Selection of Appropriate Funding Opportunity Announcements (FOAs) for the Continuation of the Innovative Technologies for Molecular Analysis of Cancer (IMAT) Program

Notice Number: NOT-CA-07-005

Update: The following update relating to this announcement has been issued:

  • March 8, 2007 - See Notice (NOT-CA-07-011) The purpose of this Notice is to announce the change, effective immediately, in the scientific contact person for the set of 12 closely-related NCI-sponsored Requests for Application (RFAs) under Innovative Technologies for Molecular Analysis of Cancer (IMAT) Program.

Key Dates
Release Date: January 5, 2007

Issued by
National Cancer Institute (NCI) (http://www.nci.nih.gov)

The NCI-sponsored Innovative Technologies for Molecular Analysis of Cancer (IMAT) Program, which is aimed at the development and integration of novel and emerging technologies in the support of cancer research, diagnosis, and treatment, now encompasses an array of 12 closely-related Funding Opportunity Announcements (FOAs). This Notice is designed to help potential IMAT applicants identify appropriate FOAs.
The IMAT Program comprises the following three related thematic components (i.e., themes):

  1. Innovative Technologies for the Molecular Analysis of Cancer, which emphasizes research projects that are centered on the inception and early stage development of new technologies for cancer research;
  2. Application of Emerging Technologies for Cancer Research, which is designed to support research projects evaluating technologies that are ready for initial clinical or laboratory application in cancer research; and
  3. Innovations in Cancer Sample Preparation, which is centered on the development of novel sample preparation technologies that are suitable for molecular analyses of cancer cells and their host environments.

For each IMAT theme, there are several parallel FOAs, meaning that they have identical scientific scope, but also that they involve different funding mechanisms with distinct submission requirements. In addition to conventional Research Project Grants (RPGs), some IMAT FOAs are directed at small businesses under the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) mechanisms.

The individual IMAT FOAs are Requests for Applications (RFAs) focused either on:

  1. Conduct of high-risk exploratory research with an emphasis on innovation (Phase I through use of the R21, R41, or R43 grant mechanisms); or
  2. Further development of a technology/application for which proof of concept has been achieved (Phase II through use of the R33, R42, or R44 grant mechanisms); or
  3. Projects that combine both Phase I and Phase II efforts in one application/award (the SBIR/STTR Fast Track mechanisms). Note: the Phased Innovation funding mechanism (combined R21/R33) is no longer used for the IMAT program.

The complete matrix of 12 IMAT FOAs is provided in Table 1 below along with details regarding the basic requirements and total amounts of set-aside funds for each theme for Fiscal Year 2007. Please note that for comprehensive information on all of the submission requirements, set-aside funds for each FOA, and the anticipated number of awards, it is absolutely essential that every applicant reads the full individual IMAT FOA before preparing and submitting an application in response to the selected FOA. Nonetheless, prospective applicants may use this table and the links to respective individual FOAs as a quick switchboard to initially identify which of the closely related active IMAT FOAs might be most appropriate.

Table 1. The matrix of IMAT RFAs and the outline of their characteristics.


Award Type

Funding Mechanism

Theme and Total Set-Aside Funds

Innovative Technologies

$3M (RPG);
$2M (SBIR/STTR)

Application of Emerging Technologies
$3M (RPG);
$2.25 M (SBIR/STTR)

Sample Preparation

$1M (RPG);
$2.25 M (SBIR/STTR)

Project Type and General Requirements

RPG

R21

Exploratory-pilot
Required: Innovative technology/approacha; Quantitative milestonesb;
Not required (but allowed): Preliminary data.

RFA-07-033

RFA-07-035

RFA-07-037

R33

Developmental
Required: Feasibility datac

RFA-07-034

RFA-07-036

RFA-07-038

SBIR

R43

Exploratory/ Phase I Required: Innovative technology/approach; Quantitative milestones;
Small Business-specific requirements.
Not required (but allowed): Preliminary data.

RFA-07-039

RFA-07-041

RFA-07-043

R44

Developmental/ Phase II Required: Feasibility datac and successful completion of Phase I project;
Small Business-specific requirements (including commercialization plan).

R43/R44

Exploratory/ Developmental Phase I/Phase II (Fast-Track)
Required: Innovation of technology/approach;
Quantitative milestones for Phase I;
Small Business-specific requirements (including commercialization plan).

STTR

R41

Exploratory/ Phase I Required: Innovative technology/approach;
Quantitative milestones required; Small Business-specific requirements.
Not required (but allowed): Preliminary data.

RFA-07-040

RFA-07-042

RFA-07-044

R42

Developmental/ Phase II Required: Feasibility datac and successful completion of Phase I project;
Small Business-specific requirements (including commercialization plan).

R41/R42

Exploratory/ Developmental Phase I/Phase II (Fast-Track)
Required: Innovative technology/approach;
Quantitative milestones for Phase I;
Small Business-specific requirements (including commercialization plan).

aWhile no preliminary data are necessary, the applicants must demonstrate the innovative nature of the particular technology or approach proposed for development.

bQuantitative milestones for each specific aim must be provided as a way of determining during the project and at its completion whether an applicant has successfully reached the specified goal. Milestones should be clearly stated as numerical quantitative specifications for relevant measures/properties.

c Detailed preliminary data must be provided in support of the feasibility of the technology or approach that is proposed for development. Such data may reflect successful completion of Phase I and associated milestones. For SBIR/STTR FOAs, feasibility data need to be largely obtained through a NIH-sponsored Phase I project.

Note on Other Related Programs: Researchers who emphasize the assessment of in vivo imaging technologies as the primary focus of their grant applications should contact the Cancer Imaging Program for information on appropriate funding opportunities. Researchers focusing on applying new bioinformatics or statistical techniques as the primary focus of their applications should consider one of the Biomedical Information Science and Technology Initiative (BISTI) opportunities.

Inquiries
Direct questions to:

Gregory J. Downing, D.O., Ph.D.
Office of Technology and Industrial Relations
National Cancer Institute
Building 31, Room 10A52, MSC 2580
Bethesda, MD 20892-2580
Telephone: (301) 496-1550
Fax: (301) 496-7807
Email: downingg@mail.nih.gov