NATIONAL LIBRARY OF MEDICINE: INSTITUTIONAL TRAINING GRANTS FOR INFORMATICS RESEARCH Release Date: March 29, 2001 RFA: RFA-LM-01-001 (see RFA-LM-06-001 for modification) National Library of Medicine (http://www.nlm.nih.gov) Letter of Intent Receipt Date: May 25, 2001 Application Receipt Date: June 22, 2001 PURPOSE The National Library of Medicine is inviting training grant applications in a single competition for support of pre-doctoral and post-doctoral training programs in informatics research. Applications may be for the creation of new training centers or for the renewal of existing NLM training program grants. Such training will help meet a growing need for investigators and leaders trained in biomedical computing and prepared to address information management issues in one or more health-relevant domains, including health care delivery, basic biomedical research, clinical and health services research, public health, and professional education. Graduates of the NLM-supported programs should be able to conduct basic or applied research at the intersection of biology and medicine with computer and cognitive sciences, and are expected to be familiar with the use and potential of modern information technology. HEALTHY PEOPLE 2010 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS- led national activity for setting priority areas. This Request for Applications (RFA) is related to one or more of the priority areas. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople/. APPLICANT ELIGIBILITY REQUIREMENTS Only domestic, non-profit, private or public institutions may apply for grants to support research training programs. The applicant institution must have a strong research program in the area(s) proposed for research training and must have the requisite staff and facilities to carry out the proposed program. The research training program director at the institution will be responsible for the selection and appointment of trainees to receive NLM support and for the overall direction of the program. Groups (or cooperatives) of health-related institutions are also eligible to apply. A single, lead institution must apply on behalf of the group, letters of agreement defining mutual responsibilities must be provided in the application and signed by authorized officials of each participating institution. However, more than one application from a single institution is undesirable, if an institution has two or more prospective Principal Investigators, NLM urges the principals to combine their proposals into one or to consult NLM staff for advice about resolving the matter. NLM encourages applications that include organizations with substantial numbers of students and faculty from racial/ethnic minorities currently under-represented in informatics, or that otherwise make provisions for promoting informatics research training among health professionals from such minorities. Trainees appointed to the training program must have the opportunity to carry out supervised research in informatics with the primary objective of developing or extending their research skills and knowledge. TRAINEE ELIGIBILITY REQUIREMENTS Positions on NLM institutional grants may not be used for study leading to the M.D., D.D.S., or other clinical, health-professional degrees except when those studies are a part of a formal combined research degree program, such as the M.D./Ph.D. Similarly, trainees may not accept NLM support for studies, which are part of residency training leading to certification in a medical or dental specialty or subspecialty, except when the residency program credits a period of full-time, postdoctoral research training toward board certification. Students enrolled in health-professional doctoral degree programs may receive support for short-term research training as described below. Additionally, health-professional students may interrupt their studies for a year or more to engage in an extended period of full-time research training before completing their professional degree. Trainees are required to pursue their research training on a full-time basis, devoting at least 40 hours per week to the program. Within the 40 hours per week training period, research trainees in clinical areas must devote their time to the proposed research training and must confine clinical duties to those that are an integral part of the research training experience. Citizenship. To be appointed to a training position supported by an NLM research training grant, an individual must be a citizen or non-citizen national of the United States or must have been lawfully admitted for permanent residence (i.e., in possession of a currently valid Alien Registration Receipt Card I-551, or must be in possession of other legal verification of such status). Non-citizen nationals are generally persons born in outlying possessions of the United States (e.g., American Samoa and Swains Island). Individuals on temporary or student visas are not eligible. Predoctoral Trainees. Predoctoral trainees must have received a baccalaureate degree by the beginning date of their NLM appointment, and must be training at the post-baccalaureate level and enrolled in a program leading to a Ph.D. in science or in an equivalent research doctoral degree program. Health-professional students who wish to interrupt their studies for a year or more to engage in