Key Dates

Related Announcements

• November 14, 2024 - Notice of Special Interest (NOSI): Implementation Science for Climate Change and Health. See NOT-CA-25-003
• October 30, 2024 - PAR-25-143 - Dissemination and Implementation Research in Health (R21 Clinical Trial Optional). See PAR-25-143
• October 30, 2024 - PAR-25-144 - Dissemination and Implementation Research in Health (R01 Clinical Trial Optional). See PAR-25-144
• October 30, 2024 - PAR-25-233 - Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed). See PAR-25-233

Issued by

National Institute of Mental Health (NIMH)

Purpose

The purpose of this Notice is to inform potential applicants of NIMH's participation, effective November 30, 2024, in NOT-CA-25-003 "Notice of Special Interest (NOSI): Implementation Science for Climate Change and Health."

The following text has been added to reflect NIMH's participation in this NOSI:

Part 1. Overview Information

Components of Participating Organizations

National Institute of Mental Health (NIMH)

Assistance Listing Number(s)

93.242

National Institute of Mental Health (NIMH)

The National Institute of Mental Health (NIMH) is interested in applications relevant to dissemination and implementation (D&I) research that support the NIMH Strategic Plan for Research. Because NIMH requires investigative teams to study the mechanisms underlying interventions (for instance, for drugs, devices and behavioral interventions directed at patients, NIMH requires  the experimental therapeutics approach), all applications that propose clinical trials to test D&I strategies should go beyond assessing just whether a strategy is effective and should include hypotheses about how, why, for whom, and/or in what circumstances the strategy is effective.  Potential approaches include but are not limited to mediation analyses (e.g., mediator mapping), moderator analysis, temporally organized dismantling designs, and partial or full factorial designs.  For multi-component or multi-level strategies (e.g., approaches that combine multiple strategies to improve intervention reach, adoption, implementation, scalability, or sustainability of an intervention such as the Collaborative Care Model), other methods to examine the combined or dismantled effects of each of the components on the ultimate outcome(s) (versus modelling such effects through target/mediator variables) could also be employed, particularly if the study is adding a new component to enhance the effect of the combined strategy. 

NIMH encourages a deployment-focused model of intervention design and testing that considers the perspective of relevant end-users (e.g., service users, providers, administrators, payers, policy makers) and the key characteristics of the settings (e.g., resources, including workforce capacity; existing clinical workflows).  To this end NIMH strongly encourages meaningful inclusion of end-users in the research (e.g., member of an advisory panels and/or inclusion as key personnel).  This attention to end-user perspectives is intended to help ensure the research findings will have clear utility to communities, practices, and/or policy makers who may benefit from those findings.
Adaptations or augmentations of existing implementation strategies should only be undertaken if there is (a) an empirical rationale for the adaptation/augmentation, (b) a clear hypothesis to understand how and why the adapted  or augmented strategy will enhance outcomes, and (c) evidence to suggest that the adapted strategy will result in a substantial improvement in implementation outcomes (e.g. reach, adoption, scalability, sustainment) associated with the strategy and/or clinical or functional outcomes associated with the intervention.  For more information, see https://www.nimh.nih.gov/funding/opportunities-announcements/clinical-trials-NOFOs.

Submit applications for this initiative using one of the following notices of funding opportunity (NOFOs) or any reissues of the announcements listed below through the expiration date listed in NOT-CA-25-003. 

It is strongly encouraged that applicants contact NIMH program staff prior to submission to ensure that applicants are responsive to the institute’s priorities and criteria.
 

Inquiries

Please direct all inquiries to:

Laura Thomas, Ph.D.
National Institute Of Mental Health (NIMH)
Phone: 301-480-1624
E-mail: [email protected]