and Human Services (HHS)
EXPIRED
NURSING RESEARCH EXPLORATORY CENTER GRANTS Release Date: May 22, 2000 RFA: NR-01-001 National Institute of Nursing Research (http://www.ninr.nih.gov) Letter of Intent Receipt Date: October 9, 2000 Application Receipt Date: November 14, 2000 PURPOSE The National Institute of Nursing Research (NINR) invites applications for exploratory center grants in key clinical and basic areas of nursing research that establish a scientific basis for the care of individuals across the life span. NINR seeks to increase the numbers of research-intensive schools of nursing through the Nursing Research Exploratory Center grants (P20s). The Exploratory Center Grant, targeted to schools of nursing that are developing research programs, will augment the research resources in schools of nursing by facilitating the growth of infrastructure to centralize resources and facilities in a specific area of inquiry that has a beginning base of research funding. By developing infrastructure components, funded investigators will have the opportunity to enhance their research productivity. HEALTHY PEOPLE 2010 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), Nursing Research Exploratory Center Grants, is related to one or more of the priority areas. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople/. ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic, for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Foreign institutions are not eligible for the center program grants. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as Principal Investigators. Institutions eligible for the Nursing Research Exploratory Center Grants are those that are developing research programs and have not been major recipients of NIH support. The institution must have at least two (2) projects funded by Department of Health and Human Services (DHHS) research support grants from selected mechanisms (specifically, R01, R15, R18, R29) or comparable peer reviewed research projects (including those funded by State governments and private foundations) related to the scientific area of nursing inquiry. Each of these projects in the research base must have at least one (1) year of committed support remaining at the time of the application receipt date. Both of the projects must be in the college, school, or department of nursing. A larger number of NIH awards in the scientific area of inquiry would strengthen an application. Institutions may not apply if they are: (1) current recipients of a NINR Core Center Grant (P30), and/or (2) ineligible for NIH Academic Research Enhancement Award (AREA) grants. An applicant organization may submit only one (1) P20 application. Joint applications will not be accepted from investigators at neighboring, independent institutions, but subcontracts are allowed if their usage enhances the development of the scientific area of inquiry and stays within the dollar limits of the RFA. Linkage with minority-serving institutions is encouraged. MECHANISM OF SUPPORT This RFA will use the National Institutes of Health (NIH) Exploratory Center Grant mechanism (P20). The purpose of this mechanism is to support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to developing interdisciplinary research programs that address areas consistent with the missions of NINR. Responsibility for the planning, direction, and execution of the proposed Center project will be solely that of the applicant. The total project period for an application submitted in response to this RFA may not exceed three (3) years, and is not renewable. This RFA is a one-time solicitation. The anticipated award date is August 2001. FUNDS AVAILABLE The NINR intends to commit approximately $2,000,000 in FY 2001 to fund seven (7) to nine (9) new grants in response to this RFA. An applicant may request a project period of three (3) years and a budget for direct costs of up to $150,000 for the first year. Cost-of-living or inflationary increases in subsequent budget years for recurring costs such as personnel and supplies may not exceed three percent (3%) escalation per year. Although the financial plans of the NINR provide support for this program, awards pursuant to this RFA are contingent upon the availability of funds and the receipt of a sufficient number of applications of outstanding scientific and technical merit. RESEARCH OBJECTIVES The National Institute of Nursing Research (NINR) has historically supported the development of research infrastructure in schools of nursing by funding centers. NINR’s current centers program consists of research center core grants (P30s), focused on key clinical and basic areas of nursing research that establish a scientific basis for the care of individuals across the life span. The Nursing Research Center Core grants provide the infrastructure to centralize resources and facilities to support an active center of excellence in a specific area of inquiry that has a strong base of research funding. However, many institutions are in the earlier stages of establishing nursing research programs. The Nursing Research Exploratory Centers RFA is designed to assist these institutions with developing research programs and a research infrastructure by augmenting the research resources in schools, colleges, or departments of nursing. Funds will support planning for new