Department of Health and Human Services


Part 1. Overview Information
Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

National Cancer Institute (NCI)
National Eye Institute (NEI)
National Heart, Lung, and Blood Institute (NHLBI)
National Human Genome Research Institute (NHGRI)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (No Longer Participating per NOT-AR-15-003)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute on Drug Abuse (NIDA)
National Institute of Environmental Health Sciences (NIEHS)
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
National Institute of Nursing Research (NINR)

Funding Opportunity Title

Lasker Clinical Research Scholars Program (Si2)

Activity Code

Si2 Intramural Clinical Research Scholar Award

Announcement Type

Reissuance of RFA-OD-13-004

Related Notices

  • June 4, 2014 - Notice NOT-14-074 supersedes instructions in Section III.3 regarding applications that are essentially the same.
  • May 16, 2014 - See Notice NOT-AR-15-003. NIAMS Withdrawing Participation immediately.

Funding Opportunity Announcement (FOA) Number

RFA-OD-14-004

Companion Funding Opportunity

None

Number of Applications

See Section III. 3. Additional Information on Eligibility.

Catalog of Federal Domestic Assistance (CFDA) Number(s)

   93.140

Funding Opportunity Purpose

This FOA solicits applications for the Lasker Clinical Research Scholars Program for the purpose of supporting the research activities during the early stage careers of independent clinical researchers. 

The program offers the opportunity for a unique bridge between the NIH intramural and extramural research communities and contains two phases.  In the first phase, Lasker scholars will receive appointments for up to 5-7 years as tenure-track investigators within the NIH Intramural Research Program with independent research budgets.  In the second phase, successful scholars will be eligible to apply for up to 5 years of NIH support for their research at an extramural research facility; or, the scholar can be considered to remain as an investigator within the intramural program.

Key Dates
Posted Date

April 24, 2014

Letter of Intent Due Date(s)

Not Applicable

Application Due Date(s)

July 29, 2014

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s)

Not Applicable

Scientific Merit Review

October/November 2014  

Advisory Council Review

January 2015

Earliest Start Date

February 2015

Expiration Date

July 30, 2014

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the instructions in the PHS 398 Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. While some links are provided, applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Looking ahead: NIH is committed to transitioning all grant programs to electronic submission using the SF424 Research and Related (R&R) format and is currently investigating solutions that will accommodate NIH’s multi-project programs. See NOT-OD-13-075 and  NIH’s Applying Electronically website for more information.

Note:  A new version of the paper PHS 398 application form and instructions (revised 8/2012) must now be used. Download the new application form and instructions from http://grants.nih.gov/grants/forms.htm.

Table of Contents

Part 1. Overview Information
Part 2. Full Text of Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information

Part 2. Full Text of Announcement


Section I. Funding Opportunity Description


Program Description

This program will address the clinical research mission of the National Institutes of Health (NIH) and will lead to better treatments for disease and to improvements in human health.  The NIH funds research and research training at extramural institutions, as well as within the NIH Intramural Research Program (IRP) to address this goal.  However, these efforts can be hindered by barriers to clinical and translational research.  Such barriers include limited research time for clinical investigators, increases in the length of time to independent careers, and access to hospital facilities and patient enrollments.

In an effort to address those barriers, the NIH has created the Lasker Clinical Research Scholars (Lasker Scholars) program that will offer applicants the opportunity to compete for a unique combination of intramural and extramural resources for clinical research. The program will support a small number of exceptional clinical researchers in the early stages of their careers to promote their development to fully independent scientists.  The program combines a period of research experience as a tenure-track Investigator in the IRP with an opportunity for additional years of independent financial support, either within the IRP or at an extramural research institution.

The program honors the contributions of Mary and Albert Lasker to the NIH and to the overall biomedical community.

