MENTORED PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD

Release Date:  April 6, 1998

PA NUMBER:  PA-98-052

P.T.

National Institute on Aging
National Institute on Alcohol Abuse and Alcoholism
National Institute of Allergy and Infectious Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Cancer Institute
National Institute of Child Health and Human Development
National Institute on Deafness and Other Communication Disorders
National Institute on Dental Research
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute on Drug Abuse
National Institute of Environmental Health Sciences
National Institute of Nursing Research
National Eye Institute
National Heart, Lung, and Blood Institute
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
Office of Alternative Medicine

Application Receipt Dates:  February 1, June 1, and October 1

THIS PROGRAM ANNOUNCEMENT (PA) USES THE "JUST IN TIME" CONCEPT (as described in
the NIH Guide for Grants and Contracts, Vol. 25, No. 10, March 29, 1996 and Vol.
25, No. 26, May 17, 1996). IT INCLUDES DETAILED MODIFICATIONS TO STANDARD
APPLICATION INSTRUCTIONS THAT MUST BE USED WHEN PREPARING APPLICATIONS IN
RESPONSE TO THIS PA.

PURPOSE

The purpose of the Mentored Patient-oriented Research Career Development Award
(K23) is to support the career development of investigators who have made a
commitment to focus their research endeavors on patient-oriented research. This
mechanism provides support for a period of supervised study and research for
clinically trained professionals who have the potential to develop into
productive, clinical investigators focussing on patient-oriented research.

For the purposes of this award, patient-oriented research is defined as research
conducted with human subjects (or on material of human origin such as tissues,
specimens, and cognitive phenomena) for which an investigator directly interacts
with human subjects.  This area of research includes: 1) mechanisms of human
disease; 2) therapeutic interventions; 3) clinical trials, and; 4) the
development of new technologies.

The National Institutes of Health (NIH) is especially interested in increasing
the number of scientists trained to conduct high-quality clinical research.
Accordingly, this award forms an important part of the NIH initiative to attract
talented individuals to the challenges of clinical research. NIH intends to
target a significant increase in funds for these entry level career development
awards.  The Mentored Patient-oriented Research Career Development Award is
intended to increase the availability of high-quality, multi-disciplinary
didactic training so that candidates interested in clinical research will be well
grounded in research on human subjects.  At the completion of the award,
candidates should have both the knowledge and the skills necessary to compete for
independent research support.  This initiative is consistent with the
recommendations of the NIH Director's Panel on Clinical Research and the
recommendations from the Institute of Medicine Committee on Addressing Career
Paths for Clinical Research.

The objectives of the Mentored Patient-Oriented Research Career Development Award
(K23) are to:

-  encourage research-oriented clinicians to develop independent research skills
and gain experience in advanced methods and experimental approaches that will
allow them to conduct patient-oriented research

-  increase the pool of clinical researchers who can conduct patient-oriented
studies, capitalizing on the discoveries of biomedical research and translating
them to clinical settings

The Mentored Patient-Oriented Research Career Development Award provides research
development opportunities for clinicians with varying levels of research
experience, who are committed to developing into independent clinical
investigators.  This Award will enable candidates holding clinical degrees (see
under ELIGIBILITY REQUIREMENTS below) to undertake up to five years( a minimum
of three years) of special study and supervised research with the goal of
developing into independent investigators capable of conducting patient-oriented
research.  While the focus of the development program is on the conduct of
patient-oriented research, there can be complementary appropriate laboratory
research directly related to the patient-oriented research proposed in the
application.

Because of the focus on a progression to independence as a researcher, the
prospective candidate for the Mentored Patient-Oriented Research Career
Development Award should propose a period of study and career development
consistent with her or his previous research and clinical experience. For
example, a candidate with limited experience in a given field of research may
find a phased developmental program lasting for five years that includes a
designated period of didactic training together with a closely supervised
research experience the most efficient means of attaining independence. A
candidate with previous research experience may require a program with
appropriate patient-oriented research and complementary laboratory research
related to the patient-oriented research for the transition to independence.  All
programs should be carefully tailored to meet the individual needs of the
candidate and must include a mentor(s) who is competent to provide the
appropriate research guidance.