research programs to facilitate growth and development, expansion or modification of existing research resources, pilot or feasibility studies, and interdisciplinary collaboration. Applicants should select a scientific area of inquiry based on a conceptually sound integration of currently funded projects in the research base. The link to nursing practice issues within the center should be explicit. Applications should contain innovative ideas consistent with NINR’s mission, and use sound methodologies. Applicants are encouraged to consider the following areas of inquiry that have been identified as specific areas of scientific opportunity: o Chronic illness experiences, such as managing symptoms, avoiding complications of disease and disability, supporting family caregivers, promoting adherence and self-management activities, and promoting healthy behaviors within the context of the chronic condition. o Cultural and ethnic considerations in health and illness, including culturally sensitive interventions to decrease health disparities among groups by focusing upon health promotion activities and chronic illness management strategies. o End of life/palliative care research, focusing on clinical management of physical and psychological symptom management, communication, ethics and clinical decision-making, caregiver support, and care delivery issues. o Health promotion and disease prevention research, particularly as it relates to lifestyle changes and healthy behavior maintenance across the lifespan. o Implications of genetic advances, including reducing factors that increase risk of disease, issues related to genetic screening, and subsequent gene therapy techniques. o Quality of life and quality of care, to include cost savings for the patient, health care system, and society. o Symptom management of illness and treatment, such as pain, cognitive impairment, fatigue, nausea and vomiting, and sleep problems. o Telehealth interventions and monitoring or other emerging technologies to promote patient education for competent self-management and to optimize the effectiveness of treatment. In addition to the above areas, applications should note the following NINR research program categories that describe the broad areas of interest; however, proposed scientific areas for this RFA are not limited to the following concepts. o Research in cardiopulmonary health and critical care, including prevention and care of individuals with cardiac or respiratory conditions. This area also includes research in critical care, trauma, wound healing, and organ transplantation. o Research in chronic illness and long-term care, including care of individuals with arthritis, diabetes, and urinary incontinence; and long-term care and caregiving. o Research in health promotion and risk behaviors, including studies of women's health; developmental transitions, such as adolescence and menopause; environmental health; and health and behavior research, such as studies of exercise, nutrition, and smoking cessation. o Research in immune responses and oncology, including care of individuals experiencing symptoms primarily associated with cancer and AIDS, such as fatigue, nausea and vomiting, and cachexia. Prevention research on specific risk factors is also included. o Research in neurofunction and sensory conditions, including pain management, sleep disorders, and symptom management for persons with cognitive impairment or chronic neurological conditions. This area also includes research on patient care in acute care settings. o Research in reproductive and infant health, including prevention of premature labor, reduction of health-risk factors during pregnancy, normal physiologic processes of labor and delivery, delivery of prenatal care, care of neonates, infant growth and development, and fertility issues. Applicants from institutions that have a General Clinical Research Center (GCRC) funded by the NIH National Center for Research Resources may wish to identify the GCRC as a resource. Details of the interactions of the exploratory center staff with the GCRC staff and research personnel may be provided in a statement describing the collaborative linkages being developed. A letter of agreement from the GCRC Program Director must be included with the application. SPECIAL REQUIREMENTS The Center must be an identifiable organizational unit either within a college or school of nursing or within a department of nursing in a university- affiliated medical center or hospital or other similar entity. A Nursing Research Exploratory Center Grant benefits from an interdisciplinary approach. When multiple organizations within an institution are represented in the application, clear lines of authority and sanction by the appropriate institutional officials must be specified. Each applicant institution must name a Center Director who will be the key figure in the administration and management of the Center grant. The Director will be responsible for the organization and operation of the Center. The Director should be experienced in conducting research and have demonstrated ability to coordinate, integrate, and provide guidance in the establishment of new programs in the scientific area of inquiry. The Director must make an appropriate time commitment. Funding is intended to support shared resources and facilities (core units) that will enhance and extend the effectiveness of research at the applicant institution. CORES A core is a shared central facility or other resource, designed to enhance productivity or in other ways benefit a group of investigators to accomplish their stated goals. The Exploratory Center grant must consist of (1) an administrative and planning core providing administrative, coordinating, planning, logistical, and/or methodological (e.g., research design, data analysis) support, and (2) a pilot/feasibility studies core. Each core should be directed by an investigator with substantial expertise related to the core. An important consideration is the degree to which core facilities will be utilized by and benefit individual ongoing and/or proposed projects and Center investigators, and will assist in the development of the scientific area of inquiry. It is not sufficient for the applicant merely to identify such shared resources. Rather, the applicant must demonstrate exactly how each core would augment or enhance the present capabilities of the investigators and make possible new activities. In addition, after an award is made, the NINR will require documentation in annual progress reports and in renewal applications that sharing of resources has been achieved. ADMINISTRATIVE CORE An Administrative Core is mandatory for all Centers, and should manage the overall activities of the Center. Its description should including the following: 1. A specified Director; 2. A description of the administrative structure; 3. A general description of overall facilities and institutional commitment. It is expected that the Center administrative structure will accomplish the following: 1. manage, coordinate, and integrate the components and activities of the Center; 2. review utilization of funds, including funds for pilot and feasibility studies; 3. manage the shared resources of the Center, such as data sets, community or clinical research facilities, or provide research design and data analysis/statistical service; 4. advise the Center Director on the activities of the Center. While the final administrative structure of the Center will, for the most part, be left to the discretion of the applicant institution, NIH's experience has demonstrated that the effective development of Center programs requires interaction among the Director, the core leaders, the Principal Investigators of research projects, appropriate institutional administrative personnel and the staff of the awarding agency. To facilitate communication between the Center staffs and the NINR, the NINR expects that each Center application will include funds for the Center Director to travel to an annual meeting in Bethesda, Maryland. An Executive Committee, consisting of the heads of both cores and the business official, should be established to assist the Director in making the scientific and administrative decisions relating to the Center. In addition to coordination of the Center, the Director, with his or her Executive Committee, will be responsible for allocation of Center funds, the identification and selection of key personnel, and the planning and evaluation of the Center activities. The complex nature of administrative requirements of the Center will necessitate the assistance of a person with business management expertise. It is important that such an official be identified and directly involved with the fiscal aspects of the Center application and grant. An appropriate amount of this individual's time and effort should be committed for this purpose. The institutional business official should be a member of the Executive Committee. While budget formulation and planning will undoubtedly begin with the Director in collaboration with the scientific staff, the business official should be involved in the process and provide consultation in matters of fiscal administration and evaluate such issues as equipment on hand versus that requested for the core facilities. An external Advisory Committee should be established and composed of scientists and administrators with expertise and experience relevant to the scientific program of the center. The Advisory Committee will comprise individuals from within the institution and at least two (2) scientists from outside the institution. This committee may also be used in evaluating the overall research programs of the Center, the effectiveness of communications within the Center, and any other activities in which problems arise for which expertise is required or desirable. The Advisory Committee should meet at least once annually. However, the nature of its responsibilities may require ad hoc meetings at more frequent intervals. A member of the NINR extramural program staff is to be invited to attend each meeting as an observer. PILOT/FEASIBILITY STUDIES CORE Pilot and/or feasibility studies are a mandatory component of the Center application. These are intended to enable eligible investigators to explore the feasibility of a concept within the scientific area of inquiry and to amass sufficient data to pursue it through other funding mechanisms. The monies provide modest research support for a limited time (one year or two years maximum with clear justification for the time length). Eligible investigators include: 1. An established investigator in the scientific area