CENTERS ON THE DEMOGRAPHY OF AGING

Release Date:  September 15, 1998

RFA:  AG-99-001

P.T.

National Institute on Aging

Letter of Intent Receipt Date:  October 16, 1998
Application Receipt Date:  November 20, 1998

PURPOSE

The National Institute on Aging (NIA), through the Demography and Population
Epidemiology unit of the Behavioral and Social Research Program, invites
applications for Research and Development Center Grants (P30) in the areas of
demography and economics of health and aging.  The Demography and Population
Epidemiology Unit supports research and training in the dynamics of population
aging using a variety of demographic and economic approaches.  Congress has urged
the further development of research on the demographic aspects of population
aging and the 1997 G8 Summit encouraged cross-national research to address the
challenges of population aging into the 21st Century (see Denver Summit
Communiqu‚ at http://www.g8denver.org/).

These center grants will support the infrastructure necessary for research, new
program development in selected areas, such as biodemography, the development of
innovative national and international networks of researchers, the recruitment
of new researchers into the field, the development and enhanced sharing of
specialized databases (e.g. HCFA records), including rapid application of
research results from these databases, and the development of statistical data
enclaves for the analysis of large-scale, often-longitudinal, databases with
linked administrative data.  Funds may also be used to develop trends in the
burdens and costs of diseases in the older population in general, and in
racial/ethnic groups (see Scientific Opportunities and Public Needs: Improving
Priority Setting and Public Input at the National Institutes of Health, National
Academy Press, 1998).

Scientific initiatives in the demography and economics of health and aging
increasingly require integration and collaboration with each other and also with
allied scientific fields such as genetics, biology, clinical medicine, and
epidemiology.  Collaboration across institutions and with international
organizations is often required.  Advances in computing technology have made new
methodologies such as macro and microsimulation and the multivariate analysis of
complex longitudinal data more practical and efficient, while raising the
obligation to protect confidentiality.  Progress in research on population aging
can be accelerated and significantly enhanced by the widespread collaboration of
investigators at multiple institutions and by the creation of innovative networks
of researchers.

Moreover, the NIA has supported the development of major data collection efforts
in areas such as long term care, retirement and economic status, and the dynamics
of health and functional change in the very old.  However, use of these and other
datasets require considerable investments of time and funding prior to conducting
any sophisticated research.  Efficiency is increased, and costs of individual
research projects can be reduced, when several researchers at the same
institution can make use of centralized data files staffed by knowledgeable data
managers.  Finally, there is a growing demand from the federal government and the
policy community for timely and appropriately synthesized research findings from
these datasets.

HEALTHY PEOPLE 2000

Each NIH PA addresses one or more of 22 Health Promotion and Disease Prevention
priority areas identified. These areas can be found via the WWW at
http://www.crisny.org/health/us/health7.html

ELIGIBILITY REQUIREMENTS

Applications may be submitted by domestic for-profit and non-profit
organizations, public and private, such as universities, colleges, hospitals,
laboratories, units of state and local governments, and eligible agencies of the
Federal government.  Foreign institutions are not eligible for center grants
(P30).  Racial/ethnic minority individuals, women, and persons with disabilities
are encouraged to apply as principal investigators.

A Center on Demography (P30) grant requires substantial pre-existing research
activity on population aging at the institution.  A minimum of at least one peer-
reviewed and externally funded, currently active research project directly and
centrally within the area of demography or economics of health and aging is
required.  Ideally, applicant institutions will have a substantial base.  Sub-
projects on NIA P01 grants may be counted as individual projects.  Although one
peer-reviewed and externally funded, currently active grant is the minimum
requirement, considerable weight will be given to significant research activity
in demography and economics of health and aging.

MECHANISM OF SUPPORT

The support mechanism for this program is the Research and Development center
grant (P30).  The center grant (P30) is an institutional award that supports a
variety of research-related activities organized around one or more common themes
or areas of interest.

The P30 is awarded competitively for no more than five years, and is expected to
lead to a competing application for another P30 or P50 Center Grant award.  The
Research and Development Center grant is a resource designed to encourage the
development and maintenance of a significant and enduring high quality research
program on population aging.  Except for pilot projects included in program
development, no funds are provided for the direct support of research projects. 
The P30 grant also helps to integrate existing projects in a specialized research
area, often with a central theme, and to encourage the scientific development of
the research area.  By making research resources more accessible, this support
is designed to enhance the productivity of other NIA-funded population aging
research and training grants.