full-time research training before completing their professional degrees are also eligible. Postdoctoral Trainees. Postdoctoral trainees must have received, as of the beginning date of the NLM appointment, a Ph.D., M.D. or comparable doctoral degree from an accredited domestic or foreign institution. Eligible doctoral degrees include, but are not limited to, the following: D.D.S., D.M.D., D.O., D.V.M., O.D., D.P.M., Sc.D., Eng.D., Dr. P.H., D.N.Sc., D. Pharm., D.S.W., and Psy.D. Documentation by an authorized official of the degree- granting institution certifying all degree requirements have been met prior to the beginning date of training is acceptable. Short-Term Health-Professional Trainees. To be eligible for short-term predoctoral research training positions, health-professional students must have completed at least one quarter in a program leading to a clinical doctorate prior to participating in the program. Individuals matriculated in a formal research degree program, or those holding a research doctorate or masters degree or a combined health-professional/research doctorate are not eligible for short-term training positions. Within schools of pharmacy, only individuals who are candidates for the Pharm.D. degree are eligible for short-term positions. Short-term research training positions should last at least 2 months but must not exceed 3 months. Individual health-professional students selected for appointment should be encouraged to obtain multiple periods of short-term research training during the years leading to their degree. Such appointments may be consecutive or may be reserved for summers or other "off-quarter periods. Librarians, Nurses, Engineers, and Computer Scientists Graduates of training programs in professions that do not customarily require a doctoral degree, such as library science, nursing, engineering, and computer science, can make important contributions to informatics research, and are also eligible for appointment to the NLM training programs. Such trainees will normally receive standard pre- doctoral stipends. However, those with professional experience of five or more years after graduation are eligible for stipends at post- doctoral levels. MECHANISM OF SUPPORT This RFA will use the T15 Training Grant mechanism. These awards are authorized by the Medical Library Assistance Act and are not a part of the National Research Service Awards Program (NRSA) of the Public Health Service. However, the policies and requirements of the NLM program are similar in most respects to NRSA awards. This RFA is a one-time solicitation. Awards will be announced in Fall of 2001 with starting date of July 1, 2002. FUNDS AVAILABLE NLM plans to make available approximately $11 million for this program in FY 2002 and expects to award 15-18 training grants. The actual number of grants made will depend on availability of funds and on the merit and scope of applications received. These awards are usually made for periods up to five years and are eligible for competitive renewal. Awards are normally made in 12-month increments with support for additional years based on satisfactory progress and the continued availability of funds. At this time, NLM has no plans for reissuance of this RFA. TRAINING OBJECTIVES Background Informatics is concerned with the acquisition, representation, storage, retrieval, and utilization of information. Information technology has become an almost ubiquitous element of informatics and informatics research because of the extraordinary power of computers and telecommunication to facilitate information management. Objectives and Site Acceptable applications must clearly indicate that the primary intent of the program is preparation for a career in informatics research. To prepare trainee for careers in a demanding research environment, the sponsorship of a research-oriented health sciences institution is critical. In most instances, academic medical centers are the preferred training sites, however, consortium training arrangements with graduate schools in library/information science, public health, and other health-related fields as well as with other institutions are encouraged. Curriculum Although a canonical set of basic courses for informatics training has not yet evolved, there is general agreement that the field is interdisciplinary, and includes, among others, components of computer science, information science, cognitive science, and knowledge of one or more domains of biomedicine. The training proposed in the application should describe clearly: o Required core courses o Elective options o Research experience o Expected competencies at end of training period Every program should be prepared to teach basic competencies that might reasonably be expected of all informaticians preparing for a career in informatics research. Further, all programs should display awareness of impending advances in information technology, including Next Generation Internet, and High Performance Computing in general. However, programs may vary in the spectrum of research experience offered, some may offer a broad variety of options while others may wish to limit projects to a more narrow area such as clinically relevant informatics, genomics/proteomics, health services research, computational biology etc. NLM is aware that informatics has historically had a heavy focus on clinically