposed supplement activities to increase or preserve the parent award's overall impact within the original scope of award:

    • · Will the administrative supplement increase or preserve the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved?

    In addition, for applications proposing clinical trials

    Does the design/research plan include innovative elements, as appropriate, that enhance its sensitivity, potential for information or potential to advance scientific knowledge or clinical practice?

    In addition, each of the following criteria will be evaluated as applicable for the proposed supplement.

    Protections for Human Subjects:

    For research that involves human subjects but does not involve one of the six categories of research that are exempt under 45 CFR Part 46, NIH staff will evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring for clinical trials.

    For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt under 45 CFR Part 46, NIH staff will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For additional information on review of the Human Subjects section, please refer to the Guidelines for the Review of Human Subjects.

    Inclusion of Women, Minorities, and Children

    When the proposed project involves human subjects and/or NIH-defined clinical research, the committee will evaluate the proposed plans for the inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion (or exclusion) of children to determine if it is justified in terms of the scientific goals and research strategy proposed. For additional information on review of the Inclusion section, please refer to the Guidelines for the Review of Inclusion in Clinical Research.

    Vertebrate Animals

    NIH staff will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following five points: (1) description of proposed procedures involving animals, including species, strains, ages, sex, and total number to be used; (2) justifications for the use of animals versus alternative models and for the appropriateness of the species proposed; (3) interventions to minimize discomfort, distress, pain and injury; and (4) justification for euthanasia method if NOT consistent with the AVMA Guidelines for the Euthanasia of Animals. Reviewers will assess the use of chimpanzees as they would any other application proposing the use of vertebrate animals. For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Animal Section.

    Biohazards

    NIH staff will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.

    2. Review and Selection Process

    Administrative supplement requests will undergo an administrative evaluation by NIH staff, but not a full peer review. Applications submitted for this funding opportunity will be assigned to the awarding component for the parent award and will be administratively evaluated using the criteria shown above.

    3. Anticipated Announcement and Award Dates

    Not Applicable

    Section VI. Award Administration Information
    1. Award Notices

    A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. This may be as an NoA for the supplemental activities only; alternatively, it may be as either a revision to the current year NoA or included as part of a future year NoA. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee's business official.

    Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.

    Any application awarded in response to this FOA will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website.  This includes any recent legislation and policy applicable to awards that is highlighted on this website. When calculating the award for additional funds, NIH will 1) prorate funding if the requested budget period is adjusted at the time of award, and 2) use the institution's current F&A rate; i.e., the rate in effect when the new funding is provided.

     Individual awards are based on the application submitted to, and as approved by, the NIH and are subject to the IC-specific terms and conditions identified in the NoA.  ClinicalTrials.gov: If an award provides for one or more clinical trials. By law (Title VIII, Section 801 of Public Law 110-85), the "responsible party" must register and submit results information for certain "applicable clinical trials" on the ClinicalTrials.gov Protocol Registration and Results System Information Website (https://register.clinicaltrials.gov). NIH expects registration of all trials whether required under the law or not. For more information, see http://grants.nih.gov/ClinicalTrials_fdaaa/ 

    Institutional Review Board or Independent Ethics Committee Approval: Grantee institutions must ensure that the application as well as all protocols are reviewed by their IRB or IEC. To help ensure the safety of participants enrolled in NIH-funded studies, the awardee must provide NIH copies of documents related to all major changes in the status of ongoing protocols.  Data and Safety Monitoring Requirements: The NIH policy for data and safety monitoring requires oversight and monitoring of all NIH-conducted or -supported human biomedical and behavioral intervention studies (clinical trials) to ensure the safety of participants and the validity and integrity of the data. Further information concerning these requirements is found at http://grants.nih.gov/grants/policy/hs/data_safety.htm and in the application instructions (SF424 (R&R) and PHS 398).

    Investigational New Drug or Investigational Device Exemption Requirements: Consistent with federal regulations, clinical research projects involving the use of investigational therapeutics, vaccines, or other medical interventions (including licensed products and devices for a purpose other than that for which they were licensed) in humans under a research protocol must be performed under a Food and Drug Administration (FDA) investigational new drug (IND) or investigational device exemption (IDE). 

    2. Administrative and National Policy Requirements

    All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.

    Recipients of federal financial assistance (FFA) from HHS must administer their programs in compliance with federal civil rights law. This means that recipients of HHS funds must ensure equal access to their programs without regard to a person's race, color, national origin, disability, age and, in some circumstances, sex and religion. This includes ensuring your programs are accessible to persons with limited English proficiency.  HHS recognizes that research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigator's scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research.

