Key Dates

Related Announcements

• October 30, 2024 - PAR-25-143 - Dissemination and Implementation Research in Health (R21 Clinical Trial Optional). See PAR-25-143
• October 30, 2024 - PAR-25-144 - Dissemination and Implementation Research in Health (R01 Clinical Trial Optional). See PAR-25-144
• October 30, 2024 - PAR-25-233 - Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed). See PAR-25-233

Issued by

National Cancer Institute (NCI)

National Heart, Lung, and Blood Institute (NHLBI)

National Institute on Aging (NIA)

National Institute of Allergy and Infectious Diseases (NIAID)

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

National Institute of Environmental Health Sciences (NIEHS)

National Institute of Nursing Research (NINR)

National Institute on Minority Health and Health Disparities (NIMHD)

Fogarty International Center (FIC)

National Center for Complementary and Integrative Health (NCCIH)

All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

Purpose

The purpose of this Notice is to inform potential applicants of the interest of the NIH Climate Change and Health Initiative (CCHI) in supporting implementation science related to climate change and health. The CCHI seeks to reduce the health threats posed by climate change across the lifespan, improve the health of people who are at increased risk from or disproportionately impacted by climate change, and build health resilience among individuals, organizations, communities, Tribal Nations, and nations around the world. This NOSI encourages applications that propose implementation studies to understand and address barriers and facilitators to the adoption, implementation, scale-up, and sustainment of effective interventions to prevent or mitigate the health effects of climate change in the United States and globally.

Background

Climate change poses substantial threats to human health across the lifespan, including communicable and non-communicable diseases, injuries, hazardous exposures, mental health, and death. Health outcomes can be affected directly by climate change through weather events such as extreme heat, wildfires, droughts, storm surges, and floods, and indirectly through a series of exposure pathways that include air and water quality, food quality, infectious diseases, and population displacement events.

Health impacts of climate change result from exposures to environmental hazards (e.g., air pollution from wildfire smoke, vector-borne illness from mosquitos), changes in health behaviors (e.g., diet, physical activity), marginalized access to resources and information, and disruptions to health services, all of which are compounded by social, economic, and environmental injustices within the United States and globally.

A range of interventions (e.g., programs, practices, technologies, tools, policies) exist to prevent or mitigate the health impacts of climate change, as well as to adapt individuals, organizations, communities, and nations to be resilient to the health impacts of climate change. These interventions include, but are not limited to, early warning systems, cooling strategies, air filtration, preparedness and climate resilience plans, appropriate use campaigns, and telemedicine. Additional examples can be found at CDC, WHO, AHRQ, and elsewhere. For effective interventions, there is a clear gap and opportunity to understand how to optimally implement them.  For other interventions for which effectiveness data are limited, there is an opportunity for studying both effectiveness and implementation.

The NIH Climate Change and Health Initiative Strategic Framework calls for health intervention research and implementation science that provides the evidence base to guide implementation of timely, effective strategies to prevent disease and disability and promote health. High priority applications will focus on understanding, developing, or testing effective implementation strategies to optimize equitable and sustainable implementation. A focus on racial/ethnic minorities and other U.S. populations that experience health disparities (defined here: https://nimhd.nih.gov/about/strategic-plan/nih-strategic-plan-definitions-and-parameters.html) and transdisciplinary research teams are highly encouraged. Applications that focus on interventions launched through funding from the Inflation Reduction Act (IRA) or the Bipartisan Infrastructure Legislation (BIL) are encouraged.

Research Objectives

This notice encourages applications that pursue innovative approaches to identifying, understanding, and developing strategies for overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based climate and health interventions. For promising interventions with limited effectiveness data, hybrid studies that assess both effectiveness and implementation are encouraged.

Research topics of interest include but are not limited to the following:

• Understand and measure readiness to implement climate mitigation and/or adaptation interventions
• Identify factors that contribute to the adoption, implementation, adaptation, sustainment, and/or scale up of evidence-based climate and health interventions in public health, community, and clinical practice;
• Conduct economic evaluations (e.g., budget impact analysis, return-on-investment analysis) of implementation strategies for climate and health interventions;
• Understand factors that influence the creation, packaging, transmission, and reception of information about effective climate and health interventions to key partners and implementers;
• Assess policies and other contextual factors that influence the success of dissemination and/or implementation efforts.
• Identify and understand effective strategies for implementing climate and health-related policies across federal, state, local and organizational settings.
• Understand and address direct and/or indirect effects of climate change and/or climate exacerbated weather events on disruptions in care, care quality, and related outcomes.
• Model impacts of climate change on healthcare system capacity, resilience, care access, care delivery patterns, catchment areas, or other aspects of healthcare delivery along the care continuum (e.g. geospatial data linkages).
• Identify, develop, and test strategies to enhance health care system climate-resilience and capacity to deliver high-quality, equitable care, particularly in the face of multiple or compounding climate-related events

