Notice of Intent to Publish an R01 Request for Applications for Mechanisms of Drug Abuse Interactions with HIV Neuropathogenesis to Accompany the Published R21

Notice Number: NOT-DA-07-001

Key Dates
Release Date: October 17, 2006

Issued by
National Institute on Drug Abuse (NIDA), ( )

The National Institute on Drug Abuse (NIDA) intends to issue a funding opportunity for R01 applications (i.e., a Request for Applications, or RFA), Mechanisms of Drug Abuse Interactions with HIV Neuropathogenesis , in the fall of 2006 as a companion to the recently (October 12, 2006) issued R21 with the same title ( ). Both the R21 and the R01 RFAs intend to solicit applications aimed at understanding how acute and chronic administration of addictive drugs affects HIV neuroinvasion, neuropathogenesis, glial activation and inflammation, and subsequent neuronal dysfunction or damage, as well as elucidate the functional, structural, and neurochemical consequences of these perturbations. Both RFAs will encourage a broad range of interdisciplinary research, using in vitro, animal and human approaches to address these interactions. It is expected that applicants will clearly define collaborative relationships that will allow interdisciplinary studies with multiple perspectives, including drug abuse, virology, neurology, neurobiology, pharmacology, toxicology, glial activation and inflammation, immunology, molecular genetics/genomics, and behavior relevant to the consequences of HIV infection. The RFAs also encourage the use of existing resources (such as genomic/proteomic databases, animal repositories, brain banks, or pre-established clinical/basic research networks) in novel ways to address interactions between drug abuse and HIV infection as appropriate.


For further information, please contact:

Dr. Diane M. P. Lawrence
National Institute on Drug Abuse
6001 Executive Boulevard , MSC 9555
Bethesda , MD 20892
Phone: 301-594-3225
Fax: 301-594-6043

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