MINORITY INTERNATIONAL RESEARCH TRAINING GRANTS Release Date: November 22, 1999 RFA: TW-00-001 Fogarty International Center Office of Research on Minority Health Letter of Intent Receipt Date: December 10, 1999 Application Receipt Date: January 14, 2000 PURPOSE Since 1993 the Fogarty International Center (FIC) and the Office of Research on Minority Health (ORMH) of the National Institutes of Health (NIH) have jointly supported scientific training programs that offer international research training opportunities to qualified minority undergraduates and graduate and medical students underrepresented in biomedical and behavioral research careers. Innovative programs that provide international research and training are supported to: 1. Encourage under-represented minority students to pursue biomedical research careers. 2. Broaden minority research efforts and scientific training to encompass international health problems. 3. Stimulate novel approaches to studying health problems that disproportionately affect underserved groups in the U.S. or in developing countries. 4. Assist minority scientists to participate in international collaborative research relationships and work effectively in the rapidly evolving global scientific environment. The Minority International Research Training (MIRT) program is a component in the long-term National Institutes of Health (NIH) strategy to decrease health disparities between minority and majority groups in the U.S. This Request for Applications (RFA) to support MIRT programs at U.S. colleges and universities contains revisions that supercede all requirements in previous MIRT RFAs. The most significant change is the increased emphasis on providing international research training experiences for undergraduate students. Proposed programs may also include graduate and medical students but should restrict faculty research to activities associated with mentorship of research trainees. Priority will be given to funding MIRT program proposals that emphasize research training related to health disparities among under-served populations in the U.S. or in developing countries. Both new and competing renewal applications are welcome. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of Healthy People 2000, a PHS- led national activity for setting priority areas. This RFA, Minority International Research Training (MIRT) Grants, is related to one or more of the priority areas. Potential applicants may obtain a copy of Healthy People 2000 at http://odphp.osophs.dhhs.gov/pubs/hp2000. ELIGIBILITY REQUIREMENTS The applicant institution and its associated consortia institutions must be U.S. colleges or universities that offer baccalaureate degrees in fields relevant to biomedical and behavioral sciences. Only one application per institution will be accepted for review. Those institutions that are currently holding a MIRT award from the FY 1999 competition are excluded. A consortium can be formed by the applicant institution that has an active international scientific research effort with institutions with limited research and training activities for the purpose of recruiting eligible student and faculty participants. Priority will be given to consortia that include Historically Black Colleges and Universities, Hispanic Serving Institutions or Tribal Colleges and Universities. Participating students and faculty must be U.S. citizens or permanent residents. Applications will be accepted for programs which recruit participants from institutions with enrollments that include substantial numbers of students and faculty who are members of socially or economically disadvantaged groups who are underrepresented in careers in biomedical and behavioral research. Studies show groups that are underrepresented in biomedical and behavioral research careers in the U.S. include but are not limited to African Americans, Hispanic Americans, Native Americans, Asian/Pacific Islanders, persons with disabilities and women. Programs should recruit participants who could most benefit from a financially supported opportunity for international scientific research experience. Programs should focus on supporting students and faculty to pursue biomedical and behavioral research careers that will most likely contribute to the elimination of health disparities that exist among disadvantaged populations in the U.S and between populations living in developing countries and the U.S. Applicants should define the nature and extent of the eligible students and faculty members of underrepresented groups available for recruitment to the program at their institution and consortium institutions. Undergraduate Participants Proposed programs should give undergraduate research training priority by selecting approximately 75% undergraduate participants out of at least ten participants per year. It is suggested that undergraduate participants have completed approximately two years of coursework in a major related to biomedical or behavioral science, a minimum GPA of 3.0 and/or show other evidence of exceptional scientific interest and talent. Previous undergraduate research experience is recommended before entering the MIRT program. Graduate and Medical Student Participants Approximately 25% of the student participants can be graduate or medical students each year. Priority should be given to students who wish to perform research especially pertinent to health disparities among underserved groups in the U.S. or in developing countries. Programs can support medical students who show evidence of commitment to pursuing a career in research. Graduate and medical students must be involved in original data collection. Routine