Key Dates

Related Announcements

PA-20-183 - NIH Research Project Grant (Parent R01 Clinical Trial Required)

PA-20-185 - NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA-20-194 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)

PA-20-195 - NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)

PAR-22-156 - Alcohol Health Services Research (R01 Clinical Trial Optional)

PAR-22-158 - Alcohol Treatment and Recovery Research (R01 Clinical Trial Required)

PA-21-110 - Pilot and Feasibility Studies in Preparation for Substance Use Prevention Trials (R34 Clinical Trial Optional)

PA-21-180 - Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

PAR-21-358 - Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

PAR-22-145 - Leveraging Health Information Technology to Address and Reduce Health Care Disparities (R01 Clinical Trial Optional)

PAR-21-081 - Addressing Health Disparities Among Immigrant Populations through Effective Interventions (R01 Clinical Trial Optional)

PAR-20-310 - Health Services Research on Minority Health and Health Disparities (R01- Clinical Trial Optional)

PA-20-184 - Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)

PAR-22-094 - Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R21 Clinical Trial Optional)

PAR-22-093 - Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)

PAR-20-150 - NIMHD Exploratory/Developmental Research Grant Program (R21 - Clinical Trial Optional)

PAR-22-105 - Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

PAR-22-109 - Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)

PAR-21-350 - Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Clinical Trials Not Allowed)

PAR-21-349 - Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Basic Experimental Studies with Humans Required)

PAR-21-039 - Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Humans Required)

PAR-21-038 - Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)

PAR-21-240 - Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)

PAR-21-241 - NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01 Clinical Trial Required)

PAR-20-154 - Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)

PAR-21-243 - Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative UG3/UH3 Clinical Trial Required)

PAR-21-242 - Data Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative U24 Clinical Trial Required)

PAR-22-027 - Mechanism for Time-Sensitive Drug Abuse Research (R21 Clinical Trial Optional)

PAR-22-230 - NINR Areas of Emphasis for Research to Optimize Health and Advance Health Equity (R01 Clinical Trial Optional)

PAR-22-231 - NINR Areas of Emphasis for Research to Optimize Health and Advance Health Equity (R21 Clinical Trial Optional)

PAR-22-233 - Time Sensitive Opportunities for Health Research (R61/R33 Clinical Trial Not Allowed

PAR-21-129 - Clinical Trials to Test the Effectiveness of Treatment, Preventive, and Services Interventions (Collaborative R01)

PAR-21-130 - Clinical Trials to Test the Effectiveness of Treatment, Preventive, and Services Interventions (R01 Clinical Trial Required)

PAR-21-131 - Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R34 -Clinical Trial Required)

PAR-21-316 - Innovative Mental Health Services Research Not Involving Clinical Trials

PAR-22-082 - Innovative Pilot Mental Health Services Research Not Involving Clinical Trials (R34 Clinical Trial Not Allowed)

Issued by

Office of Behavioral and Social Sciences Research (OBSSR)

National Institute on Aging (NIA)

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Institute on Drug Abuse (NIDA)

National Institute of Mental Health (NIMH)

National Institute of Nursing Research (NINR)

National Institute on Minority Health and Health Disparities (NIMHD)

National Center for Complementary and Integrative Health (NCCIH)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Sexual and Gender Minority Research Office (SGMRO)

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

Office of Research on Women's Health (ORWH)

Purpose

The purpose of this Notice is to highlight interest in research to improve understanding of the determinants of firearm injury, the identification of those at risk of firearm injury (including self- and other-directed, victims and perpetrators, accidental injury), the development, piloting, and testing of innovative interventions to prevent firearm injury and mortality, and the examination of approaches to improve the implementation of existing, evidence-based interventions to prevent firearm injury and mortality.

Background

Violence is defined by the World Health Organization as: the intentional use of physical force or power, threatened or actual, against oneself, another person, or against a group or community, that either results in or has a high likelihood of resulting in injury, death, psychological harm, maldevelopment, or deprivation. Violence affects people of all ages, and its impact is far-reaching. Violent victimization events are associated with not only physical injury or mortality, but also a range of acute and chronic physical and behavioral health conditions, such as obesity, cardiovascular disease, asthma, substance use disorders, depression and anxiety, sleep disturbance, impairments in cognitive development and executive functioning, and adverse birth outcomes. Findings from prior research suggest that indirect (witnessing) exposures to violence have adverse effects on behavioral and physical health that are similar to the effects of direct exposures.

