Release Date:  May 8, 1998

RFA:  TW-98-004


Fogarty International Center

Letter of Intent Receipt Date:  August 7, 1998
Application Receipt Date:  September 15, 1998


The Fogarty International Center (FIC) invites applications for Actions For
Building Capacity (ABC), a research training program issued jointly with, and
closely related to, the NIAID's International Collaborations in Infectious
Disease Research (ICIDR) program (RFA AI-98-009).

The ABC research training program will be supported by FIC through funding
applications in response to this RFA (TW-98-004).  Since the ABC is in direct
support of the ICIDR, ABC awards will only be made to awardees of ICIDR grants.

NOTE:  Investigators may apply for:  (1) an ICIDR award (in response to RFA AI-
98-009) or (2) BOTH an ICIDR award (in response to RFA AI-98-009) and an ICIDR-
Independent applications for this ABC RFA will not be accepted.

The purpose of this FIC training program, Actions for Building Capacity, is to
stimulate high quality training and to support current and future collaborative
training-related research on infectious diseases that are predominately endemic
in or impact upon people living in tropical countries.  The intent of the ABC
program is to provide training opportunities for foreign investigators which will
build research capacity and strengthen foreign and U.S. cooperation on tropical
infectious diseases.  Integration of the ABC and the ICIDR enhances the purposes
of both the ICIDR and the ABC.

The ABC will support training experiences for foreign scientists in the context
of ICIDR priority research areas (see RFA AI-98-009).  There are three
objectives:  1) to increase expertise of scientists in developing countries in
infectious disease-related biomedical, control and prevention research; 2) to
expand ongoing collaborative training in infectious disease research and
biomedical research between U.S. and foreign scientists; and 3) establish or
strengthen infectious disease research, treatment and control centers of
excellence in the home countries of trainees.


The Public Health Service (PHS) is committed to achieving the health promotion
and disease prevention objectives of  "Healthy People 2000," a PHS-led national
activity for setting priority areas.  This RFA is related to the priority area(s)
of immunization and infectious diseases.   Potential applicants may obtain a copy
of "Healthy People 2000" (Full Report:  Stock No. 017-001-00474-0 or Summary
Report:  Stock No. 017-001-00473-1) through the Superintendent of Documents,
Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800).


Applications may be submitted by domestic for-profit and non-profit
organizations; public and private institutions, such as universities, colleges,
hospitals, laboratories, etc.  All applicants for the FIC ABC grant must also
apply for the NIAID's ICIDR cooperative agreement.  The proposed PI for the NIAID
ICIDR must also be the proposed PI for the FIC ABC.  While for-profit
organizations may apply, they are strongly encouraged to develop linkages with
academic institutions to be able to offer the full range of training
opportunities included in the FIC ABC.  Racial/ethnic minority individuals and
women are encouraged to apply as Principal Investigators.  The U.S. grantee
institution is responsible for developing an affiliations(s) with an established
institution (e.g. university, research institute, federal or state health
department, hospital) in the host country.  No ABC award will be made unless the
applicant is successful in receiving an ICIDR award.  NIAID may make ICIDR awards
without ABC awards.


Awards will be made under the international training grants (D43), which limits
indirect costs to eight percent.  Fogarty will make awards to selected top
training applications.  These awards will only be made to ICIDR recipients.  The
total project period for an ABC application submitted in response to this RFA may
not exceed five years. At this time, the FIC has not determined whether and how
this solicitation will be continued beyond the present RFA.  FIC, with NIAID,
will conduct a program evaluation by the end of the fourth year of the ABC.  The
results will assist in determining the re-issuance of the RFA. If, by the end of
the fourth year of the award, the FIC has not announced their intent, due to
budget uncertainties or other reasons, to reissue the RFA, incumbents should
contact program staff before preparing a recompeting application to seek advice
on the most appropriate method of application submission.  FIC, with NIAID,
anticipate conducting a program evaluation early in the fourth year of the
program as part of the decision-process on whether to reissue this RFA.

