Notice of Intent to Publish a Funding Opportunity Announcement for Field Centers for the Multicenter AIDS Cohort Study/Women’s Interagency HIV Study Combined Cohort (MACS/WIHS-CCS) (U01)

Notice Number: NOT-HL-17-523

Key Dates
Release Date:   June 30, 2017

Estimated Publication Date of Announcement: Fall 2017
First Estimated Application Due Date: Winter 2018
Earliest Estimated Award Date: Winter 2019

Earliest Estimated Start Date: Winter 2019

Related Announcements
NOT-HL-17-522
RFA-AI-12-002
RFA-AI-13-011

Issued by
National Heart, Lung, and Blood Institute (NHLBI)

Purpose

The National Heart, Lung, and Blood Institute (NHLBI) and participating NIH Institutes and Centers (ICs) intend to publish a Funding Opportunity Announcement (FOA) that will provide support to fund Field Centers (FCs) of both the Multicenter AIDS Cohort Study (MACS) and Women’s Interagency HIV Study (WIHS). The National Institute of Allergy and Infectious Diseases (NIAID) is the primary administrative Institute for both study cohorts, established in 1984 and 1993 respectively. In this new FOA, primary stewardship will be transferred from NIAID to NHLBI and the MACS and WIHS will be funded as a single Combined Cohort Study (MACS/WIHS-CCS). The FCs will work together to investigate HIV-related comorbidities, implementation research, and NIH high priority HIV/AIDS research objectives. 

This Notice is being provided to allow potential applicants sufficient time to develop effective collaborations and responsive projects. 

The FOA is expected to be published in Fall 2017 with an expected application due date in Winter 2018.

This FOA will utilize the U01 activity code. Details of the planned FOA are provided below.

Research Initiative Details

FCs will continue follow-up of existing participants in the current MACS and WIHS studies.

As a group the consortium of investigators from the MACS/WIHS-CCS FCs collaborate to drive the MACS/WIHS-CCS research agenda. Based on the unique scientific domain expertise of investigators, each FC will propose leadership of specific research and Reading Centers. Scientific content will be coordinated consistent with the research goals specified in the FOA. Each FC will be reviewed in context of the co-funding ICs’ science interests as specified in the FOA, and the proposals contribution to a unified MACS/WIHS-CCS research agenda common to FCs and the Data Analysis and Coordinating Center.

The FCs will retain all surviving MACS/WIHS-CC participants and recruit new participants with HIV-infection as well as HIV-free individuals with known HIV-risk factors from the current FC location area. The FCs will reconsent existing participants and perform reoccurring follow-up to capture participant information regarding study-specified outcomes. The FCs will also conduct research examinations during clinic visits and manage data and biospecimens in compliance with HIPPA regulations and other good clinical practice standards.

APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.

Inquiries

Please direct all inquiries to:

Sean Altekruse
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-1290
Email: altekrusesf@nhlbi.nih.gov