The National Institutes of Health (NIH) is committed to understanding effective public health interventions to prevent violence, including firearm violence, and the trauma, injuries, and mortality resulting from violence. The Department of Health and Human Services (HHS) is committed to improving the health and well-being of the nation through Healthy People 2030 (HP2030). HP2030 establishes targets for national health objectives and monitors and catalyzes progress over time to measure the impact of research and prevention efforts. Both injury prevention and violence prevention are identified as priority areas in HP2030.

In addition to physical injury, chronic health impacts, and potential mortality, witnessing or experiencing violent victimization increases the risk of acute and chronic mental and behavioral health conditions. When firearms are involved with violent events (including suicide, intimate partner violence, child or elder maltreatment, youth and gang related violence, sexual assault, and hate crimes), the risk for injury and mortality increases. In 2020, 79% of all homicides and 53% of all suicides involved firearms. From 2019 to 2020, the firearm homicide rate increased about 35%, to its highest recorded rate in over 25 years. In addition, the firearm suicide rate remained consistently high from 2019 to 2020 with increases in some populations. As such, in 2020, firearm-related injuries became the leading cause of injury death for children and youth ages 1-19. The increase in firearm-related deaths from 2019-2020 further widened disparities by race, ethnicity and poverty. For example, firearm homicides among Black individuals increased by 39% and firearm suicide rate increased by 42% among American Indian and Alaska Native persons.

Research Objectives

Research encouraged by this NOSI is consistent with a broad public health approach to firearm injury and mortality prevention including:

1. identifying those at risk for firearm injury and mortality (self- and other-directed; victims and perpetrators; accidental injury)
2. development, piloting, and/or testing of theoretically-grounded programs to prevent firearm injury and mortality
3. implementation research to explore the barriers and facilitators to support broader adoption of effective programs.

In addition to interventions delivered by healthcare providers and systems, this NOSI encourages research delivered in community settings, and that integrates individual, family, interpersonal, community, and structural or system (e.g., criminal or juvenile justice, child welfare, drug courts) approaches to firearm injury and mortality prevention. Thus, development of cross-sector partnerships and/or integration across disparate databases may be necessary.

This NOSI is comprehensive in its consideration of risk for victimization and/or perpetration across the lifespan and across sexual and gender identities, people with developmental disabilities or cognitive impairments (e.g., Alzheimer’s disease and its related dementias), comorbid conditions (e.g., psychiatric or substance use disorders), or other at-risk populations such as pregnant and post-partum individuals, justice/legal system involved individuals, veterans, and members of the military. In addition, consideration of NIH designated health disparity populations (who are often disproportionately impacted by firearm injury and mortality), is encouraged: specifically, Blacks/African Americans, Hispanics/Latinos, American Indians/Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minorities. Please refer to specific bullets below to obtain information about priority populations for each participating institute, center, or office.

NIH is committed to supporting research to enhance diversity, equity, inclusion and accessibility (DEIA) in biomedical and behavioral sciences research. Applicants are encouraged to discuss how they will foster these principles in their proposed research activities.

Priority research topics within the scope of this FOA that could use the DEIA framework may include but are not limited to:

• Improve the ability to identify individuals at risk for firearm injury and mortality (victims and perpetrators), including suicide, homicide, and accidental injury and mortality. This may include but is not limited to: a) developing, testing, or validating innovative tools and technologies to screen and/or monitor firearm violence risk and mechanisms; b) applying advanced predictive analytic approaches (e.g., artificial intelligence, computational modeling) in situations for which these approaches can best inform risk identification, and informed by an understanding of the limits of these approaches (e.g., less precision for under-represented groups; data that reflect biases already in systems), and c) developing and testing models addressing the spread of firearm violence (e.g., social contagion).
• Develop, validate, and study implementation procedures, particularly for healthcare systems (including emergency departments and primary care) to determine who should be screened and how to screen accurately and efficiently for risk of firearm injury and mortality.
• Improve understanding of developmental, situational, structural and contextual factors associated with firearm injury and mortality that extends individual risk assessment to include factors related to the specific incident (e.g. concurrent use of alcohol or substances) as well as other potential contextual influences (e.g., current social and public health crises). In addition, consideration of multiple levels of influence (e.g., peers, family, community, and structural determinants), and interactions across these levels is encouraged.