The Lasker Scholars program aims to support successful candidates in two phases.  Applicants will respond to this Funding Opportunity Announcement (FOA) for an initial period of support through a position in the NIH IRP. Selected scholars who successfully complete the initial phase will be able to either remain within the IRP or apply for extramural grant funding in the second phase.  The first phase will support scholars in the IRP for up to 5 years, with the possibility of an extension for an additional 2 years.  Successful applicants for the Lasker Scholars Program will be appointed as independent tenure-track investigators within an NIH Institute or Center, a process that includes being hired as a full time employee at the NIH and completing the procedures required of new Federal government employees.  As Federal employees, Lasker Scholars will be subject to certain regulations and policies that will govern their relationships with outside organizations.  Nonetheless, in some cases, Lasker Scholars may be able to maintain relationships with their previous institution.  The IRP will provide space, research expenses, full salary, and Federal employee benefits. Scholars will develop independent research activities over the course of their stay in the IRP, and will be formally reviewed by a panel of senior extramural investigators every 2-4 years to evaluate their research progress. More information about the IRP can be found at http://irp.nih.gov/

Upon successfully completing the initial IRP phase of the program, the Lasker Scholar will be eligible for two options in the second phase:

Option 1. Remain in the IRP with continued intramural funding and progression to tenured senior investigator status, if consistent with formal reviews and assessments.  Retention in the IRP will be dependent on the development of a mutual agreement between the Scholar and the IRP.  Tenure at the NIH requires evaluation and approval by the NIH Deputy Director for Intramural Research.

Option 2. Scholars who successfully complete at least five years in the first phase of the program will be eligible to apply for an extramural research grant in the second phase of the program as an independent researcher. Lasker Scholars can compete for a grant that can provide direct costs of up to $500,000/year (plus applicable Facilities and Administration (F&A) costs) for up to 5 years at an extramural institution.  Scholars who choose to leave the Lasker program before completing 5 years of research in the IRP will not be eligible to compete for the Lasker Scholars Grant but will be eligible to compete for other extramural NIH research grants as announced in the NIH Guide for Grants and Contracts.  

The NIH recognizes a unique and compelling need to promote diversity in the biomedical, behavioral, clinical and social sciences research workforce. The NIH expects all of its efforts to diversify the workforce to lead to the recruitment of the most talented researchers; to improve the quality of the education and training for all researchers; to balance and broaden national perspectives in setting research priorities; to improve the ability to recruit subjects from diverse backgrounds into clinical research protocols; and to improve the Nation's capacity to address and eliminate health disparities.  The NIH encourages applications from researchers from diverse backgrounds underrepresented in biomedical research, including underrepresented racial and ethnic groups and persons with disabilities.  NIH also encourages applications from women for participation in all NIH-funded research opportunities.

Research Areas of Interest

Participating NIH Institutes and Centers, and their preferred areas of clinical research interest, are provided below.  Applications submitted in response to this FOA must include a Letter of Support from an Institute/Center Contact (see Section IV.2 Content and Form of Application Submission).  This allows the Institute/Center to verify the programmatic suitability of the applicant’s research program to this initiative.  Applicants are also encouraged to discuss their proposed research with the Institute/Center Contact listed in Section VII. Agency Contacts.

National Cancer Institute

National Eye Institute

National Heart, Lung, and Blood Institute

National Human Genome Research Institute

National Institute on Alcohol Abuse and Alcoholism

National Institute of Allergy and Infectious Diseases

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institute on Dental and Craniofacial Research

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Environmental Health Sciences

National Institute on Drug Abuse

National Institute of Mental Health

National Institute of Neurological Disorders and Stroke

National Institute of Nursing Research

Section II. Award Information
Funding Instrument

Appointment

Application Types Allowed

New

The OER Glossary and the PHS 398 Application Guide provide details on these application types.

Funds Available and Anticipated Number of Awards

It is anticipated that up to 5 awards will be made in FY 2015.

Award Budget

Not Applicable

Award Project Period

The initial phase of research in the IRP is for 5 years with the possibility of a 2 year extension.  The extramural phase of the program is for up to 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

Section III. Eligibility Information


1. Eligible Applicants

Applications will be submitted directly by the individual PD/PI, not from an organization.

Required Registrations

Applicant must have a valid Dun and Bradstreet Universal Numbering System (DUNS) number and an eRA Commons account to apply for and receive an award. 

Lasker applicants should use the following special procedures to complete their Commons registration. Applicants should register themselves as individuals in the Commons by using the applicant’s full name for the Institution Name. Once registered, a Signing Official (SO) account will be created that the applicant should use to create an individual Principal Investigator (PI) account for themselves. The registration process for eRA Commons can take 2-4 weeks.  For assistance please contact the eRA Help Desk and identify yourself as a Lasker Scholar. 

