Alzheimer's Disease and its related Dementias (AD/ADRD)-focused Administrative supplements for NIH grants that are not focused on Alzheimer's disease

Notice Number: NOT-AG-18-008

Key Dates
Release Date: April 12, 2018

Related Announcements
PA-18-591

Issued by
National Institute on Aging (NIA)
National Cancer Institute (NCI)
National Eye Institute (NEI)
National Heart, Lung, and Blood Institute (NHLBI)
National Human Genome Research Institute (NHGRI)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute on Deafness and Other Communication Disorders (NIDCD)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute on Drug Abuse (NIDA)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of General Medical Sciences (NIGMS)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute of Nursing Research (NINR)
National Institute on Minority Health and Health Disparities (NIMHD)
National Library of Medicine (NLM)
Fogarty International Center (FIC)
National Center for Complementary and Integrative Health (NCCIH)
Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)
Office of Research on Women’s Health (ORWH)
Office of Strategic Coordination (Common Fund)

Purpose

The participating Institutes and Centers (ICs) are inviting applications to expand existing awards in these ICs that are not currently focused on Alzheimer’s disease (AD) and its related dementias (ADRD) to allow them to develop a focus on AD/ADRD. Active awards with project end dates in FY 2019 or later are eligible. The award may not be in terminal no cost extension or going into no cost extension in FY2018.

As administrative supplements the work proposed needs to be within the scope of the research or training that is already supported. Center awards and resource awards are most likely to be able to justify these supplements as they tend to have a broad content scope. Some research grants will also qualify if the current research is on a related topic (such as cognitive decline in aging, caregiving, or health disparities). Other possible topics include research on the biology of neurodegeneration, on genetics, or imaging, or on pain perception and communication. Topics also include possible connections to existing conditions that are being studied: such as links to cardiovascular or other diseases, on common pathways of degeneration, on sex and gender influences in incidence, or on previously unidentified risk factors. Also work that focuses on advances in methodology, or machine learning or other modeling, or on biostatistical tools that have application to research on Alzheimer’s and its related dementias may be appropriate. NIA has developed a website that shows abstracts (from Reporter) of a sample of awards that are recognized as pursuing AD/ADRD research under current guidelines. The site also includes a description of the categories of research NIH currently identifies as Alzheimer's disease or Alzheimer's disease-related dementias.

As part of the application investigators should submit an abstract of the proposed research that shows the relevance to AD/ADRD. The work may include pilot projects, or resource development.

Investigators should submit applications as responses to the parent active administrative supplement PA: https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html

Individual requests can be no more than $250,000 in direct costs exclusive of Facilities and Administrative costs on sub-contracts (except see the information from NHGRI below). Requests may be for one year of support only.  Though supplement requests are not limited to one per parent grant, we will consider substantial additional funding to an award as beyond its scope. Also, before submitting a supplement request, principal investigators are strongly encouraged to contact their program officers in the Institute, Center or Office supporting their award to discuss whether the proposed supplement is within its scope.

Requests must be received by June 8 for funding in FY 2018.

Institute, Center and Office-specific Instructions

National Human Genome Research Institute: NHGRI in collaboration with NIA will support supplements to NHGRI grants up to $500,000 direct cost, to support research that accomplishes NIA’s research goals described in this notice. NHGRI will support studies that provide generalizable methods and knowledge in all three scientific areas of genome sciences, genomic medicine and genomics and society. Work proposed in supplements must fall within the scope of the aims of the NHGRI grant to be supplemented.

Investigators are encouraged to contact their NHGRI Scientific Program Officer for the grant to be supplemented before preparing an application, to discuss the relevance of the proposed research to the parent grant and to the Institute's research priorities.
National Institute of General Medical Sciences: As NIGMS’s MIRA program provides support for an investigator's overall program of research within the Institute’s mission, MIRA awardees are not eligible for this supplement program.