relevant topics, and that health care delivery continues to offer a rich variety of important research questions for informaticians. However, the remarkable emergence of very large datasets in genomics, neuroscience, clinical research, health services research and other domains has resulted in a rapidly expanding interest among basic and clinical scientists in the potential of informatics for facilitating research and for creating knowledge. NLM believes there will be high demand for specialists capable of applying informatics to biomedical research. Core training for informaticians should include exposure to the informatics of biomedical research. Length of Training and Degrees Awarded The credentials of informatics trainees and the philosophies of training directors differ widely. NLM acknowledges that the length of training proposed, as well as whether or not degrees are offered, are matters for each program to decide for itself. However, the likelihood that a trainee will have achieved competence within the time-frame proposed will be a matter of judgment for the review group when it evaluates the application. SPECIAL TRACKS (Optional, if included in application, provide sufficient detail to permit evaluation of the training to be offered.) Librarians Because of NLM’s strong interest in increasing the pool of health science librarians sophisticated in informatics, additional training slots will be offered to those who appoint health science librarians as trainees. Applicants interested in offering training for health science librarians as an option within their basic program should describe plans for such a special track. Librarians eligible for such appointments include those planning on returning to administration as well as those interested in informatics research careers. Dentists National Institute of Dental and Craniofacial Research (NIDCR) plans to support through this RFA up to three trainees interested in dental informatics. The training positions will be distributed among one or more sites depending on the relevance and assessment of proposed programs. The objective of this effort is to develop highly qualified investigators committed to a research career in oral health informatics, which integrates and applies the computer, information, and cognitive sciences to oral health and disease. Trainees can be individuals with a D.D.S., D.M.D., M.D., or equivalent degree, or pre- and post-Ph.D. It is essential that research training activities specifically apply informatics to areas pursued by the NIDR. These include: (1) the etiology, epidemiology, pathogenesis, prevention, diagnosis and treatment of dental caries, periodontal and oral soft tissue diseases, oral cancer, oral manifestations of AIDS and HIV infection, salivary gland conditions, craniofacial anomalies, orofacial pain, and temporomandibular disorders, (2) the molecular and cellular study of the development, structure and function of teeth, jaws, oral mucosa, bone, connective tissue, and salivary glands, (3) behavioral, social, cultural, economic, and health care delivery issues related to oral health and disease, (4) biomaterials, dental implants, biomimetics, and tissue engineering, (5) fluoride and nutrition, and (6) oral conditions prevalent among older Americans, a particular gender, minorities, people with particular systemic diseases, and other individuals and groups at high risk for oral health problems. Applicants interested in providing training in dental informatics as an option within their general program should describe their plans for such a special track. Support of training slots by NIDCR will be based on the Initial Review Group"s recommendation and priority score, relevance of the proposed project, program interests and the availability of funds. Information System Administrators The preparation of competent scientists remains the primary goal of the training program. However, NLM recognizes that informatics specialists are often called upon for assistance in addressing information needs of a health center, and strongly encourages program directors to provide trainees with some exposure to the problems of managing and integrating health enterprise information systems. As an exception to research as the career goal of these training programs, NLM will accept a training track within the Informatics Research Training Program that emphasizes information system administration. Such trainees are expected to take the core informatics courses, but may complete their training with projects that focus on administration, systems, and business areas instead of more traditional informatics research projects. TRAINEE TERMS OF APPOINTMENT Trainee appointments are normally made in 12-month increments. No trainee may be appointed for less than 9 months during the initial period of appointment, except with the prior approval of NLM or when health- professional students are appointed to approved, short-term research training positions. No individual trainee may receive more than 4 years of aggregate NLM support at the predoctoral level or 3 years of support at the postdoctoral level, including any combination of support from institutional training grants and individual fellowship awards. Any extension of the total duration of trainee support at either the predoctoral or postdoctoral level requires approval by NLM