Department of Health and Human Services
Part 1. Overview Information
Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)

Funding Opportunity Title

Shared Instrumentation Grant (SIG) Program (S10)

Activity Code

S10 Biomedical Research Support Shared Instrumentation Grants  

Announcement Type
Related Notices

Funding Opportunity Announcement (FOA) Number


Companion Funding Opportunity


Number of Applications

There is no limit on the number of applications an institution may submit, provided the applications are for different types of equipment. See Section III. 3. Additional Information on Eligibility.

Catalog of Federal Domestic Assistance (CFDA) Number(s)


Funding Opportunity Purpose

The Shared Instrument Grant (SIG) program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems that cost at least $50,000. The maximum award is $600,000. Types of instruments supported include, but are not limited to: X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell-sorters, and biomedical imagers.

Key Dates
Posted Date

January 13, 2015

Open Date (Earliest Submission Date)

April 29, 2015

Letter of Intent Due Date(s)

Not Applicable

Application Due Date(s)

May 29, 2015, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on this date .

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s)

Not Applicable

Scientific Merit Review

August - November 2015

Advisory Council Review

January 2016

Earliest Start Date

February 1, 2016

Expiration Date

May 30, 2015

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 1. Overview Information
Part 2. Full Text of the Announcement

Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information

Part 2. Full Text of Announcement
Section I. Funding Opportunity Description

The purpose of this funding opportunity is to continue the Shared Instrumentation Grant (SIG) Program administered by ORIP. The objective of the Program is to make available to institutions expensive research instruments that can only be justified on a shared-use basis and that are needed for NIH-supported projects in basic, translational or clinical areas of biomedical/behavioral research. The SIG Program provides funds to purchase or upgrade a single item of expensive, specialized, commercially available instrument or an integrated instrumentation system. An integrated instrumentation system is one in which the components, when used in conjunction with one another, perform a function that no single component could provide. The components must be dedicated to the system and not used independently.

Types of supported instruments include, but are not limited to: x-ray diffractometers, electron and confocal microscopes, mass and nuclear magnetic resonance (NMR) spectrometers, protein and DNA sequencers, biosensors, cell sorters, and biomedical imagers. Applications for "stand alone" computer systems (supercomputers, computer clusters and storage systems) will only be considered if the instrument is solely dedicated to the research needs of a broad community of NIH-supported investigators.

The SIG Program will not support requests for:

  • an instrument with a base cost of less than $50,000;
  • multiple instruments bundled together or a series of complementary related instruments; 
  • software, unless it is integral to the operation of a piece of equipment;
  • purely instructional equipment, institutional administrative management systems, clinical management systems;
  • instruments used for clinical (billable) care;
  • general purpose equipment or an assortment of instruments to furnish a research facility and equipment for routine sustaining infrastructure (such as, standard machine shop equipment, standard computer networks, autoclaves, hoods and equipment to upgrade animal facilities).

Instruments must be for research purposes only. Applications for research on advancing the design or for the development of new instrumentation are not appropriate for this Funding Opportunity Announcement (FOA).

Foreign-made equipment is allowable.

Applicants are advised to discuss with the SIG Scientific/Research Contact (See Section VII) any questions about appropriate types of equipment, eligibility, and Program requirements, prior to submitting an application for an integrated instrumentation system.

To promote cost effectiveness, to encourage optimal sharing among individual investigators, research groups and departments, and to foster a collaborative multidisciplinary environment, the instrument should be integrated in a centralized core facility, whenever possible.

Each applicant institution must propose a Program Director/Principal Investigator(PD/PI) who can assume administrative/scientific oversight responsibility for the requested instrumentation. See Section III.1 for qualifications for the PD/PI. An Advisory Committee must be named to assist the PD/PI in administering the grant and overseeing the usage of the instrument. For details on the composition of the Advisory Committee, see Section IV.2 under "Administration." The PD/PI and the Advisory Committee are responsible for the development of guidelines for:

  • Maximum utilization of the instrument, including time allocation;
  • A detailed plan for the day-to-day management and safe operation of the instrument;
  • If appropriate, a plan to ensure that access to the instrument is limited to users whose projects have received approval from institutional human subjects, animal welfare or biosafety committees;
  • A financial plan for the long term operation and maintenance of the instrument during the post award period;
  • The relocation of the instrument within or outside the institution or changes of ownership, if such changes are necessary;
  •  Naming a new PD/PI if such a need arises due to the departure of the current PD/PI.

