U.S. Department of Health and Human Services
Public Health Service
Grant Application
PHS 398 (Revised 6/2009)
See the 11/23/2009 NIH Guide Notice NOT-OD-10-016 for important changes to this version.
All notable changes made to PHS 398 instructions and form pages are listed at the bottom of this page (updated 5/20/2010).
Downloadable Instructions and Form Files
*** Applicants using the PHS 398 application for intended due dates on or AFTER September 25, 2013, must use the 08/2012 version of the application instructions instructions and forms. Please return to the NIH Forms and Applications web page, http://grants.nih.gov/grants/forms.htm, to access the 8/2012 version. ***
PHS 398 Instructions - 6/2009 Revision MS Word (1.2 MB) PDF (1.1 MB)
PHS 398 Fillable Forms - 6/2009 Revision
The links below allow for the downloading of individual and combined form files in MS Word and PDF formats. Some of the files are large and may take a few minutes to download. Please see the Adobe Acrobat or PDF Forms section of the "Help Downloading Files" page for information on using the fillable PDF forms.
| Fillable Individual PHS 398 Forms (These forms are to be used only with paper submissions using the PHS 398. Do not use the PDF samples provided below in an SF424 (R&R) application. These are fillable PDF forms which will cause an error in the electronic submission of an SF424 (R&R) application. See the SF424 (R&R) application page for appropriate formats to be used for electronic submission.) |
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| Form Page 1: Face Page | MS Word (88 KB) | PDF (310 KB) |
| Form Page 1-continued: Additional form for use only if Multiple PD/PIs are proposed. Do not include if submitting a single-PD/PI application. | MS Word (76 KB) | PDF (254 KB) |
| Form Page 2: Summary, Relevance, Project/Performance Sites, Senior/Key Personnel, Other Significant Contributors, and Human Embryonic Stem Cells | MS Word (117 KB) | PDF (369 KB) |
| Project/Performance Site Format Page - use only if additional space is needed. | MS Word (92 KB) | PDF (269 KB) |
| Form Page 3: Research Grant Table of Contents | MS Word (79 KB) | PDF (701 KB) |
| Form Page 4: Detailed Budget for Initial Budget Period | MS Word (89 KB) | PDF (309 KB) |
| Form Page 5: Budget for Entire Proposed Project Period | MS Word (86 KB) | PDF (573 KB) |
| Biographical Sketch Format Page | MS Word (38 KB) | PDF (599 KB) |
| Biographical Sketch Sample | MS Word (61 KB) | PDF (46 KB) |
| Resources Format Page | MS Word (39 KB) | PDF (225 KB) |
| Checklist Form Page | MS Word (84 KB) | PDF (506 KB) |
| Continuation Format Page | MS Word (36 KB) | PDF (202 KB) |
| Targeted/Planned Enrollment Table Format Page | MS Word (57 KB) | PDF (267 KB) |
| Inclusion Enrollment Report Format Page | MS Word (95 KB) | PDF (325 KB) |
| Mailing Address | MS Word (38 KB) | PDF (27 KB) |
| Other Support Format Page: Example | MS Word (47 KB) | PDF (38 KB) |
| All Personnel Report Format Page | MS Word (96 KB) | PDF (279 KB) |
| Combined PHS 398 Forms File
Does NOT include the Biographical Sketch page, Continuation Page, or any of the Sample/Example pages (Biosketch Sample, Other Support Sample). See Individual Form file links above. |
Combined PHS 398 Form Files (MS Word) (569 KB) |
Combined PHS 398 Form Files (PDF) (1 MB) |
For Questions Related to:
- Application Procedures/Forms Submission: contact GrantsInfo at [email protected] or 301-945-7573.
Note: Other software packages for completing these applications may be available from other sources; however, it is essential that the type size and format specifications are met. Otherwise application processing may be delayed, or the application may be returned to the applicant without review.
Disclaimer: Reference to these software packages neither constitutes nor should be inferred to be an endorsement or recommendation of any product, service, or enterprise by the National Institutes of Health, any other agency of the United States Government, or any employee of the United States Government. No warranties are stated or implied.
Notable Changes Made to PHS 398
- "Authorized Organizational Representative" is changed throughout to "Authorized Organization Representative" for consistency with grants.gov; requirement for the commons ID role for multiple PD/PIs and affiliation for contact PD/PI is clarified; the prohibition on using the appendix to circumvent page limits per NOT-OD-10-077 is emphasized; the timeline for resubmission of grandfathered application is clarified in Part I, 2.7 and Part II, 1.3 per NOT-OD-10-080; the continuous application submission policy in Part I, 2.14 is updated per NOT-OD-10-090; the Research Strategy instructions are edited to address situations with multiple Specific Aims; and the ClinicalTrials.gov requirements in Part II, 2.1.6 and Vertebrate Animal section of the Research Plan in Part I, 5.5.10 are clarified. (5/20/2010)
- Part I, Section 5.5.3 Research Strategy is clarified to indicate that preliminary studies and progress should be incorporated into Significance, Innovation and Approach, and Part III, Section 2.1.2 is updated to include certification that human embryonic stem cells will be used in accordance with any restrictions (see NIH Guide NOT-OD-10-029). (1/12/2010)
- New PHS 398 (Rev. 6/09) instructions and forms posted 11/23/2009. See the 11/23/2009 NIH Guide Notice NOT-OD-10-016 for important details regarding changes made to this version. (11/23/2009)
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