For ongoing or newly implemented climate mitigation and/or adaptation interventions (e.g., efforts to reduce exposure to air pollution, increase active transport, reduce consumption of processed foods, early warning systems, disaster preparedness plans) and for which there is limited effectiveness evidence:

• Hybrid studies to assess effectiveness and factors that influence implementation (e.g., readiness, feasibility, acceptability) of the intervention in public health, community, or healthcare delivery settings
• Theory-informed studies to understand barriers and facilitators that influence adoption and integration of climate mitigation and/or adaptation interventions

Non-responsive Applications

• Studies that solely assess the health effects of climate change
• Studies that assess the effectiveness of interventions solely measured by health outcomes with no assessment of implementation efforts

Application and Submission Information

This Notice applies to application due dates on or after February 5, 2025, and subsequent receipt dates through January 7, 2028. Please note that the three NOFOs listed below expire January 08, 2028.

Submit applications for this initiative using one of the following notices of funding opportunity (NOFOs) or any reissues of these announcements through the expiration date of this Notice. 

Please be advised that not all Institutes and Centers that are signed on to this NOSI participate in all three of these NOFOs. 

Please check the individual NOFOs to see which Institutes and Centers (ICs) are participating.   

All instructions in the SF424 (R&R) Application Guide and the funding opportunity announcement used for submission must be followed, with the following additions:

• For funding consideration, applicants must include “NOT-CA-25-003” (without quotation marks) in the Agency Routing Identifier field (box 4b) of the SF424 R&R form. Applications without this information in box 4b will not be considered for this initiative.

Note: Investigators planning to submit an application in response to this NOSI are strongly encouraged to contact and discuss their proposed research (aims) with an NIH program officer listed on this NOSI and/or on the listed NOFO well in advance of the chosen application receipt date.

Applications nonresponsive to terms of this NOSI will not be considered for the NOSI initiative.

Applications nonresponsive to terms of this NOSI will not be considered for the NOSI initiative.

Inquiries

Please direct all inquiries to the contacts in Section VII of the listed notice of funding opportunity with the following additions/substitutions:

Scientific/Research Contact(s)

Gila Neta, Ph.D.
National Cancer Institute (NCI)
Telephone: 240-276-6785
Email: gila.neta@nih.gov

Jennifer N. Baumgartner, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)
Phone: 301-402-4084 
Email: jennifer.baumgartner@nih.gov

Mary Masterson, Ph.D.
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-827-6113
Email: mary.masterson@nih.gov

Emerald Nguyen, Ph.D.
National Institute on Aging (NIA)
Telephone: 301-555-1212
E-mail: emerald.nguyen@nih.gov

Adriana Costero-Saint Denis, Ph.D.
National Institute of Allergy and Infectious Diseases (NIAID)
Telephone: 301-496-2544
E-mail: acostero@niaid.nih.gov

Rebecca Lenzi, Ph.D.
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Telephone: 301-496-7677
Email: rebecca.lenzi@nih.gov 

Randy Capps, Ph.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 301-827-5423
Email: randy.capps@nih.gov 

Ashlinn Quinn, Ph.D.
National Institute of Environmental Health Sciences (NIEHS)
Telephone: 984-287-4647
Email: ashlinn.quinn@nih.gov

Nadra Tyus, DrPH, MPH
National Institute of Nursing Research (NINR)
Email: nadra.tyus@nih.gov

Arielle Gillman, Ph.D.
National Institute of Minority Health and Health Disparities (NIMHD)
Telephone: 301-435-0060  
Email: arielle.gillman@nih.gov

Marya Levitanova, Ph.D.
Fogarty International Center (FIC)
Telephone: 301-496-1653
E-mail: ml531h@nih.gov
 

Peer Review Contact(s)

Examine your eRA Commons account for review assignment and contact information (information appears two weeks after the submission due date).

Financial/Grants Management Contact(s)

Crystal Wolfrey
National Cancer Institute (NCI)
Telephone: 240-276-6277
Email: wolfreyc@mail.nih.gov
 

Ryan Blakeney
National Institute on Aging (NIA)
Phone: 301-451-9802
E-mail: blakeneyr@mail.nih.gov

Robert Kirker 
National Institute of Allergy and Infectious Diseases (NIAID)
Telephone: 301-451-3176
Email: robert.kirker2@nih.gov

Erik Edgerton
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Phone: 301-594-7760
E-mail: erik.edgerton@nih.gov

Margaret Young
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Telephone: 301-642-4552
Email: margaret.young@nih.gov

Jenny Greer
National Institute of Environmental Health Sciences (NIEHS)
Phone: 984-287-3332 or 919-892-4180
Email: jenny.greer@nih.gov

Priscilla Grant, JD
National Institute on Minority Health and Health Disparities (NIMHD)
Phone: 301-594-8412
E-mail: pg38h@nih.gov

Ron Wertz
National Institute of Nursing Research (NINR)
Telephone: 301-594-2807
Email: wertzr@mail.nih.gov

Mollie Shea
Fogarty International Center (FIC)
Phone: 240-669-2960
E-mail: mollie.shea@nih.gov