The PD/PI also will be responsible for:

  • Requesting no-cost extensions of the project period, if needed.
  • Preparing (and working with the Institution to submit) a Final Progress Report at the end of the project period, that describes the purchased instrument, a list of all users and publications resulting from use of the instrument, and a description of the value of the instrument to the investigators and to the institution as a whole. See Section VI.3.
  • Submitting Annual Equipment Usage Reports to the NIH for a period of four years after the final progress report. See Section VI.3.
Section II. Award Information
Funding Instrument

Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed


The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types.

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. ORIP intends to fund an estimate of 80 awards, corresponding to a total of about $40 million, in fiscal year 2016.

Award Budget

Applications will be accepted that request a single, commercially available instrument or integrated system which costs at least $50,000. There is no upper limit on the cost of the instrument, but the maximum award is $600,000. Since the cost of the various instruments will vary, it is anticipated that the size of the award also will vary.

Award Project Period

Awards are made for one year only.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

Section III. Eligibility Information
1. Eligible Applicants
Eligible Organizations

Higher Education Institutions

  • Public/State Controlled Institutions of Higher Education
  • Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

  • Hispanic-serving Institutions
  • Historically Black Colleges and Universities (HBCUs)
  • Tribally Controlled Colleges and Universities (TCCUs)
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education

  • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • Other

Under the general research support authority of Section 301(a) (3) of the Public Health Service Act, Shared Instrumentation Grant awards are made to public and non-profit domestic institutions only. These institutions include health professional schools, other academic institutions, hospitals, health departments, and research organizations. Federal institutions, foreign institutions, and for-profit institutions are not eligible to apply. A Federal institution is defined by the NIH as a Cabinet-level department or independent agency of the executive branch of the Federal Government or any component organization of such a department or agency.

Foreign Institutions

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Required Registrations

Applicant Organizations

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

  • Dun and Bradstreet Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.
  • System for Award Management (SAM) (formerly CCR) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
  • eRA Commons - Applicants must have an active DUNS number and SAM registration in order to complete the eRA Commons registration. Organizations can register with the eRA Commons as they are working through their SAM or registration. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
  • – Applicants must have an active DUNS number and SAM registration in order to complete the registration.

Program Directors/Principal Investigators (PD(s)/PI(s))

All PD(s)/PI(s) must have an eRA Commons account.  PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

The PD/PI chosen for this application should have documented (in the biographical sketch) technical expertise directly related to the type of the chosen instrument. The PD/PI does not need to have an NIH research grant or any other research support but is expected to be an expert on the requested instrument. The PD/PI may be a Core director or non-tenured faculty member of the applicant organization, must be affiliated with the applicant organization, and must be registered on eRA Commons.

Multiple PDs/PIs are not allowed under the S10 mechanism.

2. Cost Sharing

This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

3. Additional Information on Eligibility
Number of Applications

The NIH will not accept duplicate or highly overlapping applications under review at the same time.  This means that the NIH will not accept:

  • A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.
  • A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.
  • An application that has substantial overlap with another application pending appeal of initial peer review (see NOT-OD-11-101).

In addition, the NIH will not accept a resubmission (A1) application that is submitted later than 37 months after submission of the new (A0) application that it follows.  The NIH will accept submission:

  • To an RFA of an application that was submitted previously as an investigator-initiated application but not paid;
  • Of an investigator-initiated application that was originally submitted to an RFA but not paid; or
  • Of an application with a changed grant activity code.

There is no restriction on the number of applications an institution can submit to the SIG and/or High-End Instrumentation (HEI) Programs each year provided the applications request different types of equipment. Concurrent SIG and/or HEI applications for the same instrument (or the same type of instrument with added special accessories to meet the HEI budget requirement) are not allowed, in general. If two or more S10 (either SIG or HEI) applications are submitted for similar equipment from the same institution, documentation from a high level institutional official must be provided stating that this is not an unintended duplication, but part of a campus wide instrumentation plan. A single application requesting more than one type of instruments (for example, a mass spectrometer and a confocal microscope) is not appropriate for this FOA. Applicants are advised to discuss with the SIG Scientific/Research Contact (see Section VII) potential duplicates before submitting two applications for the same type of instrument.

