Notice of Intent to Publish a Funding Opportunity Announcement for Maximizing the Scientific Value of Existing Biospecimen Collections: Scientific Opportunities for Exploratory Research (R21 Clinical Trial Not Allowed)

Notice Number: NOT-OD-19-100

Key Dates

Release Date:May 02, 2019
Estimated Publication Date of Funding Opportunity Announcement: August 01, 2019
First Estimated Application Due Date: October 08, 2019
Earliest Estimated Award Date: May 08, 2020
Earliest Estimated Start Date: July 08, 2020

Related Announcements

Issued by
National Institutes of Health (NIH)

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

National Cancer Institute (NCI)

National Heart, Lung, and Blood Institute (NHLBI)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

National Institute on Drug Abuse (NIDA)

National Institute of Environmental Health Sciences (NIEHS)


To inform the research community that The National Institutes of Health (NIH) Tobacco Regulatory Science Program (TRSP), participating NIH Institutes and Centers (ICs) and the United States Food and Drug Administration (FDA) Center for Tobacco Products (CTP) intends to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit R21 applications for research stimulating exploratory research relevant to the mission of the Food and Drug Administration (FDA) - Center for Tobacco Products (CTP) using existing (publicly available) biospecimen currently stored in repositories in the United States. This will include, but not be limited to, collections associated with the Population Assessment of Tobacco and Health (PATH) Study, the National Health and Nutrition Examination Survey (NHANES), the National Heart, Lung and Blood Institute’s (NHLBI) Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC), and the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Proposed research should seek to maximize the scientific value of these stored collections and to provide researchers with an opportunity to generate preliminary data for subsequent research proposals. While other publicly available datasets would be considered, depending on analyses to be conducted, nationally representative analyses will receive priority. These applications need to provide justification why the data set is unique and the research questions cannot be answered from a publicly available, nationally representative, data set.

Research Initiative Details


Funding Information

Estimated Total Funding NIH, via support from the FDA Center for Tobacco products (CTP), intends to fund up to 7 R21s for fiscal year 2020. Future year funding will depend on availability of funds
Expected Number of Awards 7
Estimated Award Ceiling The combined budget for direct cost for the entire project period may not exceed $275,000. No more than $200,000 in direct costs may be requested in a single year.
Primary CFDA Numbers 93.077

Anticipated Eligible Organizations

Public/State Controlled Institution of Higher Education
Private Institution of Higher Education
Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education)
Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education)
Small Business
For-Profit Organization (Other than Small Business)
State Government
Indian/Native American Tribal Government (Federally Recognized)
County governments
City or township governments
Special district governments
Independent school districts
Public housing authorities/Indian housing authorities
Indian/Native American Tribally Designated Organization (Native American tribal organizations (other than Federally recognized tribal governments)
U.S. Territory or Possession
Indian/Native American Tribal Government (Other than Federally Recognized)
Non-domestic (non-U.S.) Entity (Foreign Organization)
Regional Organization
Applications are not being solicited at this time.


Please direct all inquiries to:

Tobacco Regulatory Science Program
Office of Disease Prevention