NIH GUIDE, Volume 21, Number 41, November 13, 1992


P.T. 34




  Screening of Drugs/Agents 


National Institute of Allergy and Infectious Diseases

The Developmental Therapeutics Branch, Basic Research and Development

Program, Division of AIDS, National Institute of Allergy and Infectious

Disease (NIAID), NIH has a requirement to apply established

biochemically-based enzymatic or non-enzymatic assays to screen agents

for inhibition of one or more steps in the metabolism of

AIDS-associated opportunistic pathogens.  These biochemical prescreens

are considered particularly useful for rapid testing of compounds.

Examples of such assays may include, but not be limited to:  protein

synthesis, dihydrofolate reductase, and dihydropteroate synthase. The

major effort of this contract will involve the screening of a large

number of compounds.  A secondary focus of this contract will be

development/modification of automated biochemical assays and their

application to drug testing against opportunistic infections in AIDS.

It is anticipated that some assays will require isolation of enzymes

from relevant microorganisms or cloning to obtain the protein.

However, most of the enzymes and recombinant proteins required for the

development of assays in this project will be provided by the AIDS

Reference and Reagent Repository.  Other non-enzymatic assays may be

developed /used to evaluate drug activities in vitro.  At the present

time, NIAID has one contract that is scheduled to end in 1993 to screen

agents in enzymatic assays.

This NIAID sponsored project will take approximately three years to

complete.  A level-of-effort, cost reimbursement contract is

anticipated.  It is expected that one award will be made.

This is an announcement for an anticipated Request for Proposal (RFP).


be issued on or about November 12, 1992, with a closing date

tentatively set for January 15, 1993.


Requests for the RFP may be directed in writing to:

Cyndie Cotter

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

6003 Executive Boulevard

Bethesda, MD  20892

To receive a copy of the RFP, please supply this office with three

self-addressed mailing labels.  Telephone inquiries will not be honored

and all inquiries must be in writing.  A short- form version of the RFP

will be provided first, which includes only the Statement of Work and

the Evaluation Criteria to be used for selection of the awardee.  After

examining this, a full-text version of the RFP must be requested, in

writing, for those offerors interested in responding.  FAX requests are

acceptable for the full-text version only (FAX:  301-402-0972).  All

proposals from responsible sources will be considered by the NIAID.

This advertisement does not commit the Government to award a contract.


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