Major and Minor User Groups

A Major User group composed of three (or more) individuals must be identified. Each member of this group must be a PD/PI on a distinct NIH award with one of the following activity codes: R01, DP1, DP2, P01, P50, R37, and U01. (The requirement is one award per investigator, with more awards per investigator allowed.  An award given to multi-PDs/PIs is counted only once towards fulfilling this requirement.)  Once this eligibility requirement has been met, additional users with active NIH research awards can be added as Major or Minor Users. Major Users must have substantial interests in and needs for the instrument. PDs/PIs of NIH training grants (T mechanism) and contracts are not eligible to be Major or Minor Users, solely based on such funding. Investigators with funding from sources such as other Federal agencies (e.g., NSF, DoE, DoD), private foundations or academic institutions can be added as Major or Minor Users provided they are engaged in basic, translational or clinical areas of biomedical/behavioral research. Major Users can be researchers from the same department or from several departments, divisions or schools at the applicant institution, or from nearby or regional institutions.

To demonstrate the clear need for the requested instrument, the projects supported by NIH research grants should together require at least 75 percent of the Accessible User Time (AUT) – see Section Other Project Information for the definition of AUT. Major Users supported by NIH grants should require at least 35 percent of the AUT.

The user group must meet the eligibility requirement at the time of submission and at a later time if/when the application is considered for funding by the SIG Program staff.

Section IV. Application and Submission Information
1. Requesting an Application Package

Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the "Apply for Grant Electronically" button in this FOA or following the directions provided at

2. Content and Form of Application Submission

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, including Supplemental Grant Application Instructions except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

For information on Application Submission and Receipt, visit Frequently Asked Questions – Application Guide, Electronic Submission of Grant Applications.

Page Limitations

All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed, with the following exceptions or additional requirements:

For this FOA, there is no overall page limit for the entire Instrumentation Plan. However, there are specified page limits for each section of the Instrumentation Plan as described below. The sections cannot exceed the page limit including tables, graphs, figures, diagrams, and charts. Although there is no overall page limit, applicants are reminded to be informative yet succinct. It is expected that the length of the Plan's narrative will depend on the type of the requested instrument and the number of users. To be successful an application does not have to reach the page limits described here.

  • Introduction to Resubmission: 3 pages (if applicable)
  • Justification of Need: 9 pages in total
  • Technical Expertise: 3 pages in total
  • Research Projects section must not exceed 30 pages in total. This section should be divided into  two subsections: Research Projects of Major Users and Research Projects of Minor Users. The limit is 6 pages per Major User; however, three or fewer pages are STRONGLY recommended.
  • Summary Table(s): 6 pages in total
  • Administration (Organizational / Management Plan): 6 pages in total
  • Institutional Commitment: 3 pages in total
  • Overall Benefit: 3 pages in total

Note: Letters of Support and Bibliography & References Cited Section are not included in the page limitations.

Instructions for Application Submission

The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this FOA.

SF424(R&R) Cover

All instructions in the SF424 (R&R) Application Guide must be followed.

Descriptive Title: Enter the generic name of the instrument requested in the title (for example, 600MHz NMR Spectrometer or High Throughput DNA Sequencer).

Proposed Project: Enter start date of 02/01/2016 and end date of 01/31/2017.

Estimated Project Funding:

Total Federal Funds Requested: Enter the total Federal funds for the requested instrument.

This entry cannot exceed $600,000 which is the maximum award under the SIG Program. If the cost of the instrument is more than $600,000 enter $600,000 (or any lower amount of the requested Federal Funds).

Total Non-Federal Funds: If Total Federal Funds Requested (described immediately above) and Total Federal & Non-Federal Funds (described immediately below) are not the same, enter the difference in this line. Explain how the difference will be paid in the Equipment section on the SF424 (R&R) Other Project Information component (described below).

