Release Date:  November 19, 2001

RFA:  RFA-NR-02-003

National Institute of Nursing Research

Letter of Intent Receipt Date:  March 29, 2002
Application Receipt Date:       April 25, 2002


The National Institute of Nursing Research (NINR) invites applications from 
recently graduated doctorally prepared nurse scientists or doctorally prepared 
nurse scientists venturing into novel areas of research for the career 
transition program. The overall goals of this program are to support 
outstanding individuals to obtain a research training experience at the NIH in 
the intramural research laboratories and to facilitate their successful 
transition to an extramural environment as independent researchers.  The NINR 
Career Transition Award will provide up to three years of support for 
postdoctoral research training in an NINR or NIH intramural clinical or basic 
laboratory followed by up to two years of support for an independent program 
of research in an extramural institution.  It is anticipated that recipients 
of the NINR Career Transition Award will continue their program of research 
with a research project grant (R01) after completion of the NINR Career 
Transition Award.


The Public Health Service (PHS) is committed to achieving the health promotion 
and disease prevention objectives of "Healthy People 2010," a PHS-led national 
activity for setting priority areas.  This Request for Applications (RFA), 
NINR Career Transition Award, is related to one or more of the priority areas.  
Potential applicants may obtain a copy of "Healthy People 2010" at


Registered Nurses (RN) who are recent recipients of a doctoral degree or its 
equivalent and who have demonstrated the potential for a highly productive 
research career are eligible to apply.  During the NIH intramural phase of the 
award, the candidate is expected to devote 100% full-time effort on research 
training.  During the extramural phase, the candidate must spend a minimum of 
75 percent of full-time professional effort conducting research and engaging 
in research career development activities for the two years of the award.

Candidates must be U.S. citizens or non-citizen nationals, or must have been 
lawfully admitted for permanent residence and possess an Alien Registration 
Card (I-151 or I-552) or some other verification of legal admission as a 
permanent U.S. resident at the time of the award.  Non-citizen nationals, 
although not U.S. citizens, owe permanent allegiance to the U.S.  They are 
usually born in lands that are not states, but are under U.S. sovereignty, 
jurisdiction, or administration.  Individuals on temporary or student visas 
are not eligible.

To progress to the extramural support phase, the candidate must have a formal 
tenure-track (or equivalent) offer from an extramural institution by the end 
of the second year of the intramural experience and will be evaluated by an 
internal NINR review board, not a traditional NIH study section.  Because the 
purpose of this initiative is to ease the transition of newly awarded doctoral 
candidates into postdoctoral education, current principal investigators on PHS 
research grants are not eligible.


This RFA will use the National Institutes of Health (NIH) career transition 
(K22) award mechanism.  Responsibility for the planning, direction, and 
execution of the proposed project will be solely that of the applicant.  The 
total period of combined support is up to five years (up to three years 
intramural, up to two years extramural).  There is no grant award associated 
with the intramural phase.  Awards are not renewable.  Total cost of the 
intramural phase is based on the candidate's experience and research expenses, 
not to exceed $125,000 per year; those for the extramural phase cannot exceed 
$125,000 plus fringe benefits per year in direct costs.  The final two years 
of the scholar's research program will be supported by the extramural 
institution to which the scholar is recruited and will be funded through an 
extramural, non-competing, NINR Career Transition Award (K22) mechanism.

This RFA is one-time solicitation.  The anticipated award date is September 
30, 2002.


It is anticipated that applications for the NINR Career Transition Award will 
be solicited annually through the re-issuance of this RFA.  NINR anticipates 
funding up to three awards in FY 2002 and has set-aside up to $375,000 total 
costs annually for salary and research expenses.  The funding level will be 
dependent upon the number of meritorious applications received, funds 
available, and the particular resource needs for the proposed project.



Intramural scientists and facilities at the NIH provide an infrastructure for 
the research training and career development of promising new scientists who 
will subsequently enter the extramural biomedical and health care research 
community and have the potential to become leaders in their fields of 
investigation.  The goal of the NINR Career Transition Award program is to 
provide highly qualified developing doctorally prepared registered nurses with 
an opportunity to receive postdoctoral research training in an NIH intramural 
research laboratory or clinical research department.  Transition funding will 
be provided upon completion of the fellowship for the continuation of their 
program of research in an extramural institution.