HEALTHY PEOPLE 2000

The Public Health Service is committed to achieving the health promotion and
disease prevention objectives of "Healthy People 2000," a PHS-led national
activity for setting priority areas.  This PA, Mentored Patient-oriented Research
Career Development Award, is related to the priority area of human resource
development.  Potential candidates may obtain a copy of "Healthy People 2000"
(Full Report:  Stock No. 017-001-00474-0 or Summary Report: Stock No.
017-001-00473-1) from the Superintendent of Documents, Government Printing
Office, Washington, DC 20402-9325 (telephone 202/512-1800) or electronically
(http://odphp.osophs.dhhs.gov/pubs/hp2000).

ELIGIBILITY REQUIREMENTS

Candidates must have a clinical degree or its equivalent: M.D., D.D.S., D.M.D.,
D.O., D.C., O.D., N.D. (Doctor of Naturopathy), and doctorally prepared nurses. 
In addition, individuals holding the Ph.D. degree may apply for the award if they
have been certified to perform clinical duties, such as a clinical psychologist,
clinical geneticist, etc.  Candidates must have also completed their clinical
training, including specialty and, if applicable, subspecialty training prior to
receiving an award.  However, candidates may submit an application prior to the
completion of clinical training.  Candidates must identify a mentor with
extensive research experience, and must be willing to spend a minimum of 75
percent of full-time professional effort conducting research career development
and clinical research.

Applications may be submitted, on behalf of candidates, by domestic, non-Federal
organizations, public or private, such as medical, dental, or nursing schools or
other institutions of higher education.  Minorities, women and individuals with
disabilities are encouraged to apply.  At time of award, candidates must be
citizens or noncitizen nationals of the United States, or have been lawfully
admitted to the United States for permanent residence (i.e., in possession of a
currently valid Alien Registration Receipt Card I- 551, or other legal
verification of such status).  Noncitizen nationals are generally persons born
in outlying possessions of the United States (i.e., American Samoa and Swains
Island).  Individuals on temporary or student visas are not eligible.

Former principal investigators on NIH research project (R01), FIRST Awards (R29),
SBIR/STTR awards, sub-projects of program project (P01) or center grants (P50),
K08 awards, or the equivalent, are not eligible. Former principal investigators
of an NIH Small Grant (R03) or Exploratory/Developmental Grants (R21) remain
eligible. A candidate for the Mentored Patient-oriented Research Career
Development Award may not concurrently apply for any other PHS award that
duplicates the provisions of this award nor have another application pending
award. Mentored Patient-oriented Research Career Development Award recipients are
strongly encouraged to apply for independent research grant support, either
Federal or private, during the latter period of this award.  However, since the
K23 is a full professional effort award, time doing research is subsumed under
the salary support already provided.

MECHANISM OF SUPPORT

Awards in response to this program announcement will use the K23 mechanism.
Planning, direction, and, execution of the program will be the responsibility of
the candidate and her/his mentor on behalf of the applicant institution. The
project period may be for up to five years with a minimum of three years. Awards
are not renewable. Specific K23 application instructions have been modified to
reflect "JUST IN TIME" streamlining efforts being examined by the NIH. "JUST IN
TIME" postpones the collection of certain information that currently must be
included in all competing applications when submitted. The "JUST IN TIME" concept
allows applicants to submit certain information only when there is a possibility
for an award. It is anticipated that these changes will reduce the administrative
burden for the applicants, applicant institutions, reviewers, and NIH staff.

AWARDS AVAILABLE

The overall goal of the NIH is to support approximately 80 competing awards in
Fiscal Year 1999 and in each succeeding year through Fiscal Year 2003. The actual
number of awards to be made by each Institute or Center will vary yearly and will
be dependent upon the number and quality of applications submitted and funds
available.

RESEARCH OBJECTIVES

A.  Environment:  The institution must have a well-established research and
clinical career development program. It must also have faculty qualified in
clinical research with emphasis on patient-oriented research to serve as mentors. 
The institution must be able to demonstrate a commitment to the development of
the candidate as a productive, independent investigator.  The candidate, mentor,
and institution must be able to describe an in-depth, multi disciplinary career
development program that will utilize the relevant research and educational
resources.

B.  Program:  The award provides up to five consecutive 12-month awards. At least
75 percent of the recipient's full-time professional effort must be devoted to
the goals of this award.  The remainder may be devoted to other clinical,
teaching, or other research pursuits consonant with the objectives of the award. 
Both the didactic and the research phases of an award period must be designed to
develop the necessary knowledge and research skills in scientific areas relevant
to the career goals of the candidate.  Candidates must demonstrate they have
received or will participate in courses such as: data management, epidemiology,
study design, hypothesis development, drug development, etc., as well as the
legal and ethical issues associated with research on human subjects.