The applicant organization's administrative support (including that available
through the companion ICIDR award) must provide the necessary management for the
transfer of funds and material to the off-site component.  Indirect costs will
not be paid on any expense incurred by the foreign institution(s).  Travel,
salaries, and fringe benefits will be subject to the applicant institution's
rules and regulations.

Grants will be made as D43 training grant awards for a project period of up to
five years.  Continued support during this period depends on satisfactory
performance of both the NIAID ICIDR and FIC ABC as judged by: annual progress
reports; site visits and meetings of program directors; career progress of
trainees (e.g., positions occupied, first author publications, presentations,
research undertaken and research awards received); and development of national
capacity for infectious disease related research, control and prevention,
including the establishment or strengthening of model infectious disease centers
of excellence in the home countries of trainees.  Assessment of performance will
be made jointly by FIC and NIAID.  Special program reviews will be conducted by
the FIC and NIAID.


Approximately $500,000 is anticipated for support of this program in FY 1999. 
Awards under this Fogarty capacity building program will only be made to
successful ICIDR applicants.  The maximum allowable support for the first year
is $54,000 ($50,000 direct costs plus 8% = $4,000).  A budget of approximately
$100,000 may be requested for years 02 to 05.  Depending on the availability of
funds for support of ABC in the future, FIC will consider this requested increase
when making future-year awards.


Scope of Training

Training Objectives

A.  The integration of the FIC Actions for Building Capacity (ABC) program and
the NIAID ICIDR will facilitate training of foreign scientists in the context of
ICIDR research priority areas and facilitate sustainable collaborative research
between the U.S. and foreign countries.  The establishment and strengthening of
scientific linkages between U.S. and foreign investigators stimulates self-
sufficiency of the collaborating foreign institution and enhances the scientific
infrastructure for additional international collaborative arrangements.  The
linkage of the ICIDR research and the ABC training programs is responsive to the
recommendations of the Committee on International Science, Engineering and
Technology Working Group on Emerging and Re-emerging Infectious Diseases which
specifically recommends the following actions by the U.S. government: 
"Encouraging and assisting other countries to make infectious diseases detection
and control a national priority; and, preserving existing U.S. Government
activities that enhance other countries abilities to prevent and control emerging
and re-emerging health threats." (As printed in Infectious Disease├żA Global
Health Threat, Report of the National Science and Technology Council Committee
on International Science, Engineering, and Technology Working Group on Emerging
and Re-emerging Infectious Diseases.  September 1995.)

B.  Specific Objectives:

Training Plan:  The training plan should include U.S.-based, long-term (usually
a minimum of two years) training leading to an advanced degree or to provide
postdoctoral training.  The ABC will promote and facilitate training courses
targeted toward specific needs, such as learning laboratory techniques and
transfer of medical informatics, biotechnology and other methods required to
support infectious disease research efforts in the home countries of the trainees
involved in the ICIDR research projects.  When a specific scientific course is
given by one ABC program it is expected that this course will be open to trainees
of other ABC award institutions.  Training activities will be coordinated,
facilitated and monitored by a training advisory group comprised of ABC PI's,
major foreign collaborators and the FIC and NIAID program officers or their

C.  Types of Training:

1.  Pre-doctoral training in infectious disease-related and biomedical research
disciplines, and data management and analysis in support of that research, which
may lead to an M.S. or Ph.D. or equivalent degree for individuals with or without
previous field research experience.  A masters or Ph.D. degree must be in support
of the ICIDR research.  The duration of training is estimated to range from about
two to four years.  In general, academic courses will be taken at the U.S. ICIDR
institution.  Field studies and research could be conducted in the U.S. but, to
the extent possible, should occur in the trainees' home country in the context
of the ICIDR project.  Active involvement in on-going research and prevention
projects is vital for a successful research and/or public health training
experience.  Innovative ways to involve trainees in ICIDR research projects
conducted in their home countries is encouraged.

