NIEHS is issuing this Notice of Special Interest (NOSI) to address the urgent need for mission-relevant research to understand the impact of environmental exposures on Coronavirus Disease 2019 (COVID-19) and its causative agent, the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). NIEHS is particularly interested in applications that will provide insight into the role of environmental exposures in pathogenicity, transmission, individual susceptibility, or prevention and intervention strategies.

Background

The rapid global spread of SARS-Cov-2 and the prevalence of COVID-19 disease has raised concern from the public, health professionals, and the research community. Information on the pandemic is changing daily with the latest public health information available from the Centers for Disease Control and Prevention (https://www.coronavirus.gov/) and latest research information available from the National Institutes of Health (https://www.nih.gov/health-information/coronavirus). There are compelling research questions regarding the role of environmental exposures in the spread of the virus, individual susceptibility to infection, and the severity and progression of disease. Exposure to environmental chemicals or other pollutants can contribute to compromised function of diverse systems (pulmonary, cardiovascular, neuronal) and may impact host immune function. Individuals whose environmental exposures are disproportionately high, reflecting lower socioeconomic status or other health disparities, may have an elevated risk of COVID-19. Studying the role of environmental exposures and susceptibility factors will aid in gaining comprehensive understanding in combating spread as well as severity of the COVID-19 pandemic.

Research Objectives

NIEHS seeks to promote rapid understanding of the potential contributions of current and past exposure to environmental agents that may exacerbate COVID-19 susceptibility, disease severity, and progression. Examples of environmental exposures relevant to the NIEHS mission include: toxic chemicals, air pollutants, second hand tobacco smoke, e-cigarette vapors, metals, and other environmental chemical exposures that may impact health outcomes. In addition, some health outcomes that are linked to environmental exposures (asthma, diabetes, and other pulmonary, cardiovascular, and metabolic diseases) are also risk factors for COVID-19. NIEHS is accepting applications addressing COVID-19 through the administrative supplement, urgent competitive revision, and time-sensitive mechanisms (see Application Information below).

Possible research interests include but are not limited to the following:

• Examine the role of environmental exposures in impacting individual susceptibility to SARS-Cov-2 infection, or the development and severity of COVID-19 disease.
• Investigate the role of lifestyle factors (e.g. diet, physical activity) as modifiers of the effects of environmental exposures on the development or severity of COVID-19 disease.
• Leverage existing biological samples or data from human or animal research studies to test hypotheses examining the impact of environmental exposures on susceptibility to SARS-Cov-2 infection and COVID-19 disease severity or progression (e.g. detection of SARS-Cov-2 infection in an existing environmental epidemiology study).
• Utilize previously developed research tools or technology platforms that can be applied to understand how environmental exposures impact COVID-19 spread, or disease progression and severity (e.g. personal exposure monitoring, geospatial mapping, risk modeling tools, biomarkers to detect infection).
• Apply multi-omics approaches that can accelerate identification of biomarkers/metabolic signatures of infection or disease progression using animal models as well as in study participants of existing environmental health studies.
• Understand the role of exposure-induced perturbations in respiratory microbiome and its contributions to COVID-19 susceptibility and disease progression.
• Assess the impact of COVID-19-related interventions (including social or physical distancing or public health messaging) on changes in the spread of COVID-19 as well as environmental exposures and related human health outcomes.
• Determine the potential health effects of increased personal/community use of disinfection products for COVID-19 control.
• Develop or apply educational, community-based, or other public health strategies that address the intersection between environmental exposures and COVID-19.
• Identify climate or weather-related factors that influence population susceptibility to SARS-Cov-2 infection and COVID-19 disease.
• Examine the potential impact of environmental health disparities on the spread of COVID-19 disease.

Pre-award costs may be incurred from January 20, 2020 through the public health emergency period and prior to the date of the federal award.

Funds awarded using appropriations provided by the Coronavirus Preparedness and Response Supplemental Appropriations Act, 2020, will be issued in unique subaccounts in the HHS Payment Management System, and will require separate financial reporting from any other funds awarded.