The NINR Career Transition Award consists of an Intramural Support Phase and 
an Extramural Support Phase.  The total period of combined intramural and 
extramural support will be up to five years.  Initially, up to three years of 
the research training program will be provided in the Intramural Support Phase 
in which the salary of the awardee will be commensurate with his/her level of 
experience.  The final two years of the program, the Extramural Support Phase, 
will provide salary and funds for supplies, equipment and technical support 
thorough the NIH Career Transition Award.  Transition from the intramural 
phase of support to the extramural phase will be based upon the success of the 
recipient's postdoctoral research training program as determined by a formal 
internal NINR scientific progress review. 

To progress to the Extramural Support Phase, the candidate must have a formal 
tenure-track (or equivalent) offer from an extramural institution by one year 
before the move to the Extramural site and will be evaluated by an internal 
NINR review board, not a traditional NIH study section. This review will take 
place no later than the end of the second year of the Intramural Support 
Phase, and will include the evaluation of a research plan to be carried out at 
the extramural institution.  Recipients approved to proceed with the 
Extramural Support Phase will receive notification of approval in writing from 
the NINR.  

By the end of the recipient's second year of the Intramural Support Phase, the 
Dean of the extramural institution must provide a letter of commitment to the 
candidate by providing protected research time, infrastructure, and space 
needed to perform the proposed research. Funds from the institution for 
equipment and supplies (and if necessary, salary) are encouraged to supplement 
the K22 award if needed. 

Intramural Research at the NIH

The NINR intramural research program is located on the Bethesda campus.  In 
addition, NIH intramural research opportunities are available with other NIH 
institutes, such as the National Institute on Aging, the National Cancer 
Institute, the National Institute of Environmental Health Sciences, and the 
National Human Genome Research Institute.  For example, at the National 
Institute on Aging, research opportunities are possible in conjunction with 
the Baltimore Longitudinal Study of Aging or with other on-going studies.  At 
the National Cancer Institute opportunities are available with the Division of 
Cancer Epidemiology and Genetics.  At the National Human Genome Research 
Institute there are both laboratory and clinical opportunities.

To assist the applicant in finding a sponsor for this research training and 
career development experience, a listing of NIH intramural research 
opportunities can be accessed through the following website The website 
identifies individual Institutes and Centers, describes intramural 
laboratories and clinical research services, and the topic areas of interest 
within the institutes and centers.  Names and phone numbers of scientists are 
listed on the websites, and prospective applicants are encouraged to contact 
the scientists directly and dialogue with them about the potential for a 
laboratory and/or clinical postdoctoral research training experience.  
Applicants are also invited to contact Dr. Melinda Tinkle (see INQUIRIES) for 
assistance in exploring potential intramural sponsors for this research 
training and career development experience.

It is recommended that the candidate obtain a commitment from the intramural 
scientist before completing the K22 application.  When completing the 
application, the candidate should describe: 1) how the specific laboratory 
postdoctoral intramural experience will enhance his/her projected research 
career; and, 2) identify specific research training objectives. Research 
training objectives should include how the intramural research experience will 
assist the candidate in developing a unique program of research at an 
extramural institution. It is essential for the candidate to identify a mentor 
(usually the scientist who has committed to the postdoctoral research 
training) in the NIH intramural laboratory AND provide a letter of support 
from the mentor stating his/her willingness to accept the candidate for a 
postdoctoral research training opportunity, characteristics of the 
laboratory's infrastructure including space for the candidate, computer 
accessibility, seminar attendance, and if needed, academic course work and/or 
clinical rounds. 

It is strongly recommended that potential candidates receive guidance 
regarding research and mentoring opportunities with NINR and with other NIH 
institute intramural research programs by contacting staff identified in the 
Inquiries section below.


Intramural Support Phase:

The budget for the Intramural Support Phase includes the candidate's salary 
and research expenses determined by the NINR Division of Intramural Research.  
There is no grant award associated with the intramural phase. Total costs for 
the intramural phase are based on the candidate's experience and research 
expenses and is not to exceed $125,000 per year.  The salary must be 
commensurate with the level of training and experience specified in the 
Federal pay schedule and will be negotiated with NINR at the time of an award.  