• Develop and/or pilot innovative and culturally competent interventions delivered online, in healthcare, and/or community settings (e.g., schools/childcare, workplaces, justice/legal settings, social service or public health agencies, assisted living facilities) to prevent injury and mortality and revictimization/repeat injury or retaliatory firearm violence among those at risk.
• Hybrid effectiveness-implementation trials designed to test the effectiveness of preventive, intervention, and service interventions while also examining factors or testing strategies to improve implementation or dissemination efforts.
• Improve understanding and promotion of potential protective factors at the individual, family, community and structural levels (and their interactions) that could be enhanced to reduce the negative effects of risk exposure (e.g., resilience).
• Conduct implementation research with existing evidence-based interventions (e.g., safe storage counseling, lethal means counseling, motivational interviewing (e.g., safERteens), community-based violence interrupter programs) to assess barriers at multiple levels (e.g., provider, social, environmental, system, structural or policy); improve fidelity, adherence, adoption and scale-up of these programs; and rigorously test strategies for implementing evidence-based interventions with fidelity and potential for sustainability.
• Apply precision health and personalized medicine strategies to public health questions that determine for whom various firearm injury and mortality prevention programs are likely to be most effective.
• Assess the impact of combining public health and criminal justice (crime prevention) approaches to reduce firearm injury and mortality. This includes the evaluation of natural experiments involving changes in or natural variation of various firearm laws and policies as well as laws and policies that may influence the impact of firearm injury and mortality prevention efforts (e.g., changes in alcohol or marijuana access and distribution, community policing programs, child welfare policies, clinician-reporting policies).

Eunice Kennedy Shriver Institute of Child Health and Human Development (NICHD)

The NICHD supports research aimed at advancing the science of trauma and injury prevention and care for pediatric populations, with the goal of reducing the leading causes of morbidity and mortality in children. The Institute encourages research projects to develop new methods, interventions, and measurement tools to improve clinical outcomes in children who have been exposed to violence and other traumatic events.. For this NOSI, the NICHD is interested in research on the epidemiology of violence and inflicted and unintentional injuries as it relates to the use of firearms. Research projects may include but not be limited to studies that address:

• understanding means and types of violence and their inter-relationships, the spread of violence in domestic, international and humanitarian contexts, particularly as it relates to the use of firearms,
• intimate partner violence (IPV) including risk factors that contribute to IPV and risk factors contributing to the escalation of such violence.
• trauma-informed care and systems of care, including studies examining processes for understanding and responding appropriately to child psychological trauma and its effects. Of particular interest is research on acute and long-term psychological effects of chronic vs episodic exposure to firearm violence and the development and implementation of response and preparedness strategies to treat and prevent further traumatization.

National Center for Complementary and Integrative Health (NCCIH)

NCCIH is interested in supporting research on the development and testing of theoretically-grounded programs to prevent firearm injury and mortality that incorporate complementary or integrative approaches with physical and/or psychological therapeutic inputs, (often called mind and body interventions). NCCIH will also support dissemination and implementation research of evidenced based interventions that include mind and body components and that have proven efficacious for prevention of firearm injury and prevention. Mind and body interventions include various mind-based approaches (e.g., mindfulness, hypnosis, guided imagery), body-based approaches (e.g., spinal manipulation, massage, mobilization, acupuncture), meditative movement approaches (e.g., yoga, tai chi, qi-gong), music and art therapy approaches, or a combination of these approaches (e.g., meditation and yoga, or mindfulness-based stress reduction MBSR).

For more details on NCCIH’s approach to funding clinical trials, including a description of our available FOA s, please see https://nccih.nih.gov/grants/funding/clinicaltrials. NCCIH will not accept applications to the parent R01 or R21 in response to this NOSI.

National Institute of Mental Health (NIMH)

NIMH encourages research focused on reducing suicide risk through preventive, therapeutic, and services interventions that focus on responsible storage and lethal means safety. Applicants interested in learning more about NIMH priorities on research on aggression and violence against others are encouraged to view this published Notice of Special of Interest.