Total Federal & Non-Federal Funds: Enter the total cost of the instrument from the quote.

Program Income: Enter zero it as does not apply to the SIG Program.

NOTE: A warning will be generated during submission for any S10 with a budget in excess of $500,000. This warning can be ignored.

SF424(R&R) Project/Performance Site Locations

All instructions in the SF424 (R&R) Application Guide must be followed.  

SF424(R&R) Other Project Information

All instructions in the SF424 (R&R) Application Guide must be followed.

Project Summary/Abstract: The Project Summary/Abstract is meant to serve as a succinct and accurate description of the requested instrument and the need of the research projects for the instrument. State the application's broad, long-term objectives, concisely describing how access to the instrument will enhance the health-related goals of the research projects. This section should be informative to other persons working in the same or related fields and understandable to a scientifically or technically literate reader.

NOTE: The Project Summary/Abstract must be no longer than 30 lines of text.

Project Narrative: Using no more than two or three sentences, describe the relevance of this research to public health. In this section be succinct and use plain language that can be understood by a general, lay audience.

Bibliography & References Cited: List only these publications that demonstrate the researchers' expertise in operation and usage of the requested instrument or are relevant to research projects which will be supported by the instrument. References of the research project narratives of Major and Minor Users may appear in this section under each user's name or users may list such references at the end of their individual research sections.

Facilities & Other Resources: Not Applicable. Do not include an attachment here.

Equipment: Describe the requested instrument by stating its manufacturer, model number, and specific features and any accessories. Provide a detailed budget breakdown of the main instrument and requested accessories, including tax and import duties, if applicable. An itemized quote, with any appropriate discount, from a vendor is required. The quote must be scanned and combined in a single attachment with the equipment description as part of this upload. As described above in SF424 Cover form, include an explanation of Total Non-Federal Funds in this section (if applicable). If human or infectious materials, which could create a potential biohazard, are to be analyzed, funds for accessory containment equipment for the instrument may be requested in the budget.

Do not describe the need for the instrument or accessories here - compare instructions in  the Justification of Need section.

Other Attachments: Instrumentation Plan (in lieu of Research Plan section). The entire Instrumentation Plan (with the sections described below) must be saved as a single pdf file (named Instrumentation Plan) and attached via Other Attachments. Organize the Instrumentation Plan in the specified order (described below) starting each section with the appropriate section heading (i.e. Justification of Need, Technical Expertise, Research Projects, etc.). Do not include links to websites for further information. Do not include animations.

  • Introduction: Only in the case of a resubmission, include an Introduction describing the changes that have been made in response to comments in the previous review.
  • Justification of Need: Name the requested instrument. Compare performance of the requested model with other similar instruments available on the market. Justify the need for specific features and special accessories of the requested instrument. Each such accessory must be utilized by at least half of the Major Users. Explain why the chosen model and its manufacturer are the most suitable for your user group. If feasible, you may include preliminary data to justify your choice. Provide an inventory of similar instruments existing at your institution, neighboring research institutions, or otherwise accessible; describe why each similar instrument is unavailable or inappropriate for the proposed research. If similar instruments are listed as "unavailable," add a letter to the Letters of Support section from the instrument manager explaining why the instrument is not available to your user group.

Include specific documentation on the current usage and downtime of each of these existing instruments in annual hours and a realistic estimate of the projected usage for the requested instrument. Use of tables may clarify the presentation. Tables included within this section will count towards the specified page limit.

For the requested instrument, define and justify the Accessible User Time (AUT) which is the number of annual hours the instrument can be used for any research purpose. AUT hours may be limited by the times an instrument operator is available (if an operator is required), site or building access schedules, estimated or scheduled maintenance, start-up and standardization, and any other factors that take time away from use of the instrument. Justify (table format is suggested) the AUT for the proposed instrument based on the individual situation at the applicant institution. AUT for the same instrument may differ among different institutions.