Application and Submission Information

To better understand the role of environmental exposures in SARS-Cov-2 transmission and COVID-19 disease incidence and progression, NIEHS encourages applications to be submitted using the following opportunities:

• If you are applying for a supplement for additional work within the scope of your funded NIEHS grant, apply to PA-18-591, Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) or its re-issued equivalent.
  • P42 awardees are eligible for this mechanism.
• If you are applying for support for work that is related to your funded NIEHS grant, but outside of the scope of the grant, apply to PA-18-935, Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement - Clinical Trial Optional) or its re-issued equivalent.
  • The parent award must be active when the supplement application is submitted (e.g. within the originally reviewed and approved project period), regardless of the time remaining on the current project.

• NIEHS considers the COVID-19 pandemic to be an unpredictable event that provides a limited window of opportunity to collect human biological samples or environmental exposure data (e.g measuring levels of pollutants in air or water during a long period of social distancing due to COVID-19). If you are applying for a new R21 grant that does not build off of an existing NIEHS grant, apply to RFA-ES-19-011 Mechanism for Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) , provided the time-sensitive criteria described therein are met.

The use of each mechanism described should carefully be considered in the context of the support needed to meet goals of the research question, and the purpose of the mechanism. Applicants are encouraged to contact the Program Officer of the parent grant, or the program contacts listed on this NOSI for guidance. More details about recommendations and other funding opportunities can be found on the NIH Office of Extramural Research Coronavirus Disease 2019 (COVID-19): Information for NIH Applicants and Recipients of NIH Funding webpage (https://grants.nih.gov/grants/natural_disasters/corona-virus.htm).

All instructions in the SF424 (R&R) Application Guide PA-18-591, PA-18-935 or RFA-ES-19-011 must be followed, with the following additions:

• Application Due Dates for all programs: May 1, 2020; June 1, 2020; July 1, 2020; August 3, 2020; September 1, 2020; October 1, 2020; November 2, 2020; December 1, 2020; January 4, 2021; February 1, 2021; March 1, 2021; April 1, 2021; May 3, 2021, by 5:00 PM local time of applicant organization. This NOSI expires May 4, 2021.
• For funding consideration, applicants must include "NOT-ES-20-020" (without quotation marks) in the Agency Routing Identifier field (Box 4b) of the SF424 (R&R) Form. Applications without this information in Box 4b will not be considered for this initiative.
• Administrative supplement applications to PA-18-591 must use the application form package with the Competition ID of FORMS-E-ADMINSUPP-RESEARCH". This FOA will be reissued with a FORMS-F-ADMINSUPP-RESEARCH package on May 25, 2020. Submissions to PA-18-591 must be completed by June 25, 2020 (see NOT-OD-20-026 for details.) Submissions to the reissued FOA will be accepted on or after May 25, 2020 through the expiration date of this Notice. In addition, the process for Streamlined Submissions using the eRA Commons cannot be used for this initiative.
• Competitive revision applications to PA-18-935 must use the application form package with the Competition ID of NOT-ES-20-020-FORMS-E." This FOA will be reissued with a NOT-ES-20-020-FORMS-F package on May 25, 2020. Submissions to PA-18-935 must be completed by June 25, 2020. Submissions to the reissued FOA will be accepted on or after May 25, 2020 through the expiration date of this Notice
• Requests may be for only one year of support for supplements and competitive revisions, and up to two years for RFA-ES-19-011.
• The Research Strategy section of the application is limited to 6 pages for PA-18-591 and PA-18-935. See RFA-ES-19-011 for page limits.

Applications nonresponsive to terms of this NOSI will be not be considered for the NOSI initiative.

Please direct all inquiries to the contacts in Section VII of the listed funding opportunity announcements with the following additions/substitutions:

Scientific/Research Contacts:

Anika Dzierlenga, Ph.D.

Genes, Environment, and Health Branch

National Institute of Environmental Health Sciences

Telephone: (984) 287-3125

Email: [email protected]

Heather Henry, Ph.D.

Hazardous Substances Research Branch

National Institute of Environmental Health Sciences

Telephone: (984) 287-3268

Email: [email protected]

Bonnie Joubert, Ph.D.

Population Health Branch

National Institute of Environmental Health Sciences

Telephone: (984) 287-3276

Email: [email protected]

Sri Nadadur, Ph.D.

Exposure, Research, and Technology Branch

National Institute of Environmental Health Sciences

Telephone: (984) 287-3296

Email: [email protected]