If adequate preliminary data does not exist, investigators are encouraged to conduct pilot effectiveness trials to evaluate the feasibility, tolerability, acceptability and safety and preliminary effectiveness of approaches to improve clinical outcomes, to modify risk factors, or to improve service delivery, and for obtaining the preliminary data needed as a pre-requisite to a larger-scale effectiveness trial (e.g., comparative effectiveness study, pragmatic trial).

Examples of relevant research topics include but are not limited to:

• Feasibility studies to explore the degree to which efficacious lethal means safety interventions generalize to typical healthcare and community settings and studies that aim to increase the clinical impact of interventions by optimizing and enhancing intervention effects beyond those observed in efficacy trials.
• Studies to examine/adapt parameters of evidence-informed lethal means safety interventions (e.g., dose, duration, method of administration) that impact generalization of efficacious interventions to practice settings.
• Effectiveness trials that test multi-modal or integrative intervention approaches that involve simultaneously combining or sequencing responsible storage interventions (e.g., lethal means counseling, lockbox installation or distribution) for synergistic effects.
• Effectiveness trials that incorporate tailoring variables into participant assignment algorithms and employ sequential randomization and iterative evaluation of treatment effects to test responsible storage approaches (e.g., MOST/SMART adaptive treatment designs).
• Effectiveness trials that involve intervention personalization based upon community and/or service user characteristics and preferences for receiving lethal means safety information.
• Effectiveness trials that leverage or utilize state, territory, or tribal level policies into intervention delivery strategies to reduce suicide risk.
• Effectiveness trials that examine the utility of technology-based approaches to significantly improve the delivery of responsible storage interventions and services.
• Effectiveness trials that test or compare patient-, provider- or systems-level services interventions designed to increase sustained responsible storage practices, including approaches to reduce empirically documented outcome disparities experienced by people in specific subgroups.
• Studies that test diffusion strategies (i.e., dissemination and implementation) to improve adoption of responsible storage interventions in practice settings.
• Studies that test provider-, organizational-, or systems-level interventions to increase the uptake, fidelity, and sustained use of evidence-based responsible storage interventions (e.g., studies comparing approaches to provider training and supervision).
• Developing and evaluating performance feedback systems, decision support tools, and quality improvement processes, which can be utilized across a range of systems (e.g., primary care, schools, criminal justice system, child welfare agencies) to optimize the delivery of effective safe storage interventions.
• Evaluating existing strategies to enhance lethal means safety treatment engagement and adherence (e.g., shared decision-making or behavioral economic approaches to behavior change).
• Improving the dissemination, implementation, and delivery of evidence-based lethal means safety practices in community mental health centers and other non-specialty care settings (e.g., primary medical care, schools, online and virtual communities).

NIMH encourages projects testing the effectiveness of preventive, therapeutic, or services interventions that are designed as hybrid effectiveness-implementation trials, as appropriate, depending on the level of pre-existing effectiveness evidence and implementation readiness. Thus, in addition to testing the effectiveness of a preventive or therapeutic intervention, NIMH encourages effectiveness trials that are designed to assess and examine consumer-, provider- and setting- level factors that might be associated with implementation fidelity (i.e., as Hybrid Type-I trials) or to simultaneously test strategies to promote successful implementation (i.e., as Hybrid Type II trials). Likewise, studies that are primarily aimed at testing an implementation or dissemination strategy should be designed to also assess the outcomes and effectiveness of the intervention/approach that is being implemented, as appropriate and feasible (i.e., as Hybrid Type III trials).

NIMH support for clinical trials research follows an experimental therapeutics approach, whereby clinical trials are designed, not only to test the intervention effects on outcomes of interest, but also to inform understanding of the intervention’s mechanisms of action. As such, applications that propose to develop and/or test the efficacy/effectiveness of preventive, therapeutic or services interventions must include specification of the intervention target(s)/mechanism(s) and assessment of intervention-induced changes in the presumed target mechanism(s) that are hypothesized to account for the intervention outcome. See the Support for Clinical Trials at NIMH web page for additional information regarding dedicated FOAs for NIMH clinical trials. Please note that NIMH does not accept clinical trials/interventional studies in response to the NIH parent FOAs.

National Institute of Nursing Research (NINR)

The National Institute of Nursing Research (NINR) supports research to solve pressing health challenges and inform practice and policy - optimizing health and advancing health equity into the future. NINR discovers solutions to health challenges through the lenses of health equity, social determinants of health, population and community health, prevention and health promotion, and systems and models of care. Drawing on the strengths of nursing's holistic, contextualized perspective, core values, and broad reach, NINR funds multilevel and cross-sectoral research that examines the factors that impact health across the many settings in which nurses practice, including homes, schools, workplaces, clinics, justice settings, and the community. Observational, intervention, and implementation research are of interest to NINR.