  • Technical Expertise: Describe the technical expertise present at the institution to set up, run and maintain the instrument. Specify who will operate the instrument, train new users, ensure that it is operated safely and is appropriately maintained. If the requested instrument produces data which is complex to interpret, address technical support for data collection, handling, and analysis. Likewise, if the instrument requires complex sample preparation or consultation for experimental designs, describe the expert individuals who will serve in that capacity.
  • Research Projects: Divide this section into two subsections: Research Projects of Major Users and Research Projects of Minor Users.
  • All Major Users must have substantial need for the requested instrument. Detailed eligibility requirements for Major Users are described in Section III 3. Since the projects have been previously peer reviewed, describe the details of each project only as necessary to explain how the requested instrument will benefit the project's research objectives. (Do not simply copy the Specific Aims section from your funded application.) Present sufficient technical details about types of samples or specific experimental protocols to be employed by each user to allow evaluation of whether the instrument is appropriate, would be effectively employed, and would provide advantages over other methods and other similar existing or new instruments. In particular, explain the need for special features and accessories of the requested instrument by describing the specific studies that utilize these options as at least half of the Major Users must need any of these special options. If available, preliminary data may be used to illustrate the benefit of the requested instrument to research projects.
  • Minor Users are additional users with active research grants. Eligibility information for Minor Users is described in Section III 3. Include a brief summary of the benefit the requested instrument will bring to their research.
  • Summary Table(s): Show tables summarizing Research Projects of: 1) Major Users and 2) Minor Users. Each table should have the following columns: User's name, grant number: for NIH awards list the complete grant numbers (e.g. 5R01HL123451-01A1), brief title of the project, grant start and end dates, and estimated number of AUT hours. If there are multiple Major or Minor Users funded by the same grant, clearly indicate their names and their total estimated percentage of use of the instrument for projects supported by that grant. In addition, make a separate table to indicate the users' needs for any requested accessories.
  • Administration (Organizational/Management Plan): Describe the organizational plan to administer the grant. In particular, describe how the instrument will be utilized, how requests to use the instrument will be made, how time will be allocated among Major and Minor Users, and how new users will be enlisted. Describe typical day-by-day management of the instrument.

List the names and titles of the members of the local Advisory Committee. The membership of this Committee should be broad, to balance interests of different users and should include members without conflicts of interest (non-users of the requested instrument) who can resolve disputes, if they arise. The membership of this Committee should include at least one senior institutional official who will represent the financial commitment of the institution. Major and Minor, and other active Users of the instrument may be members, but none may Chair the Advisory Committee. The PD/PI cannot be a voting member of the Advisory Committee.  The Advisory Committee should meet on a regular basis and should submit an annual report which will become part of the Final Progress Report and the Annual Usage Reports (see Section VI.3). 

Describe a plan for managing access to the instrument if users' projects involve human subjects, vertebrate animals or biohazards such as infectious materials.

Submit a specific financial plan for long-term operation and maintenance of the instrument. Explain how various operational costs will be met; specifically, costs associated with routine operation of the instrument, maintenance, and support personnel. The financial plan MUST include a table for year one of operation with approximate dollars for anticipated expenditures and anticipated income showing how these estimates were derived. For year one specific dollar amount are required; for year 2 - 5 approximate dollars are recommended.

Typically, during year one, the maintenance costs are fully covered by one year manufacturer's warranty. In subsequent years, costs of maintenance must be considered in the financial plan. Include a description of projected changes of the financial plan over the subsequent four years:

  • Operation:  Include salary support of expert personnel to operate the instrument and provide its routine care and standardization.
  • Maintenance: May include a service contract, or funds for local technical personnel (and parts) who will maintain the instrument if such personnel are qualified to do so.
  • Supplies: Necessary supplies for operating the instrument such as chemicals, cryogenics, and other expendable items.
  • Anticipated Income: Enumerate the sources of income such as charge back fee structure, grants, or institutional support.
  • Institutional Commitment: Describe the institutional infrastructure available to support the instrumentation; including space to house the instrument and site for sample preparation, if needed.

Confirm the institutional support toward the maintenance and operation of the instrument. Describe institutional support for personnel. In particular, confirm that the institution will commit to provide backup of the financial plan for five years from installation of the instrument or for its effective lifetime. The PD/PI, upon recommendations and approval of the Advisory Committee, may request permission from the NIH for any future changes to this commitment due to unforeseen alterations in the use of the instrument (i.e., transfer of title to another institution, trade-in towards a more advanced instrument, etc.). The review panel will evaluate the time of institutional support of the financial plan for this instrument in terms of consistency with the expected usable lifetime for the instrument dependent upon the type of requested instrument.

