Announcing the Availability of the Application Guide for the Pilot Transition from PureEdge to Adobe-based SF424 (R&R) Grant Application Forms (RFA-AI-08-020, RFA-DE-09-001 and RFA-DE-09-002)

Notice Number: NOT-OD-08-098

Update: The following update relating to this announcement has been issued:

Key Dates
Release Date: August 1, 2008

Issued by
National Institutes of Health (NIH) (

This notice announces the availability of an SF424 (R&R) Application Guide for the new Adobe Pilot Forms Version for electronic submission of grant applications to NIH. Please note that this Adobe Application Guide should only be used for Funding Opportunity Announcements (FOAs) specifying use of Adobe Reader application packages (see specific FOAs referenced below). The Adobe Application Guide is available in Word and PDF formats.

Although both the Adobe and PureEdge SF 424 (R&R) forms contain the same form fields and requirements, the Adobe Guide provides Adobe screen shots and Adobe-specific navigation instructions. Updated SF424 (R&R) Application Guides (General and SBIR/STTR) for FOAs using PureEdge forms are also available at

Applicants should follow the usual process for seeking support with any electronic submission issues arising with the new Adobe Reader forms. Questions on form functionality or submission of the forms to should be directed to the Contact Center. If you encounter a technical issue that threatens NIH’s timely receipt of your application, work with the Contact Center and be sure to contact the eRA Help Desk at NIH to document the issue and provide us with the Contact Center tracking number.

NIH FAQs on the transition to the Adobe forms may be found at:

Background: On July 2, 2008 NIH identified three Funding Opportunities Announcements (FOAs) to pilot the transition from PureEdge to Adobe-based grant application forms (as detailed in the May 23, 2008 NIH Guide notice (NOT-OD-08-073). Each of the pilot FOAs have application due dates in mid to late October.

  • RFA-AI-08-020 Immune Defense Mechanisms at the Mucosa (R21)
  • RFA-DE-09-001 Harnessing Inflammation for Reconstruction of Oral and Craniofacial Tissues (R01)
  • RFA-DE-09-002 Harnessing Inflammation for Reconstruction of Oral and Craniofacial Tissues (R21)

Note: RFA-DE-09-001 and RFA-DE-09-002 were originally posted in the NIH Guide on June 25, 2008 with PureEdge application forms. These FOAs were reposted on July 1, 2008 with the new Adobe application forms. Those who downloaded the original application package must download and use the new Adobe forms for submission. No other aspects of these announcements (e.g., area of scientific interest, requirements, deadlines) were changed in any way.


Questions about this Notice should be directed to:

Office of Policy for Extramural Research Administration
Office of Extramural Research
National Institutes of Health
Telephone: 301-435-0949