Related Announcements

NOT-NS-22-050: Notice of Special Interest (NOSI) in NINDS mission relevant Pain Research

PA-20-185 NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA-20-183 Research Project Grant (Parent R01 Clinical Trial Required)

PA-20-184 Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)

PA-21-219 Joint NINDS/NIMH Exploratory Neuroscience Research Grant (R21 Clinical Trial Optional)

PAR-19-315 Discovery of Biomarkers and Biomarker Signatures for Neurological and Neuromuscular Disorders (R61/R33 Clinical Trial Optional)

PAR-19-158 Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed)

PAR-19-159 Bioengineering Research Grants (BRG) (R01 Clinical Trial Required)

PAR-21-315 Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)

RFA-NS-21-021 Translational Neural Devices (UG3/UH3 - Clinical Trial Optional)

PAR-21-236 NINDS Exploratory Clinical Trials (U01 - Clinical Trial Required)

PA-21-050 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)

PA-21-051 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)

PA-21-052 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31-Diversity)

PAR-21-032 NINDS Ruth L. Kirschstein National Research Service Award (NRSA) for Training of Postdoctoral Fellows (F32 Clinical Trial Not Allowed)

PA-20-187 NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)

PA-20-188 NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)

PA-20-189 NIH Pathway to Independence Award (Parent K99/R00 Independent Basic Experimental Studies with Humans Required)

PAR-21-271 Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed)

PAR-21-272 Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Required)

PAR-21-273 Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Basic Experimental Studies with Humans Required (BESH))

PA-20-201 Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Basic Experimental Studies with Humans Required)

PA-20-202 Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required)

PA-20-203 Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)

PA-20-204 Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required)

PA-20-205 Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)

PA-20-206 Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)

PAR-21-153 NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01 Clinical Trial Required)

PAR-21-234 NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01 Independent Clinical Trial Not Allowed

PAR-20-049 NINDS Postdoctoral Mentored Career Development Award (K01 - No Independent Clinical Trial Allowed)

PAR-20-050 NINDS Postdoctoral Mentored Career Development Award (K01 - Clinical Trial Required)

PA-20-174 Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed)

PA-20-173 Independent Scientist Award (Parent K02 Independent Basic Experimental Studies with Humans Required)

PA-20-171 Independent Scientist Award (Parent K02 - Independent Clinical Trial Required)

PAR-21-327 Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Required)

PAR-21-328 Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Not Allowed)

Issued by

National Institute of Neurological Disorders and Stroke (NINDS)

Purpose

This Notice of Special Interest (NOSI) is issued by the National Institute of Neurological Disorders and Stroke (NINDS) to outline NINDS priorities for applications in the field of headache and migraine research in Fiscal Year 2022. Recognizing the urgent need to increase the study of neurological conditions associated with pain such as headache and migraine, the Fiscal Year 2022 draft budgets from the President, House, and Senate each include proposals to increase funding for pain research within NINDS mission. With this NOSI, NINDS wishes to inform the science community of the headache and migraine research opportunities that will present themselves, if funds become available. To be considered for funding through this initiative in Fiscal Year 2022, applications will need to be submitted to corresponding due dates starting in January or February 2022 so they can undergo Scientific Merit and NINDS Advisory Council review for the September 2022 Council round.

For funding consideration, applicants must include NOT-NS-22-051 (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative. Applications deemed nonresponsive to the terms of this notice will not be considered for this initiative.

Background:

Although there is still some uncertainty about the final availability of funds, we are excited by the potential to accelerate discovery and therapy development in this critical area, and we hope to encourage investigators to consider submitting applications that can advance our knowledge of the nature of pain and its treatment. Despite the prevalence of headache and migraine and the recent success in treatment opportunities, many questions remain regarding the pathophysiology, progression, and the multitude of endogenous and exogenous factors that influence headache and migraine. The following topic areas are not intended to be comprehensive or exhaustive. Synergistic studies that reach across two or more of these areas are encouraged. Interdisciplinary and multidisciplinary research is especially encouraged, as is research that involves specific cooperation between basic, translational, and clinical scientists.

Research areas of interest include:

Basic Science and Mechanistic Headache Research

• Hypothesis-driven research that will elucidate mechanistic differences between pediatric and adult headache (developmental biology)
• Given the variation in sex differences in adult, children and adolescents, investigations of the role of sex hormones in headache and migraine pathogenesis
• Studies of Tension Type Headache
• Studies of Trigeminal autonomic cephalalgias (TACs) such as cluster headache, paroxysmal hemicrania and short-lasting unilateral neuralgiform headache
• Studies of Post traumatic headache in adult, children and adolescents
• Exploration of mechanisms of onset and progression of headache in pediatric population
• Studies of pain associated with light and sound in individuals with headache and migraine
• Exploration of mechanisms of nervous system hypersensitivity including hyperalgesia, photophobia, phonophobia, and allodynia associated with migraine
• Exploration of inflammatory processes related to headache and migraine
• Basic research on the mechanisms and treatments of medication overuse headache (MOH)