C.  Mentor(s):  The recipient must receive appropriate mentoring throughout the
duration of the program.  Where feasible, women, minority individuals and
individuals with disabilities should be involved as mentors and serve as role
models.  Candidates must name a primary mentor, who together with the applicant
is responsible for planning, direction, and execution of the program.  Candidates
may also nominate additional mentors as appropriate to the goals of the program.

D.  Allowable Costs:

1.  Salary:  The NIH will provide salary for the award recipient of up to $75,000
per year plus commensurate fringe benefits for a minimum of 75 percent effort. 
Although a greater effort may be proposed, the maximum allowable salary is
$75,000.  The institution may supplement the NIH contribution with non-Federal
funds up to a level that is consistent with the institution's salary scale. 
Institutional supplementation of salary must not require extra duties or
responsibilities that would interfere with the purpose of the award. In
exceptional cases, if the Institution's salary structure exceeds the maximum
allowable salary of $75,000, NIH may be able to make case by case adjustments,
either in the initial salary or the salary in future years. Applicant
Institutions should request such an exception as part of the JUST IN TIME process
when it is known there is a possibility for an award.

Direct salary is exclusive of fringe benefits and facilities and administrative
costs.  The total salary requested must be based on a full-time, 12-month staff 
appointment. It must be consistent both with the established salary structure at
the institution and with salaries actually provided by the institution from its
own funds to other staff members of equivalent qualifications, rank, and
responsibilities in the department concerned.  If full-time, 12-month salaries 
are not currently paid to comparable staff members, the salary proposed must be
appropriately related to the existing salary structure.

2.  Research Development Support:  The NIH will provide generally up to $25,000
per year for the following expenses:  (a) tuition, fees, and books related to
career development; (b) research expenses, such as supplies, equipment and
technical personnel; c) travel to research meetings or training; (d) statistical
services including personnel and computer time.  In exceptional cases, the
Research Development Support costs may be as high as $50,000, but such costs will
only be awarded in those cases where the need for such higher costs is well
documented and adequately justified.

3.  Ancillary Personnel Support:  Salary for mentors, secretarial, and
administrative assistance etc., is not allowed.

4.  Facilities and Administrative costs:  These costs will be reimbursed at 8
percent of modified total direct costs.

E.  Evaluation:  In carrying out its stewardship of human resource-related
programs, the NIH may request information essential to an assessment of the
effectiveness of this program.  Accordingly, recipients are hereby notified that
they may be contacted after the completion of this award for periodic updates on
various aspects of their employment history, publications, support from research
grants or contracts, honors and awards, professional activities, and other
information helpful in evaluating the impact of the program.

F.  Other Income:  Fees resulting from clinical practice, professional
consultation, or other comparable activities required by the research and
research-related activities of this award may not be retained by the career award
recipient. Such fees must be assigned to the grantee institution for disposition
by any of the following methods:

The funds may be expended by the grantee institution in accordance with the NIH
policy on supplementation of career award salaries and to provide fringe benefits
in proportion to such supplementation.  Such salary supplementation and fringe
benefits payments must be within the established policies of the grantee
institution.

The funds may be used for health-related research purposes.

The funds may be paid to miscellaneous receipts of the U.S. Treasury.  Checks
should be made payable to the Department of Health and Human Services, NIH and
forwarded to the Director, Division of Financial Management, NIH, Bethesda,
Maryland 20892.  Checks must identify the relevant award account and reason for
the payment.

Awardees may retain royalties and fees for activities such as scholarly writing,
service on advisory groups, or honoraria from other institutions for lectures or
seminars, provided these activities remain incidental and provided that the
retention of such pay is consistent with the policies and practices of the
grantee institution.

Usually, funds budgeted in an NIH supported research or research training grant
for the salaries or fringe benefits of individuals, but freed as a result of a
career award, may not be rebudgeted.  The awarding component will give
consideration to approval for the use of released funds only under unusual
circumstances.  Any proposed retention of funds released as a result of a career
award must receive prior written approval of the NIH awarding component.