Although the center grant is primarily designed to support a research center at
a specific institution, some centers may also wish to assume a national or
international role in making research resources available to the larger
scientific community, and galvanizing scientists at several institutions through
the development of networks.  Centers are also encouraged to collaborate with
other NIA-funded Centers, including the ROYBAL, Alzheimer's Disease Centers, and
the Claude D. Pepper Older Americans Independence Centers.  Information about
these Centers is available from the program staff listed under INQUIRIES.  The
Center support may therefore be used to create or assemble new databases and
methodologies for the larger research community.  These centers may also develop
and maintain innovative national and international research networks on
population aging.  Resources may also be used to disseminate research findings
more widely and in a more effective and timely manner to the scientific, federal,
and policy communities.  Consortium arrangements are permissible, provided that
the applicant institution meets the eligibility requirements.  In addition to
these functions, it is anticipated that one of the centers funded under this RFA
will also serve as a coordinating center in order to encourage collaboration and
networking among the NIA Demography Centers.

FUNDS AVAILABLE

The NIA anticipates that at least $3,000,000 in total costs per year for five
years will be committed to fund applications in response to this RFA.  Although
this program is provided for in the financial plans of the NIA, awards are
contingent on the availability of funds for this purpose.  The NIA expects to
make between six and ten awards.  Direct costs of the awards are expected to vary
between $100,000 and $500,000 depending upon the scale of activity that can be
reasonably supported by the institution in terms of the current level of funded
research on population aging.  No request may exceed $700,000 total costs in the
first year, with a three percent per annum inflation increase allowable in
subsequent years. However, in addition to the $700,000 limit, up to $100,000 in
direct costs (plus any indirect costs) may be separately requested for the
functions of a coordinating center.

If any NIA Research and Development P30 Center award from this RFA is made to an
institution with an NICHD-funded P30 Population Center also receiving
supplementary NIA funds, then it is anticipated that the NIA supplementary
support will be replaced by direct NIA funding.

RESEARCH OBJECTIVES

The center grant for this RFA minimally consists of (1) an administrative and
research support core, which will provide coordination, research planning,
logistical, and centralized data and technical support, and (2) a program
development core providing for small scale pilot studies related to program
development or methodological innovation.  In addition, an application may elect
to include (3) an external innovative national or international network core, (4)
an external research support and dissemination core, (5) a statistical data
enclave core, and (6) a coordinating center function.

Each proposed Center should focus on one or more scientific themes or areas
directly relevant to population aging.  Important initiatives and priorities
within population aging include (see also NIA Program Announcement "Secondary
Analysis in Demography and Economics of Aging" PAS-98-041):

o  Biodemography of aging:  including the demographic aspects of heritability and
familial aggregation of disease and longevity; incorporation of genetic and
disease variables into demographic models and age-specific mortality rates; and
the social roles of the elderly in nature.

o  Investigation of trends in chronic disease and disability, especially of the
factors underlying the recent trend in declining disability, in the older
population. Determination and estimation of causal factors underlying the trend.

o  Estimation of the impact of changing trends in the functional status and
health of the older population on Medicare and other health care costs.
Estimation of the impact of medical interventions on future lifetime health care
economic costs.

o  Economic and demographic analyses of the impact of aging-related biomedical
and social research and resulting new technologies and interventions.

o  Forecasting life and active life (health) expectancy, medical services and
long term care usage. Modeling risk factor trajectories and trends in non-
communicable disease disability and mortality in developed and developing
countries, with emphasis on aging populations. Analyses and projections of the
epidemiological transition in developing countries.  Improved analysis and
projections of the global burden of disease (e.g., incorporating microdata on
risk factors to model the impact of interventions), and critical analyses of
emerging methodologies for resource allocation in the health sector.

o  Evaluations and simulations of the impact of changes in DHHS and SSA policies
(e.g., changing the age of eligibility for Medicare and Social Security benefits)
on the health, functioning, and labor supply of the older population.

o  Stochastic forecasting and simulations of the Social Security program and of
changes in Social Security policy.  Macroeconomic simulations of changes in
Social Security policy on, e.g., national saving, investment and economic growth. 
Interactions of Social Security with other public and private programs.