clinical or lab work, coursework or training in scientific techniques alone are not the objective of the training supported by this RFA except in so far as they allow the students to be involved in original data collection. U.S. Faculty Participants The program director should be a full-time faculty member at the applicant institution and principal investigator for the application. The program director will be responsible for selecting and matching student participants and faculty mentors, screening training plans for foreign sites and coordinating the activities of the program in which all trainees participate. The program director is also responsible for coordinating evaluations of program participants and submitting annual progress reports and trainee tracking data to the Fogarty International Center. Therefore, program directors should show evidence of experience at administering multifaceted international research programs involving significant student training activity. Other U.S. faculty participants who will serve as mentors for student participants must have doctoral degrees and full-time appointments at the applicant institution or at an institution in an associated consortium. U.S. faculty mentors should show evidence of their ongoing collaboration with the proposed foreign training site institution including sources of funding for research conducted there and recent publications resulting from that research. U.S. faculty mentorship may be supported at foreign sites in developing countries. A proposed training plan should be submitted describing possible student research projects, research skills to be taught and estimating the time that the mentor will spend with students in research and training activities before, during (if necessary) and after travel to the foreign site. Proposed U.S. faculty mentors should also provide evidence of experience in successfully training undergraduate or graduate students in international research. If a minority faculty member is not available, any faculty member who meets the eligibility criteria may serve as a mentor. Foreign Faculty Participants International research training should be planned at universities or research institutions where U.S. faculty participants have ongoing collaborative research relationships. Foreign research collaborators with doctoral degrees and full-time positions can serve as mentors for students training at the foreign site(s). Foreign collaborators should provide a letter of collaboration. Information describing the foreign site institutional research effort and productivity in the student project research field and documenting the sources of funding for this research should be submitted. A proposed training plan should be submitted describing possible student research projects, research skills to be taught and estimating the time that the mentor will spend with students in research and training activities during their time at the foreign site. Students must be involved in original data collection, not routine clinical or lab work. In order to build ongoing international collaborations, it is recommended that groups of two or more student trainees visit the same foreign research site(s) associated with a program each year during the life span of the award unless FIC approves a well justified change of sites. MECHANISM OF SUPPORT This RFA will use the NIH institutional training grant (T37) award mechanism. Responsibility for the planning, direction and execution of the proposed project will be solely that of the applicant. The total project period for an application submitted in response to this RFA should not exceed four years. The anticipated award date for the FY 2000 competitive review is June 1, 2000. Each training grant award must not exceed a total of $200,000 per year, including direct and indirect costs. Applicants are encouraged to propose the most effective program with a well justified budget most appropriate to their institutional setting. Allowable Costs All budget items should be itemized on the NRSA substitute budget pages OO and PP in the categories noted in parentheses. 1. During the training period at the foreign site, a minimum of 10-12 weeks, stipends of $800 per month may be requested for junior or senior undergraduates and stipends of $1225 per month may be requested for graduate and medical students. (Stipends-predoctoral) 2. For U.S. faculty mentors, stipends of up to $1250 per month may be requested for the training period, approximately 10-12 weeks, if no other federal salary support is available during the time requested to work at the foreign site. (Stipends-postdoctoral) 3. A $500 honorarium may be offered to the foreign mentors from developing country institutions that do not charge student bench fees or tuition. (Other) 4. Funds to support student research costs (such as lab supplies, computer access, small equipment) at the foreign site may be requested for up to a maximum level of $600 per month per student. The anticipated costs should be itemized for each foreign site and justification should be provided as to why these expenses cannot be covered by funding that already supports faculty research at the foreign site. (Training related expenses) 5. Funds for tuition, fees and self-only medical insurance expenses associated with the international research experience may be requested up to a maximum level of $1500 per student participant. Tuition at the U.S. institution for trainees during travel to the foreign site will be allowed only if such charges are required of all persons in similar training status at that institution. Bench fees at foreign institutions are allowed