Expired PA-14-161: Translational Research to Help Older Adults Maintain their Health and Independence in the Community (R01)

Part 1. Overview Information

Participating Organization(s)	National Institutes of Health (NIH)
Components of Participating Organizations	National Institute on Aging (NIA) National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Funding Opportunity Title	Translational Research to Help Older Adults Maintain their Health and Independence in the Community (R01)
Activity Code	R01 Research Project Grant
Announcement Type	Reissue of PA-11-123
Related Notices	May 10, 2017 - New NIH "FORMS-E" Grant Application Forms and Instructions Coming for Due Dates On or After January 25, 2018. See NOT-OD-17-062. NOT-OD-16-004 - NIH & AHRQ Announce Upcoming Changes to Policies, Instructions and Forms for 2016 Grant Applications (November 18, 2015) NOT-OD-16-006 - Simplification of the Vertebrate Animals Section of NIH Grant Applications and Contract Proposals (November 18, 2015) NOT-OD-16-011 - Implementing Rigor and Transparency in NIH & AHRQ Research Grant Applications (November 18, 2015) June 4, 2014 - Notice NOT-14-074 supersedes instructions in Section III.3 regarding applications that are essentially the same.
Funding Opportunity Announcement (FOA) Number	PA-14-161
Companion Funding Opportunity	PA-14-159, R21 Exploratory/Developmental Grant
Number of Applications	See Section III. 3. Additional Information on Eligibility.
Catalog of Federal Domestic Assistance (CFDA) Number(s)	93.866, 93.286
Funding Opportunity Purpose	This Funding Opportunity Announcement (FOA) invites applications using the R01 award mechanism for translational research that moves evidence-based research findings toward the development of new interventions, programs, policies, practices, and tools that can be used by organizations in the community to help older adults remain healthy and independent, productively engaged, and living in their own homes and communities. The goal of this FOA is to support translational research involving collaborations between academic research centers and community-based organizations with expertise serving or engaging older adults (such as city and state health departments, city/town leadership councils, educational institutions, workplaces, Area Agencies on Aging, and organizations funded or assisted by the Corporation for National and Community Service) that will enhance our understanding of practical tools, techniques, programs and policies that communities across the nation can use to more effectively respond to needs of the aging population.

Key Dates

Posted Date	March 20, 2014
Open Date (Earliest Submission Date)	May 5, 2014
Letter of Intent Due Date(s)	Not Applicable
Application Due Date(s)	Standard dates apply, by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
AIDS Application Due Date(s)	Standard AIDS dates apply, by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
Scientific Merit Review	Standard dates apply
Advisory Council Review	Standard dates apply
Earliest Start Date	Standard dates apply
Expiration Date	May 8, 2017
Due Dates for E.O. 12372	Not Applicable

Required Application Instructions

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 1. Overview Information
Part 2. Full Text of the Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Funding Opportunity Description

Purpose

This Funding Opportunity Announcement (FOA) invites applications for translational research that moves evidence-based social and behavioral research findings towards the development of new interventions, programs, policies, practices, and tools that can be used by community-based organizations (for example, city and state health departments, city/town leadership councils, educational institutions, workplaces, Area Agencies on Aging, and organizations funded or assisted by the Corporation for National and Community Service) to help older adults remain healthy, independent, productively engaged, and living in their own homes and communities. Invited applications would address what is commonly referred to as "T2" research, or research at the second stage of the translational continuum. Such research focuses on the adoption and implementation of best practices in the community across a wide range of public, private, academic and other healthcare and policy settings.

Background

NIA has long been the primary sponsor of research in social and behavioral sciences on the processes of aging at both the individual and societal levels. This long-term investment in research has generated a large body of knowledge about how people change over the adult life course (both physically and in such areas as cognition, motivation, emotion, personality, and memory), on the inter-relationships between older people and social institutions, and on the economic impact of both changing age-composition of the population and public/private programs that serve older populations. Recent years have seen an explosion of fundamental insights at both (i) the population level, on the antecedents and impact of changing social, demographic, economic, and health characteristics of the older population, and (ii) the individual level, on the bio-psychosocial processes linking health and behavior, cognitive and emotional functioning, and subjective well-being. Translating this knowledge into practical advances to benefit the health and well-being of older Americans has increasingly become a priority for the NIA.