  • Overall Benefit: Explain how the instrument will impact NIH funded research and contribute to the institution's long-range biomedical research goals.
  • Letters of Support: All letters of support should be combined in a single file named Letters of Support and uploaded as a separate attachment via Other Attachments. This combined file should include, as applicable,
    • letters from institutional officials;
    • institutional back-up for the proposed financial plan;
    • and letters about inventory of instruments at the institution which are unavailable to the PD/PI (mentioned in the Justification of Need Section).
    • The institution must also provide a table that provides information about instrument performance of all previous S10 awards for instruments awarded or installed within the past five years. The table should have the following columns: S10 grant number, year of award, installation date of the instrument, PD/PI's name, generic name of instrument, current instrument status (i.e., in use, traded-in, transferred, non-functional), actual AUT, status of maintenance agreement, and number of publications citing the S10 award. If the instrument is currently non-functional, the institution must provide a supplementary explanatory text.
    • If human or infectious materials, which could create a potential biohazard, are to be analyzed, a signed letter from the institutional biosafety officer stating the proposed containment plan was reviewed and that the plan adheres to documented biosafety regulations. This letter is required in the application, if applicable,
SF424(R&R) Senior/Key Person Profile

All instructions in the SF424 (R&R) Application Guide must be followed. 

Include profiles of the PD/PI, the Major Users, the Minor Users, and the technical person(s) responsible for the maintenance and operation of the instrument. For the Major (Minor) Users, select "Other" under Project Role. Then complete the Other Project Role Category by inserting Major (Minor) User. For technical person(s), select "Technician" for Project Role field. Follow the instructions in the SF424 (R&R) Application Guide for Additional Senior/Key Person Profile(s) if there are more than 8 Major Users.

NOTE: Current and Pending Support. Since Just-in-Time does not apply to the S10 mechanism, this FOA requires current and pending support for the Program Director(s)/Principal Investigator(s), each Major and Minor User and/or technician at the time of application submission.

PHS 398 Cover Page Supplement

All instructions in the SF424 (R&R) Application Guide must be followed.  

Appendix:  Do not use the Appendix to circumvent page limits. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide.

Planned Enrollment Report

When conducting clinical research, follow all instructions for completing Planned Enrollment Reports as described in the SF424 (R&R) Application Guide. 

PHS 398 Cumulative Inclusion Enrollment Report

When conducting clinical research, follow all instructions for completing Cumulative Inclusion Enrollment Report as described in the SF424 (R&R) Application Guide.

3. Submission Dates and Times

Part I. Overview Information contains information about Key Dates. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission.

Organizations must submit applications to (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH's electronic system for grants administration. NIH and systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to on or before the application due date.  If a Changed/Corrected application is submitted after the deadline, the application will be considered late.

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.

4. Intergovernmental Review (E.O. 12372)

This initiative is not subject to intergovernmental review.

5. Funding Restrictions

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Pre-award costs are allowable only as described in the NIH Grants Policy Statement.

Under the S10 mechanism, funding requests are limited to the purchase cost of the instrument only. Support for technical personnel, service contracts, extended warranties, and supplies are not allowable. Cost sharing towards purchase of the instrument is not required. If the amount of funds requested does not cover the total cost of the instrument, the application should describe the proposed source(s) of funding for the balance of the cost of the instrument. Documentation of the availability of the remainder of funding, signed by an appropriate institutional official, should be included in the application and must be presented to NIH prior to issuance of award.

The program does not provide facilities and administrative (F&A) costs or support for construction or alterations or renovations. Matching funds are not required. However, commitment of an appropriate level of institutional support to ensure the associated sustaining infrastructure is expected and should be described. Appropriate Grants will be awarded for a period of one year and are not renewable. Supplemental applications will not be accepted.