o  Analyses of the fiscal effects of population aging, in the US and
internationally.

o  Health, work and retirement, including:  implications of population aging for
public and private retirement programs (national and international) and for
income security of future retirees; impacts on the labor supply of older workers;
labor demand of older workers; analyses of the health and functional capacity for
work of older persons; determinants of retirement, family labor supply, and
saving; consequences of retirement for health and functioning; comparative
studies of labor force activity; effects of psychological factors (e.g.,
expectations, risk taking, altruism, time preferences, etc.) and mental health
characteristics (e.g., depression) on economic behaviors (e.g., savings and
transfers); economic and demographic analyses of employer- and organizational-
level determinants of labor force participation at older ages.

o  Interactions between health and economic status over time; relationship
between health and wealth; role of social cohesion as a mediating factor;
improved measures of socioeconomic position for aging populations; economic
determinants of health promotion and disease prevention behaviors.

o  Studies of the health and economic status of diverse racial and ethnic older
populations. Variables of interest include the effects of lifelong poverty, birth
weight, access to employer-provided health insurance, recency and circumstances
of immigration; the strain of physically demanding work; wealth, income and
early- life health status; saving and investment choices; and experiences of
discrimination.

o  Demography and economics of dementia and Alzheimer's Disease, and of AIDS in
older populations.

o  General demographic analyses of population aging and analyses of past, current
and future cohorts of retirees, including the baby boom generation; historical
demographic and epidemiological research on the aging process and on the
determinants of health and mortality in older populations; migration and
immigration; the impact of state and small area characteristics on health;
improved descriptive analyses of centenarian populations; macro and micro
dynamics of intergenerational exchanges; use of public and private resources in
the period before death; and comparative international analyses of population
aging using Census and other data.

Applicants may address several areas.  These areas are not intended to be
prescriptive.  Applicants may redefine these areas, merging and combining topics
according to their own perspectives of the future course of the population
sciences related to aging.  Comparative international research is encouraged,
particularly when the research is clearly relevant to population aging within the
United States.  Wherever possible special attention should be given to the
demographic and economic aspects of the health and well-being of special older
populations such as the oldest old, Blacks and Hispanics, and older women.

Cores

In addition to (A) an administrative and research support core and (B) a program
development core, both of which are required, each proposed Center may also
request funding for (C) an external innovative national or international network
core, and/or (D) an external research resources support and dissemination core,
and/or (E) a statistical data enclave core, and/or (F) a coordinating center
function.  Applications are not required to include requests for cores C, D, E,
and F.  The following limitations apply to the maximum amount that may be
requested for average annual direct costs over five years, excluding the indirect
costs associated with consortia:  core A, up to $320,000; core B, up to $160,000;
core C, up to $100,000, core D, up to $200,000, core E, up to $200,000; and core
F up to $100,000.  Given these constraints plus the limitation on total annual
costs, no institution will be able to submit an application for all four optional
cores for the full amounts.  Therefore, each institution should decide on an
optimal mix of topical foci and cores, and within cores, of specific core
functions and levels of effort.  Further, in order to maximize flexibility and
permit the uneven distribution over the life of the Center, the dollar limit for
each core is set in terms of average annual costs over the life of the requested
center rather than simple annual costs.  However, the $700,000 total cost limit
(plus an allowable three percent escalation for inflation and exclusion of funds
requested for coordinating center functions) cannot be exceeded in any year.

Applicants are also encouraged to compete for the Coordinating Center function.
The Coordinating Center will serve to encourage collaboration and net-working
among the NIA Demography Centers.  Funds of up to $100,000 in direct costs (plus
indirect costs) may be separately requested for these functions above the
$700,000 total cost limit.  Although NIA will fund only one Coordinating Center,
other centers may propose coordinating functions that would exist independently
from the Coordinating Center, such as the development of a series of research
briefs which highlight research findings from all the NIA Demography Centers.