National Institute on Aging (NIA)

NIA welcomes basic behavioral, psychological, social, and economic research focused on causes and consequences of direct (as a victim or perpetrator) and indirect (as a witness) exposure to firearm violence and injury and research to develop and test interventions aimed at middle-aged and older adults for the treatment and prevention of firearm injury and mortality in the context of homicide, intimate partner violence, elder mistreatment, and suicide. NIA is especially interested in research that examines and addresses health disparities and health equity in NIA-designated priority populations, as specified in the NIA Health Disparities Research Framework, and gender-based-violence. NIA encourages projects that include assessments of housing and living conditions, household composition, sexual orientation and gender identity, and health and disability status. Firearm injury and prevention studies related to Alzheimer's Disease-Related Dementias (AD/ADRD) are particularly welcome.

NIA is interested in supporting integrated care interventions that develop clinical and community linkages or leverage and build on existing programs which are designed in accordance with the NIH Stage Model. To this end, NIA solicits projects focused on: intervention development, refinement, modification, and adaptation and pilot testing (Stage I); traditional efficacy testing (Stage II); and efficacy testing with real-world providers (Stage III). Applications proposing to adapt existing interventions are expected to provide evidence to support the need for tailored strategies. All applications are expected to include a management plan for mitigating bias in the detection and measurement of firearm violence exposure.

Priority areas of interest to NIA include, but are not limited to:

• Longitudinal effects of exposure to firearm violence.
• Risk factors for accidental and intentional firearm injury and exposure.
• Clinical and economic impact of firearm violence.
• Impact of personalized preventive firearm programs on health care utilization.
• Development of point-of-care screening tools for the early detection of direct and indirect exposure to firearm violence.
• Family history screening tools to identify individuals and families at risk of exposure to firearm violence.
• Strategies to facilitate disclosure of firearms possession for older adults at risk of inflicting harm to self or others. Interventions to prevent re-victimization and re-perpetration of firearm violence.
• Interventions to mitigate the adverse effects of exposure to firearm violence and to reduce perpetration of violence by midlife or in older age.
• Strategies to improve the effectiveness of promising community- and societal-level interventions for the prevention or reduction of firearm violence.

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

The National Institute on Alcohol Abuse and Alcoholism (NIAAA; https://www.niaaa.nih.gov/) supports research projects focused on the epidemiology, prevention, and treatment of alcohol-related violence. The use and misuse of alcohol often is a factor in various forms of other- and self-directed violence, including intimate partner violence, dating violence, elder abuse, child maltreatment, bullying, sexual assault, homicide, and suicide, forms of violence that often involve use of a firearm. Fruitful research investigations may be conducted in the human laboratory or in the field. Proposed interventions may focus on the perpetrators of the violence, the victims, and/or potential bystanders.

National Institute on Drug Abuse (NIDA)

NIDA is interested in a wide variety of research that examines connections between substance use and firearms violence, particularly firearm-related research that has implications for the prevention or treatment of substance use. Possible areas of research include, but are not limited to:

• Qualitative or mixed-method research examining the motivation to commit firearms violence or carry a firearm for individuals who use or sell drugs.
• Research on the use of illicit drug markets to transport and sell firearms (e.g., pathways used to bring firearms into and throughout the U.S., gang involvement in firearm sales, firearms recovered during illegal drug busts, etc.) and the relation between these illicit drug markets and firearm violence.
• Studies examining the relation between the locations of firearm outlets and substance use in neighborhoods and how these neighborhood dynamics impact firearms-related violence.

• Secondary data analyses examining the connections between substance-use-related behaviors (e.g., substance use, misuse or use disorder; environmental measures of substance use for example in the workplace or at school, etc.) and firearm behaviors (e.g., firearm violence perpetration and victimization, firearm possession, firearm carrying behaviors, etc.).
• Expansion of existing longitudinal studies that either (1) add measures of firearm violence or possession to studies that already include robust measures of substance use, or (2) add measures of substance use to studies that already include robust measurement of firearm violence or possession.
• Expansion of firearm violence prevention services or interventions to include strategies to prevent or treat substance misuse or use disorder.
• Research that examines the effectiveness of substance use disorder treatment engagement in reducing firearms-related violence perpetration and victimization.
• Studies that develop and test novel interventions designed to prevent substance use, misuse, or use disorder and firearms-related violence perpetration and victimization, particularly studies testing mechanisms of action.

