NIH Modification to Guidance on Marking Changes in Resubmission Applications

Notice Number:


Key Dates

Release Date: December 4, 2014

Related Announcements


Issued by

National Institutes of Health (NIH)


This Notice informs the applicant community of a modification for how NIH would like applicants to mark changes in their Resubmission applications. NIH has removed the requirement to identify 'substantial scientific changes' in the text of a Resubmission application by 'bracketing, indenting, or change of typography'.

Effective immediately, it is sufficient to outline the changes made to the Resubmission application in the Introduction attachment. The Introduction must include a summary of substantial additions, deletions, and changes to the application. It must also include a response to weaknesses raised in the Summary Statement. The page limit for the Introduction may not exceed one page unless indicated otherwise in the Table of Page Limits.


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Telephone: 301-710-0267

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