2.  Postdoctoral research experiences, generally of two years duration for
foreign health scientists.

3.  Training of up to four weeks (or more if needed) in focused research
methodologies, such as molecular epidemiology, immunologic technologies and
clinical trial design.  It is anticipated that at least one such course will be
given each year, preferentially in a host country.

4.  Training of about three to six months duration conducted in the U.S. in
laboratory procedures and research techniques for example, development of pilot
biomedical studies for individuals with M.S. and M.D. or Ph.D. degrees.

D.  Trainees:

Trainees shall be individuals who are, or are expected to be, involved in
infectious diseases biomedical research activities in their home country.  The
following categories of foreign individuals are eligible for training:

1.  Health professionals (M.D., D.D.S./D.M.D., Ph.D., or equivalent).

2. Professionals with a bachelors or masters degree in a basic or health science.

3.  Medical technicians and health care workers (short courses).

4.  Allied health professionals such as behavioral scientists, nurses and social
workers (short courses).

5.  Current or former FIC trainees involved in advanced research training in
their home countries.


Each awardee will have a U.S. Principal Investigator (PI) and a Major Foreign
Collaborator (MFC). The PI and MFC will be responsible for the overall conduct
of the ABC.

Training Advisory Group.  The ICIDR Executive Committee will establish a Training
Advisory Group (TAG) to coordinate and facilitate training activities (See RFA
AI-98-009). The ABC PI and MFC will be predominantly responsible for progress
made by the trainees.  The TAG will include ABC PIs (who will also be ICIDR PIs),
the MFC for each ABC, the Fogarty Program Officer or designee and the NIAID
Program Officer or designee.  The TAG will have responsibility for reviewing,
coordinating, and facilitating training plans (and in-country training courses)
tied to research supported under the ICIDR, and for enhancing the progress of

Training in Responsible Conduct of Research.  Applicants are required to include
training in responsible conduct of research as a part of the program.  An award
will not be made unless a description of such training is included.

Recruitment and Selection Plan.  The applicant institution must include a plan
describing the recruitment and selection procedures for trainees, a detailed
description of peer review for training-related and advanced in-country research
(re-entry grants), and plans for continued collaboration with former trainees. 
Degree candidates must meet all entrance requirements of the U.S. degree granting
institution. The grant applications should clarify and completely specify:  (a)
criteria and procedures for the selection of trainees as, for example, by a
committee composed of U.S. and foreign investigators at participating
institution(s) and (b) a mechanism for internal peer review of applications to
support in-country research projects.

Tracking System For Long Term Impact.  As part of their obligations under this
program, awardees are required to design and implement a system to fully track
and document the long-term impact of this training program on:  (1) the careers
of current and former trainees; (2) research capacity in the home institution of
trainees; (3) types of positions the proposed trainees may assume upon completion
of training; (4) the contributions to future NIH international infectious disease
prevention and clinical research efforts; and (5) the establishment or
strengthening of infectious disease research centers of excellence in the home
countries of trainees.   Examples of such impact include how training received
under the program has allowed participants to assume more responsible positions
upon returning home, how continuing collaborations with former trainees resulted
in the funding of infectious disease prevention or collaborative research
projects for which trainees were either principal investigators or co-
investigators, and publications in which trainees were first authors and which
were based upon support under this program.

Coordination and Collaboration.  Coordination and collaboration of the ABC
Program with other FIC award programs and affiliated institutions, especially
when operating within the same country, will be of benefit to all partners.  The
coordination of activities among training sites will be facilitated by the FIC,
in conjunction with NIAID, and will include organization of joint meetings to be
held during international and regional scientific or public health meetings. 
Program applicants are strongly encouraged to include plans, if possible for
coordination and collaboration with other FIC training programs:  these include
the FIC AIDS International Training and Research Program (AITRP), the
International Training and Research Program in Emerging Infectious Diseases
(ITREID) the International Training and Research Program in Environmental and
Occupational Health (ITREOH), the International Training and Research Program in
Population and Health, the International Cooperative Biodiversity Groups Program,
the Minority International Research Training Program (infectious disease related
activities), the newly established Medical Informatics Program and with other
NIH-sponsored programs when working in common countries and/or regions.