of inquiry with a proposal for testing the feasibility of a new or innovative idea that is conceptually related but represents a clear and distinct departure from his/her ongoing research interest; 2. An established, supported investigator with no previous work in the scientific area of inquiry who will test the applicability of his/her expertise on a conceptually related problem; 3. A new investigator who has not been a Principal Investigator in the past, or who is not currently funded with an DHHS research project grant (e.g., R01, R15, P01, R29). Applications must propose a minimum of three (3) and a maximum of five (5) pilot and/or feasibility studies to be carried out during the first year. A minimum of three pilot/feasibility studies must be determined acceptable by the reviewers. Standard guidelines for IRB/IACUC approval apply. The theoretical basis for the pilot and/or feasibility studies must be clearly explicated. An interdisciplinary approach should be utilized to promote the collaboration of nurse scientists with scientists of other disciplines as appropriate. Each pilot and/or feasibility study is limited to fifteen pages of description for the Research Plan, Sections a through d, and should delineate the question being asked, detail the procedures to be followed, and discuss how the data will be analyzed. The application must indicate how the proposed pilot/feasibility study fits within the scientific area of nursing inquiry selected for the Center, and how the investigator satisfies the eligibility criteria listed above. The application should indicate how the proposed pilot/feasibilities were selected. Subsequent pilot/feasibility studies (a minimum of two (2) ongoing each year) will be developed during the course of the award. A description of how the pilot and/or feasibility studies will be reviewed and selected in the future must be provided. Results of each pilot and/or feasibility study must be in the Center's annual progress reports to the NINR along with the plan used to solicit the new pilot and/or feasibility studies. For pilot and/or feasibility studies involving clinical research, NIH requires applicants to give special attention to the inclusion of women, minorities and children in study populations. Study populations must be described in the research design and methods section for each pilot and/or feasibility study. If women, minorities or children are not included in the study populations for the clinical studies, a specific justification for each of these exclusions must be provided. Applications without such documentation will not be accepted for review. Further information about this policy may be requested from NINR staff. The application must describe the process that will be used to review pilot and/or feasibility studies for future years of the proposed center. The review process may be carried out by the Advisory Committee, by an ad hoc Review Committee, by a mail review, or by a combination of these methods. It is recommended that the Center Director utilize at least two (2) scientists with expertise relevant to the scientific area of inquiry of the Center from outside the institution during the review process. EVALUATION PLAN A plan for evaluating progress toward aims and/or goals of both cores and the overall Center is required. This plan should include the specific criteria and methods that will be used for the evaluation. The plan should specify the types of evaluation information that will be submitted in the Center’s annual progress reports. Annual progress reports of the funded Exploratory Centers will be reviewed by NINR staff. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification are provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43 All investigators proposing research involving human subjects should read the "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research," which was published in the Federal Register of March 28, 1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts, Vol. 23, No. 11, March 18, 1994, and is available on the web at: http://grants.nih.gov/grants/guide/notice-files/not94-100.html. INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of NIH that children (i.e., individuals under the age of 21) must be included in all human subjects research, conducted or supported by the NIH, unless there are scientific and ethical reasons not to include them. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines" on the Inclusion of Children as Participants in Research Involving Human Subjects that was published in the NIH Guide for Grants and Contracts, March 6, 1998, and is available at the following URL address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html Investigators also may obtain copies of these policies from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. URLS IN NIH GRANT APPLICATIONS OR APPENDICES All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Reviewers are cautioned that their anonymity may be compromised when they directly access an Internet site. LETTER OF INTENT Prospective applicants are asked to submit a letter of intent that includes a descriptive title of the proposed research, the name, address, and telephone number of the Principal Investigator, the identities of other key personnel and participating