Notice of Intent to Publish a Funding Opportunity Announcement for a Data Analysis and Coordinating Center for the Multicenter AIDS Cohort Study/Women’s Interagency HIV Study Combined Cohort (MACS/WIHS-CCS) (U24)

Notice Number: NOT-HL-17-522

Key Dates
Release Date: June 30, 2017

Estimated Publication Date of Announcement: Fall 2017
First Estimated Application Due Date: Winter 2018
Earliest Estimated Award Date: Winter 2019
Earliest Estimated Start Date: Winter 2019

Related Announcements

Issued by
National Heart, Lung, and Blood Institute (NHLBI)


The National Heart, Lung, and Blood Institute (NHLBI) and participating NIH Institutes and Centers (ICs) intend to publish a Funding Opportunity Announcement (FOA) that will provide support to fund a single Data Analysis and Coordinating Center (DACC) for the Multicenter AIDS Cohort Study and Women’s Interagency HIV Study Combined Cohort (MACS/WIHS-CCS). The National Institute of Allergy and Infectious Diseases (NIAID) is the current primary administrative NIH Institute for both study cohorts, established in 1984 and 1993 respectively. In this new FOA, primary stewardship will be transferred from NIAID to NHLBI and the MACS and WIHS will be funded as a single Combined Cohort Study (MACS/WIHS-CCS). The DACC will coordinate research on HIV-related comorbidities and NIH high priority HIV/AIDS research objectives.

This Notice is being provided to allow potential applicants sufficient time to develop effective collaborations and responsive projects.

The FOA is expected to be published in Fall 2017 with an expected application due date in Winter 2018.

This FOA will utilize the U24 activity code. Details of the planned FOA are provided below.

Research Initiative Details

The DACC will coordinate research protocol implementation across Field Centers (FCs) to advance research goals specified in the FOA. The DACC will facilitate investigator-initiated efforts by bringing concepts for emerging scientific opportunities and funding opportunities to the attention of researchers via MACS/WIHS-CCS organizational committees, semi-annual meetings, and scientific working groups. The DACC will coordinate FCs with centralized Reading Centers and training to implement protocols, provide centralized support for data analyses, and review and approve suitable data sharing requests. The DACC will participant in publication of high impact MACS/WIHS-CCS research articles.

The DACC will manage data standard setting and the central MACS/WIHS-CCS information technology (IT) infrastructure. The DACC will coordinate with FCs to assure that data quality control requirements are met, and that MACS/WIHS-CCS investigators comply with IT security requirements and HIPPA regulations. The DACC will address issues that require a coordinated MACS/WIHS-CCS response arising from sources including the MACS/WIHS-CCS Observational Study Management Board, Institutional Review Boards, and Community Advisory Boards.



Please direct all inquiries to:

Sean Altekruse
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-1290