Research Scope

Applications are encouraged across a broad range of topics relevant to the translation of evidence-based behavioral and social science research on aging. The evidence-based approach proposed in submitted applications for translation into practice should be based on research that has already been tested and found to have efficacy, with findings published in the peer-reviewed literature that also demonstrate reliable links between hypothesized mechanisms and modifiable outcomes at the individual or population level.

Applications should also be able to demonstrate that the proposed approach has reasonable potential for practicability and scalability.

Applications should also show evidence of collaboration between academic research centers and community-based organizations (as defined above) that leads to new interventions, policies, practices and tools that can be used by community-based organizations to help older adults remain healthy, independent, productively engaged, and living in their own homes and communities for as long as possible. Ideally such collaborative applications will result in partnerships that will move evidence-based science findings into practice. Applications are especially encouraged that involve community-based organizations as full partners in each phase of work (e.g., from conception, design, conduct, analysis, interpretation, conclusions to communication of results). Such community-partnered research processes offer the potential to generate better-informed hypotheses, develop more effective interventions, and enhance the translation of the research results into practice.

Applications may focus on a single topic area but are encouraged to propose the use of multidisciplinary and interdisciplinary approaches to translation.

Further, applications should provide evidence of scalability by demonstrating that what is learned in a given community-academic setting can be used in larger provider and community based networks. Resulting research should include an evaluative element to demonstrate program and cost effectiveness.

Examples of potential community partners include, but are not limited to:

The Administration for Community Living’s Administration on Aging (AoA)

AoA advances its mission by working with and through the national Aging Network that includes 56 State and Territorial Units on Aging (SUA), 629 Area Agencies on Aging (AAA), 246 Indian Tribal and Native Hawaiian organizations, nearly 20,000 direct service provider organizations, and more than 500,000 volunteers. AoA’s programs complement existing medical and health care systems and support some of life’s most basic functions, such as providing assistance in elders homes to help them with bathing or preparing food. The network also helps consumers learn about and access the services and supports that are available in the community and addresses issues related to caregivers.

Organizations funded or assisted by the Corporation for National and Community Service (CNCS)

Organizations funded or assisted by CNCS include private nonprofit organizations and public agencies across the United States. CNCS is a federal agency that engages more than 4 million Americans in service through Senior Corps, AmeriCorps, and the Social Innovation Fund. CNCS and its network funds or otherwise assists over 70,000 community and faith-based organizations throughout the United States. Through its programs, CNCS taps the power of citizens to improve lives, solve problems, strengthen communities, and build the capacity of the nonprofit sector. CNCS’s Senior Corps programs connect Americans aged 55+ with the organizations as mentors, coaches or companions to people in need, or to contribute their job skills and expertise to community projects and organizations. For more information about CNCS please see http://www.nationalservice.gov/

NOTE: Applications focused on the provision of mental health services for the treatment of mental disorders, or on the provision of disease-specific clinical health care are not appropriate to this FOA.

The following are examples of potential application topics of interest. Other research that provides a link between science and practice is also invited.

Translation of research results that focus on positive health behavior change (e.g., improvements in diet, increasing physical activity); especially, recent results from the literature on self-regulation and behavioral economics (e.g., the use of nudges and defaults, explicit manipulation of gain and loss frames).
Translation of research that supports adaptive health-care and financial decision making for older adults and their families related to topics such as insurance, retirement, treatment options, and long term care.
Translation of research on how subjective well-being is impacted by aging-relevant life transitions, including changes in employment or health status, marital status, and social engagement, where potential modifiable factors at the individual or social structural level have been identified that might serve as cost-effective intervention targets at the community level to promote improvements or maintenance of subjective well-being in later life.
Translation of research results to enhance mobility and improve home and community-based services, to enable older adults to remain in the community (e.g. transportation, including older-driver skills building, and in-home services such as personal care).
Translation of research results and models that focus on cost-effective health promotion and disease and disability prevention (e.g. physical fitness programs; social engagement and volunteering; and interventions that remediate cognitive or physical decline).
Translation of research that supports informal caregiving in a family setting, such as REACH II.
This includes evaluation of the impact on caregivers in terms of their health, functioning, and well-being. Of particular interest are models that build the clinical and non-clinical skills of unpaid caregivers (e.g., training/skills building on medication management; nutrition; assistance with ADL and IADL management; and self-management).
Translation research that seeks to improve the physical, psychological, and emotional well-being of older at-risk and vulnerable adults (e.g., caregivers, minorities, persons with limited English proficiency, geographically and socioeconomically disadvantaged individuals).
Translation of research results on chronic care models that improve coordination of care, reduce fragmentation, prevent unnecessary or burdensome hospitalizations, and improve health outcomes.
Translation research that enhances social connections and the role of older individuals in promoting productive aging, such as volunteerism.
Translation of research on the impact of arts-based programs on the cognitive health, physical functioning, emotional well-being and social connectedness of older adults living in the community.
Translation of research on workplace factors that promote flexibility, productivity, and work-family balance to enhance the health and well-being of older workers and to maintain older adults in the workplace.

