Notice of Change in Application Due Date for NHLBI NOFOs PAR-25-025 and PAR-25-026
Notice Number:
NOT-HL-27-002

Key Dates

Release Date:
October 20, 2026
Effective Date:
October 20, 2026

Related Announcements

December 05, 2024 - NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required). See NOFO PAR-25-025.
December 05, 2024 - NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required). See NOFO PAR-25-026.

Issued by

National Heart, Lung, and Blood Institute (NHLBI)

Purpose

The purpose of this notice is to inform potential applicants of a change in the key dates for notices of funding opportunity (NOFO) PAR-25-025 "NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required)" and PAR-25-026 "NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)". Specifically, 1 additional receipt date has been added for new applications and resubmission/revision applications. The NOFO will now expire on February 4, 2027.

The following sections of PAR-25-025 and PAR-25-026 have been updated in bold italics to reflect the additional receipt date and new expiration date. 

Currently Reads

Part 1. Overview Information

Key Dates

The following table includes NIH standard due dates marked with an asterisk.

Application Due Dates

Review and Award Cycles

New

Renewal / Resubmission / Revision (as allowed)

AIDS - New/Renewal/Resubmission/Revision, as allowed

Scientific Merit Review

Advisory Council Review

Earliest Start Date

February 03, 2025

February 03, 2025

May 07, 2025 *

July 2025

October 2025

December 2025

June 04, 2025

June 04, 2025

September 07, 2025 *

November 2025

January 2026

April 2026

October 02, 2025

October 02, 2025

January 07, 2026 *

March 2026

May 2026

July 2026

February 03, 2026

February 03, 2026

May 07, 2026 *

July 2026

October 2026

December 2026

June 04, 2026

June 04, 2026

Not Applicable

November 2026

January 2027

April 2027

October 02, 2026

October 02, 2026

Not Applicable

March 2027

May 2027

July 2027

All applications are due by 5:00 PM local time of applicant organization. 

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Expiration Date

January 08, 2027

Due Dates for E.O. 12372

Not Applicable

Revised to Read

Part 1. Overview Information

Key Dates

The following table includes NIH standard due dates marked with an asterisk.

Application Due Dates

Review and Award Cycles

New

Renewal / Resubmission / Revision (as allowed)

AIDS - New/Renewal/Resubmission/Revision, as allowed

Scientific Merit Review

Advisory Council Review

Earliest Start Date

February 03, 2025

February 03, 2025

May 07, 2025 *

July 2025

October 2025

December 2025

June 04, 2025

June 04, 2025

September 07, 2025 *

November 2025

January 2026

April 2026

October 02, 2025

October 02, 2025

January 07, 2026 *

March 2026

May 2026

July 2026

February 03, 2026

February 03, 2026

May 07, 2026 *

July 2026

October 2026

December 2026

June 04, 2026

June 04, 2026

Not Applicable

November 2026

January 2027

April 2027

October 02, 2026

October 02, 2026

Not Applicable

March 2027

May 2027

July 2027

February 03, 2027

February 03, 2027

Not Applicable

July 2027

October 2027

December 2027

All applications are due by 5:00 PM local time of applicant organization. 

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Expiration Date

February 04, 2027

Due Dates for E.O. 12372

Not Applicable

All other aspects of the NOFO remain the same.

Inquiries

Please direct all inquiries regarding this Notice to:

Scientific/Research Contact(s)

Division of Lung Diseases
National Heart, Lung, and Blood Institute (NHLBI)
Email: [email protected]
Subject: NOT-HL-27-002

Division of Blood Diseases and Resources
Clinical Trials
National Heart, Lung, and Blood Institute (NHLBI)
Email: [email protected]
Subject: NOT-HL-27-002

Division of Cardiovascular Sciences
National Heart, Lung, and Blood Institute (NHLBI)
Email: [email protected], [email protected]
Subject: NOT-HL-27-002

Financial/Grants Management Contact(s)

Office of Grants Management
National Heart, Lung, and Blood Institute (NHLBI)
Email: [email protected]
Subject: NOT-HL-27-002