Applicants proposing purchase of an instrument that the institution is planning to lease prior to award are urged to consult with their institutional sponsored projects office and the NIH Grant Management Office regarding applicable NIH policy prior to executing the leasing agreement. If the leasing agreement was executed more than one year prior to submission of the SIG application, the applicant must provide strong justification for the requested Federal funds. This justification must demonstrate that the leased instrument is considered state-of-the-art at the time of submission — appropriate award adjustments may be necessary. Execution of a purchase order or agreement, making a down payment or other formal commitment to purchase the equipment prior to award will automatically eliminate an applicant from eligibility for an award.  

6. Other Submission Requirements and Information

Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide.  Paper applications will not be accepted.

Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.

For assistance with your electronic application or for more information on the electronic submission process, visit Applying Electronically. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Guidelines for Applicants Experiencing System Issues.

Important reminders:

All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF424(R&R) Application Package. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH. See Section III of this FOA for information on registration requirements.

The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization's profile in the eRA Commons and for the System for Award Management. Additional information may be found in the SF424 (R&R) Application Guide.

See more tips for avoiding common errors.

Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review, NIH. Applications that are incomplete or non-compliant will not be reviewed.

Post Submission Materials

Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-13-030.

Section V. Application Review Information
1. Criteria

Only the review criteria described below will be considered in the review process. As part of the NIH mission, all applications submitted to the NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer review system.

Overall Impact

Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).

Scored Review Criteria

Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.

Justification of Need

Is the need for the instrument clearly and adequately justified? Is the equipment essential and appropriate?  Are all specific features and special accessories of the requested instrument well justified; in particular, by their need of Major Users? Is Accessible User Time (AUT) well defined and explained? Is AUT reasonable? Justification of selection of proposed instrument may include but is not limited to comparison with other commercially available instruments of similar function.

Technical Expertise

Does the institution have the technical expertise to make effective use of the requested equipment? How well qualified are the participating investigators or other assigned personnel to operate and maintain the instrument, conduct the projects, and evaluate the research results, including analysis and interpretation of data? How will new users be trained? How will biosafety procedures be implemented? 

Research Projects

Will research with the requested instrument advance the knowledge and understanding of the proposed projects? How will the research projects of individual Users be enhanced?  Do Users adequately justify the requested instrument for the needs of their specific projects? If accessories are requested for the instrument, do at least half of the Major Users require each of the accessories for their research projects?


Is the plan for the management and maintenance of the requested instrument appropriate? Is the membership of the Advisory Committee broadly based to oversee the use of the instrument for the appropriate range of biomedical investigators, to balance interests of different users, and to resolve disputes (if they arise)? How will research time be allocated among the projects? Are the sharing arrangements equitable? If needed, are the policies to manage projects which have human subjects, animals or biohazards adequate? Is the financial plan for the instrument for five years or the expected lifetime of the instrument reasonable and secured, balancing anticipated expenditures and anticipated income? Is the expected usable lifetime of the instrument reasonable?

Institutional Commitment

Did the Institution provide the required letter of commitment to back-up the submitted financial plan in the event of a shortfall of income? Is the institutional commitment to back-up the financial plan provided for a time period consistent with the expected effective lifetime of the requested instrument? Has the institution provided the required "Letter of Support" table listing previous S10 instruments awarded and installed within the past five years? Is the management of awarded S10 instruments adequate?  Does the Institution provide adequate infrastructure support for the requested instrument including space to house the instrument and site for sample preparation, if needed?   

Additional Review Criteria

As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items.

Protections for Human Subjects

Generally Not Applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

Inclusion of Women, Minorities, and Children 

Generally Not Applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

Vertebrate Animals

Generally Not Applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.


Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.


For Resubmissions, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.


Not Applicable


Not Applicable

Additional Review Considerations

As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.

Applications from Foreign Organizations

Not Applicable

Select Agent Research

Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).

Resource Sharing Plans

Not Applicable

Budget and Period of Support

Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.

2. Review and Selection Process

Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by the Center for Scientific Review, in accordance with NIH peer review policy and procedures, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons.

As part of the scientific peer review, all applications:

  • May undergo a selection process in which only those applications deemed to have the highest scientific and technical merit (generally the top half of applications under review) will be discussed and assigned an overall impact score.
  • Will receive a written critique.

