February 4, 2022
This Notice has been reissued as NOT-AG-23-001
Reissue of NOT-AG-20-032 - NIA Caenorhabditis Intervention Testing Program (CITP) Announces A Call for Compounds to Test for Anti-Aging Activity in Caenorhabditis
National Institute on Aging (NIA)
The National Institute on Aging (NIA) Caenorhabditis Interventions Testing Program (CITP) was established to test compounds purported to extend lifespan and/or delay the onset of disease and disability. The NIA CITP aims to identify pharmacological interventions that increase lifespan and/or healthspan in a robust manner using a genetically diverse set of Caenorhabditis strains. The CITP is comprised of four major components: three screening centers and a data coordination center. The principal investigators at the three screening centers are (1) Monica Driscoll – Rutgers, The State University of New Jersey; (2) Patrick Phillips - University of Oregon; (3) Gordon Lithgow – Buck Institute. (4) The data coordination center is also headed by Patrick Phillips at the University of Oregon.
The CITP is a collaborative effort between the study sites and the sponsors who recommend interventions for study. The sponsor’s role is to provide the rationale for investigating the intervention(s) and make recommendations on the dose, route, and timing for administration of the intervention, and propose assays and measurements to document the efficacy of the intervention. The sponsor will have access to all data developed from the study, will assist in analysis of the data, and will be a co-author on resulting publications. Sponsors’ proposals for specific interventions are reviewed by an Access Panel and accepted proposals will be prioritized by the CITP Steering Committee.
All results of these studies will be published and the data publicly available. Any delays to publications will be reviewed by the CITP Steering Committee, whose decision will be final.
The NIA CITP is soliciting proposals for compounds to enter the study in calendar years 2022 - 2023. This is not a funding opportunity announcement, but rather a solicitation of suggestions for compounds to be tested in the CITP. The deadline for receipt of proposals is May 1, 2022. Information on the NIA CITP and guidelines for proposal development are posted at this website and the CITP website. Proposals should be submitted electronically to Dr. Max Guo at Max.Guo@nih.gov.
Max Guo, Ph.D.
National Institute on Aging