Notice of Special Interest for Collaborative Activities to Enhance the Nanomaterials Health Implications Research (NHIR) Consortium Efforts (Admin Supp - Clinical Trial Not Allowed)

Notice Number: NOT-ES-19-013

Key Dates
Release Date: May 6, 2019

Related Announcements

Issued by
National Institute of Environmental Health Sciences (NIEHS)



The NIEHS is providing an administrative supplemental funding opportunity to promote collaborations within the Nanomaterials Health Implications Research (NHIR) Consortium and/or to bring other investigators with additional expertise, tools, systems, and assays to enhance the research outcome from NHIR consortium efforts.

The investigators funded through these FOAs may request supplemental funding:

  • Nanomaterials Health Implications Research (NHIR): Engineered Nanomaterials Resource and Coordination Core (U24) (RFA-ES-15-012)
  • Nanomaterials Health Implications Research (NHIR): Comprehensive Evaluation of Interactions between Engineered Nanomaterials and Biological System (U01) (RFA-ES-15-013)

This supplemental support should be supported by strong preliminary data generated by the NHIR PD/PI laboratory using the NHIR engineered nanomaterials (ENMs). The research strategy should demonstrate how the new collaboration (with another NHIR PI or non-NHIR collaborator) will enhance or take advantage of novel approaches that may not be possible within the currently funded efforts.

Only a NHIR PD/PI can submit this request; however, new collaborator(s) can be supported through a sub-contract mechanism following NIH administrative supplement submission procedures. Only one administrative supplement can be submitted per NHIR U01/U24 grant.

Recipients of supplemental funds under this announcement will be expected to present findings at the annual NHIR consortium meeting. Funds for travel to consortium meetings should not be included in this supplemental request.

Scope of Support

The objectives of NHIR Consortium are to: produce comprehensive biological response profiles for diverse ENMs using in vitroandin vivo models and relevant routes of exposure to gain understanding on potential molecular, biochemical and pathophysiological alterations at target and secondary organs; and work collaboratively, as appropriate, to integrate efforts and capitalize from other model systems and expertise of NHIR to enrich our knowledge base on ENM-biological interactions.

To promote additional collaborative efforts and to bring additional expertise, cell culture, or animal models that are not currently investigated in the NHIR consortium, the examples of topics of interest include, but are not limited to:

  • Studies to look at non-target effects of NHIR ENM impacts from an inhalational exposure studies in animals
  • Studies using organoid cultures to look at molecular alterations using omics technologies
  • Studies to expand protein corona from in vitro and in vivo systems
  • Studies to extend to get sub-chronic impacts of NHIR ENMs based on in vitro or acute exposure studies
  • In vitro or in vivo studies to develop computational dosimetry predictions

Application and Submission Information

Applications for this initiative must be submitted using the following opportunity or its subsequent reissued equivalent.

  • PA-18-591 - Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

All instructions in the SF424 (R&R) Application Guide and PA-18-591 must be followed, with the following additions:

  • Application Due Date – June 4, 2019, by 5:00 PM local time of applicant organization.
  • The expiration date is June 5, 2019.
  • For funding consideration, applicants must include “NOT-ES-19-013” (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.
  • Requests may be for one year of support only.
  • The Research Strategy section of the application is limited to 6 pages.
  • The process for Streamlined Submissions using the eRA Commons cannot be used for this initiative.
  • Applicants are strongly encouraged to notify NIEHS program staff in order to facilitate efficient processing of the request.
  • The budget cannot exceed $75,000 in total costs.


Please direct all inquiries to:

Srikanth S. Nadadur, PhD
Exposure, Response, and Technology Branch