Extramural Support Phase:

1.  Salary:  The NIH will provide up to $50,000 in salary plus fringe benefits 
to the NINR Career Transition Award recipient.  The total salary requested 
must be based on a full-time, 12-month faculty or staff appointment.  It must 
be consistent with the established salary structure at the institution and 
with salaries actually provided by the institution from its own funds to other 
faculty or staff members of equivalent qualifications, rank, and 
responsibilities in the department concerned.  There should be no less than 75 
percent effort devoted by the candidate specifically to the proposed program 
of research.  The institution may supplement the NIH contribution up to a 
level that is consistent with the institution's salary scale; however, 
supplementation may not be from Federal funds unless specifically authorized 
by the Federal program from which such funds are derived.  In no case may PHS 
funds be used for salary supplementation.  Institutional supplementation of 
salary must not require extra duties or responsibilities that would interfere 
with the purpose of the Career Transition Award.  Under expanded authorities, 
institutions may re-budget funds within the total costs awarded, but may not 
re-budget funds involving the salary component of the budget.

2.  Research Support: The NINR will provide up to $75,000 per year for (a) 
research expenses, such as supplies, equipment, consultants, patient care 
costs, and technical personnel; (b) travel to research meetings or training; 
and (c) statistical service, including personnel and computer time. 

Total direct costs for the Extramural Support Phase cannot exceed $125,000 
plus fringe benefits per year.  

3.  Ancillary Personnel Support: Salary for secretarial and administrative 
assistance, etc., is not allowed.

4.  Facilities and Administrative (F&A) Costs: F&A costs will be reimbursed at 
eight percent of modified total direct costs.


Acceptance into the NINR Career Transition Award program does not convey any 
commitment or intent of the NINR to consider the awardee for a tenure track 
position within the NINR.  The NINR Career Transition Award is specifically 
intended to give a postdoctoral research training experience to candidates who 
will pursue their career in the extramural scientific research community.  
However, the NINR Career Transition Awardee is not explicitly precluded from 
applying for available tenure track positions at the NIH.  If an awardee 
obtains a NIH position, the NINR Career Transition Award will be terminated.


It is the policy of the NIH that women and members of minority groups and 
their sub-populations must be included in all NIH-supported clinical research 
projects unless a clear and compelling justification is provided indicating 
that inclusion is inappropriate with respect to the health of the subjects or 
the purpose of the research. This policy results from the NIH Revitalization 
Act of 1993 (Section 492B of Public Law 103-43).

All investigators proposing clinical research should read the AMENDMENT "NIH 
Guidelines for Inclusion of Women and Minorities as Subjects in Clinical 
Research - Amended, October, 2001," published in the NIH Guide for Grants and 
Contracts on October 9, 2001 
a complete copy of the updated Guidelines are available at 
The amended policy incorporates: the use of an NIH definition of 
clinical research; updated racial and ethnic categories in compliance with the 
new OMB standards; clarification of language governing NIH-defined Phase III 
clinical trials consistent with the new PHS Form 398; and updated roles and 
responsibilities of NIH staff and the extramural community.  The policy 
continues to require for all NIH-defined Phase III clinical trials that: a) 
all applications or proposals and/or protocols must provide a description of 
plans to conduct analyses, as appropriate, to address differences by 
sex/gender and/or racial/ethnic groups, including subgroups if applicable; and 
b) investigators must report annual accrual and progress in conducting 
analyses, as appropriate, by sex/gender and/or racial/ethnic group 


It is the policy of NIH that children (i.e., individuals under the age of 21) 
must be included in all human subjects research, conducted or supported by the 
NIH, unless there are scientific and ethical reasons not to include them.  
This policy applies to all initial (Type 1) applications submitted for receipt 
dates after October 1, 1998.

All investigators proposing research involving human subjects should read the 
"NIH Policy and Guidelines" on the Inclusion of Children as Participants in 
Research Involving Human Subjects that was published in the NIH Guide for 
Grants and Contracts, March 6, 1998, and is available at the following URL 

Investigators also may obtain copies of these policies from the program staff 
listed under INQUIRIES.  Program staff may also provide additional relevant 
information concerning the policy.