• Studies that examine the effectiveness of embedding firearm safety or violence prevention interventions into SUD treatment, recovery or harm reduction programs.
• Research on the impact of firearm policies (e.g., laws prohibiting people with substance use disorders from obtaining firearms; state executive orders declaring firearm outlets as essential businesses during the COVID-19 pandemic, etc.) on both overall and substance-related firearm injuries and fatalities.

National Institute on Minority Health and Health Disparities (NIMHD)

The mission of NIMHD is to lead scientific research to improve minority health and reduce health disparities. Populations that experience health disparities include African Americans/Blacks, Hispanic/Latinos, American Indians/Alaska Natives, Asians, Native Hawaiians, and other Pacific islanders, socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minority (SGM) populations. NIMHD is especially interested in the innovative application of community-engaged research approaches and utilization of the NIMHD Research Framework to address the continuum of firearm injury and mortality prevention efforts among populations that experience health disparities and individuals with intersecting health disparity population membership, across multiple levels of influence (i.e., individual, community, societal).

The Office of Behavioral and Social Sciences Research (OBSSR) does not have grant-making authority and can only support grants deemed meritorious after review by one of the ICs participating in this announcement and after a co-funding request is initiated through the IC. Please contact the relevant IC Scientific/Research Contact(s) listed for questions regarding IC research priorities and funding. For additional information about OBSSR’s research priorities and interests, please refer to the OBSSR Strategic Plan.

Office of Disease Prevention (ODP)

The ODP is the lead office at the NIH responsible for assessing, facilitating, and stimulating research in disease prevention. In partnership with the 27 NIH Institutes and Centers, the ODP strives to increase the scope, quality, dissemination, and impact of NIH-supported prevention research. The ODP is interested in providing co-funding support for research that has strong implications for disease and injury prevention and health equity that include innovative and appropriate research design, measurement, and analysis methods. Furthermore, the ODP has a specific interest in projects that develop and/or test preventive interventions. For this NOSI, the ODP is interested in preventive interventions addressing suicide, intimate partner violence, and community violence involving firearms

The ODP does not award grants; therefore, applications must be relevant to the objectives of at least one of the participating NIH Institutes and Centers (IC) listed in this announcement. Please contact the relevant IC Scientific/Research Contact(s) listed for questions regarding IC research priorities and funding. The ODP only accepts co-funding requests from NIH Institutes and Centers. For additional information about ODP’s research priorities and interests, please refer to the ODP Strategic Plan for Fiscal Years 2019 2023.

Office of Research on Women's Health (ORWH)

The Office of Research on Women’s Health (ORWH) is part of the Office of the Director of NIH and works in partnership with the NIH Institutes and Centers to ensure that women's health research is part of the scientific framework at the NIH, and throughout the scientific community. ORWH is interested in co funding applications that include adequate plans to address sex as a biological variable (SABV), including plans to disaggregate data by sex/gender with a focus on examining sex and gender influences.

Applicants are encouraged to discuss applications with the ORWH contact listed under Agency Contacts. The 2019 2023 Trans-NIH strategic plan for women's health research: "Advancing Science for the Health of Women highlights research priorities to improve the health of women. The overarching themes of the Strategic Plan include but are not limited to sex determinants, evidence-based interventions, advancing women in biomedical research, and innovative approaches. Information on the strategic plan can be reviewed at Trans NIH Strategic Plan for Women's Health Research.

Sexual & Gender Minority Research Office (SGMRO)

The SGMRO coordinates research and activities related to the health and well-being of sexual and gender minorities (SGM; defined for NIH research in NOT-OD-19-139) by working directly with the NIH ICOs and serves as a liaison for the research community to ensure SGM populations are considered and represented in research activities across the agency.