Office of Strategic Coordination:  Common fund awardees who are interested in applying should contact Dr. Ravi Basavappa in the Office of Strategic Coordination (Common Fund) before applying.

Review process

Each IC will conduct administrative reviews of applications from their IC separately. NIA will make funds available for up to ten awards from each of the participating ICs and is allocating up to $20 million for this cross-IC program.


Each IC will conduct administrative reviews of applications from their IC separately. NIA will make funds available for up to ten awards from each of the participating ICs and is allocating up to $20 million for this cross-IC program.
 
Criteria:

1.      Is the work proposed within the scope of the active award?
2.      Is the work proposed focused on Alzheimer’s disease or its related dementias?
3.      Is the work likely to stimulate additional activity leading to progress on AD/ADRD?

Inquiries

Please direct all inquiries to:

Robin A. Barr
National Institute on Aging (NIA)
Telephone: 301-402-7715
E-mail: BarrR@mail.nih.gov

Crystal Wolfrey
National Cancer Institute (NCI)
Telephone: 240-276-6277
E-mail: wolfreyc@mail.nih.gov

Martha Flanders
National Eye Institute (NEI)
Telephone: 301-451-2020
E-mail: Martha.flanders@nih.gov

Jue Chen, Ph.D.
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0550
Email: jue.chen@nih.gov

Bettie Graham
National Human Genome Research Institute (NHGRI)
Telephone: 301-496-7531
E-mail: grahambj@exchange.nih.gov

Abraham Bautista
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-443-9737
E-mail: Bautista@mail.nih.gov

Melinda Nelson
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Telephone: 301-435-5278
E-mail: nelsonm@exchange.nih.gov

Randy King
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Telephone:301-451-4780
E-mail: randy.king@nih.gov

Judith Cooper
National Institute on Deafness and Other Communication Disorders (NIDCD)
Telephone: 301-496-5061
E-mail: cooperj@nidcd.nih.gov

Preethi Chander
National Institute of Dental and Craniofacial Research (NIDCR)
Telephone: 301-827-4620
E-mail: Preethi.chander@nih.gov

Luke Stoekel
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Telephone: 301-741-9223
E-mail: luke.stoeckel@nih.gov

Kevin Walton
National Institute on Drug Abuse (NIDA)
Telephone: 301-827-5980
kevin.walton@nih.gov

Jonathan Hollander
National Institute of Environmental Health Sciences (NIEHS)
Telephone: 984-287-3269
E-mail: jonathan.hollander@nih.gov

Janna Wehrle
National Institute of General Medical Sciences (NIGMS)
Telephone: 301451-6446
E-mail: wehrlej@nigms.nih.gov

Jovier Evans
National Institute of Mental Health (NIMH)
Telephone: 301-443-1369
E-mail: jevans1@mail.nih.gov

Roderick Corriveau
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-5680
E-mail: roderick.corriveau@nih.gov

Lois Tully
National Institute of Nursing Research (NINR)
Telephone: 301-594-5968
E-mail: lois.tully@nih.gov

Adelaida Rosario
National Institute on Minority Health and Health Disparities (NIMHD)
Telephone: 301-402-1366
E-mail: Adelaida.rosario@nih.gov

Hua-Chuan Sim
National Library of Medicine (NLM)
Telephone: 301-594-4882
E-mail: simh@mail.nlm.nih.gov

Marya Levintova
Fogarty International Center (FIC)
Telephone: 301-496-1653
E-mail: levintovam@mail.nih.gov

David Clark
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-496-6966
E-mail: clarkda@mail.nih.gov

Stephanie Murphy
Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)
Telephone: 301-435-0744
E-mail: Stephanie.murphy@nih.gov

Chyren Hunter
Office of Research on Women’s Health (ORWH)
Telephone: 301-402-1770
Email: hunterc@mail.nih.gov

Ravi Basavappa
Office of Strategic Coordination (OSC)
Telephone: 301-435-7204
E-mail: ravikumar.basavappa@nih.gov