NIH policy requires education on the protection of human subject participants 
for all investigators submitting NIH proposals for research involving human 
subjects.  This policy announcement is found in the NIH Guide for Grants and 
Contracts Announcement dated June 5, 2000, at the following website:


All applications and proposals for NIH funding must be self-contained within 
specified page limitations.  Unless otherwise specified in an NIH 
solicitation, internet addresses (URLs) should not be used to provide 
information necessary to the review because reviewers are under no obligation 
to view the Internet sites.  Reviewers are cautioned that their anonymity may 
be compromised when they directly access an Internet site.


Prospective applicants are asked to submit a letter of intent that includes a 
descriptive title of the proposed research, the name, address, and telephone 
and fax numbers of the Principal Investigator, the identities of other key 
personnel and participating institutions, and the number and title of the RFA 
in response to which the application may be submitted.  Although a letter of 
intent is not required, is not binding, and does not enter into the review of 
a subsequent application, the information that it contains allows NINR staff 
to estimate the potential review workload and plan the review.

An e-mail or FAX letter of intent is acceptable.

The letter of intent is to be sent by March 29, 2001 to:

John E. Richters, Ph.D. 
Chief, Office of Review 
National Institute of Nursing Research 
45 Center Drive (Natcher Building), Room 3AN12 
Bethesda, MD  20892-6300 
Phone:  (301) 594-5971  Fax (301) 451-5645


Potential applicants are encouraged to contact Dr. Melinda Tinkle, at the 
address listed under INQUIRIES, prior to application submission.  Questions 
regarding the extramural phase may be addressed to Dr. Hilary Sigmon. 

The PHS 398 research grant application instruction and forms (rev. 5/2001) at must be used in applying for 
these grants.  This version of the PHS 398 is available in an interactive, 
searchable format.  For further assistance, contact Grantsinfo, Telephone 
(301) 710-0267, Email:   

The application must address the following issues:


o  Establish the candidate's commitment to a career in biomedical or 
behavioral research.
o  Establish the candidate's potential to develop and pursue a successful 
program of research as an independent investigator.
o  Establish the candidate's ability to work with other scientists in an 
interactive research environment.
o  Summarize the candidate's immediate and long-term career objectives, 
explaining how the award will contribute to their attainment.
o  Letters of recommendation.  Three sealed letters of recommendation 
addressing the candidate's potential for a research career must be included as 
part of the application.  One should be from a thesis advisor or mentor, if 
the candidate is in a doctoral or postdoctoral research setting.  These 
letters should address the candidate qualifications as already outlined.

Research Plan

o  Describe the research plan, including the scientific objectives and 
specific aims, and the use of a basic or clinical approach to a scientific 
research problem sufficient to justify two years of support in the extramural 
phase, i.e., what are the research goals and potential avenues of research 
that will be undertaken based upon the intramural research training?  The 
candidate must describe the research plan as outlined in form PHS 398 (rev. 
5/01) including sections on the Specific Aims, Background and Significance, 
Progress Report/Preliminary Studies, Research Design and Methods.


o  Do NOT provide any dollar figures in the application.  The final budget 
will be negotiated when a selected applicant accepts a position and will be 
within the allowable costs specified above.
o  For candidates who receive approval for transition to extramural support, a 
budget will be submitted as part of the form PHS 2590 non-competing 
application as discussed below in Extramural Support Phase.

Career Development Plan

o  Applicant should describe the research training and career development 
plan, incorporating consideration of the candidate's goals and prior 
experience.  The applicant should describe a systematic plan to obtain the 
necessary scientific background and research training experience to launch an 
independent research career (including the need for any courses, mentoring 
format, plans for immersion into the laboratory, research techniques or 
methods, .etc).

Sponsor's Statement (Intramural Phase)

o The application must include a statement from the sponsor including 
information on research qualifications and previous experience as a research 
supervisor.  The application must also include information to describe the 
sponsor's research support related to the candidate's research plan and nature 
of the supervision that will occur during the proposed award period.