Given the increased emphasis on infectious disease research training and research
globally, FIC will also facilitate coordination and collaboration with other
government agencies (e.g., CDC, USAID, DoD, etc.) and with bilateral and
multilateral international organizations, including the World Health Organization
(WHO), Pan American Health Organization (PAHO), and in-country projects funded

Allowable Costs

The following cost categories are allowable and serve only as a guide under the
training portion considering the limited amount of funds available particularly
for the first year.

A.  Stipend and Salary

1.  Living allowance (stipend) comparable to trainee's professional level, in
accordance with grantee institutional policies but not to exceed $35,000 per
annum while undergoing training in the U.S.;

2.  Living allowance (stipend) while conducting in-country dissertation research
or in-country advanced research training (re-entry grants) at a level comparable
to that received by similar professionals in-country, in accordance with grantee
institutional policies, but also not to exceed $35,000 per annum;

3.  Stipend support (not to exceed $35,000 per year) for foreign and (with prior
FIC approval) for U.S. postdoctoral researchers;

4.  In general, for the purposes of this award U.S.-based faculty would not be
supported in the first year of this program.  It is expected that the companion
ICIDR would support U.S. faculty participation in research training activities
conducted in-country.  In years 2-5, resources permitting, support (pro-rated
salary, up to 10 percent of annual salary or $10,000, whichever is less) could
be considered, to enable U.S. faculty to be involved in advanced research
training activities conducted in-country;

B.  Travel

1.  Round trip economy class air fare between the U.S. and home country (during
the five years, two trips for M.S./Ph.D. candidates and advanced research
trainees, one for all others);

2.  Travel and per diem for the program director and faculty colleagues to
provide guidance to students conducting dissertation-related field studies and/or
advanced research training in their home countries;

3.  Travel and per diem for faculty presenting short-term, in-country courses;

4.  Travel for participation in networking and program coordination meetings.

C.  Tuition

Tuition, not to exceed 20% of total direct costs.  Exceptions to this policy
require prior approval from the FIC.

D.  Training Related Expenses

1.  Allowance for the grantee institution of up to $600 monthly per student to
cover health insurance, scientific meetings, and incidental research expenses;

2.  Support of up to $7,500 for in-country field research in partial fulfillment
of the M.S./Ph.D. training program;

3.  Research support of up to $10,000 per trainee to facilitate the conduct of
advanced research training (re-entry grants) in the home country conducted by
current and/or former FIC program trainees; the program director is expected to
have projects submitted for this funding peer reviewed by the U.S. institution
in accordance with plans outlined in the grant application.


It is the policy of the NIH that women and members of minority groups and their
sub-populations must be included in all NIH supported biomedical and behavioral
research projects involving human subjects, unless a clear and compelling
rationale and justification are provided that inclusion is inappropriate with
respect to the health of the subjects of the purpose of the research.  This
policy results from the NIH Revitalization Act of 1993 (Section 492B of Public
Law 103-43).

All investigators proposing research involving human subjects should read the
"NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical
Research," which has been published in the Federal Register of March 28, 1994 (FR
59 14508-14513) and the NIH Guide for Grants and Contracts, Vol. 23, No. 11,
March 18, 1994.

Investigations carried out under the ABC will be in accordance with U.S.
government guidelines, including obtaining any required single project assurances
(and possibly multiple project assurances) from the NIH Office for Protection
from Research Risks.