Headache Research Tool Development

• Age and developmentally appropriate tools to monitor headaches, including characterization and responses to therapy
• Development and validation of animal models of headache and migraine phases and genetic models, including the evaluation of sex differences in those animal models

Basic Science and Clinical Headache Research in Humans

• Differences in headache-relevant developmental pharmacology (esp. pharmacodynamics) from infancy to adolescence
• Exploratory clinical trials of promising assets (drugs, biologics, devices, and/or other non-pharmacological treatments) for the treatment of headache in adults, children, and adolescents
• Comparative effectiveness studies of established headache treatment approaches in adult and pediatric populations
• Comparative effectiveness studies of established headache treatment approaches during early childhood, middle childhood, and adolescence
• Evaluation of the influence of sex/gender in symptomatic presentation of migraine and nervous system hypersensitivity as it relates to pain
• Basic and clinical research on the mechanisms and treatments of medication overuse headache

Studies of other primary headache such as nummular headache, hypnic headache and new daily persistent headache (NDPH) are also responsive to this NOSI.

For information regarding additional NINDS priorities for applications in the field of pain research, see NOT-NS-22-050: Notice of Special Interest (NOSI) in NINDS mission-relavent Pain Research

Program Directors/ Principal Investigators planning to submit applications are strongly encouraged to contact NINDS scientific program staff when developing their projects.

Application and Submission Information

This notice applies to due dates on or after February 5, 2022 and subsequent receipt dates through May 8, 2022.

Submit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.

• PA-20-185 NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
• PA-20-183 Research Project Grant (Parent R01 Clinical Trial Required)
• PA-20-184 Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)
• PA-21-219 Joint NINDS/NIMH Exploratory Neuroscience Research Grant (R21 Clinical Trial Optional)
• PAR-19-315 Discovery of Biomarkers and Biomarker Signatures for Neurological and Neuromuscular Disorders (R61/R33 Clinical Trial Optional)
• PAR-19-158 Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed)
• PAR-19-159 Bioengineering Research Grants (BRG) (R01 Clinical Trial Required)
• PAR-21-315 Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)
• RFA-NS-21-021 Translational Neural Devices (UG3/UH3 - Clinical Trial Optional)
• PAR-21-236 NINDS Exploratory Clinical Trials (U01 - Clinical Trial Required)
• PA-21-050 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)
• PA-21-051 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)
• PA-21-052 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31-Diversity)
• PAR-21-032 NINDS Ruth L. Kirschstein National Research Service Award (NRSA) for Training of Postdoctoral Fellows (F32 Clinical Trial Not Allowed)
• PA-20-187 NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)
• PA-20-188 NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)
• PA-20-189 NIH Pathway to Independence Award (Parent K99/R00 Independent Basic Experimental Studies with Humans Required)
• PAR-21-271 Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed)
• PAR-21-272 Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Required)
• PAR-21-273 Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Basic Experimental Studies with Humans Required (BESH))
• PA-20-201 Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Basic Experimental Studies with Humans Required)
• PA-20-202 Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required)
• PA-20-203 Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)
• PA-20-204 Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Basic Experimental Studies with Humans Required)
• PA-20-205 Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)
• PA-20-206 Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)
• PAR-21-153 NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01 Clinical Trial Required)
• PAR-21-234 NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01 Independent Clinical Trial Not Allowed
• PAR-20-049 NINDS Postdoctoral Mentored Career Development Award (K01 - No Independent Clinical Trial Allowed)
• PAR-20-050 NINDS Postdoctoral Mentored Career Development Award (K01 - Clinical Trial Required)
• PA-20-174 Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed)
• PA-20-173 Independent Scientist Award (Parent K02 Independent Basic Experimental Studies with Humans Required)
• PA-20-171 Independent Scientist Award (Parent K02 - Independent Clinical Trial Required)
• PAR-21-327 Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Required)
• PAR-21-328 Career Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Not Allowed)

All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:

• For funding consideration, applicants must include NOT-NS-22-051 (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative.

Applications nonresponsive to terms of this NOSI will not be considered for the NOSI initiative.

Inquiries

Scientific/Research Contact(s)
Michael Oshinsky, PhD
National Institute of Neurological Disorders and Stroke (NINDS)
Email: michael.oshinsky@nih.gov

Adam L. Hartman, MD
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-9135
E-mail:adam.hartman@nih.gov

Rebecca Hommer, MD
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-827-2257
E-mail:rebecca.hommer@nih.gov

Peer Review Contact(s)

Examine your eRA Commons account for review assignment and contact information (information appears two weeks after the submission due date).

Financial/Grants Management Contact(s)

Chief Grants Management Officer
National Institute of Neurological Disorders and Stroke (NINDS)
Email:ChiefGrantsManagementOfficer@ninds.nih.gov