The initial application for the NINR Career Transition Award program will NOT 
be processed through your current institution; therefore, follow the 
supplemental guidelines below for the face page:

The applicant must provide her/his signature in item 14; signature is not 
required for item 15.

Leave items 9-13 and 15 on the face page blank.

Enter in item 6 (Dates of Proposed Period of Support) the combined 4 to 5 
years of support needed to complete the intramural and the extramural support 
phases of the NINR Career Transition Award Program.

Utilize the "Research Career Award" Table of Contents page, but re-label the 
page, "Career Transition Award."  This page is included in the Form 398 packet 
and will facilitate organizing the research and career development components 
of the application.  Add a "Career Development Plan" under "Section II: 
Specialized Information."

The RFA label available in the PHS 398 (rev. 5/2001) application form must be 
affixed to the bottom of the face page of the application.  Type the RFA 
number on the label.  Failure to use this label could result in delayed 
processing of the application such that it may not reach the review committee 
in time for review.  In addition, the RFA title and number must be typed on 
line 2 of the face page of the application form and the YES box must be 
marked. The RFA label is also available at:

Submit a signed, typewritten original of the application, including the
Checklist, and three signed photocopies, in one package to:

BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

At the time of submission, two additional copies of the application must be 
sent to:

John E. Richters, Ph.D. 
Chief, Office of Review 
National Institute of Nursing Research 
45 Center Drive (Natcher Building), Room 3AN12 
Bethesda, MD  20892-6300 

Applications must be received by April 25, 2002.  If an application is 
received after that date, it will be returned to the applicant without review. 

The Center for Scientific Review (CSR) will not accept any application in 
response to this RFA that is essentially the same as one currently pending 
initial review, unless the applicant withdraws the pending application.  The 
CSR will not accept any application that is essentially the same as one 
already reviewed. This does not preclude the submission of substantial 
revisions of applications already reviewed, but such applications must include 
an Introduction addressing the previous critique.


Upon receipt, applications will be reviewed for completeness by the CSR and 
responsiveness to the RFA by NINR staff.  Incomplete and/or non-responsive 
applications will be returned to the applicant without further consideration.  
Applications that are complete and responsive to the RFA will be evaluated for 
scientific and technical merit by an appropriate initial peer review group, 
convened by the NINR Division of Extramural Activities in accordance with the 
review criteria stated below.  As part of the initial merit review, all 
applications will receive a written critique and undergo a process in which 
only those applications deemed to have the highest scientific merit, generally 
the top half of the applications under review, will be discussed,
assigned a priority score, and receive a second level review by the National 
Advisory Council for Nursing Research (NACNR).

Review Criteria

The peer review criteria for applications submitted in response to this RFA 


o  Capacity and commitment to pursue an independent research career;
o  Potential to develop into an outstanding independent research scientist who 
will make significant contributions to the field;
o  Quality and breadth of prior scientific training and experience including, 
where appropriate, the record of previous research support and publications;
o  Ability to plan, develop, and organize a program of research that will make 
full use of the support offered under this award.

Research Plan

o  A sound research plan that is consistent with the candidate's level of 
research development must be provided;
o  Usefulness of the intramural research plan as a vehicle for enhancing or 
expanding existing research skills as described in the career development 
o  Scientific and technical merit of the research question, design and 
methodology, judged in the context of the candidate's previous training and 
o  Adequacy of plans to include both genders, children, and minorities and 
their subgroups as appropriate for the scientific goals of the research. 
Plans for the recruitment and retention of subjects will also be evaluated, 
where appropriate.

Career Development Plan

o  Appropriateness of the career development plan, considering the candidate's 
goals and prior experience;
o  The consistency of the career development plan with the candidate's 
research plan and potential for contributing to the scientific literature.

Intramural Training Plan

o  Appropriateness of the intramural training plan, considering the 
candidate's goals and prior experience;
o  The logical sequence and scientific rigor of the intramural training plan 
with the candidates research plan;
o  Potential of the scholar to contribute to the scientific literature.


o  Appropriateness of the sponsor's research interests and qualifications to 
the career development needs of the candidate;
o  Adequacy of the nature and extent of supervision that will occur during the 
proposed award period;
o  Adequacy of the proposed mentoring plan.