in the category of tuition. Tuition for specific coursework related to the project, such as language courses at the U.S. or foreign institution can be supported. The program may provide funds to cover fees for passports, visas, Centers for Disease Control and Prevention recommended vaccinations and prophylactic drugs. Students and faculty should be required to have medical insurance coverage while travelling to a foreign site. If institutional or personal medical insurance does not cover participants, self-only medical insurance may be charged to the grant. All expenses in the category of tuition, fees and insurance should be itemized and justified for each foreign site. (Tuition, fees and insurance) 6. Foreign living expenses of up to $1000 per month may be requested for participants. Budgets should provide a list of costs and description of living conditions at each foreign site. Additional funds (up to $2000 per month) may be requested for U.S. faculty mentors with thorough justification of increased need. (Trainee travel) 7. Students from consortium institutions may be supported for travel and per diem expenses to attend orientation and responsible conduct of research presentations as well as post-travel activities associated with the MIRT program at the director’s institution. (Trainee travel) 8. Economy class round trip airfare on U.S. carriers (to the maximum extent possible) and local ground transportation to the foreign site may be requested. Anticipated costs should be provided for travel to each foreign site. (Trainee travel) 9. Travel expenses may be requested for short-term visits (less than 1 month) of foreign faculty mentors to the U.S. applicant institution or associated consortia institutions to participate in MIRT program associated student training and related collaborative research activities such as planning, writing scientific manuscripts or grants, etc. Short-term travel expenses may include economy class round trip airfare on U.S. carriers (to the maximum extent possible) plus per diem at U.S. government rates. Current U.S. government per diem allowances can be checked at this web site: http://www.gsa.gov/Portal/gsa/ep/contentView.do?contentId=17943&contentType=GSA_BASIC. (Trainee travel) 10. The applicant institution may request up to ten percent of total direct costs to support the principal investigator and/or other personnel for administrative efforts related to the MIRT program. The administrative responsibilities and time commitment for personnel receiving salary support should be thoroughly described. To calculate the maximum amount allowed, take 10% of the sum of the expenses from all other categories. (Other) 11. Funds may be requested for administrative expenses such as photocopying, MIRT course materials, long distance phone/fax costs, etc. directly related to the MIRT program. (Training related expenses) 12. Funds may be requested to cover expenses related to MIRT program evaluation requirements such as post-travel meetings, internet access and computer software needed for Web based reporting and tracking of student trainees. The purchase of one computer to be devoted to MIRT activities may be requested with sufficient justification. A laptop model computer is recommended for additional MIRT use at foreign sites. (Training related expenses) 13. Funds should be requested (flight plus per diem for two days for each year of the award) for the MIRT program director to attend an annual network meeting in Washington, D.C., sponsored by Fogarty International Center and the Office of Research on Minority Health. (Trainee travel) 14. Funds may be requested to support MIRT students to present their research findings at national scientific conferences. (Trainee travel) 15. Facilities and administrative expenses (indirect costs) should be included in the budget request at a rate of eight percent of allowable direct costs. (Checklist form page II) FUNDS AVAILABLE The Fogarty International Center and the Office of Research on Minority Health intend to commit approximately $1,800,000 to fund 9 to 10 new and/or competing renewal awards in FY 2000. An applicant may request a project period of up to four years and an annual budget of up to $200,000 total costs. Because the nature and scope of the projects proposed vary, it is anticipated that the size of each award will vary. Although the financial plans of the Fogarty International Center and the Office of Research on Minority Health provide support for this program, awards pursuant to this RFA are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications. At this time, it is not known if competing renewal applications beyond FY 2000 will be accepted and /or if this RFA will be reissued after FY 2000. TRAINING OBJECTIVES The Minority International Research Training grants are designed to offer research training opportunities to qualified eligible students and faculty to participate in international biomedical and behavioral research programs abroad. The proposed training program is expected to increase awareness of international research issues and opportunities, acquaint students with a range of career opportunities in biomedical and behavioral research and encourage participants to pursue post-baccalaureate degrees and careers in biomedical and behavioral research especially related to minority health problems. The program is also expected to enhance the training efforts and international collaborative research activities of the faculty participants. The following specific objectives have been identified based on the overall goals for the MIRT program: 1. To support research experience for qualified eligible undergraduate students in international laboratories under the mentorship of outstanding U.S. and foreign scientists including: o Training in experimental design, interpretation of data and the use of current scientific equipment and analytical methods. o Knowledge of the scientific literature associated with their projects, biomedical research ethics and cultural aspects affecting scientific and medical issues at the foreign site. o Experience in the written and oral presentation of scientific research. o Encouragement to complete a baccalaureate degree and enter graduate or professional school to pursue a biomedical or behavioral research career. 