A.  Administrative and Research Support Core (MANDATORY)

The Administrative and Research Support core manages the activities of the Center
and provides shared resources such as datasets.  The application must name a
Center Director who will provide the overall scientific management and
coordination of the Center.  The Center Director must be an experienced
researcher with appropriate experience in research on population aging.  It is
recommended that an Advisory Committee be established to assist the Director in
making the scientific and administrative decisions relating to the Center,
including the allocation of funds for pilot studies.  While it is recommended
that this Committee include one or more members outside of the applicant
institution, any such members should not be contacted or named in the application
until after initial and secondary review in order to facilitate review by not
limiting the potential pool of reviewers.  The objective of this core is to
accomplish the following:

1.  Plan, coordinate, review and manage the Center's activities, including the
funding of pilot studies.

2.  Purchase and provide facilities or services such as centralized data
libraries, including the purchase of hardware such as workstations, high capacity
storage devices (hardware or equipment purchases may not exceed 15 percent of
requested funding), and data files; development of user-friendly data files;
salary for data managers; and cost effective data processing for the
Institution's research and training on population aging.  Facilities and services
should have the potential for general use at the institution, and must not be for
the sole use of any single project.  Any overlap with activities funded or
proposed through NICHD center grants must be clearly specified.  Salary support
may be requested for the scientific director, core technical staff, consultants,
and advisors. Travel funds should be requested to attend an annual NIA-sponsored
meeting of scientific center directors, and may be requested for researchers to
attend other scientific meetings, for training of technical and scientific staff,
for new program development, and for travel related to outreach and network
functions.

B.  Program Development Core (MANDATORY)

Each Center grant application must include a program development core.  The
objective of this support is to allow the institution to develop sufficient
preliminary information to permit the submission of applications for peer-
reviewed research or career development projects.  This core must include at
least one small-scale project that will lead to new program development.  Any
overlap with activities funded or proposed through NICHD center grants must be
clearly specified.  The new pilot or development projects should address research
topics listed above. Funds may be requested for:

1.  Small-scale projects, which may include pilot or feasibility projects.  These
small-scale projects are ordinarily limited to two years but may be extended with
appropriate justification.  The application must describe the proposed use of
funds for the first two years of the proposed center.  Adequate detail should be
provided in order to allow for the evaluation of the scientific value and
significance of the proposed activities.  Provision should be made in the
Administrative and research support core for the institutional review of new
projects.  The description of all pilot projects, and any results must be
reported in the Center's annual progress report to the NIA.

2.  Optional salary support for (a) new faculty development in demography of
aging; (b) increasing the critical mass of the scientific research staff; and (c)
the development of new program areas and methodologies.  Salary support is
limited to tenure track faculty (or equivalent in research organizations), and
five years per individual.  The total annual salary support cannot exceed $75,000
in direct costs (salary and fringe benefits) from the Center grant, and the
institution is expected to supplement any such salary costs with funds from other
sources.  As a target, it is expected that scientists supported through this
mechanism will either compete successfully for grant support or receive
substantial support from the institution by the end of the third year.

C.  External Innovative Network Core (OPTIONAL)

This optional core differs from the new program development core in that it
explicitly is for the development of networks beyond the applicant institution's
boundaries, including internationally; hence the designation, external. Any
overlap with activities funded or proposed through NICHD center grants must be
clearly specified.  Funds may be requested for:

1.  The development of innovative research networks on topics consistent with the
Center's goals that will serve to enhance research not only at the institution,
but more generally within the field, as well as in relation to other relevant
disciplines.  Such networks might include electronic bulletin boards, workshops,
funding for pilot projects, and the development of common research resources.

2.  The development of innovative international networks that advance the goals
of the 1997 G8 Summit language, which encouraged cross-national research to
address the challenges of population aging into the 21st Century (see Denver
Summit Communiqu‚ at http://www.g8denver.org/).  Additional topics include, but
are not limited to:  international comparative analyses of the oldest old, of
living arrangements, retirement, and pension systems; database construction and
analysis of international census microdata; development of databases suitable for
research in biodemography of aging; coordination of US and international
demography or economics of aging research; development of projection
methodologies for cross-national comparisons of population size and
characteristics of the oldest old; modeling risk factor trajectories in non-
communicable disease disability and mortality with emphasis on aging populations;
global cost and impact of various diseases prevalent in older populations; and
international comparisons of treatments for various diseases and conditions
prevalent in older populations.

3.  Outreach activities that will encourage and nurture the development of
minority researchers.  Such activities may include, e.g., sponsoring workshops
on minority populations and issues, developing networks of minority researchers,
and providing mentorship opportunities.