Investigators may obtain copies of these documents from Dr. Joel Breman (listed


Prospective applicants are asked to submit, by August 7, 1998, a letter of intent
that includes a descriptive title of the overall proposed research; the name,
address and telephone number of the Principal Investigator; the country(ies) and
possible institutions to which the U.S. institution will be linked; and the
number and title of this RFA.  Although the letter of intent is not required, is
not binding, does not commit the sender to submit an application, and does not
enter into the review of subsequent applications, the information that it
contains allows NIH staff to estimate the potential review workload and to avoid
conflict of interest in the review.  The letter of intent is to be sent to Dr.
Joel Breman with a copy to Dr. Hortencia Hornbeak at the addresses listed under


Applications are to be submitted on the standard research grant application form
PHS 398 (rev. 5/95), using the instructions for Institutional National Research
Service Awards on page V-1.  Application kits are available at most institutional
offices of sponsored research and may be obtained from the Division of Extramural
Outreach and Information, National Institutes of Health, 6701 Rockledge Drive,
MSC 7910, Bethesda, MD 20892-7910, telephone (301) 710-0267, email:

For purposes of identification and processing, item 2 on the face page of the
application must be marked "YES" and the RFA number "TW-98-004" and the words
"ACTIONS FOR BUILDING CAPACITY" must be entered on the face page.

Applications must be received by September 15, 1998.  The RFA label available in
the application form PHS 398 must be affixed to the bottom of the face page. 
Failure to use this label could result in delayed processing of the application
such that it may not reach the review committee in time for review.

Submit a signed, typewritten original of the application, including the
checklist, and three signed, exact, single-sided photocopies, in one package to:

6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

At the time of submission, two additional exact copies of the grant application
and all five sets of any appendix material must be sent to Dr. Hornbeak at the
address listed under INQUIRIES.


Upon receipt, applications will be reviewed for completeness by the Center for
Scientific Review (CSR) and for responsiveness by FIC staff; those judged to be
incomplete will be returned to the applicant without review.  Those considered
to be non-responsive will be returned without review.

NIAID will conduct the initial scientific review on behalf of the FIC, as part
of the overall review of the ICIDR and ABC applications.  Applications that are
complete and responsive to the RFA will be evaluated for scientific and technical
merit by a peer review group convened by the NIAID in accordance with the review
criteria stated below.  As part of the initial merit review, all applications
will be discussed, assigned a priority score and receive a written critique as
well as receive a second level review by the FIC Advisory Board.

Review Criteria

Applicants for an ABC training award must also have applied for an ICIDR research
award.  The scientific evaluation of each application will include assessment of
the linkage between proposed training and the research defined in the ICIDR
application.  Evidence of support for the ABC from collaborating institutions and
host governments must be submitted with the application.

A.  Significance

1.  The expected public health and scientific contributions of the proposed

2.  The demonstrated capacity and/or potential to achieve sustained research and
training efforts, and to build clinical and operational research and public
health capacity within a country.

B.  Approach

1.  Balance in the proposed training program to provide breadth of training
opportunities in the field of academic-based, infectious diseases-related
training in biomedical and clinical sciences and prevention research;

2.  The mix of long- and short-term training to achieve the goals of this RFA,
including focused efforts to build long-term biomedical, clinical and operational
research and public health capacity at a model infectious disease center of
excellence within a collaborating country;

3.  Adequacy of proposed procedures and criteria for 1) recruitment, review and
selection of trainees, and 2) peer review of research and infectious disease
control and prevention projects;

4.  Adequacy of plans to include an adequate representation of women among
foreign trainees.

C.  Innovation

1.  Plans for trainees to become involved in infectious diseases-research,
control and prevention projects conducted in their home countries; and

2.  Adequacy and creativity of plans including use of the modern information
technology to facilitate access to scientific information, distance learning,
coordination and research collaboration.