2. To support eligible graduate and medical student training in an international setting that provides unique opportunities for research relevant to their dissertation or clinical studies, contributes to the completion of advanced biomedical or behavioral science degrees and results in scientific conference presentations and publications. 3. To facilitate research collaborations between minority scientists and scientists at centers of excellence in biomedical and behavioral research abroad resulting in expanded research capabilities, scientific conference presentations, publications and subsequent grant applications for continuing research support. The Fogarty International Center and Office of Research on Minority Health recognize that there will be significant differences in the institutional environments, participants and approaches to international research collaboration among applicant programs. Therefore, applicants should define the goals, methods to achieve these goals and specific measurable objectives (such as recruitment success, scientific productivity, career outcomes, etc.) to assess their program with reference to the overall goals described above. SPECIAL REQUIREMENTS Program Evaluation The Program Director will be required to interact regularly with Fogarty International Center staff who will closely monitor the progress of each training grant program through in-depth reviews of annual progress reports, network meetings and site visits. Applications should include a description of how the program will be evaluated by its participants and how the scientific training and research progress of all participants will be monitored. A progress report will be required at the end of each budget year. Data on each current and previous participant will be submitted via the Internet to a web based tracking system that will be used to monitor the impact of the program on the careers of these participants. Therefore, applicants should describe their capability to monitor and submit data on current participants as well as previous participants (including those from consortium institutions) via the Internet. Details of the required format for the narrative progress report and instructions for submission of data to the Web tracking system will be provided by the Fogarty International Center when grants are awarded. Responsible Conduct of Research Applicants should describe plans for mandatory teaching of responsible conduct in biomedical research to all trainees including the topics, format, participation of faculty, instructional materials, and the frequency and duration of the training provided and how trainee attendance will be monitored. If the proposed program accepts students from other institutions, an explanation of how they will participate in this training must be provided. If the plan is unacceptable to application reviewers, the application will not be considered for an award until an acceptable plan is provided. Protection of Research Subjects Applicants should be aware that provisions for the protection of human research subjects and laboratory animals must be met in research done in both domestic and foreign institutions including obtaining any necessary single project assurances. Applicants should see Title 45 CFR, Part 46 for information concerning Department of Health and Human Services regulations for the protection of human subjects and the PHS Policy on the Humane Care and Use of Laboratory Animals. These are available from the office for Protection from Research Risks, National Institutes of Health, 6100 Executive Boulevard, MSC 7507, Rockville, MD 20892-7507 (http://www.hhs.gov/ohrp/). INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their sub-populations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public law 103-43). All investigators proposing research involving human subjects should read the NIH Guideline for Inclusion of Women and Minorities as subjects in Clinical Research which was published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts Vol.23 No.11, March 18, 1994, available on the web at: http://grants.nih.gov/grants/guide/notice-files/not94-100.html. For international research, the frame of reference for inclusion of minorities in research is whether the participants would be considered to be minorities in the U.S. population. Programs are encouraged to include adequate representation of women in selecting foreign and U.S. participants. INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of NIH that children (i.e. individuals under the age of 21) must be included in all human subjects research conducted or supported by the NIH unless there are scientific and ethical reasons not to include them. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the NIH Policy and Guidelines on the Inclusion of Children as Participants in Research Involving Human subjects that was published in the NIH Guide for Grants and contracts, March 6, 1998 and is available at: http://grants.nih.gov/grants/guide/notice-files/not98-024.html. Investigators also may obtain copies of these policies from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. LETTER OF INTENT Prospective applicants are asked to submit a letter of intent that includes a descriptive title of the proposed research training, the name, address, email address, telephone and fax number of the Program Director, the identities of other key personnel and participating institutions and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding and does not enter into the review of a subsequent application, the information that it contains allows the Fogarty International staff to estimate the potential review workload and avoid conflict of interest in the review. The letter of intent is to be sent to the program staff listed under INQUIRIES by the receipt date listed in the heading of this RFA. APPLICATION PROCEDURES The research grant application form PHS 398 (rev. 4/98) is to be used in applying for these grants. Applicants should use the additional instructions for preparing Institutional NRSA applications on pages V1-V7 in Form 398 when preparing their applications. These forms are available at most institutional offices of sponsored research and from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301-710-0267, email: GrantsInfo@nih.gov. The RFA label available in the PHS 398 application form must be affixed to the bottom of the face page of the application. The RFA label and line 2 of the application form must indicate the RFA number. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number must be typed on line 2 of the face page of the application form and the YES box must be marked. The sample RFA label available at: http://grants.nih.gov/grants/funding/phs398/labels.pdf has been modified to allow for this change. Please note this is in pdf format. Submit a signed, typewritten original of the application, including the Checklist and three signed photocopies in one package to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) At the time of submission, two additional copies of the application must be sent to: Helen Sunshine, Ph.D. Office of Scientific Review National Institute of General Medical Sciences Room 1AS.13fF 45 Center Drive MSC 6200 Bethesda, MD 20892-6200 Telephone: (301) 594-2881 FAX: (301) 480-8506 Email: sunshinh@nigms.nih.gov Applications must be received by the application receipt date listed in the heading of this RFA. If an application is received after that date, it will be returned to the applicant without review. The Center for Scientific Review (CSR) will not accept any application in response to this RFA that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. The CSR will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of substantial revisions of an application already reviewed, but such applications must include an introduction addressing the previous critique. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for completeness by CSR and responsiveness by the Fogarty International Center. Incomplete and/or non- responsive applications will be returned to the applicant without further consideration. Applications that are complete and responsive to the RFA will be evaluated for educational and scientific merit of the proposed training by an appropriate peer review group convened by the National Institute of General Medical Sciences in accordance with the review criteria stated below. As part of the initial merit review, the peer review group will discuss all applications, assign a priority score and provide a written critique that will be sent to the applicants. Applications then receive a second level of review by Fogarty International Center Advisory Board before funding decisions will be made. Review Criteria The goals of NIH supported research are to advance our understanding of biological systems, improve the control of disease and enhance health. In their written and oral comments, reviewers will be asked to discuss the following aspects of the application in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered in assigning the overall score, weighing them as appropriate for each application. Note that the application does not need to be strong in all categories to be judged likely to have major impact and thus deserve a high priority score. Significance 1. Adequacy of the proposed program to provide international research training experiences likely to encourage participants to pursue biomedical or behavioral research careers by entering graduate or health professional programs. 2. Adequacy of the proposed program to enhance minority scientist participation in international collaborative research relationships 3. Adequacy of proposed program to promote research related to health disparities in populations in the U.S. or in developing countries. Approach 1. Adequacy of the student selection process including: o A recruiting and application process that captures a pool of the best qualified eligible undergraduates (and graduate/medical students, if included) who could most benefit from an international research experience in terms of encouraging their pursuit of a biomedical research career. o If applicable, adequacy of the plans for the management and participation of the students and faculty of the consortium institutions in the program. o Methods and criteria for selecting student and U.S. and foreign faculty participants. o Process of matching students to U.S. and foreign mentors and research projects. 