G.  Special Leave:  Leave to another institution, including a foreign laboratory,
may be permitted if directly related to the purpose of the award. Only local,
institutional approval is required if such leave does not exceed 3 months.  For
longer periods, prior written approval of the NIH funding component is required. 
To obtain prior approval, the award recipient must submit a letter to the NIH
describing the plan, countersigned by his or her department head and the
appropriate institutional official.  A copy of a letter or other evidence from
the institution where the leave is to be taken must be submitted to assure that
satisfactory arrangements have been made. Support from the career award will
continue during such leave.

Leave without award support may not exceed 12 months. Such leave requires the
prior written approval of the NIH funding component and will be granted only in
unusual situations.  Support from other sources is permissible during the period
of leave.  Such leave does not reduce the total number of months of program
support for which an individual is eligible.  Parental leave will be granted
consistent with the policies of the NIH and the grantee institution.

H.  Termination or Change of Institution:  When a grantee institution plans to
terminate an award, the NIH funding component must be notified in writing at the
earliest possible time so that appropriate instructions can be given for
termination.  If the individual is moving to another eligible institution, career
award support may be continued provided:

A new career award application is submitted by the new institution;

All conditions of the award are met at the new institution including the presence
of a qualified mentor;

The period of support requested is no more than the time remaining within the
existing award period; and

The new application is submitted far enough in advance of the requested effective
date to allow the necessary time for review.

The funding component may require a review by an initial review group and/or the
appropriate National Advisory Council or Board.  Alteratively, review may be
carried out by staff within the NIH funding component depending upon the
circumstances.

The NIH may discontinue an award upon determination that the purpose or terms of
the award are not being fulfilled. In the event an award is terminated, the
Director of the NIH shall notify the grantee institution and career award
recipient in writing of this determination, the reasons therefor, the effective
date, and the right to appeal the decision.

A final progress report, invention statement, and Financial Status Report are
required upon either termination of an award or relinquishment of an award in a
change of institution situation.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

For research projects involving human subjects, it is the policy of the NIH that
women and members of minority groups and their subpopulations must be included
in all NIH supported biomedical and behavioral research projects involving human
subjects unless a clear and compelling rationale and justification is provided
that inclusion is inappropriate with respect to the health of the subjects or the
purpose of the research.  This policy results from the NIH Revitalization Act of
1993 (Section 492B of Public Law 103-43).  All investigators proposing research
involving human subjects should read the "NIH Guidelines For Inclusion of Women
and Minorities as Subjects in Clinical Research," which has been published in the
Federal Register of March 28,1994 (FR 59 14508-14513), and in the NIH GUIDE FOR
GRANTS AND CONTRACTS of March 18, 1994, Vol. 23, No 11. It is also available
electronically at http://www.nih.gov/grants/guide/notice-files/not94-100.html

Investigators may obtain copies from these sources or from the program staff or
contact person listed below.  Program staff may also provide additional relevant
information concerning the policy.

NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS PARTICIPANTS IN
RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by NIH,
unless there are scientific and ethical reasons not to include them. This policy
applies to all applications submitted in response to this Program Announcement. 
All investigators proposing research involving human subjects should read the
"NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS PARTICIPANTS IN
RESEARCH INVOLVING HUMAN SUBJECTS" that was published in the NIH GUIDE FOR GRANTS
AND CONTRACTS, March 6, 1998 and is available at the following URL address:
http://www.nih.gov/grants/guide/notice-files/not98-024.html

As part of the scientific and technical merit evaluation of the research plan,
reviewers will be instructed to address "the adequacy of plans for including
children as appropriate for the scientific goals of the research, or
justification for exclusion.

APPLICATION PROCEDURES

This is an NIH-wide program announcement for Mentored Patient-oriented Research
Career Development Award . Therefore, all candidates are strongly encouraged to
contact the staff person in the relevant institute or center listed under
INQUIRIES. Such contact should occur early in the planning phase of application
preparation. Such contact will help ensure that applications are responsive to
the goals and policies of the individual institute or center.

Applicants who will be using a General Clinical Research Center(GCRC) are
requested to include a letter of agreement from either the GCRC program director
or the principal investigator with the application.