4.  Technical assistance activities intended to support users of large NIA funded
databases who are outside the NIA Demography Centers, including innovations
resulting in the development of a "virtual" Center for those at other
institutions.

D.  External Research Resources Support and Dissemination Core (OPTIONAL)

This optional core differs from Core A in that its objective is the communication
and dissemination of research resources, findings and new concepts and techniques
within and beyond the institution.  Applicants are encouraged to propose
innovative and creative methods of dissemination. Any overlap with activities
funded or proposed through NICHD center grants must be clearly specified.  Funds
may be requested for, but are not limited to:

1.  The dissemination of new methodologies and important databases to the larger
scientific community.  Encouragement is given for the development, support, and
sharing of user-friendly databases and specific analytic methodologies resulting
from grants, contracts, and cooperative agreements, both within the institution,
and nationally to appropriate researchers.  Such dissemination might include,
e.g., research and training workshops, development of user-friendly extract files
with imputed variables, newsletters, and electronic bulletin boards providing
technical support.  Development of innovative approaches to dissemination is also
encouraged.

2.  The timely dissemination of well-synthesized research results to the Federal
government, scientific community, and policy making community.  Strong
encouragement is given for the dissemination of research results from NIA
sponsored databases on the topics listed above under "Research Objectives".  Such
dissemination might include briefings, training seminars, working paper series,
and research briefs, and newsletters.  Encouragement is also given to translating
basic demographic and economic research into research briefs that are easily
accessible.

3.  The dissemination and development of new research techniques and concepts to
the larger demography and economics of aging and health research communities. 
Such dissemination might include workshops and training institutes.  The value-
added components to any on-going activities should be clearly specified.

E.  Statistical Data Enclave Core (OPTIONAL)

Demographic and economic aging research depends heavily on large-scale, often-
longitudinal, databases with linked administrative (e.g., HCFA and SSA) data,
geocoding, and, potentially, genetic data.  The advent of cheap and powerful
computers plus the internet, coupled with increased public and legislative
sensitivity, has created a new environment for this type of research.  Increased
emphases on cross-national research must deal with international laws on
confidentiality and transmission of health data across borders. Any overlap with
activities funded or proposed through NICHD center grants must be clearly
specified.  Funds may be requested for, but are not limited to:

1.  Development of leading-edge analytic methods; development of new statistical
techniques to mask individual identities in microdata while maintaining the
maximum research value of the data.  Development of methodology for linking
administrative data with longitudinal data sources and distributing the linked
files.

2.  Statistical analyses of risk disclosure for public use files.

Methodological research on the merits and drawbacks of various identity masking
strategies.

4.  Establishing a secure data enclave for analysis of longitudinal data with
sensitive linked administrative records.

F.  Coordinating Center Function (OPTIONAL)

Applicants are encouraged to apply for the coordinating center function in order
to promote collaboration and networking among the NIA Demography Centers.  Funds
of up to $100,000 in direct costs (plus indirect costs) may be requested to
arrange annual meetings or produce bibliographic or other special reports that
would be of benefit to all NIA Demography Centers. Any overlap with activities
funded or proposed through NICHD center grants must be clearly specified. 
Coordinating Center functions may include, but are not limited to, establishing
a multi-center website, coordinating conferences, preparing annual reports and
research briefs of center research findings, and funding multi-center activities,
including travel to workshops.  Although NIA will fund only one Coordinating
Center, other centers may propose coordinating functions that would exist
independently from the Coordinating Center, such as the development of a series
of research briefs which highlight research findings from all the NIA Demography
Centers.

SPECIAL REQUIREMENTS

The institution and pertinent departments must show a strong commitment to the
Center's support.  Such commitment may be provided as dedicated space, salary
support for investigators, release time, new staff positions, dedicated
equipment, clerical support, or other financial support for the proposed Center.

In the mandatory Administrative and Research Support core, travel funds should
be requested to attend an annual NIA-sponsored meeting of scientific center
directors, and may be requested for researchers to attend other scientific
meetings, for training of technical and scientific staff, for new program
development, and for travel related to outreach and network functions.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of the NIH that women and members of minority groups and their
sub-populations must be included in all NIH supported biomedical and behavioral
research projects involving human subjects, unless a clear and compelling
rationale and justification is provided that inclusion is inappropriate with
respect to the health of the subjects or the purpose of the research.  This
policy results from the NIH Revitalization Act of 1993 (Section 492B of Public
Law 103-43).

