Revised PHS 2590 (DHHS Public Health Service Noncompeting Continuation Progress Report) Now Available

Notice Number: NOT-OD-08-030

Key Dates
Release Date: January 4, 2008

Issued by
National Institutes of Health (NIH), (

EFFECTIVE DATE: The newly revised Continuation Progress Report for a DHHS Public Health Service Grant (PHS 2590, rev. 11/07) instructions and forms are now available and will be accepted immediately. All progress reports received on or after March 1, 2008 must use the new instructions and forms. During the transition period the previous version (interim revision 04/2006) will continue to be available, and progress reports using the previous version will be accepted through February 29, 2008.

The newly revised instructions and forms are available at The forms available on the website continue to be provided in two formats MS Word and PDF-fillable using Adobe Acrobat Reader Software. Free Adobe Software may be accessed at Applicants are strongly encouraged to access the instructions and forms via the Internet because they provide valuable links to current policy documents and allow easy navigation of the instructions. For further information, contact

Please read the instructions carefully. This edition of the PHS 2590 implements a number of important policy changes, including NIH Policy for Sharing of Data Obtained in NIH-Supported or Conducted Genome-Wide Association Studies, and registration of clinical trials in as required by Public Law 110-85.

One significant change to the PHS 2590 is the business process for submission of the continuation progress report. As of March 1, 2008, only the signed original continuation progress report is required to be submitted to the centralized mailing address (No additional copies required).
The additional changes are highlighted below.

Notable Changes to the PHS 2590 Instructions (rev. 11/07):

Implementation of Grants.Gov Terminology

As part of the ongoing effort to keep the PHS 2590, 398 and the SF424 (R&R) synchronized, new terminology is implemented in the PHS2590:



Non-Competing Continuation Progress Report

Continuation Progress Report

Competing/Administrative Supplement

Revision application

Principal Investigator

Program Director/Principal Investigator (PD/PI)

Key Personnel

Senior/key Personnel

Performance site

Project/performance site

Duly authorized representative

Authorized Organizational Representative

Instruction modifications

  • Restructuring of instructions for consistency with the SF424(R&R) and PHS398 format. Numerous clarifications provided; redundancies removed; references updated. A numerical reference system is incorporated to more closely parallel the SF424 (R&R) and PHS398 instructions.
  • SNAP question #3 instruction rewritten to clarify the meaning of Total approved budget.

Instructions for Career Development Award Applications

  • Term mentor is used in place of sponsor. Also, there is specific guidance for programs that include a requirement to become a mentor.

Institutional Research Training Application Including Ruth L. Kirschstein-NRSA Applications

  • Instructions and forms are renamed to acknowledge that there are institutional training programs that are not Ruth L. Kirschstein National Research Service Awards.
  • Replaced the use of the Human Subject Inclusion Enrollment Report for reporting trainee diversity with a new Trainee Diversity Report form page.
  • The NIH diversity recruitment and retention policy is implemented, defining three categories of candidates: racial and ethnic minorities underrepresented in science, individuals with disabilities, and individuals from disadvantaged backgrounds.

Registration Reminders

  • Addition of requirement for DUNS and CCR registration as part of the Federal Financial Assistance Transparency Act (FFATA).

Progress Report Narrative for T’s and K s

  • Maximum Length of progress report narrative expanded from 2 pages to 4 pages for Training and Career Development Awards.

Changes of note to specific form and format pages:

Face Page

  • Redesigned to include FFATA data.
  • Removed boxes for Full IRB or Expedited Review.
  • Item 11a. PI/PD name, telephone and fax number information has been incorporated into item 2a and 2e.

Project/Performance Site Format Page

  • The Project/Performance Site Format Page (Form Page 1-Continued) created to collect information for each project/performance site as required by the Federal Financial Accountability and Transparency Act.

Checklist Page (Form Page 6)

  • Assurances/Certifications itemized list removed from form and refers grantees to the list in the instructions and to the URL to Part III of the 398 for definitions.


Inquires about preparing a specific progress report should be directed to the program official and/or grants management specialist of the awarding institute or center.

Inquiries on any changes to the forms and instructions may be directed to:

Grants Info
Office of Extramural Research
National Institutes of Health
Telephone: 301-945-7573
TTY: 301-451-5936