    For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this FOA. HHS provides general guidance to recipients of FFA on meeting their legal obligation to take reasonable steps to provide meaningful access to their programs by persons with limited English proficiency. Please see http://www.hhs.gov/ocr/civilrights/resources/laws/revisedlep.html. The HHS Office for Civil Rights also provides guidance on complying with civil rights laws enforced by HHS. Please see http://www.hhs.gov/ocr/civilrights/understanding/section1557/index.html; and http://www.hhs.gov/ocr/civilrights/understanding/index.html. Recipients of FFA also have specific legal obligations for serving qualified individuals with disabilities. Please see http://www.hhs.gov/ocr/civilrights/understanding/disability/index.html. Please contact the HHS Office for Civil Rights for more information about obligations and prohibitions under federal civil rights laws at http://www.hhs.gov/ocr/office/about/rgn-hqaddresses.html or call 1-800-368-1019 or TDD 1-800-537-7697. Also note it is an HHS Departmental goal to ensure access to quality, culturally competent care, including long-term services and supports, for vulnerable populations. For further guidance on providing culturally and linguistically appropriate services, recipients should review the National Standards for Culturally and Linguistically Appropriate Services in Health and Health Care at http://minorityhealth.hhs.gov/omh/browse.aspx?lvl=2&lvlid=53.

    In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Defense Authorization Act of Fiscal Year 2009 (Public Law 110-417), NIH awards will be subject to the Federal Awardee Performance and Integrity Information System (FAPIIS) requirements.  FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award.  An applicant, at its option, may review information in the designated integrity and performance systems accessible through FAPIIS and comment on any information about itself that a Federal agency previously entered and is currently in FAPIIS.  The Federal awarding agency will consider any comments by the applicant, in addition to other information in FAPIIS, in making a judgement about the applicant's integrity, business ethics, and record of performance under Federal awards when completing the review of risk posed by applicants as described in 45 CFR Part 75.205 "Federal awarding agency review of risk posed by applicants."  This provision will apply to all NIH grants and cooperative agreements except fellowships.

    Cooperative Agreement Terms and Conditions of Award

    Any supplements to Cooperative Agreements will be subject to the same Cooperative Agreement terms and conditions as the parent award.

    3. Reporting

    Reporting requirements will be specified in the terms and conditions of award as applicable to the supplemental activities. In most non-competing continuation applications, the progress report and budget for the supplement must be included with, but clearly delineated from, the progress report and budget for the parent award. The progress report must include information about the activities supported by the supplement even if support for future years is not requested. Continuation of support for the supplement activities in the remaining years of the competitive segment of the grant will depend upon satisfactory review by the NIH awarding component of progress for both the parent award and the supplement project, the research proposed for the next budget period, and the appropriateness of the proposed budget for the proposed effort. This information is submitted with the Research Performance Progress Report (RPPR) and financial statements as required in the NIH Grants Policy Statement.

    The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.

    In accordance with the regulatory requirements provided at 45 CFR 75.113 and Appendix XII to 45 CFR Part 75, recipients that have currently active Federal grants, cooperative agreements, and procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 for any period of time during the period of performance of a Federal award, must report and maintain the currency of information reported in the System for Award Management (SAM) about civil, criminal, and administrative proceedings in connection with the award or performance of a Federal award that reached final disposition within the most recent five-year period.  The recipient must also make semiannual disclosures regarding such proceedings. Proceedings information will be made publicly available in the designated integrity and performance system (currently FAPIIS).  This is a statutory requirement under section 872 of Public Law 110-417, as amended (41 U.S.C. 2313).  As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available.  Full reporting requirements and procedures are found in Appendix XII to 45 CFR Part 75 – Award Term and Conditions for Recipient Integrity and Performance Matters.

    Section VII. Agency Contacts

    We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.