Applications are to be submitted on the grant application form PHS 398 (rev. 5/95
use the instructions in Section IV as appropriate) and will be accepted on or
before the receipt dates indicated in the application kit.  Forms are available
at most institutional offices of sponsored research and from the Division of
Extramural Outreach and Information Resources, National Institutes of Health,
6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, Phone (301) 435-0714,
FAX: (301) 480-0525, Email: asknih@od.nih.gov.  Forms are also available on the
NIH Website at http://www.nih.gov/grants/funding/phs398/phs398.html

To identify the application as a response to this program announcement, check
"YES" on item 2 of page 1 of the application and enter "PA-98-052 MENTORED
PATIENT-ORIENTED RESEARCH CAREER DEVELOPMENT AWARD."

Submit a signed, typewritten original of the application with Checklist, and five
signed photocopies, in one package to:

Center for Scientific Review (formerly Division of Research Grants)
National Institutes of Health
6701 Rockledge Drive, Room 1040 - MSC 7710
Bethesda, MD  20892-7710
Bethesda, MD  20817-7710 (for express/courier service)

The application must contain the following:

Candidate

o  A description of the candidate's commitment to a career in patient-oriented
research.

o  Evidence of the candidate's potential to develop into an independent
investigator.

o  A description of immediate and long-term career objectives, explaining how the
award will contribute to their attainment.

o  A commitment of at least 75 percent effort to the clinical research program.

o  Three sealed letters of recommendation addressing the candidate's potential
for a research career. The mentor's statement (see below) should not be included
as one of the letters of recommendation, although the mentor(s) may submit a
separate letter(s) of recommendation.

Career Development Plan

o  A description of the career development plan, incorporating consideration of
the candidate's goals and prior experience.  It must describe a systematic plan
to obtain the necessary theoretical and conceptual background, in addition to the
research experience, necessary to launch an independent research career. 
Candidates must describe the availability of courses such as research design,
biostatistics, epidemiology, and ethical and regulatory issues at their
institution and the integration of these studies into their career development
plan.

Less experienced candidates may require a phased developmental period in which
the first one to two year(s) of the award are largely of a didactic nature
followed by a period of intense, supervised research experience. Candidates with
more experience at the time of application may need a shorter developmental
period and may already have an adequate theoretical background. In any case, the
career development plan must be tailored to the needs of the individual candidate
and the ultimate goal of achieving independence as a clinical researcher.

o  Candidates must describe plans to receive instruction in the responsible
conduct of research. These plans must detail the proposed subject matter, format,
frequency, and duration of instruction.  No award will be made if an application
lacks this component.

Research Plan

o  A description of the clinical research plan. The research plan must be
described as outlined in form PHS 398 including sections on the Specific Aims,
Background and Significance, Progress Report/Preliminary Studies, Research Design
and Methods.  The candidate should consult with the mentor regarding the
development of this section.

Mentor's Statement

o  The application must include information on the mentor(s) including
information on research qualifications in the research area proposed by the
candidate and previous experience as a research supervisor.  The application must
also include information to describe the nature and extent of supervision that
will occur during the proposed award period.

Environment and Institutional Commitment

o  The sponsoring institution must document a strong, well-established research
and training program related to the candidate's area of interest including a
high-quality research environment with staff capable of productive collaboration
with the candidate. The sponsoring institution also must provide a statement of
commitment to the candidate's development into a productive, independent
investigator.

Budget Instructions

The total direct costs must be requested in accordance with the K23 program
guidelines, following the budget instructions described below.

o  Face page-As a reminder, Item 7 should be completed to indicate direct costs 
requested and Item 8 should reflect total costs (direct plus Facilities and 
administrative).

o  Detailed Budget for Initial Budget Period - Do not complete form page 4 of the
PHS 398 (rev. 5/95).  It is not required nor will it be accepted at the time of
application.  In some cases it may be requested prior to award.

o  Budget for Entire Proposed Period of Support - Do not complete the categorical
budget table on form page 5 in the PHS 398 (rev. 5/95).  Only the requested total
direct costs for each year and total direct costs for the entire proposed period
of support should be shown.

o  Begin the budget justification in the space provided, using continuation pages
as needed.

List the name, role on project and percent effort for all project personnel
(salaried or unsalaried) and provide a narrative justification for each person
based on his/her role on the project and proposed level of effort.

Identify all consultants by name and organizational affiliation and describe the
services to be performed.

Provide a narrative justification for any major budget items, other than
personnel, that are requested for the conduct of the project that would be
considered unusual for the scope of research.  No specific costs for items or
categories should be shown.