Following peer review, the written evaluations and priority score assigned to 
the application by the initial review group will be sent to the candidate.

Intramural Support Phase

Successful candidates will be selected based on priority score ranking, 
programmatic needs, and available resources.

Extramural Support Phase

The NINR will conduct a formal scientific progress review no later than the 
end of the second year of the Intramural Support Phase to determine whether or 
not the awardee will be recommended for the extramural phase of support.  At 
the same time, the awardee will prepare a revised research plan for the 
Extramural Support Phase of the award and submit a letter from the institution 
offering the extramural faculty position.  This review will be conducted by an 
NINR Progress Review Committee composed of members of the NINR Selection 
Committee, and other intramural and extramural staff and other reviewers as 
needed.  The results of the review will constitute a final evaluation of the 
Intramural Support Phase and be presented in writing to the awardee.  Approval 
will result in eligibility for the extramural phase of funding of the Career 
Transition Award, and up to a third additional year of intramural support to 
facilitate the transition to an extramural laboratory.


Letter of Intent Receipt Date:    March 29, 2002
Application Receipt Date:         April 25, 2002
Peer Review Date:                 June 2002
Council Review:                   September 2002
Earliest Anticipated Start Date:  September 30, 2002


Applications will compete for available positions/funds with all other scored 
applications submitted in response to this RFA.  The following will be 
considered in making award decision: qualifications and potential of the 
applicant and quality of the proposed research project as determined by peer 
review; mentor/awardee match, availability of intramural NIH resources; 
programmatic priorities; and availability of funds. 

Evaluation of Scientific Progress

Intramural Support Phase

Each awardee's research progress will be evaluated on an annual basis as with 
all other intramural scientific research programs.  For this purpose, the 
awardee will prepare an annual progress report that will be evaluated by the 
corresponding laboratory/branch chief and the NINR Division of Intramural 
Research.  Additionally, the NINR will conduct a formal scientific progress 
review no later than the end of the second year (See section on Selection 
Process, Extramural Support Phase).

Extramural Support Phase

The awardee will be required to submit a form PHS 2590 non-competing 
continuation application for the final year of extramural support.  The 
application should provide a description of the research and career progress 
of the awardee, including: 1) publications in press or submitted; 2) current 
investigator-initiated research grant support, and 3) all applications 
submitted for investigators-initiated research grant support.  After the 
completion of this award, periodic updates on various aspects of employment 
history, publications, support from research grants or contracts, honors and 
awards, professional activities, and other information helpful in evaluating 
the impact of the program may be solicited from the awardee. 


Inquiries concerning this RFA are encouraged.  The opportunity to clarify any 
issues or questions from potential applicants is welcome.

Address questions related to the intramural support phase to:

Melinda M. Tinkle, PhD, RN 
Intramural Program Director for Research and Training
National Institute of Nursing Research
Building 31, Room 5B-13
Bethesda, MD  20892-2078
TELEPHONE:  (301) 402-7889
FAX:  (301) 480-2479

Address questions related to the extramural support phase to:

Hilary D. Sigmon PhD, RN
Program Director
National Institute of Nursing Research
Building 45, Room 3AN12 - MSC 6300
Bethesda, MD  20892-6300
TELEPHONE:  (301) 594-5970
FAX:  (301) 480-8260

Address inquiries regarding fiscal matters to:

Ms. Cindy McDermott
Chief Grants Management Officer
National Institute of Nursing Research
Building 45, Room 3AN12 - MSC 6300
Bethesda, MD  20892-6300
TELEPHONE:  (301) 594-6869
FAX:  (301) 480-8260


This program is described in the Catalog of Federal Domestic Assistance No. 
93.361.  Awards are made under authorization of Sections 301 and 405 of the 
Public Health Service Act as amended (42 USC 241 and 284) and administered 
under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 
74 and 92.  This program is not subject to the intergovernmental review 
requirements of Executive Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant recipients to provide a smoke-free 
workplace and promote the non-use of all tobacco products.  In addition, 
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain 
facilities (or in some cases, any portion of a facility) in which regular or 
routine education, library, day care, health care, or early childhood 
development services are provided to children.  This is consistent with the 
PHS mission to protect and advance the physical and mental health of the 
American people.

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