D.  Investigator(s)

1.  Qualifications of the program director to lead and the named faculty to
participate in the proposed training and research program;

2.  Active research support of the program director and participating faculty.

E.  Environment

1.  The strength of resources and training environment in-country as evidenced
by 1) the quality of teaching and the in-country research facilities and other
resources; 2) the availability of high-quality candidates chosen on the basis of
merit; and 3) past history of success of former trainees returning to their home
countries and their continued involvement in the program; for example, the
participation of past trainees in advanced in-country research and as faculty and
mentors for new trainees; and

2.  Training environment in the U.S., including the institutional commitment, the
caliber of preceptors, the quality of teaching and research facilities and

F.  The initial review group will also examine the adequacy of the process for
providing for the protection of human and animal subjects and the safety of the
research environment, and plans to include training in responsible conduct of
research and training in the operation of IRBs, data and safety monitoring boards
and community advisory boards as a part of the program.  IRBs in the home
countries of trainees will be responsible for determining the adequacy of
inclusion of women and minorities in research involving human subjects in their


The following will be considered in making funding decisions:

Whether NIAID plans to make a companion ICIDR award and:

1.  the extent and effectiveness of efforts made by applicants in developing 
biomedical and prevention research training programs necessary to support
infectious diseases-research and biomedical research efforts in the home
countries of trainees including efforts made to focus resources to build long-
term clinical research, operational research and public health capacity at a
model infectious diseases center in the home country of trainees;

2.  cost-effectiveness of programs;

3.  efforts made to collaborate with other NIH ICDs, CDC, and USAID programs and
institutions and with other organizations;

4.  the extent to which proposed training programs support and complement other
NIH international infectious diseases research efforts;

5.  availability of funds including the capability to expand (at least double)
training and capacity building efforts should additional resources become
available for this purpose from FIC or other sources;

6.  program balance among critical research and public health training areas of
emphasis such as, but not limited to, U.S. academic training; and

7.  geographic distribution among countries included in applications under
consideration, including the need for a given program to work in a specific

Before any funds can be expended from this award, the grantee institution must
show evidence of approval for collaborative research and training between the
U.S. and foreign countries and institutions included in the program through an
endorsement from the Minister of Health or other appropriate government official
as well as from the collaborating institutions.


Written and telephone inquiries concerning this RFA are strongly encouraged.  The
opportunity to clarify any issues or questions from potential applicants is

Direct inquiries regarding ABC programmatic (training scope and eligibility)
issues to:

Joel G. Breman, M.D., D.T.P.H.
Division of International Training and Research
Fogarty International Center
31 Center Drive, Room B2C39, MSC 2220
Bethesda, MD  20892-2220
Telephone:  (301) 496-1653
FAX:  (301) 402-0779

Direct inquiries regarding review issues and special instructions for application
preparation; and mail two copies of the application and all five sets of
appendices to:

Hortencia Hornbeak, Ph.D.
Division of Extramural Activities
National Institute of Allergy and Infectious Diseases
6003 Executive Boulevard, Room 3C16
Bethesda, MD  20892
Telephone:  (301) 496-7291
FAX:  (301) 402-2638

Direct inquiries regarding ABC fiscal matters to:

Ms. Silvia Mandes
Division of International Training and Research
Fogarty International Center
31 Center Drive, Room B2C39, MSC 2220
Bethesda, MD  20892-2220
Telephone:  (301) 496-1653
FAX:  (301) 402-0779


Letter of Intent Receipt Date:  August 7, 1998
Application Receipt Date:       September 15, 1998
Scientific Review Date:         February 1999
FIC Advisory Board:             May 18, 1999
Earliest Award Date:            June 1999


Awards are made under authorization of the Public Health Service Act, Title IV,
part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285)
and administered under PHS grants policies and Federal regulations 42 CFR 52 and
45 CFR Part 74.  This program is not subject to the intergovernmental review
requirements of Executive Order 12372 or to Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a smoke-
free workplace and promote the non-use of all tobacco products.  In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain
facilities (or in some cases, any portion of a facility) in which regular or
routine education, library, day care, health care or early childhood development
services are provided to children.  This is consistent with the PHS mission to
protect and advance the physical and mental health of the American people.

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