Facilities and administrative costs will be calculated at the time of the award
using the 8% rate.  Applicants will be asked to identify any exclusions prior to
award.

If consortium/contractual costs are requested, provide the percentage of the
subcontract total costs (direct plus facilities and administrative) relative to
the total direct costs of the overall project.  The subcontract budget
justification should be prepared following the instructions provided above.

Biographical Sketch

A biographical sketch is required for all key personnel, following the modified
instructions below.  Do not exceed the two-page limit for each person.

o  Complete the education block at the top of the form page;

o  List current position(s) and those previous positions directly relevant to the
application;

o  List selected peer-reviewed publications directly relevant to the proposed
project, with full citation;

o  Provide information on research projects completed and/or research grants
participated in during the last five years that are relevant to the proposed
project.  Title, principal investigator, funding source, and role on project must
be provided.

Other Support

Do not complete the other support page (format page 7 of the PHS 398 (rev.
5/95)).  Information on active support for key personnel will be requested prior
to award.  A completed checklist will be required prior to award.

REVIEW CONSIDERATIONS

Applications will be reviewed for completeness by the Center for Scientific
Review and for responsiveness to this program announcement by the appropriate
Institute or Center staff.  Incomplete or non-responsive applications will be
returned to the applicant without further consideration.  Applications that are
complete and responsive to the program announcement will be evaluated for
scientific and technical merit by a peer review group convened by the appropriate
Institute/Center in accordance with the standard NIH peer review procedures.  As
part of the initial merit review, all applications will receive a written
critique and undergo a process in which only those applications deemed to have
the highest scientific merit, generally the top half of applications under
review, will be discussed, assigned a priority score, and receive a second level
review by the appropriate national advisory council or board.

The following review criteria will be applied:

Candidate

o  Quality of the candidate's academic and clinical record,

o  Potential to develop as an independent clinical researcher focussing on
patient-oriented research;

o  Commitment to a career in patient-oriented research.

Career Development Plan

o  Likelihood that the career development plan will contribute substantially to
the scientific development of the candidate;

o  Appropriateness of the content and duration of the proposed didactic and
research phases of the award;

o  Consistency of the career development plan with the candidate's career goals
and prior research experience; and

o  Quality of the proposed training in responsible conduct of research.

Research Plan

Reviewers recognize that an individual with limited research experience is less
likely to be able to prepare a research plan with the breadth and depth of that
submitted by a more experienced investigator.  Although it is understood that K23
applications do not require the level of detail necessary in regular research
grant applications, a fundamentally sound research plan must be provided. In
general, less detail is expected with regard to research planned for the later
years of the award, but the application should outline the general goals for
these years.

o  Appropriateness of the research plan to the stage of research development and
as a vehicle for developing the research skills as described in the career
development plan;

o  Scientific and technical merit of the research question, design and
methodology;

o  Relevance of the proposed research to the candidate's career objectives; and

o  Adequacy of the plan's attention to gender and minority issues associated with
projects involving human subjects.

o  Adequacy of plans for including children as appropriate for the scientific
goals of the research, or justification for exclusion.

Mentor

o  Appropriateness of mentor's research qualifications in the area of this
application;

o  Quality and extent of mentor's proposed role in providing guidance and advice
to the candidate;

o  Previous experience in fostering the development of researchers; and

o  History of research productivity and support.

Environment and Institutional Commitment

o  Applicant institution's commitment to the scientific development of the
candidate and assurances that the institution intends the candidate to be an
integral part of its research program;

o  Adequacy of research facilities and the availability of appropriate
educational opportunities;

o  Quality and relevance of the environment for scientific and professional
development of the candidate; and

o  Applicant institution's commitment to an appropriate balance of research and
clinical responsibilities.

Budget

o  Justification of the requested budget in relation to career development goals
and research aims.

AWARD CRITERIA

Applications will be assigned to an Institute or Center based on referral
guidelines.  The Institute or Center will notify the applicant of the Advisory
Board or Council's action shortly after its meeting.  Funding decisions will be
made based on the recommendations of the initial review group and Advisory
Council/Board, the need for research personnel in specific program areas, and the
availability of funds.  The NIH policy on submission of revised(amended)
applications limits the number of such amended applications to two.

INQUIRIES

Written and telephone inquiries concerning this program announcement are strongly
encouraged especially during the planning phase of the application. Below is a
listing of each institute's or center's program contact.