Requests for extension must be made in writing by the trainee, endorsed by the director of the training program and the appropriate institutional official, and addressed to the NLM Program Officer. The request must include a sound justification for an extension of the limits on the period of support. TRAINEE COSTS Stipends NLM training awards provide funds in the form of stipends to graduate students and postdoctoral trainees. A stipend is provided as a subsistence allowance to help trainees defray living expenses during the research training experience. It is not provided as a condition of employment with either the Federal Government or the awardee institution. Stipends must be paid to all trainees at the levels stipulated by NLM stipend schedules, which follow NRSA levels. The stipend rates shown are for FY2001. Applicants should contact the NLM individuals listed at the end of this announcement or consult the NIH Guide for recent information on stipend rates. Predoctoral Trainees. The stipend for predoctoral trainees in FY 2001 is $16,500. For appointments of less than a year, the stipend will be based on a monthly proration that is $1,375 Postdoctoral Trainees. The current annual stipend for postdoctoral trainees is determined by the number of FULL years of relevant postdoctoral experience at the time of appointment. Relevant experience may include research experience (including industrial), teaching, internship, residency, clinical duties, or other time spent in full-time studies in a health- related field following the date of the qualifying doctoral degree. Postdoctoral stipend rates in FY 2001 are as follows: Postdoctoral Years of Experience 0 $28,260 1 $29,832 2 $35,196 3 $36,996 4 $38,772 5 $40,460 6 $40,332 7 or more $44,412 No departure from the established stipend schedule may be negotiated by the institution with the trainee. The stipend for each additional full year of stipend support is the next level in the stipend structure and does not change in the middle of an appointment. Increase of Stipend The grantee institution may provide supplementation or additional support to offset the cost of living on the condition that such supplementation does not require any additional effort from the trainee. Federal funds may not be used for supplementation unless specifically authorized under the terms of both the program from which such supplemental funds are to be received and the program whose funds are to be supplemented. Under no circumstances may Department of Health and Human Services (DHHS) funds be used for supplementation. An institution may also provide additional compensation to a trainee in the form of compensation (as salary and/or tuition remission) for services such as teaching, clinical care, or serving as a research assistant. A trainee may receive compensation for services as a research assistant or in some other position on a Federal research grant, including a DHHS research grant. However, compensated services should occur on a limited, part-time basis apart from the normal research training activities, which require a minimum of 40 hours per week. In addition, compensation may not be paid from a research grant supporting research that is part of the research training experience. Under no circumstances may the conditions of stipend supplementation or additional compensation interfere with, detract from, or prolong the trainee"s approved training program. Educational Loans or G.I. Bill. An individual may make use of Federal educational loan funds and assistance under the Veterans Readjustment Benefits Act (G.I. Bill). Such funds are not considered supplementation or compensation. Concurrent Awards. An NLM traineeship may not be held concurrently with another federally sponsored fellowship or similar Federal award that provides a stipend or otherwise duplicates provisions of the NLM program. Tax Liability Internal Revenue Code Section 117 applies to the tax treatment of all scholarships and fellowships. Under that section, non-degree candidates are required to report as gross income all stipends and any monies paid on their behalf for course tuition and fees required for attendance. Degree candidates may exclude from gross income (for tax purposes) any amount used for tuition and related expenses such as fees, books, supplies, and equipment required for courses of instruction at a qualified educational organization. The taxability of stipends, however, in no way alters the relationship between NLM trainees and institutions. NLM stipends are not considered salaries. In addition, trainees supported by NLM are not considered to be in an employee-employer relationship with NLM or the awardee institution. It must be emphasized that the interpretation and implementation of the tax laws are the domain of the Internal Revenue Service (IRS) and the courts. PHS takes no position on what the status may be for a particular taxpayer, and it does not have the authority to dispense tax advice. Individuals should consult their local IRS office about the applicability of the law to their situation and for information on their tax obligations. Details of NIH Policies on administering stipends, on stipend supplementation, on other compensation, on educational loans, on concurrent awards and on advice on the tax liability of stipends are available from: National Research Service Award