NHLBI MINORITY INSTITUTION RESEARCH SCIENTIST DEVELOPMENT AWARD (K01) Release Date: May 25, 1999 RFA: HL-99-019 National Heart, Lung, and Blood Institute Letter of Intent Receipt Date: July 1, 1999 Application Receipt Date: August 26, 1999 PURPOSE This program provides research support to faculty members at minority institutions who have the interest and potential to conduct high quality research in the areas of cardiovascular, pulmonary, hematologic, or sleep disorders. Important goals are to enhance the institution's science programs and to assist in the acquisition of "hands on" research opportunities for minority students at the applicant's institution. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), NHLBI Minority Institution Faculty Mentored Research Scientist Development Award (K01), is related to one or more of the priority areas. Potential applicants may obtain a copy of "Healthy People 2000" at the following URL address: http://www.crisny.org/health/us/health7.html ELIGIBILITY REQUIREMENTS A. Minority School The Institution must be a domestic medical or non-medical college, university or equivalent school in which students of underrepresented minority ethnic groups including Blacks, Hispanics, American Indians, Alaska Natives, and Pacific Islanders comprise a majority (more than 50%) of the school's enrollment. It must have ongoing staff and facilities required for the proposed program. The program director at the minority school will be responsible for the selection and appointment of trainees and the overall direction of the training program. B. Faculty Development Award Candidate Candidates for this award are minority school faculty members who: 1) are citizens of the United States, non-citizen nationals or permanent residents at the time of application; 2) have a doctoral degree or equivalent in a biomedical or behavioral science; 3) wish to receive specialized training in cardiovascular, pulmonary, hematologic, or sleep disorders research; 4) have the background and potential to benefit from the training; and 5) are committed to providing research opportunities for students at their institution. C. Mentor at Nearby Research Center Each candidate must also identify and complete arrangements with a nearby mentor (within approximately 100 miles) who is recognized as an accomplished investigator in the research area proposed and who will provide guidance for the awardee's development and research plan. Arrangements with mentors at institutions greater than 100 miles from the applicant institution will be considered, but must be justified strongly and outlined clearly in the application. Plans for intensive training of the applicant and their student(s) during the summer period (2 - 3 months) as well as during the academic year should be developed with the mentor. The commitment of the mentor and the mentor's departmental chair to both the summer and academic year training periods must be documented in the application. The mentor must provide an annual evaluation of the faculty member's career development. This evaluation is to be included as part of the Application for Continuation Grant if an award is made. D. Student Research Assistants Student research assistants are underrepresented minority students enrolled at the applicant (minority) institution who are : 1) citizens of the United States, noncitizen nationals, or permanent residents at the time of application; 2) have declared a major or concentration in a biomedical or behavioral science; 3) have at least an overall B grade point average; 4) have the potential and desire to pursue an advanced degree in the biomedical or behavioral sciences; and 5) wish to receive research training in areas relevant to cardiovascular, pulmonary, hematologic, or sleep disorders research. At least one and a maximum of two students may participate on the project simultaneously as research assistants. Students are expected to participate in the program for a minimum of two years. The candidate should identify the student(s) proposed for the first two-year period and provide a brief summary of their interest in behavioral and/or biomedical science and any previous laboratory experience. The candidate should describe how (s)he will foster student interest in graduate school in behavioral or biomedical research and a career in scientific research in areas related to heart, lung, blood, or sleep disorders. For the purpose of this announcement, underrepresented minority students are defined as individuals belonging to a particular ethnic or racial group that has been determined by the applicant institution to be underrepresented in biomedical or behavioral research. Nationally, NHLBI considers Black, Hispanic, Native American, and Pacific Islander students to be underrepresented. MECHANISM OF SUPPORT This RFA will use the NHLBI Minority Institution Faculty Mentored Research Scientist Development Award (K01) mechanism of support. However, specific application instructions have been modified to reflect "JUST-IN-TIME" streamlining efforts implemented by NIH in the NIH GUIDE FOR GRANTS AND CONTRACTS, Vol. 25, No. 10, March 29. This process allows applicants to submit certain information only when there is a possibility for an award. It is anticipated that these changes will reduce the administrative burden for the applicants, applicant institutions, reviewers, and Institute staff. For this RFA, no detailed budget is required. However, total direct costs for all years must be provided in addition to the name, role on project, percent effort, and narrative justification for all project personnel. Instructions for completing the Biographical Sketch have also been modified. In addition, Other Support information for the applicant is not required as part of the initial application. However, Other Support information is required for the mentor and co-mentor. If there is a possibility for an award, necessary budget, Other Support information will be requested by NHLBI staff following the initial review. The Application Procedures section of this RFA provides specific details of modifications to standard PHS 398 application kit instructions. FUNDS AVAILABLE The estimated funds (total costs) available for the first year of support for the entire program is expected to be $400,000 in fiscal year 2000. The actual