ANIMAL MODELS OF HUMAN PAPILLOMAVIRUS INFECTIONS FOR EVALUATION OFEXPERIMENTAL THERAPIES



NIH GUIDE, Volume 21, Number 28, August 7, 1992



RFP:  NIH-NIAID-DMID-93-05



P.T. 34



Keywords:

  Viral Studies (Virology) 

  Disease Model 

  Pathogenesis 



National Institute of Allergy and Infectious Diseases



The Antiviral Research Branch of the Division of Microbiology and

Infectious Diseases, National Institute of Allergy and Infectious

Diseases, is seeking investigators to employ appropriate animal model

systems of human papillomaviral infections to evaluate the efficacy of

experimental therapies and provide basic information on the natural

history and pathogenesis of papillomavirus infections.



Current treatment for papillomavirus infection is limited to topical

therapies which destroy tissue, are limited to visible lesions, and are

associated with unacceptably high recurrence rates.  Consequently,

there is a clear need to identify effective systemic chemotherapeutic

agents.  The availability of animal model systems mimicking human

papillomavirus infection makes it feasible to continue a program to

identify therapeutic agents for these infections.



The primary objective of the Animal Models Program of the Antiviral

Research Branch is to evaluate experimental therapies for potential

clinical efficacy and toxicity in animal models of clinically important

human viral infections.



In addition, the animal models are used to study disease pathogenesis

and host response to infection.  In the future, when appropriate, these

models will also be used for a limited amount of vaccine evaluation and

pharmacokinetic studies.  Animal models that are predictive of human

response to a therapeutic intervention are invaluable for the

identification of experimental therapies with the best clinical

potential.  They are also important for evaluation of dosing regimens,

combination drug therapies and delivery strategies.  The animal models

program has made many significant contributions to the development of

new therapies.  This recompetition is planned to assure the

continuation of this vital resource for the development of antiviral

therapies.  This program currently includes models of the following

infections:  influenza, parainfluenza, respiratory syncytial virus,

measles, neonatal herpes, herpes encephalitis, genital herpes,

varicella zoster virus, cytomegalovirus, and papillomaviruses.



The emphasis for this solicitation will be to support animal models

that:  (a) share significant features of pathology and natural history

with human papillomavirus infections, (b) utilize either a human virus

or an animal virus with considerable homology to the human virus, and

(c) have been, or can be expected to be, predictive for human efficacy.

As in the past, basic studies on model development, disease

pathogenesis, and natural history will be encouraged as an adjunct to

the primary focus on therapeutic evaluation. Occasionally, when

appropriate, these models will also be utilized for vaccine evaluation

and for pharmacokinetic analysis of a compound.



Any contract awarded will be subject to the Department of Health and

Human Services regulations regarding the animal subjects in research.

This announcement is a new solicitation.  The issuance of the RFP will

be on or about August 4, 1992 and proposals will be due at close of

business on September 21, 1992.  It is expected that two contracts with

a five-year period of performance will be awarded as a result of this

solicitation.



The request for the RFP should be addressed to:



Mr. Carl Henn

Contracting Officer

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

6003 Executive Boulevard

Bethesda, MD  20892



Please provide this office with two self-addressed mailing labels.



This advertisement does not commit the Government to award a contract.



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