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

Eligible applicants include physicians and dentists (including MD, MD/PhD, DO, DDS, DMD, RN/PhD, or equivalent clinical doctoral degree from an accredited domestic or foreign institution) who have a professional license to practice clinically in the U.S.  The program is intended for investigators at the early stages of their careers.  At the time the application for the initial IRP phase is submitted, applicants must be no more than 10 years from completion of their core residency training.  Applicants who have completed their core residency in June 2004 are still eligible. Applicants will generally have completed or be completing a post-residency clinical fellowship, and will have demonstrated sufficient patient-oriented research experience to qualify for a tenure-track level appointment. Applicants do not have to be U.S. citizens or permanent residents, although selected Scholars must qualify for and maintain appropriate visa/residency status throughout the program.

2. Cost Sharing

This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

3. Additional Information on Eligibility


Number of Applications

Eligible individuals may submit only one application in response to this FOA.

NIH will not accept any application that is essentially the same as one already reviewed within the past thirty-seven months (as described in the NIH Grants Policy Statement), except for submission:

Section IV. Application and Submission Information


1. Address to Request Application Package

Applicants are required to prepare applications according to the current PHS 398 application forms in accordance with the PHS 398 Application Guide.

2. Content and Form of Application Submission

It is critical that applicants follow the instructions in the PHS 398 Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Application Submission

Applications must be prepared using the PHS 398 research grant application forms and instructions for preparing a research grant application. Submit a signed, typewritten original of the application, including the checklist, five signed photocopies and all copies of the Appendix files in one package to:

Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710 (U.S. Postal Service Express or regular mail)
Bethesda, MD 20817 (for express/courier service; non-USPS service)

Page Limitations

All page limitations described in the PHS 398 Application Guide and the Table of Page Limits must be followed, with the following modifications:

Instructions for Application Submission

All instructions in the PHS 398 Application Guide must be followed, with the following exceptions and additional instructions.

Cover Letter

Applicants are encouraged to include a cover letter with the application. Place the letter at the beginning of the application.

Face Page

All instructions in the PHS 398 Application Guide must be followed.

Item numbers 6 through 10.  Leave blank

Item number 11.  Enter DUNS number

Item Numbers 12 through 14. Leave blank, applications will be submitted directly from applicants.

Description, Project/Performance Sites, Senior/Key Personnel, Other Significant Contributors, Human Embryonic Stem Cells

All instructions in the PHS 398 Application Guide must be followed.

Table of Contents

All instructions in the PHS 398 Application Guide must be followed.

Detailed Budget for Initial Budget Period

Do not complete this form. Applicants accepted into the program will be funded by the NIH Intramural Research Program.  Successful Lasker Scholars who later apply for the extramural funds will request direct costs and F&A costs at that time.

Budget for Entire Proposed Period of Support

Do not complete this form. Applicants accepted into the program will be funded by the NIH Intramural Research Program.  Successful Lasker Scholars who later apply for the extramural funds will request direct costs and F&A costs at that time.

Biographical Sketch

All instructions in the PHS 398 Application Guide must be followed.

Resources

Rather than indicate the resources available, describe the resources that the proposed research will need.  Indicate how the proposed research will take advantage of the unique features of the scientific environment, subject populations, or collaborative arrangements of the NIH Intramural Research Program.

Checklist

Type of application: Check 'New application'

Program Income:  Leave blank
Assurances/Certifications: Leave blank
Facilities and Administrative costs (F&A)/Indirect Costs:  Leave blank

Research Plan

Follow the instructions in the PHS398 Application Guide, with the following additional instructions.

Specific Aims: State concisely the goals of the proposed research and summarize the expected outcome(s), including the impact that the results of the proposed research will have on human health.  List succinctly the specific objectives of the research proposed, e.g. to challenge an existing paradigm or clinical practice, create a novel design, solve a specific problem, test a stated hypothesis, address a critical barrier to progress in the field, or devlop new technology.

Research Strategy:

(a) Significance – Explain the importance of the problem or critical barrier to progress in the field that the proposed project addresses.  Explain how the proposed project will improve the field, as well as the effect on human health.  Describe how the field will be changed if the proposed aims are achieved.