Violence is a major concern for members of the SGM community. In an effort to increase SGM-focused research and knowledge related to violence and health, the SGMRO sponsored and coordinated the 2021 Scientific Workshop on Violence & Related Health Outcomes in Sexual & Gender Minority Communities. The workshop focused on five research areas (demographics and epidemiology; risk factors and pathways; preventive interventions; treatment-focused interventions; and ethics and logistical challenges) across four domains of violence (family of origin abuse, peer/friend victimization, romantic/sexual partner violence, and community violence). Key findings and opportunities are summarized and discussed in the Final Workshop Summary Document for consideration by investigators submitting SGM-related applications to this Notice.

The SGMRO does not have grant-making authority and can only support grants deemed meritorious after review by one of the ICs participating in this announcement and after a co-funding request is initiated through the IC. Please reach out to the relevant Scientific/Research Contact(s) identified in this announcement with any questions about IC-specific research priorities and funding. More SGM- and SGMRO-specific information is available in the NIH Strategic Plan to Advance Research on the Health and Well-being of Sexual and Gender Minorities FY 2021-2025 and on the Office’s Research Resources webpage.

Application and Submission Information

Research proposed in applications must be ideologically and politically unbiased as defined in the NIH Grants Policy Statement (GPS) sections 4.1.10 and 4.1.17.

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NIH funds may not be used, in whole or in part, to advocate or promote gun control or to support lobbying activities, as outlined in Section 4 of the NIH GPS.

Applicants must select the IC and associated FOA to use for submission of an application in response to this NOSI. The selection must align with the IC requirements listed in order to be considered responsive to that FOA. Non-responsive applications will be withdrawn from consideration for this NOSI.

In addition, applicants using NIH Parent Announcements (listed above) will be assigned to those ICs on this NOSI that have indicated those FOAs are acceptable and based on usual application-IC assignment practices.

This notice applies to due dates on or after February 5th, 2023 and subsequent receipt dates through February 5th, 2026.

Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice

All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:

• For funding consideration, applicants must include NOT-OD-23-039 (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.

• Applicants planning to submit an application in response to this NOSI are strongly encouraged to contact and discuss their proposed research/aims with an NIH Program Officer listed on this NOSI well in advance of the grant receipt date.

Applications nonresponsive to terms of this NOSI will not be considered for the NOSI initiative.

Inquiries

The Office of Behavioral and Social Sciences Research (OBSSR) facilitates this Notice on behalf of the participating NIH Institutes and Centers (ICs). As OBSSR cannot accept assignment of applications or directly fund or manage awards, contact one of the IC-based officials below regarding the suitability of the proposed project for this NOSI and the IC's research portfolio.

Scientific/Research Contact(s)

Dara R. Blachman, Ph.D.
Office of Behavioral and Social Sciences Research (OBSSR)
Email:[email protected]

Lanay M. Mudd, Ph.D., FACSM
National Center for Complementary and Integrative Health (NCCIH)
Phone: 301-594-9346
Email:[email protected]

Melissa Gerald,Ph.D.
National Institute on Aging (NIA)
Phone: 301-402-4156
E-mail:[email protected]

Valerie Maholmes, PhD, CAS
Eunice Kennedy ShriverNational Institute of Child Health and Human Development (NICHD)
Telephone: 301-496-1514
Email:[email protected]

Barbara Ann Oudekerk, Ph.D.
National Institute on Drug Abuse (NIDA)
Phone: (301) 827-0641
E-mail:[email protected]

Stephen O Connor, Ph.D.
National Institute of Mental Health (NIMH)
Phone: (301) 480-8366
E-mail: stephen.o [email protected]

Crystal Barksdale, PhD, MPH
National Institute on Minority Health and Health Disparities (NIMHD)
Phone: 301-402-1366
E-mail:[email protected]

Karen Huss, PhD, RN, ANP-BC, FAAN, FAAAAI, FAHA
National Institute of Nursing Research (NINR)
Telephone: 301-594-5970
Email:[email protected]

Robert Freeman, Ph.D.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Phone: 301443-8820
E-mail: [email protected]

Jennifer Alvidrez, PhD
Office of Disease Prevention (ODP)
Telephone: 301-827-0071
Email: [email protected]

Lisa Begg, Dr.P.H.,RN
Office of Research on Women's Health (ORWH)
Phone: 301-496-3975
E-mail:[email protected]

Christopher Barnhart, PhD
Sexual & Gender Minority Research Office (SGMRO)
Telephone: 301-594-8983
Email:[email protected]