Resources for Applicants:

Stokes, Donald E. 1997. PASTEUR’s QUADRANT: BASIC SCIENCE AND TECHNOLOGICAL INNOVATION. Washington, DC: Brookings Institution Press.

Summary report from 2009 NIH meeting on the Science of Behavior Change: https://commonfund.nih.gov/documents/SOBC_Meeting_Summary_2009.pdf

Summary report from 2013 White House workshop on Psychological Science and Behavioral Economics in the Service of Public Policy http://www.nia.nih.gov/about/events/2013/white-house-workshop-psychological-science-and-behavioral-economics-service-public

National Academy of Sciences Report from the Panel on Measuring Subjective Well-Being in a Policy-Relevant Framework: http://www.nap.edu/catalog.php?record_id=18548

Section II. Award Information

Funding Instrument	Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.
Application Types Allowed	New Renewal Resubmission Revision The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types.
Funds Available and Anticipated Number of Awards	The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Award Budget	Application budgets are not limited but need to reflect the actual needs of the proposed project.
Award Project Period	The scope of the proposed project should determine the project period. The maximum period is 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Higher Education Institutions

Public/State Controlled Institutions of Higher Education
Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

Hispanic-serving Institutions
Historically Black Colleges and Universities (HBCUs)
Tribally Controlled Colleges and Universities (TCCUs)
Alaska Native and Native Hawaiian Serving Institutions
Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education

Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

For-Profit Organizations

Small Businesses
For-Profit Organizations (Other than Small Businesses)

Governments

State Governments
County Governments
City or Township Governments
Special District Governments
Indian/Native American Tribal Governments (Federally Recognized)
Indian/Native American Tribal Governments (Other than Federally Recognized)
Eligible Agencies of the Federal Government
U.S. Territory or Possession

Other

Independent School Districts
Public Housing Authorities/Indian Housing Authorities
Native American Tribal Organizations (other than Federally recognized tribal governments)
Faith-based or Community-based Organizations
Regional Organizations
Non-domestic (non-U.S.) Entities (Foreign Institutions)

Foreign Institutions

Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Required Registrations

Applicant Organizations

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

Dun and Bradstreet Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.
System for Award Management (SAM) (formerly CCR) Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
NATO Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.
eRA Commons - Applicants must have an active DUNS number and SAM registration in order to complete the eRA Commons registration. Organizations can register with the eRA Commons as they are working through their SAM or Grants.gov registration. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
Grants.gov Applicants must have an active DUNS number and SAM registration in order to complete the Grants.gov registration.

Program Directors/Principal Investigators (PD(s)/PI(s))

All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.

2. Cost Sharing

This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

3. Additional Information on Eligibility

Number of Applications

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

NIH will not accept any application that is essentially the same as one already reviewed within the past thirty-seven months (as described in the NIH Grants Policy Statement), except for submission:

To an RFA of an application that was submitted previously as an investigator-initiated application but not paid;
Of an investigator-initiated application that was originally submitted to an RFA but not paid; or
Of an application with a changed grant activity code.

Section IV. Application and Submission Information

1. Requesting an Application Package

Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the Apply for Grant Electronically button in this FOA or following the directions provided at Grants.gov.

2. Content and Form of Application Submission

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

For information on Application Submission and Receipt, visit Frequently Asked Questions Application Guide, Electronic Submission of Grant Applications.

Page Limitations

All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.

Required and Optional Components

The forms package associated with this FOA includes all applicable components, required and optional. Please note that some components marked optional in the application package are required for submission of applications for this FOA. Follow all instructions in the SF424 (R&R) Application Guide to ensure you complete all appropriate optional components.

Instructions for Application Submission

The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this FOA.

SF424(R&R) Cover