CORE IMMUNOLOGY LABORATORY FOR ASSESSMENT OF AIDS VACCINES INPRIMATES



NIH GUIDE, Volume 21, Number 37, October 16, 1992



RFP:  NIH-NIAID-DAIDS-93-15



P.T. 34



Keywords:

  AIDS 

  Vaccine 

  Immunology 

  Bioassay 



National Institute of Allergy and Infectious Diseases



The National Institute of Allergy and Infectious Diseases (NIAID),

National Institutes of Health (NIH) has a requirement to provide for

the centralized performance of immunological assays to support

preclinical AIDS vaccine trials in primates.  The purpose of this

contract is to support the NIAID in its mission to stimulate research

towards discovery and testing of prototype vaccines for the acquired

immunodeficiency syndrome (AIDS).  The NIAID requires a Primate Core

Immunology Laboratory to assay specimens from macaques, chimpanzees,

or other primates for humoral and cellular immune responses induced

by immunization with prototype Simian Immunodeficiency Virus (SIV)

and Human Immunodeficiency Virus (HIV) vaccines.  This effort will

support the research of AIDS investigators, including three SIV

Vaccine Evaluation Units (SIV VEU), a Chimpanzee Unit, the National

Cooperative Vaccine Evaluation Group (NCVDG), the AIDS Vaccine

Evaluation Group (AVEG), and other programs initiated by NIAID.

Specifically, the selected contractor will be responsible for:  (1)

performing specific evaluations of cellular immune responses induced

by vaccination; (2) performing specific evaluations of humoral immune

responses induced by vaccination; (3) adapting, standardizing,

providing quality assurance, and performing any newly developed

immunological assays that may be identified during the period of the

contract as offering potential for assessment of vaccine safety and

immunogenicity; (4) receiving, cataloging, tracking, and maintaining

an inventory of the specimens arriving for evaluation; and (5)

maintaining test result database and transferring data to the AIDS

Vaccine Clinical Trials Network (AVCTN) Data Coordinating and

Analysis Center (DCAC).  This is an announcement for an anticipated

Request for Proposals (RFP).  The issuance of RFP

NIH-NIAID-DAIDS-93-15 will be on or about October 16, 1992, and

proposals will be due by the close-of-business on January 5, 1993.

It is anticipated that one contract will be awarded as a result of

this solicitation and that the contract will have a five-year period

of performance.  A completion type cost-reimbursement contract is

anticipated.  Requests for the RFP must be directed in writing to --



Kristi Hofacker, Contract Specialist

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

6003 Executive Boulevard

Bethesda, MD  20892



Provide this office with three self-addressed mailing labels.

Telephone inquiries will not be honored and all inquiries must be in

writing.  A short-form version of the RFP will be provided first.

That version includes only the Statement of Work and the Evaluation

Criteria to be used for selection of the awardee.  After examining

this document, a full-text version of the RFP must be requested, in

writing, for those offerors interested in responding. FAX requests

are acceptable for full-text versions of the RFP only (FAX:

301-402-0972).  All proposals from responsible sources will be

considered by the NIAID.  This advertisement does not commit the

Government to award a contract.



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