institutions, and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review. The letter of intent is to be sent by the letter of intent receipt date listed to: Dr. Mary Stephens-Frazier Scientific Review Administrator National Institute of Nursing Research Building 45, Room 3AN-12 Bethesda, MD 20892-6300 Telephone: (301) 594-5971 or 6906 FAX: (301) 480-8260 e-mail: frazierm@mail.nih.gov APPLICATION PROCEDURES The research grant application form PHS 398 (rev. 4/98) is to be used in applying for these grants. These forms are available at most institutional offices of sponsored research and from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267, email: GrantsInfo@nih.gov. Potential applicants are encouraged to obtain a copy of the Nursing Research Exploratory Center Grants Application Guidelines, which contain sample tables and additional information on the application format and contents. These Application Guidelines are available upon request from 301/594-6906. Page Limitations: Each core is limited to 25 pages and each pilot study is limited to 15 pages for the Research Plan sections a through d. Lesser numbers of pages are acceptable. Budget: A separate budget page, with appropriate justification pages, is required for each core and pilot study. The RFA label available in the PHS 398 (rev. 4/98) application form must be affixed to the bottom of the face page of the application. Type the RFA number on the label. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number must be typed on line 2 of the face page of the application form and the YES box must be marked. The sample RFA label available at: http://grants.nih.gov/grants/funding/phs398/label-bk.pdf has been modified to allow for this change. Please note this is in pdf format. Submit a signed, typewritten original of the application, including the Checklist, and three signed, photocopies, in one package to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) At the time of submission, two additional copies of the application must be sent to: Dr. Mary Stephens-Frazier Scientific Review Administrator Division of Extramural Activities National Institute of Nursing Research Building 45, Room 3AN-12 MSC 6300 Bethesda, MD 20892-6300 Telephone: (301) 594-6906 Applications must be received by the application receipt date listed in the heading of this RFA. If an application is received after that date, it will be returned to the applicant without review. The Center for Scientific Review (CSR) will not accept any application in response to this RFA that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. The CSR will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of substantial revisions of applications already reviewed, but such applications must include an introduction addressing the previous critique. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for completeness by the CSR and responsiveness by NINR. Incomplete and/or non-responsive applications will be returned to the applicant without further consideration. Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by an appropriate peer review group convened by NINR in accordance with the review criteria stated below. As part of the initial merit review, all applications will receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of the applications under review, will be discussed, assigned a priority score, and receive a second level review by the National Advisory Council for Nursing Research. Review Criteria The goals of NIH-supported research are to advance our understanding of biological systems, improve the control of disease, and enhance health. In the written comments, reviewers will be asked to give careful consideration of the information in the SPECIAL REQUIREMENTS section of the RFA and the review criteria listed below in order to judge the likelihood that the proposed Center will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered in assigning the overall score, weighting them as appropriate for each application. Note that the application does not need to be strong in all categories to be judged likely to have major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward. RESEARCH BASE 1. Focus and depth of funded investigations that are currently in progress. 2. Presence of current and emerging collaborations and interactions among investigators with common research interests within the area of scientific inquiry, and among the investigators within the research base. 3. Impact that funded investigators have made in their respective fields, as indicated by publications and other factors. 4. The qualifications, experience, and commitment of the Center investigators responsible for the individual research projects, and their willingness to interact with each other. 5. The appropriateness of the investigators as participants of the Center, and whether their activities warrant core support. ADMINISTRATIVE CORE 1. The adequacy of the Administrative core to manage the overall activities of the Center. 2. The appropriateness and relevance of the proposed core and the modes of operation, facilities, and potential for contribution to ongoing nursing research. 