All investigators proposing research involving human subjects should read the
"NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical
Research," which have been published in the Federal Register of March 28, 1994
(FR 59 14508-14513) and in the NIH Guide for Grants and Contracts, Vol. 23, No.
11, March 18, 1994.

Investigators also may obtain copies of the policy from the program staff listed
under INQUIRIES.  Program staff may also provide additional relevant information
concerning the policy.

NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS PARTICIPANTS IN
RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by the
NIH, unless there are scientific and ethical reasons not to include them.  This
policy applies to all initial (Type 1) applications submitted for receipt dates
after October 1, 1998.  The scientific goals of this RFA are focused on aging;
therefore, this policy is waived for applications responding to it. Reviewers
will not consider the inclusion of children as part of the initial review.

LETTER OF INTENT

Prospective applicants are asked to submit, by October 16, 1998, a letter of
intent that includes a descriptive title of the proposed research, the name,
address, and telephone number of the Principal Investigator, the identities of
other key personnel and participating institutions, and the number and title of
the RFA in response to which the application may be submitted.  Although a letter
of intent is not required, is not binding, and does not enter into the review of
a subsequent application, the information that it contains allows NIA staff to
estimate the potential review workload and avoid conflict of interest in the
review.

The letter of intent is to be sent to:

Richard M. Suzman, Ph.D.
Behavioral and Social Research Program
National Institute on Aging
7201 Wisconsin Avenue, Suite 533, MSC 9205
Bethesda, MD  20892-9205
Telephone:  (301) 496-3138
FAX:  (301) 402-0051
Email:  Suzman@nih.gov

APPLICATION PROCEDURES

The research grant application form PHS 398 (rev. 5/95) is to be used in applying
for these grants.  Applications kits are available at most institutional offices
of sponsored research and from the Division of Extramural Outreach and
Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC
7910, Bethesda, MD 20892-7910, telephone (301) 435-0714, email:
GrantsInfo@nih.gov. Applications are also available on the World Wide Web at 
http://www.nih.gov/grants/funding/phs398/phs398.html.

Applications should follow instructions in the PHS 398 form, with the following
exceptions.  The Description and Key Personnel Section (PHS 398, page 2) should
concisely state the overall goals of the entire Exploratory Center and clearly
state the contribution of each component to the overall goals.  Key personnel for
the entire Center for Demography, including any consultants and consortium
collaborators, should be listed alphabetically.

The text of the application should begin with an overview that presents a
succinct plan for the center as a whole, with a clear description of ongoing and
pending research projects in population research related to aging, the major
theme(s) and rationale(s) for the exploratory center, the organization of the
administrative and new program development cores and their relationship to
ongoing research and training projects in the demography and economics of health
and aging (including oversight activities), the extent of institutional,
departmental, and interdepartmental cooperation, and a summary program budget. 
Issues related to institutional commitment and settings, and the mechanisms that
will ensure the coherence of the project should be described.  The introduction
is limited to 8 pages, followed by separate sections that fully document each
core component.  Institutions proposing to undertake the coordinating center
function may use up to an additional three pages to describe the research plan
and accompanying budget for this function.

Except for Core B, PHS 398 sections a-d of the Research Plan for each core
component is limited to 10 pages.  For Core B, the maximum length is 20 pages.
Each core should be prepared as a separate section that begins on a new page of
the application.  Complete information, including a fully justified budget, is
required for each core component.  Appendix materials should be kept to a minimum
as per the instructions in form PHS 398.  Applications exceeding the specified
page limits will be returned to the applicant without review.

Applications involving human subjects must be reviewed and approved by the
appropriate Institutional Review Board (IRB) prior to submission.  Applications
without IRB approval are incomplete and will be returned.

The RFA label available in the PHS 398 (rev. 5/95) application form must be
affixed to the bottom of the face page of the application.  Failure to use this
label could result in delayed processing of the application such that it may not
reach the review committee in time for review.  In addition, the RFA title, and
number, must be typed on line 2 of the face page of the application form and the
YES box must be marked.