Applications will be assigned to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications submitted in response to this FOA. Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board. The following will be considered in making funding decisions:

  • Scientific and technical merit of the proposed project as determined by scientific peer review.
  • Availability of funds.
  • Relevance of the proposed project to program priorities.
  • Program balance among various types of instruments supported and geographic distribution of awards.
3. Anticipated Announcement and Award Dates

After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons

Information regarding the disposition of applications is available in the NIH Grants Policy Statement.

Section VI. Award Administration Information
1. Award Notices

Applicant should ignore eRA/Commons system-generated JIT requests which are typically sent soon after peer review. If an application is considered for funding ORIP SIG Program staff will send PD/PI special instructions on how to submit a JIT update, from the e-mail address

A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee's business official.

Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.

Any application awarded in response to this FOA will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website.  This includes any recent legislation and policy applicable to awards that is highlighted on this website.

2. Administrative and National Policy Requirements

All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General  and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.

Cooperative Agreement Terms and Conditions of Award

Not Applicable

3. Reporting

When multiple years are involved, awardees will be required to submit the Research Performance Progress Report (RPPR) annually and financial statements as required in the NIH Grants Policy Statement.

A final progress report, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement.

The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later.  All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at on all subawards over $25,000.  See the NIH Grants Policy Statement for additional information on this reporting requirement.

Final Progress Report

At the expiration of the grant, a Final Progress Report (FPR) is required that describes the purchased instrument, and a list of all users and description of the value of the instrument to the investigators and to the institution as a whole. This report is needed by the NIH for informing the public, administrative and Congressional officials about the research resources it supports. The following information must be included in the SIG FPR:

  • Information about the award and the instrument:
  • Grant Number: 1S10OD#####-01
  • Principal Investigator: (Name, Institution, Department, Address)
  • Funding Period
  • Name of Instrument (including manufacturer and model)
  • Total Purchase Cost
  • Total SIG Award Amount
  • Other Sources of Funding (if appropriate)
  • Instrument Installation Date
  • List of users, their funding and hours of use
  • List of publications, if available. This publication list should be consistent with the NIH Public Access Policy.
  • A narrative describing the impact of the instrument on the research community, specific research accomplishments, and administration and operation of the instrument
  • A report from the Advisory Committee

The SIG FPR must be submitted electronically through the Closeout module in eRA Commons. For facilitation of FPR preparation, the SIG Scientific Research/Contact staff will contact grantees prior to the due date for report and provide specific instructions.

Annual Instrument Usage Report

In addition, for the period of four years after the FPR, on the anniversaries of the expiration of the award, Annual Instrument Usage Reports (AURs) must be provided to the NIH. These reports will include analogous information requested in S10 FPR (as listed above in Final Progress Report section) about the usage and operation of the instrument, including a report from the Advisory Committee, research which benefited from the instrument, and research outcomes as documented by publications.

For facilitation of AUR preparation, the SIG Scientific Research/Contact staff will contact grantees prior to the due date for report and provide specific instructions.


Any publications and other research reports which arise from experiments conducted using the instrument must acknowledge the SIG award.

Section VII. Agency Contacts

We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.

Application Submission Contacts

eRA Commons Help Desk (Questions regarding eRA Commons registration, submitting and tracking an application, documenting system problems that threaten submission by the due date, post submission issues)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)

Finding Help Online:
Email: Customer Support (Questions regarding registration and submission, downloading forms and application packages)
Contact CenterTelephone: 800-518-4726

GrantsInfo (Questions regarding application instructions and process, finding NIH grant resources)
Telephone: 301-710-0267

Scientific/Research Contact(s)

Abraham Levy, PhD
Office of Research Infrastructure Programs (ORIP)
Telephone: 301-435-0777

Peer Review Contact(s)

Nuria Assa-Munt, PhD
Center for Scientific Review (CSR)
Telephone: 301-451-1323

Financial/Grants Management Contact(s)

Ms. Gloria Berrios
National Center for Advancing Translational Sciences (NCATS)
Office of Research Infrastructure Programs (ORIP)
Telephone: 301-435-0875

Section VIII. Other Information

Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Authority and Regulations

Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Parts 74 and 92.

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