    Application Submission Contacts

    eRA Service Desk (Questions regarding ASSIST, eRA Commons registration, submitting and tracking an application, documenting system problems that threaten submission by the due date, post submission issues)
    Finding Help Online: http://grants.nih.gov/support/ (preferred method of contact)
    Telephone: 301-402-7469 or 866-504-9552 (Toll Free)

    Grants.gov Customer Support (Questions regarding Grants.gov registration and submission, downloading forms and application packages)
    Contact Center Telephone: 800-518-4726
    Email: support@grants.gov

    GrantsInfo (Questions regarding application instructions and process, finding NIH grant resources)
    Email: GrantsInfo@nih.gov (preferred method of contact)
    Telephone: 301-945-7573

    Scientific/Research Contact(s)

    Liz Perruccio
    National Cancer Institute (NCI)
    Telephone: 240 276-6178
    Email: liz.perruccio@nih.gov

    Tina Gatlin
    National Human Genome Research Institute (NHGRI)
    Telephone: 301-402-2851
    Email: gatlincl@mail.nih.gov  

    Melissa Gerald
    National Institute on Aging (NIA)
    Telephone: 301-451-4503
    Email: geraldmel@mail.nih.gov

    Phillip Renzullo
    National Institute of Allergy and Infectious Diseases (NIAID)
    Telephone: 240-627-3041
    Email: prenzullo@mail.nih.gov

    Carl C. Baker
    National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
    Telephone: 301-594-5032
    Email: bakerc@mail.nih.gov

    Alberto Rivera-Rentas
    National Institute on Deafness and Other Communication Disorders (NIDCD)
    Telephone: 301-402-6251
    Email: riverara@nidcd.nih.gov

    Melissa Riddle
    National Institute of Dental and Craniofacial Research (NIDCR)
    Telephone: 301-451-3888
    Email: riddleme@nidcr.nih.gov

    Jeffrey Schulden
    National Institute on Drug Abuse (NIDA)
    Telephone: 301-402-1526
    Email: schuldenj@nida.nih.gov

    Tamara Bavendam, M.D.
    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
    Telephone: 301-594-4733
    Email: tamara.bavendam@nih.gov

    Susannah Allison
    National Institute of Mental Health (NIMH)
    Telephone: 240-627-3861
    Email: allisonsu@mail.nih.gov

    Rebecca Henry, PhD, BSN, RN
    National Institute of Nursing Research (NINR)
    Telephone: 301-594-5976
    Email: rebecca.henry@nih.gov

    Jennifer Alvidrez
    National Institute on Minority Health and Health Disparities (NIMHD)
    Telephone: 301-594-9567
    Email: jennifer.alvidrez@nih.gov

    Lanay Mudd, Ph.D.
    National Center for Complementary and Integrative Health NCCIH)
    Telephone: 301-594-9346
    lanay.mudd@nih.gov

    Kate Winseck
    Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)
    Telephone: 301-827-5583
    Email: winseckk@mail.nih.gov

    Vanessa A. White
    Office of AIDS Research (OAR)
    Telephone: 301-594-4668
    Email: vanessa.white@nih.gov

    Victoria Cargill
    Office of Research on Women's Health (ORWH)
    Telephone: 301-402-1770
    Email: CargillV@od.nih.gov

    Karen Parker
    Sexual & Gender Minority Research Office (SGMRO)
    Telephone:301-402-9852
    Email: KLParker@mail.nih.gov

    Peer Review Contact(s)

    Not Applicable

    Financial/Grants Management Contact(s)

    Crystal Wolfrey
    National Cancer Institute (NCI)
    Telephone: 240-276-6277
    Email: wolfreyc@mail.nih.gov

    John Bladen
    National Institute on Aging (NIA)
    Telephone: 301-402-7730
    Email:  bladenj@mail.nih.gov

    Deanna Ingersoll
    National Human Genome Research Institute (NHGRI)
    Telephone: (301) 402-0733
    Email: ingersolld@mail.nih.gov

    Judy Fox
    National Institute on Alcohol Abuse and Alcoholism (NIAAA)
    Telephone: 301-443-4704
    Email: jfox@mail.nih.gov

    Tseday Girma
    National Institute of Allergy and Infectious Diseases (NIAID)
    Telephone: 240-669-5896
    Email: Tseday.Girma@nih.gov

    Melinda Nelson
    National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
    Telehone: 301-435-5278
    Email: nelsonm@exchange.nih.gov 

    Lora Kutkat
    DPCPSI
    Telehone: 301-402-9852
    Email: Lora.Kutkat@nih.gov

    Section VIII. Other Information

    Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

    Authority and Regulations

    Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Part 75.

    NIH Office of Extramural Research Logo
    Department of Health and Human Services (HHS) - Home Page
    Department of Health
    and Human Services (HHS)
    USA.gov - Government Made Easy
    NIH... Turning Discovery Into Health®


    Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.