amount may vary, depending on the response to the RFA and availability of funds. Three new awards are anticipated. BACKGROUND Measurements of health status indicate that Americans today are, on the whole, healthier than at any other time in our history. Life expectancy has increased while infant mortality statistics indicate that fewer infants are dying at birth or in the first few months of life. Diseases that disabled or killed at the start of the century have virtually disappeared. In spite of this national trend toward better health, there is a continuing disparity in the burden of death and illness experienced by Blacks and other minority Americans. This segment of the population continues to be over represented among those in poor health and has remarkably higher death rates from cardiovascular, pulmonary, and hematologic diseases. Despite a recent decline in the death rate from coronary heart disease, cardiovascular disease continues to be the number one cause of death in the United States, accounting for almost one million deaths annually. An estimated 68 million Americans are estimated to have diseases of the heart and blood vessels, resulting in a large burden of acute and chronic illness and disability. Heart and blood vessel diseases cost the economy tens of billions of dollars per year in lost wages, reduced productivity, and expenses for medical care. Diseases of the lung also constitute a major national health problem. About one in every five persons has some chronic respiratory problem resulting in an annual estimated cost to the nation of over $29 billion. In the newborn, the most common cause of death is neonatal respiratory distress syndrome (RDS). Respiratory failure during the neonatal period may be implicated in development of adult respiratory disease as well. Of the adult respiratory diseases, emphysema and chronic bronchitis are major causes of death. Fibrotic and immunologic lung diseases are serious causes of lung problems in the young adult. Asthma, emphysema and chronic bronchitis represent particularly pressing health problems, affecting an estimated 17 million Americans. Moreover, the death rate and prevalence of these conditions have increased at an alarming rate over the past 15 years. As a disabling disease, chronic obstructive pulmonary disease is a leading cause of worker retirement on Social Security disability payments. Disorders of the blood, including congenital or acquired disorders or deficiencies, are another major causes of death and disability in the United States. Disorders of the blood affect not only the blood itself, but the tissues and organs through which it flows. Recent research findings have revealed the widespread involvement of thrombosis in the pathology of numerous disorders, including the development of atherosclerosis and coronary thrombosis. Aggressive therapy for cancer has resulted in the increased susceptibility of patients to bleeding disorders and has increased the demand for blood products for therapeutic purposes. A significant segment of the population has inherited blood disorders, such as sickle cell disease, hemophilia, or Cooley's anemia, which require life-long hematologic attention and blood product support. Chronic disorders of sleep affect an estimated 40 million Americans. Sleep problems affect men and women of every age, race, and socioeconomic class. Many people are unaware of their illness and are not receiving adequate treatment. About 20 million adults have chronic insomnia. Sleep apnea, a cessation of breathing during sleep, is the second most common sleep disorder. It affects about 12 million Americans. Other startling statistics include the following: about 25 percent of American children aged 1 to 5 have a sleep disturbance; an estimated 250,000 people suffer from narcolepsy; more than 50 percent of Americans aged 65 and older have a sleep problem; and disturbed sleep is among the reasons most frequently cited by caretakers for institutionalization of older Americans. Each year, sleep disorders, sleep deprivation, and daytime sleepiness contribute a substantial burden to national health care. Additional costs to society for such consequences as lost worker productivity, accidents, and the contribution of sleep disorders to other serious health problems such as heart disease and stroke are just being identified and studied. The National Heart, Lung, and Blood Institute (NHLBI) continues its commitment to address these important medical challenges. One way of meeting these challenges is to increase the pool of well trained investigators, especially in minority groups where the proportion of biomedical investigators is strikingly lower than the percentage of minority U.S. citizens. While 12 percent of the population is Black, less than 0.25 percent of persons holding a Ph.D. in science are Black. The figures are even lower for Black Ph.D.s in the biomedical sciences. Furthermore, the number of doctorates, both M.D.s and Ph.D.s, in other ethnic minority groups (such as American Indians or Hispanics) is proportionally lower than for Blacks. Vigorous recruitment is underway throughout the government, academic institutions, hospitals, research institutions, and industry. The Minority Institution Mentored Research Scientist Development Award is designed to address this critical need by increasing the research and academic capabilities of faculty members at minority schools. In doing so, the faculty will become more able to prepare and direct their students to pursue advanced degrees and ultimately careers in biomedical and behavioral research thus increasing the pool of well trained biomedical and behavioral investigators in cardiovascular, pulmonary, hematologic, and sleep disorders research. Because it is important to sustain the faculty's research program following the initial period, recipients may reapply for an additional five year period of support. More than one applicant from each institution may apply. Former awardees within three years of the end of their award may also apply for the additional five year period. At the end of the period of support, it is anticipated that the applicant will be prepared to apply for other types of NIH support such as the Research Project Grant (R01), Academic Research Enhancement Award (AREA, R15), or Minority Biomedical