(b) Innovation – Explain how the application challenges and seeks to shift current clinical practice or research paradigms.  Describe any novel theoretical concepts, approaches or methodologies, instrumentation or intervention(s) to be developed or used, and any advantage over existing methodologies, instrumentation, or intervention(s).  Explain any refinements, improvements, or new applications of theoretical concepts, approaches or methodologies, instrumentation or interventions.

(c) Approach – Describe the overall strategy, methodology, and analyses to be used to accomplish the specific aims of the project.  Include how the data will be collected, analyzed and interpreted.  Discuss potential problems, alternative strategies, and benchmarks for success anticipated to achieve the aims.  If the project is in the early stages of development, describe any strategy to establish feasibility, and address the management of any high risk aspects of the proposed work.  Include preliminary data, if appropriate.  Point out any procedures, situations, or materials that may be hazardous to personnel and precautions to be exercised.

(d) Candidate Information – Describe your previous research experience, and its relationship to the proposed research plan.  Describe your career goals and objectives.  A length of up to 1 page is suggested for this section.

Bibliography and References Cited: Provide a bibliography of any references cited in the Research Plan.

Letters of Support: Include the Letter of Support from the NIH IRP (see Section IV.6).

Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the PHS 398 Application Guide.

Appendix: Do not use the appendix to circumvent page limits. Follow all instructions for the Appendix (please note all format requirements) as described in the PHS 398 Application Guide.

3. Submission Dates and Times

Part I. Overview Information contains information about Key Dates. 

Information on the process of receipt and determining if your application is considered “on-time” is described in detail in the PHS 398 Application Guide.

Applicants may track the status of the application in the eRA Commons, NIH’s electronic system for grants administration.

4. Intergovernmental Review (E.O. 12372)

This initiative is not subject to intergovernmental review.

5. Funding Restrictions

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Pre-award costs are allowable only as described in the NIH Grants Policy Statement.

6. Other Submission Requirements and Information

Applications must be postmarked on or before the due dates in Part I. Overview Information.

Applications must be received on or before the due dates in Part I. Overview Information. If an application is received after that date, it will not be reviewed.

Upon receipt, applications will be evaluated for completeness by the Center for Scientific Review and responsiveness by components of participating organizations, NIH. Applications that are incomplete and/or nonresponsive will not be reviewed.  

Letters of Support

In order to assure the programmatic appropriateness of the proposed research to the goals of the NIH intramural research program, applicants must obtain a Letter of Support, which will then be included with the full application.  Applicants must submit a Biosketch, and a summary of research interests that includes an abstract of the proposed research.  The summary should be no more than 2 pages. The deadline for submitting this information is June 2, 2014. Applicants whose research is relevant to the intramural research program will be provided with a Letter of Support.  Submit the request for a Letter of Support online at http://irp-positions.nih.gov/job/laskerscholar

Letters of Reference

Letters of reference are an important component of the Lasker Clinical Research Scholar application. Applicants should arrange to have four letters of reference submitted on their behalf.  Applications that are missing letters of reference will not be reviewed. Late letters will not be accepted.  Applicants are responsible for monitoring the submission of letters to ensure that the letters have been submitted prior to the submission deadline.  Applicants are encouraged to check the status of their letters in their eRA Commons accounts.

To submit a letter of reference, the referee will need the following information:

Letters of reference are confidential to the extent permitted by law. Email confirmations will be sent to both the applicant and the referee. Note: Since email can be unreliable, it is the applicant’s responsibility to check the status of letters of reference periodically in the Commons.

Instructions for Referees:

Letters may be submitted to the Commons at (https://public.era.nih.gov/commons/public/reference/submitReferenceLetter.do?mode=new) beginning June 3, 2014, and must be submitted no later than 5:00 p.m. (EST), July 29, 2014.  Late letters will not be accepted and applications missing letters of reference may not be reviewed.

The applicant’s name should be placed at the top of the letter.  Although signatures are not required, the letter must include a signature block with the referee’s full name, title, institution, and contact information.

In two pages or less, describe the applicant’s qualities that support the applicant’s claim to possess the scientific, leadership and management skills necessary to conduct successful, independent clinical research.  When possible, give specific examples that illustrate these qualities.