Guidelines. http://grants.nih.gov/training/nrsa.htm Other trainee costs Institutional Costs NLM provides institutional costs of $6000 per year per trainee (other than short-term trainees) to defray the costs of other research training expenses, including faculty salaries, staff salaries, consultant costs, equipment, research supplies, and faculty travel. Under exceptional circumstances, which can include providing accommodations for a trainee with disabilities, it is possible to request additional institutional costs. Requests for additional costs must be explained in detail and carefully justified in the application. Consultation with NLM program staff in advance of such requests is advised. Short-term Trainee Costs The institution may receive up to $167 per month to offset the cost of tuition, fees, health insurance, travel, supplies, and other expenses for each short-term, health-professional research trainee. Health Insurance In order to adjust policies to facilitate the recruitment of women and individuals from disadvantaged backgrounds as required by Section 487 of the Public Health Service Act (as amended), NLM will allow costs associated with family health insurance for trainees who have families and are eligible for family health insurance coverage at the sponsoring institution. Self-only health insurance will continue to be an allowable cost for trainees without families. Institutions may include the cost of family health insurance for trainees who are eligible for this coverage in the calculation of the combined cost of tuition, fees, and health insurance. Tuition Formula NLM will award 100% of the combined costs of tuition, fees, and health insurance up to $3,000 and 60 percent of the combined costs above $3,000. Grantees are reminded that the tuition formula is used for award calculation purposes only. Actual costs may be higher. Trainee Travel Trainee travel, including attendance at scientific meetings that the institution determines to be of importance to the individual"s research training, is an allowable trainee expense. NLM’s base formula for travel allows up to $500 per year per predoctoral trainee and up to $1,000 per year per postdoctoral trainee. In their proposed budgets, applicants should request additional trainee travel funds for a two-day meeting each year, to be held at the National Library of Medicine in Bethesda or at one of the training sites. The purpose of these meetings will be to exchange information among trainees, program directors, NLM program staff, and other selected participants. Support for travel to a research training experience away from the primary institution is also permitted. Such experiences are acceptable as a complement to the course work, expertise, and experiences available at the parent institution. Letters requesting such training may be submitted to NLM at any time during the award period, and should explain the type of opportunities for training available, how these opportunities differ from those offered at the parent institution, and the relationship of the proposed experience to the trainee"s career stage and goals. Facilities and Administration Expenses A facilities and administration allowance (indirect cost allowance) based on eight percent of total allowable direct costs (this excludes amounts for tuition, fees, health insurance, and equipment) may be requested. URLs IN NIH GRANT APPLICATIONS OR APPENDICES All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, Internet addresses (URLs) should not be used to provide information necessary to the review since reviewers are under no obligation to view the Internet sites. Reviewers are cautioned that their anonymity may be compromised when they directly access an Internet site. LETTER OF INTENT Prospective applicants are asked to submit, by May 21, 2001, a letter of intent that includes the name, address, and telephone number of the Principal Investigator, the identities of other key personnel and participating institutions, and the number and title of this RFA. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows NCCAM staff to estimate the potential review workload and plan the review. Mail or fax the letter of intent to: Dr. Merlyn Rodrigues Office of Scientific Review Division of Extramural Programs, National Library of Medicine Rockledge One Building, Suite 301 6705 Rockledge Drive Bethesda, MD 20892 APPLICATION PROCEDURES Applications are to be submitted on grant application form PHS 398 (rev. 4/98). Section V of that form contains special instructions for Institutional National Research Service Awards (T32). Application kits are available at most institutional offices of sponsored research and may be obtained from: Division of Extramural Outreach and Information Resources National Institutes of Health 6701 Rockledge Drive, MSC 7910 Bethesda, MD 20892-7910 Phone (301) 710-0267 Email: GRANTSINFO@NIH.GOV. Applications are also available on the Internet at http://grants.nih.gov/grants/funding/phs398/phs398.html. Applications Requesting Short-term Training for Health Professional Students. Applicants who wish to include a request for short-term research training positions should identify short-term positions separately within the "stipends" and "training related expenses" categories on the budget page. Under "stipends," short-term positions should be listed in the "other" category. Tuition, fees, health insurance, and trainee travel, and other expenses, are to be included in "training related expenses." The description of the short-term research training program should be included in the application for the regular research training program, but should be separated from the description of the regular program within each section of the application. Applicants must observe the 25-page limit on the narrative section. The title (INSTITUTIONAL TRAINING PROGRAMS FOR INFORMATICS RESEARCH) and number (RFA-LM-01-001) of this RFA must be typed on line 2 of the face page of the application form and the YES box must be marked. Submit a signed, printed, original of the application, and three signed photocopies in one package to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) At the time of submission, two additional copies of the application and appendices should be sent to: Dr. Merlyn Rodrigues Office of Scientific Review Division of Extramural Programs, National Library of Medicine Rockledge One Building, Suite 301 6705 Rockledge Drive Bethesda, MD 20892 It is important to send these copies at the same time as the original and three copies are sent to the Center for Scientific Review. These copies are used to identify conflicts of interest and to help ensure the appropriate and timely review of the application. Applications must be received by June 22, 2001. If an application is received after that date, it will be returned to the applicant without review. The Center for Scientific Review (CSR) will not accept any application in response to this RFA that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. The CSR will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of substantial revisions of applications already reviewed, but such applications must include an introduction addressing the previous critique. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for completeness by the CSR and responsiveness by the NLM. Incomplete and/or non-responsive applications will be returned to the applicant without further consideration. Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by an appropriate peer review group convened by NLM in accordance with the review criteria stated below. As part of the initial merit review, all applications will receive a written critique and may undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of the applications under review, will be discussed, assigned a priority score, and receive a second level review by the NLM Board of Regents. REVIEW CRITERIA o Objectives, design, and direction of the training with attention to course offerings, research experiences, and expected competencies described above under TRAINING OBJECTIVES o Caliber of preceptors as researchers, including successful competition for research support o Training environment including the institutional commitment o Recruitment and selection plans, and availability of high quality candidates o Recruitment record (for recompeting programs) o Research efforts and publication record of trainees (for recompeting programs) o Success of program graduates in career development and productivity (for recompeting programs) ADDITIONAL REVIEW CRITERIA (Not included in determining priority score but must be satisfactory to NLM before an award will be made) o Recruitment Plan For Women and Minorities. Applications must include a plan for recruitment of women and under-represented minorities into the training program. Recompeting programs are expected to report on recruitment and retention of under-represented groups in the preceding grant period. o Training In The Responsible Conduct Of Research. Applications must include a description of a program to provide instruction in scientific integrity and the responsible conduct of research. (See the NIH Guide for Grants and Contracts, Volume 21, Number 43, November 27, 1992.) AWARD CRITERIA NLM’s funding decisions will be based on o Quality of the proposed project as determined by peer review o Recommendation by the Board of Regents, o Availability of funds o Program priorities o Geographic and curriculum distribution needs of NLM’s training portfolio INQUIRIES Inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Dr. Carol Bean Division of Extramural Programs, National Library of Medicine Rockledge One Building, Suite 301 6705 Rockledge Drive Bethesda, MD 20892 Telephone: (301) 594-4882 FAX: (301) 402-2952 Email: beanc@mail.nlm.nih.gov Direct inquiries regarding fiscal matters to: Mr. Chris Robey Grants Management Specialist Division of Extramural Programs, National Library of Medicine Rockledge One Building, Suite 301 6705 Rockledge Drive Bethesda, MD 20892 Telephone: (301) 496-4221 FAX: (301) 402-0421 Email: robeyj@mail.nlm.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance, Medical Library Assistance, 13.879. Grants will be awarded under the authority of the Public Health Service Act, Section 472 (42 USC 286b-3) and administered under PHS grant policies and Federal Regulations, most specifically at 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to review by a Health Systems Agency nor to the requirements of OMB Circular A-95. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with PHS mission to protect and advance the physical and mental health of the American people.


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