Research Support Program (MBRS, S06.) PROVISIONS OF THE AWARD Salary The awardee will receive salary support up to a maximum of $75,000 plus fringe benefits per year for five years. All funds must be used to support the awardee. The level of support will be based upon the candidate's actual salary and must be consistent with the established salary structure of the minority institution for persons of equivalent qualifications, experience, and rank. The actual salary level will be determined by the proportion of effort devoted to this program. Awardees must commit 100 percent of effort during summer and/or off-quarter periods and at least 25 percent of effort during the academic year. Supplementation of the awardee's salary from non-Federal sources is permissible. Supplementation of the awardee's salary from other Federal funds is not allowed unless explicitly authorized by both the program from which funds are derived and the NHLBI. In no case may other NIH funds be used to supplement salary support of the awardee. In addition to salary support for the candidate, support for up to 5 percent of the mentor's salary during the summer experience may also be requested. If funds are to be transferred to the mentor's institution for the mentor's salary, arrangements for the transfer of funds and the conduct of activities should be formalized in a subcontract agreement with the mentor's institution. A letter of intent from each institution must be submitted with the application. A maximum of $8.50 per hour plus fringe benefits may be requested for the student research assistant(s). Level of support and hours worked during the academic year should reflect the institution's policy for student work-study programs. Students must commit 100% effort during the summer and off-quarter periods and at least 25% effort during the academic year. Students are expected to participate in the program for a minimum of two years. Students must be U.S. citizens or non-citizen nationals, or must have been lawfully admitted to the United States for permanent residence (i.e. in possession of a currently valid Alien Registration Receipt Card I-551 or other legal verification of such status.) Research Support Up to $36,000 per year beyond that requested for the candidate's, mentor's, and students' salaries will be provided for research support. Details regarding the apportionment of these funds between the minority institution and the mentor's institution must be worked out with the mentor and agreed to by representatives of both institutions. A statement of agreement must be provided in the application. See the PHS 398 for information on Consortium/Contractual Agreements. These research support funds may be used for: o Personnel: support for technical personnel; o Equipment: limited to specialized research equipment essential to the proposed program; in accordance with PHS policy, title to such equipment will vest with the grantee institution; o Supplies: consumable supplies essential to the proposed program; o Travel: domestic travel for the awardee that is essential to the proposed program; and o Other: publication costs, computer costs, or other costs necessary for the research program. Student Housing and Travel The applicant institution is encouraged to provide no-cost housing and meals to the students during the summer or off-quarter periods if the training will be provided at a local institution, as a commitment to the student's development and as an incentive to participate in the program. If training is not at a local institution, up to $500 per month per student during the summer only may be requested for housing. Funds to allow the student(s) to travel to a scientific meeting should also be requested. Indirect Costs Facilities and administrative (indirect) costs will be provided at a rate of 8 percent of the total direct costs of each award, exclusive of equipment. The indirect cost rate on a subcontract with the mentor's institution may not exceed 8 percent. INCLUSION OF WOMEN AND MINORITIES IN STUDY POPULATIONS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH-supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research," which have been published in the Federal Register of March 28, 1994 (FR 59 15508-14513) and in the NIH Guide for Grants and Contracts, Vol. 23, No. 11, March 18, 1994, available at the following URL address: https://grants.nih.gov/grants/guide/notice-files/not94-100.html NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of NIH that children (i.e., individuals under the age of 21) must be included in all human subjects research conducted or supported by the NIH unless there are scientific and ethical reasons not to include them. This policy applies to all initial (type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines on the Inclusion of Children as Participants in Research Involving Human Subjects" that was published in the NIH Guide for Grants and Contracts, March 6, 1998, and is available at the following URL address: https://grants.nih.gov/grants/guide/notice-files/not98-024.html LETTER OF INTENT Prospective applicants are asked to submit, by July 1, 1999, a letter of intent that includes the name, address, and telephone number of the Principal Investigator, the identities of other key personnel and participating institutions, and the number and title of the RFA in response to which the application may be submitted. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains allows NHLBI staff to estimate the potential review workload and to avoid conflict of interest in the review. The letter of intent is to be sent to Dr. C. James Scheirer at the address listed under APPLICATION PROCEDURES. APPLICATION PROCEDURES The research grant application Form PHS 398 (Rev. 4/98) is to be used in applying for these grants. This form is available at the applicant institution's office of sponsored research. An application may also be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, Maryland, 20892-7910, telephone 301/710-0267, e-mail: grantsinfo@nih.gov; and at the following URL address: https://grants.nih.gov/grants/funding/phs398/phs398.html When submitting the application, identify the NHLBI Minority Institution Faculty Mentored Research Scientist Development Award on the face page. The RFA label available in the PHS 398 application form must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, the RFA title and number (HL-99-019) must be typed on line 2 of the face page of the application form and on the RFA label and the YES box must be marked. The sample RFA label available at: https://grants.nih.gov/grants/funding/phs398/label-bk.pdf has been modified to allow for this change. Please note this is in pdf format. Submit a signed, typewritten original of the application and three signed photocopies in one package to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040, MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) At the time of submission, send two additional copies of the application to: Dr. C. James Scheirer Division of Extramural Affairs National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7924 Bethesda, MD 20892-7924 Telephone: (301) 435-0266 FAX: (301) 480-3541 Email: js110j@nih.gov It is important to send these two copies at the same time as the original and three copies are sent to the Center for Scientific Review (CSR). These copies are used to identify conflicts and help ensure the appropriate and timely review of the applications. Applications must be received by August 26, 1999. If an application is received after that date, it will be returned to the applicant without review. The CSR will not accept any application in response to this RFA that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. The CSR will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of substantial revisions of the applications already reviewed, but such applications must include an introduction addressing the previous critique. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for completeness by the Center for Scientific Review and responsiveness by the NHLBI. Incomplete and/or non- responsive applications will be returned to the applicant without further consideration. Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by a Special Emphasis Panel in the Division of Extramural Affairs, NHLBI, in accordance with the review criteria stated below. As part of the initial merit review, a process may be used by the initial review group in which applications receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of applications under review, will be discussed assigned a priority score, and receive a second level review by the National Heart, Lung, and Blood Advisory Council. Review Criteria The following criteria will be considered in the evaluation of the proposed Minority Institution Faculty Mentored Research Scientist Development Award program: Candidate -- The candidate's overall competence as demonstrated by academic record and research performance, potential for a career as an independent researcher, and commitment toward pursuit of an academic research career and toward the enhancement of the scientific program at the minority institution. Career Development Plan -- The adequacy of the research career development plan, based on the candidate's past research experience, training, and career goals as demonstrated by such things as maintenance of a research laboratory, attendance at scientific meetings, and participation in journal clubs and research seminars. Research Project -- Scientific merit of the proposed research project and its appropriateness as a vehicle for developing the candidate's research skills. Training Students -- The candidate's record of and an outline of future plans for involving students in research and guiding them to science graduate programs and careers in academic biomedical and behavioral research. Mentor(s) -- The mentor's accomplishments in the scientific research area(s) proposed, experience and record in training investigators, and commitment for the duration of a candidate's research development. A curriculum vitae with relevant publications and a list of current and pending research support must be included for all sponsors. Mentors should also include a list of current and past research trainees (not more than the last 10 years) with information on their current positions. Environment -- The applicant institution's ability to provide adequate facilities, resources, and opportunities necessary for the candidate's training, and the institutional commitment to the candidate. If different from the applicant institution, the quality and extent of interaction of the faculty in the basic and clinical sciences, and the quality of the research and research training programs at the mentor's institution. Institutional commitment -- The institution's commitment to the development of the candidate. Other Considerations -- The personnel category will be reviewed for appropriate staffing based on the requested percent effort and justification provided. Because the research training environment provides a powerful context in which to promote responsible research practices, all competing applications must include a description of formal or informal activities or instruction related to the responsible conduct of research that will be incorporated into the proposed research training program. Award Criteria The following will be considered in making funding decisions: o Scientific, technical, and career development merit of the application as determined by peer review; o Availability of funds; and o Program balance among the research areas of the announcement. INQUIRIES Potential applicants are strongly encouraged to contact NHLBI staff prior to preparation of an application. Joyce I. Creamer, M.B.A. Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7952 Bethesda, MD 20892-7952 Telephone: (301) 435-0064 FAX: (301) 480-0867 Email: CreamerJ@gwgate.nhlbi.nih.gov For fiscal and administrative matters, please contact: Marie Willett Division of Extramural Affairs National Heart, Lung, and Blood Institute 6701 Rockledge Drive, MSC 7926 Bethesda, MD 20892-7926 Telephone: (301) 435-0144 FAX: (301) 480-3310 Email: marie_willett@nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance, Numbers 93.233, 93.837, 93.838, and 93.839. Awards are made under the authority of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grant policies and Federal Regulations at 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or a Health Systems Agency Review. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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