Direct inquiries regarding programmatic issues to:

Mary D. Leveck, Ph.D., R.N.
Scientific Program Administrator
National Institute of Nursing Research
Building 45, Room 3AN-12
Bethesda, MD  20892-6300
Telephone:  (301) 594-5963
FAX:  (301) 480-8260
Email:  mary_leveck@nih.gov

James A. Lipton, DDS, Ph.D.
National Institute of Dental Research
Natcher Building, Room 4AN-18J
Bethesda, MD  20892-6402
Telephone:  (301) 594-2618 or 594-7710
FAX:  (301) 480-8318
Email:  liptonj@de45.nidr.nih.gov

Maria Y. Giovanni, Ph.D.
Research Training Officer
National Eye Institute
6120 Executive Boulevard, Suite 350
Bethesda, MD  20892-7164
Telephone:  (301) 496-0484
FAX:  (301) 480-3246
Email:  myg@nei.nih.gov

Andrea Baruchin, Ph.D.
Office of Science Policy and Communication
National Institute on Drug Abuse
Parklawn Building, Room 10A 55
Rockville, MD  20857
Telephone:  (301) 443-6071
FAX:  (301) 443-6277
Email:  abaruchi@ngmsmtp.nida.nih.gov

Richard Fuller, M.D.
Division of Clinical and Prevention Research
National Institute on Alcohol Abuse and Alcoholism
6000 Executive Boulevard
Bethesda, MD  20892-7003
Telephone:  (301) 443-1206
FAX:  (301) 443-8774
Email:  rfuller@willco.niaaa.nih.gov

Daniel A. Sklare, Ph.D.
Division of Human Communication
National Institute on Deafness and Other Communication Disorders
6120 Executive Boulevard, Room 400C
Bethesda, MD  20892-7180
Rockville, MD  20852 (for express/courier service)
Telephone:  (301) 496-1804
FAX:  (301) 402-6251
Email:  daniel_sklare@nih.gov

Joseph S. Drage, M.D.
Training and Special Programs Officer
National Institute of Neurological Disorders and Stroke
7550 Wisconsin Avenue, Room 1016
Bethesda, MD  20892
Telephone:  (301) 496-4188
FAX:  (301) 402-4370
Email:  jd66x@nih.gov

Milton J. Hernandez, Ph.D.
Office of Research on Minority and Women's Health
National Institute of Allergy and Infectious Diseases
Solar Building, Room 3C21
Bethesda, MD  20892-7630
Telephone:  (301) 496-3775
FAX:  (301) 402-0369
Email:  mh35c@nih.gov

Michael J. Galvin, Ph.D.
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233, EC-23
Research Triangle Park, NC  27709
Telephone:  (919) 541-7825
FAX:  (919) 541-5064
Email:  galvin@niehs.nih.gov

Thomas P. Blaszkowski, Ph.D.
Division of Epidemiology and Clinical Applications
National Heart, Lung and Blood Institute
6701 Rockledge Drive, Room 8106
Bethesda, MD  20892-7938
Telephone:  (301) 435-0417
FAX:  (301) 480-1864
Email:  blaszkot@gwgate.nhlbi.nih.gov

Joyce Creamer, M.B.A.
Division of Blood Diseases and Resources
National Heart, Lung and Blood Institute
6701 Rockledge Drive, Suite 10170
Bethesda, MD  20892-7590
Telephone:  (301) 435-0064
FAX:  (301) 489-0867
Email:  creamerj@gwgate.nhlbi.nih.gov

Bette A. Houston
Division of Blood Diseases and Resources
National Heart, Lung and Blood Institute
6701 Rockledge Drive, Room 10154
Bethesda, MD  20892-7950
Telephone:  (301) 435-0061
FAX:  (301) 480-0868
Email:  houstonb@gwgate.nhlbi.nih.gov

Mary S. Reilly, M.S.
Division of Lung Diseases
National Heart, Lung and Blood Institute
6701 Rockledge Drive, Room 10112
Bethesda, MD  20892-7952
Telephone:  (301) 435-0222
FAX:  (301) 480-3557
Email:  mr50w@nih.gov