2. Adequacy of pre-travel trainee instruction in: o Responsible conduct of research, particularly considerations associated with the projects at the foreign site(s). o Scientific preparation of the student participants (in lab safety, technical writing, statistical methods, computer program training, scientific literature related to their research, theoretical basis of techniques used, etc.). o Cultural preparation (familiarity with foreign site scientists, foreign language, international studies, etc.). 3. Adequacy of the proposed research at the foreign site(s) for student and faculty participants including: o Providing research experience in areas related to health disparities in populations in the U.S. and developing countries o Appropriate student research projects, training schedules and research skills taught and other mentored activities. o Qualifications of the program director (graduate degrees, areas of research, quality and quantity of publications, training record). o Qualifications of the U.S. and foreign mentors (graduate degrees, areas of research, quality and quantity of publications, training record). Biographical Sketch (page FF) and Other Support (page GG) forms should be submitted for each U.S. and foreign mentor. o Assistance with common student trainee problems (such as health and safety concerns, social isolation and poor communication or lack of regular constructive critique from mentors, etc.). 4. Adequacy of the post-travel activity including: o Analysis of research samples or data collected. o Summarizing scientific results of the training experience in required written reports and oral presentations by the student and faculty participants. o Written evaluation of quality of overseas research experience by student and faculty participants. 5. Adequacy of the methods used by the program to monitor the impact of the international research training experience on the subsequent careers of the student and faculty participants (past and present). Innovation 1. Overall creativity of overall design for providing international research training experience. 2. Introduction of new ways to enhance minority scientist participation in international collaborative research. 3. Novelty of approaches to encourage the study of health problems that disproportionately affect underserved populations in the U.S. and in developing countries Investigators Adequacy of the qualifications of the principal investigator, U.S. and foreign faculty participants to direct the international research training activities of the student projects and act as effective mentors for the trainees based on scientific research experience and student training records. Environment Adequacy of the foreign site(s) selected for the research described including sources of support for the research training there. A Resource form (page HH) should be submitted for each foreign site lab where students will be trained. The following criteria will also apply for applications for competitive renewal: 1. Progress and accomplishments of previous undergraduate and graduate student trainees supported by the MIRT program such as completions of baccalaureate degrees, entry into graduate and health professional programs to obtain a masters degree, Ph.D, M.D. or other advanced degree, pursuit of biomedical and behavioral research careers, presentations at scientific meetings and co-authored peer reviewed publications should be provided in table format. 2. Productivity of previous faculty participants including number of students mentored, expanded research capabilities, scientific conference presentations, peer reviewed publications derived from MIRT funding, grant applications submitted and funded for research support, etc should be provided in table format. In addition to the above criteria, in accordance with NIH policy, all applications will also be reviewed with respect to the following: 1. If pertinent, the adequacy of plans to include both genders and minorities and their subgroups and children as appropriate for the scientific goals of the research. Plans for the recruitment and retention of subjects will also be evaluated. 2. If pertinent, the adequacy of the proposed protection for humans, animals or the environment to the extent they may be adversely affected by the project proposed in the application. 3. Appropriateness of the budget estimates in relation to the proposed research training plans. Schedule: Letter of Intent Receipt Date: December 10, 1999 Application Receipt Date: January 14, 2000 Peer Review Date: March/April 2000 Council Review: May 2000 Earliest Anticipated Start Date: June 1, 2000 AWARD CRITERIA The criteria that will be used to make the award decisions include the scientific, technical and educational merit of the application as determined by peer review, the likelihood that the proposal will contribute to the achievement of the MIRT program’s objectives and the availability of funds. INQUIRIES Inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Barbara Sina, Ph.D. Division of International Training and Research Fogarty International Center Building 31 Room B2C39 31 Center Drive MSC2220 Bethesda, MD 20892 Telephone: (301) 496-1653 FAX: (301) 402-0779 Email: barbara_sina@nih.gov Direct Inquiries regarding fiscal matters to: Susan Bettendorf Division of International Training and Research Fogarty International Center Building 31 Room B2C39 31 Center Drive MSC2220 Bethesda, MD 20892 Telephone: (301) 496-1653 FAX: (301) 402-0779 Email: susan_bettendorf@nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.106. Awards are made under authorization of the Public Health Service Act, Title IV. Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portions of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.

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