Note: The letter submission page can be accessed without signing into the Commons, and referees do not need to be registered in the Commons.  Referees must provide the applicant’s Commons User Name (User ID) and the other information below:

Referee Information (the individual providing the letter of reference):

Post Submission Materials

Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-13-030.    

Section V. Application Review Information


1. Criteria

Only the review criteria described below will be considered in the review process. As part of the NIH mission, all applications submitted to the NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer review system.

Overall Impact - Overall

Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).

Scored Review Criteria - Overall

Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.

Significance

Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?   

Investigator(s)

Has the candidate demonstrated appropriate experience, training, and the skills to conduct innovative clinical research? Do the letters of reference indicate that the candidate has the research and leadership skills to conduct independent research? Is the clinical researcher well suited to the project? 

Innovation

Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?      

Approach

Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed? 

If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?   

Environment

Has the applicant identified the resources and major equipment that will be needed to conduct the proposed research?    

Additional Review Criteria

As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items. 

Protections for Human Subjects

Protections for Human Subjects will be evaluated after an appointment is made, and as with all research involving human subjects conducted within the IRP, will be subject to 45 CFR Part 46. Reviewers should describe any concerns at the time of review.

Inclusion of Women, Minorities, and Children 

Inclusion of Women, Minorities, and Children will be evaluated after an appointment is made. Reviewers should describe any concerns at the time of review.

Vertebrate Animals

Vertebrate Animals will be evaluated after an appointment is made.  Reviewers should describe any concerns at the time of review.

Biohazards

Biohazards will be evaluated after an appointment is made.  Reviewers should describe any concerns at the time of review.

Resubmissions

Not Applicable

Renewals

Not Applicable

Revisions

Not Applicable

Additional Review Considerations

As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.

Applications from Foreign Organizations

Not Applicable

Select Agent Research

Select Agent Research will be evaluated after an appointment is made.  Reviewers should describe any concerns at the time of review.

Resource Sharing Plans

Resource Sharing Plans will be evaluated after an appointment is made.  Reviewers should describe any concerns at the time of review.

Budget and Period of Support

Not Applicable

2. Review and Selection Process

Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s), convened by the Center for Scientific Review (CSR) in accordance with NIH peer review policy and procedures, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons.

As part of the scientific peer review, all applications:

Select candidates will be invited to the NIH campus for an interview focused on the review criteria listed above.  Applicants who are identified to progress to the interview process will be asked to provide additional information that will be used to establish the candidates’ eligibility and suitability for hire.  The applicant will receive a package of additional documents to complete if selected to proceed to this phase of the interview process.

Appeals of initial peer review will not be accepted for applications submitted response to this FOA.

Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center and will compete for available funds with all other recommended applications submitted in response to this FOA. Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board. The following will be considered in making funding decisions:

3. Anticipated Announcement and Award Dates

After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons

Information regarding the disposition of applications is available in the NIH Grants Policy Statement.

Section VI. Award Administration Information


1. Award Notices

Selected Scholars will be notified by the Scientific Director of the host NIH Institute or Center, and will receive a formal Notice of Employment from the NIH Human Resources Office. Lasker Scholars are appointed under excepted service.  These appointments will be made under time-limited Title 42 (g) or (f).  For more details on the hiring process, pay scales, and benefits, see http://hr.od.nih.gov/benefits/default.htm.

2. Administrative and National Policy Requirements

Selected Scholars will be appointed as tenure-track investigators in the NIH Intramural Research Program. Tenure-track investigators receive independent resources (staff, space, and budget), and receive mentoring from their Lab or Branch Chief, and from other senior leaders in the IRP.  Additional information concerning the philosophy and practices for IRP tenure-track investigators can be found at http://sourcebook.od.nih.gov/prof-desig/ttiphilosophy.htm and at http://sourcebook.od.nih.gov/prof-desig/investigator.

Cooperative Agreement Terms and Conditions of Award

Not Applicable

3. Reporting

During the Intramural Research Program phase, scholars will submit an annual research report for each supported project, according to the standard procedures for IRP Investigators (described at http://sourcebook.od.nih.gov/sci-prgms/annualZ01.htm).  Annual reports are maintained in a searchable database at http://intramural.nih.gov/search/index.taf?_UserReference=15E8D6CB6106892A4CC5FDA6.

Section VII. Agency Contacts

We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.