Beth Schucker, M.A.
Division of Heart and Vascular Diseases
National Heart, Lung and Blood Institute
6701 Rockledge Drive, Room 9206
Bethesda, MD  20892-7940
Telephone:  (301) 435-0535
FAX:  (301) 480-1454
Email:  schuckeb@gwgate.nhlbi.nih.gov

Lester S. Gorelic, Ph.D.
Office of Centers, Training and Resources
National Cancer Institute
6130 Executive Boulevard, Room 520
Bethesda, MD  20892-7390
Telephone:  (301) 496-8580
FAX:  (301) 402-4472
Email:  gorelicl@dcbdcep1.nci.nih.gov

Andrew Vargosko, Ph.D.
Office of Centers, Training and Resources
National Cancer Institute
6130 Executive Boulevard, Room 520
Bethesda, MD  20892-7390
Telephone:  (301) 496-8580
FAX:  (301) 402-4472
Email:  vargoska@dcbdcep1.nci.nih.gov

Richard L. Nahin, M.P.H., Ph.D.
Office of Alternative Medicine
National Institutes of Health
Building 31, Room 5B-38
Bethesda, MD  20892-2182
Telephone:  (301) 496-4792
FAX:  (301) 480-3519
Email:  nahinr@od31em1.od.nih.gov

Robin A. Barr, Ph.D.
Office of Extramural Affairs
National Institute on Aging
7201 Wisconsin Avenue, Room 2C218
Bethesda, MD  20892-9205
Telephone:  (301) 496-9322
FAX:  (301) 402-2945
Email:  rb42h@nih.gov

Richard W. Lymn, Ph.D.
Research Training Officer
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Building 45, Room 5AS-49E
Bethesda, MD  20892-6500
Telephone:  (301) 594-5128
FAX:  (301) 480-4543
Email:  richard_w_lymn@nih.gov

Ronald N. Margolis, Ph.D.
Division of Diabetes, Endocrinology and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Natcher Building, Room 5AN12J
Bethesda, MD  20892-6600
Telephone:  (301) 594-8819
FAX:  (301) 480-3503
Email:  margolisr@extra.niddk.nih.gov

Judith M. Podskalny, Ph.D.
Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases
Natcher Building, Room 6AN12E
Bethesda, MD  20892-6600
Telephone:  (301) 594-8876
FAX:  (301) 480-8300
Email:  podskalnyj@extra.niddk.nih.gov

Charles H. Rodgers, Ph.D.
Division of Kidney, Urologic and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Natcher Building, Room 6AS19J
Bethesda, MD  20892-6600
Telephone:  (301) 594-7726
FAX:  (301) 480-3510
Email:  rodgersc@extra.niddk.nih.gov

Walter L. Goldschmidts, Ph.D.
Division of Basic and Clinical Neuroscience Research
National Institute of Mental Health
Parklawn Building, Room 11-1103
Rockville, MD  20857
Telephone:  (301) 443-3563
FAX:  (301) 443-1731
Email:  wg8u@nig.gov

Leonard Mitnick, Ph.D.
Division of Mental Disorders, Behavioral Research and AIDS
National Institute of Mental Health
Parklawn Building, Room 18-105
Rockville, MD  20857
Telephone:  (301) 443-6100
FAX:  (301) 443-1731
Email:  lm32p@nih.gov

Kenneth G. Luttermen, Ph.D.
Division of Services and Intervention Research
National Institute of Mental Health
Parklawn Building, Room 10C-23
Telephone:  (301) 443-3373
FAX:  (301) 443-4045
Email:  kl21o@nih.gov

Steven L. Klein,Ph.D.
Developmental Biology, Genetics and Teratology Branch
National Institute of Child Health and Human Development
Building 61E, Room 4B01F
Bethesda, MD  20892-7510
Telephone:  (301) 496-5541
FAX:  (301) 402-4083
Email:  sk56d@nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance Nos. 93.
855 and 93.856.  Awards are made under the authority of title III, Section 301
of the PHS Act as amended.  The Code of Federal Regulations, Title 42 Part 52 and
Title 45 Part 74, are applicable to this program.  This program is not subject
to the intergovernmental review requirements of Executive Order 12372 to Health
Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a smoke-
free workplace and promote the non-use of all tobacco products.  In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain
facilities (or in some cases, any portion of a facility) in which regular or
routine education, library, day care, health care or early childhood development
services are provided to children.  This is consistent with the PHS mission to
protect and advance the physical and mental health of the American people.


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