Notice of Intent to Publish a Reissue of Funding Opportunity Announcement for the Precision Medicine Initiative Cohort Program Healthcare Provider Organization Enrollment Centers (UG3/UH3)

Notice Number: NOT-PM-16-006

Key Dates
Release Date: June 27, 2016

Estimated Publication Date of Announcement: Early Spring 2017
First Estimated Application Due Date: Late Spring 2017
Earliest Estimated Award Date: September 2017
Earliest Estimated Start Date: September 2017

Related Announcements

Issued by
National Institutes of Health (NIH)


The NIH Precision Medicine Initiative (PMI) Cohort Program intends to issue a second funding opportunity announcement (FOA) to solicit applications proposing to provide support for centers to enroll participants from U.S. healthcare provider organizations (HPOs) into the PMI Cohort Program. The goal of the PMI Cohort Program is to build a research cohort of one million or more U.S. volunteers who are engaged as partners in a longitudinal, long-term effort to transform the understanding of factors contributing to individual health and disease.

This FOA will be a second issuance to expand the catchment areas and participant populations being recruited by HPOs in the PMI Cohort Program. Awards from the first issuance of RFA-PM-16-002 will be announced on the PMI Cohort Program Funding website when they are made.

This Notice is being provided to allow potential applicants sufficient time to develop responsive projects.

The FOA is expected to be published in early Spring 2017 with an expected application due date in late Spring 2017.

This FOA will utilize the UG3/UH3 activity code. Details of the planned FOA are provided below.

Research Initiative Details

The goal of this initiative is to solicit HPOs that expand the catchment areas and participant populations for the PMI cohort program. HPOs awarded from this FOA will join a network of HPOs awarded through RFA-PM-16-002, and are expected to compliment and collaborate with activities being done by those HPOs, as well as by the Data and Research Support Center, Biobank and Participant Technologies Center. HPOs are key partners in the PMI Cohort. HPOs will be responsible for collaborating on engagement and enrollment, communication, biospecimen collection, healthcare data collection, and participant retention for the participants enrolled through their efforts. These data will be made available as a rich research resource for addressing precision medicine research questions. Awards made through this FOA will initially support a 1-year, milestone-driven development phase (UG3), with possible rapid transition to a full implementation phase (UH3). UH3s will be awarded after administrative review of eligible UG3s that have met the scientific milestone and feasibility requirements. The UG3/UH3 application must be submitted as a single application, and applicants should note specific instructions for each phase in this FOA.



Please direct all inquiries to:

Joni L. Rutter, PhD
NIH Office of the Director
Telephone: 301-827-2562