Application Submission Contacts

eRA Commons Help Desk (Questions regarding eRA Commons registration, submitting and tracking an application, documenting system problems that threaten submission by the due date, post submission issues)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)

Finding Help Online: http://grants.nih.gov/support/index.html

TTY: 301-451-5939
Email: commons@od.nih.gov

GrantsInfo (Questions regarding application instructions and process, finding NIH grant resources)
Telephone: 301-435-0714
TTY: 301-451-5936
Email: GrantsInfo@nih.gov

Scientific/Research Contact(s)

General Information

Charles R. Dearolf, Ph.D.
Assistant Director for Intramural Research
National Institutes of Health
Telephone: 301-402-1225
Email: LaskerScholar@nih.gov

National Cancer Institute (NCI)

Dr. Lee Helman (oncology)
Telephone: 301-496-4257
Email: helmanl@mail.nih.gov

Dr. Stephen J. Chanock (epidemiology)
Telephone: 240-276-7150
Email: chanocks@mail.nih.gov

National Eye Institute (NEI)

Dr. Sheldon Miller
Telephone: 301-496-3180
Email: millers@nei.nih.gov

National Heart, Lung, and Blood Institute (NHLBI)

Dr. Robert Balaban
Telephone:  301-496-2116
Email: balabanr@nhlbi.nih.gov

Dr. Richard Childs
Telephone: 301-451-7128
Email: childsr@nhlbi.nih.gov

National Human Genome Research Institute (NHGRI)

Dr. Dan Kastner
Telephone:  301-402-2023
Email: kastnerd@mail.nih.gov

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Dr. George Kunos
Telephone: 301-443-2069
Email: gkunos@mail.nih.gov

Dr. Markus Heilig
Telephone: 301-435-9386
Email: mheilig@mail.nih.gov

National Institute of Allergy and Infectious Disease (NIAID)

Dr. Kathryn Zoon
Telephone: 301-496-3006
Email: kzoon@niaid.nih.gov

Dr. Karyl Barron
Telephone: 301-402-2208
Email: kbarron@niaid.nih.gov

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Dr. John O’Shea
Telephone: 301-496-2612
Email: osheajo@mail.nih.gov

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Dr. Constantine Stratakis
Telephone: 301-594-5984
Email: stratakc@cc1.nichd.nih.gov

Ms. Brenda Hanning
Telephone: 301-451-7753
Email: HanningB@mail.nih.gov

National Institute on Dental and Craniofacial Research (NIDCR)

Dr. Robert Angerer
Telephone: 301-496-1483
Email: ra210z@nih.gov

Dr. Janice Lee
Telephone: 301-594-4591
Email: janice.lee@nih.gov

National Institute of Diabetes and Digestive and Kidney Diseases

Dr. James Balow
Telephone: 301-496-4181
Email: jimb@mail.nih.gov

Dr. Michael Krause
Telephone: 301-402-4633
Email: michaelkr@niddk.nih.gov

National Institute on Drug Abuse (NIDA)

Dr. Antonello Bonci
Telephone:  443-740-2463
Email: boncia@mail.nih.gov

National Institute of Environmental Health Sciences (NIEHS)

Dr. Darryl Zeldin
Telephone: 919-541-1169
Email: zeldin@niehs.nih.gov

National Institute of Mental Health

Dr. Maryland Pao
Telephone: 301-435-5770
Email: paom@mail.nih.gov

National Institute of Neurological Disorders and Stroke (NINDS)

Dr. Avindra Nath (Intramural)
Telephone: 301-496-1561
Email:  natha@mail.nih.gov

Dr. Stephen Korn (Extramural)
Telephone: 301-496-4188
Email: korns@mail.nih.gov

National Institute of Nursing Research (NINR)

Dr. Ann Cashion
Telephone:  301-496-0294
Email: ann.cashion@nih.gov

Dr. Jessica Gill
Telephone: 301-451-8452
Email: gillj@mail.nih.gov

Peer Review Contact(s)

Syed M. Quadri, Ph.D.
Center for Scientific Review
Telephone: 301-435-1211
Email: quadris@csr.nih.gov

Section VIII. Other Information

Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Authority and Regulations

Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Parts 74 and 92.


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NIH Funding Opportunities and Notices



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