3. Appropriate justification for the core, including the duplication of existing resources or services and anticipated future use of the core. 4. The qualifications of the Director of the Administrative core. 5. The adequacy of the multiple aspects related to the administrative structure for the center, including the ability of the center director to provide the scientific and administrative leadership for the project; strategies to promote scientific planning, interaction, implementation, and evaluation; and arrangements for the fiscal management of the grant. 6. The proposed composition and functions of the Executive Committee to support the proposed activities of the Center. 7. The proposed composition and function of the external Advisory Committee to support the proposed activities of the Center. PILOT AND/OR FEASIBILITY STUDIES CORE 1. The scientific merit of the research proposed and the importance of the information sought to the mission of the NINR. 2. The process for selecting the pilot/feasibility studies included in the application. 3. The proposed process for reviewing and selecting future pilot/feasibility studies. 4. How well the pilot/feasibility study fits into the area of scientific inquiry selected for the Center. 5. The justification for eligibility of the investigator(s) according to criteria listed in the RFA. 6. The feasibility and promise of the proposed methods. 7. The novelty or originality of the applications. 8. The training, experience, and research competence of the investigator(s). 9. The suitability of the facilities for the proposed research, including the availability of required special resources. 10. The appropriateness and justification of the requested budget for the proposed work. 11. Provisions for the protection of human subjects and the humane care of animals. 12. The qualifications of the Director of the Pilot and/or Feasibility Studies core. OVERALL CENTER CORE GRANT APPLICATION 1. The overall scientific merit and the potential of the research program for making a significant contribution to achieving the goals of the NINR. 2. The scientific gain from linking the research projects in a center grant, i.e., the degree of interrelatedness and synergism among the components of the center. 3. Evidence of collaborative and/or interdisciplinary research, and interdisciplinary approach of the Center. 4. The qualifications of the Center Director and other key investigators and the commitment of participating investigators to a common goal and to collaboration. 5. The adequacy of the available resources and the quality of the research environment. 6. The institutional commitment to the Center in terms of space, resources, administrative authority, and other necessary support, e.g., donated faculty time, and the extent to which the Center is recognized as a major element within the organizational structure of the institution. 7. The plans for developmental activities, including recruitment and expansion, insofar as these are justified by the proposed research program. 8. The plans for outreach and collaboration with other groups doing related work. 9. Provisions for the protection of human subjects and the humane care of animals. 10. A plan for evaluation of activities of the Center. 11. Appropriateness of the requested budget for the work proposed. In addition to the above criteria, in accordance with NIH policy, all applications will also be reviewed with respect to the following: o The adequacy of plans to include both genders, minorities and their subgroups, and children as appropriate for the scientific goals of the research. Plans for the recruitment and retention of subjects will also be evaluated. o The reasonableness of the proposed budget and duration in relation to the proposed research. o The adequacy of the proposed protection for humans, animals or the environment, to the extent they may be adversely affected by the project proposed in the application. Schedule Letter of Intent Receipt Date: October 9, 2000 Application Receipt Date: November 14, 2000 Peer Review Date: February 2001 Council Review: May 2001 Earliest Anticipated Start Date: August 2001 AWARD CRITERIA Award criteria that will be used to make award decisions include: o scientific merit (as determined by peer review) o availability of funds o programmatic priorities. INQUIRIES Inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or answer questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Carole Hudgings, PhD, RN, FAAN Chief, Office of Extramural Programs National Institute of Nursing Research Building 45, Room 3AN-12 MSC 6300 Bethesda, MD 20892-6300 Telephone: (301) 594-5976 FAX: (301) 480-8260 E-mail: carole_hudgings@nih.gov Direct inquiries regarding review issues to: Dr. Mary Stephens-Frazier Scientific Review Administrator Division of Extramural Activities National Institute of Nursing Research Building 45, Room 3AN-12 MSC 6300 Bethesda, MD 20892-6300 Telephone: (301) 594-6906 FAX: (301) 480-8260 E-mail: frazierm@mail.nih.gov Direct inquiries regarding fiscal matters to: Jeff Carow Grants Management Officer Office of Grants and Contracts Management National Institute of Nursing Research Building 45, 3AN-12 MSC 6300 Bethesda, MD 20892 Telephone: (301) 594-6869 FAX: (301) 480-8260 Email: jeff_carow@nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.361. Awards are made under authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and administered under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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