Submit a signed, original of the application, including the Checklist, and three
signed photocopies of the application in one package to:

CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

At the time of submission, send two additional copies of the application to:

Mary Nekola, Ph.D.
Scientific Review Office
National Institute on Aging
7201 Wisconsin Avenue, Room 2C212
Bethesda, MD  20892-9205

It is important to send these copies at the same time as the original and three
copies are sent to the Center for Scientific Review.

Applications must be received by November 20, 1998.  If an application is
received after that date, it will be returned to the applicant without review. 
The Center for Scientific Review (CSR) will not accept any application in
response to this RFA that is essentially the same as one currently pending
initial review, unless the applicant withdraws the pending application.  The CSR
will not accept any application that is essentially the same as one already
reviewed.  This does not preclude the submission of substantial revisions of
applications already reviewed, but such applications must include an introduction
addressing the previous critique.

REVIEW CONSIDERATIONS

Upon receipt applications will be reviewed for completeness by CSR and
responsiveness to the RFA by the NIA.  Incomplete and/or nonresponsive
applications will be returned to the applicant without further consideration. 
Applications that are complete and responsive will be reviewed for scientific and
technical merit review by a special study section convened by the NIA in
accordance with the criteria stated below.  As part of the initial merit review,
all applications will receive a written critique and may undergo a process in
which only those applications deemed to have the highest scientific merit,
generally the top half of applications under review, will be discussed, assigned
a priority score, and receive a second level review by the National Advisory
Council on Aging.

Review Criteria

The following set of criteria will be used in the evaluation of applications in
response to this RFA.

o  the potential for significant scientific progress in the specific areas or
themes addressed by the application, and the overall strategy for developing
research in the demography and economics of health and aging generally and
specifically within the areas or themes;

o  the level and extent of funded research directly relevant to the demography
and economics of health and aging;

o  the scientific qualifications, leadership, and research experience in aging
research of the Principal Investigator and professional staff;

o  successful training activity in the area of population aging including the
recruitment and training of junior investigators;

o  the scientific merit of the proposed pilot or new program development projects
and the adequacy of the review procedures to assess the scientific merit of
future studies;

o  the value to the institution's researchers of the support and maintenance
functions for e.g., databases and methodologies;

o  evidence of concrete commitment of the institution's administration to develop
and support research and training on population aging; provision of new resources
(e.g., co-funding or new positions); and

o  the scientific value and public good that might result from any proposed
external outreach and network building activities.

AWARD CRITERIA

The anticipated date of award is July 1, 1999.  .

Applications recommended for further consideration by the National Advisory
Council on Aging will be considered for funding on the basis of overall
scientific, clinical, and technical merit of the proposal as determined by peer
review, how well the application meets the goals and objectives of the program
as described in this RFA, including increasing the concentration of funded
activities in population research, appropriateness of budget estimates, program
needs and balance, policy considerations, adequacy of provisions for the
protection of human subjects, and availability of funds.

INQUIRIES

Inquiries concerning this RFA are encouraged.  The opportunity to clarify any
issues or questions from potential applicants is welcome.

Direct inquiries regarding programmatic issues to:

Georgeanne E. Patmios
Behavioral and Social Research Program
National Institute on Aging
Gateway Building, Suite 533
Bethesda, MD  20892
Telephone:  (301) 496-3138
FAX:  (301) 402-0051
Email:  PatmiosG@exmur.nia.nih.gov

Direct inquiries regarding fiscal matters to:

David Reiter
Grants and Contracts Management
National Institute on Aging
Gateway Building, Room 2N212
Bethesda, MD  20892
Telephone:  (301) 496-1472
FAX:  (301) 402-3672
Email:  ReiterD@exmur.nia.nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance No.
93.866.  Awards are made under authorization of the Public Health Service Act,
Title IV, Part A (Public Law 78-410), as amended by Public Law 99-158, 42 USC 241
and 285) and administered under PHS grants policies and Federal Regulations 42
CFR 52 and 45 CFR Part 74.  This program is not subject to the intergovernmental
review requirements of Executive Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a smoke-
free workplace and promote the non-use of all tobacco products.  In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain
facilities (or in some cases, any portion of a facility) in which regular or
routine education, library, day care, health care or early childhood development
services are provided to children.  This is consistent with the PHS mission to
protect and advance the physical and mental health of the American people.


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