Full Text HD-96-003
NIH GUIDE, Volume 25, Number 8, March 15, 1996
RFA:  HD-96-003
P.T. 04

  Child/Maternal Health 
  Children (Patients) 

National Institute of Child Health and Human Development
Letter of Intent Receipt Date:  August 15, 1996
Application Receipt Date:  November 13, 1996
The National Institute of Child Health and Human Development (NICHD)
supports a program of Child Health Research Centers (CHRC), intended
to provide resources to speed the transfer of knowledge gained
through studies in basic science to clinical applications that will
benefit the health of children. This will be accomplished by
increasing the number of pediatric medical centers that can stimulate
and facilitate the application of research findings to pressing
pediatric problems, as well as by increasing the number and
effectiveness of pediatric investigators who have a grounding in
basic science and research skills that can be applied to the health
problems of children.
The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This Request
for Applications (RFA), Child Health Research Centers, is related to
the priority areas of nutrition, maternal and infant health, diabetes
and chronic disabling conditions, and immunization and infectious
diseases.  Potential applicants may obtain a copy of "Healthy People
2000" (Full Report:  Stock No. 017-001-00474-0 or Summary Report:
Stock No. 017-001-00473-1) through the Superintendent of Documents,
Government Printing Office, Washington, DC 20402-9325 (telephone
Applications may be submitted by domestic for-profit and non-profit
organizations, public and private, such as universities, colleges,
hospitals, units of State and local governments, and eligible
agencies of the Federal government.
A CHRC grant is awarded to a children's hospital or a department of
pediatrics of an approved medical school in the United States of
America that has as a primary teaching site either a general
children's hospital or a children's program, with an identifiable
organizational structure that is part of a larger medical
institution.  Recipient institutions must have the clinical pediatric
specialties and subspecialties and the discrete clinical and research
facilities sufficient to ensure the linkage of basic research and
clinical applications that will meet the purposes of the CHRC
The CHRC must have a strong, well-established research base, resting
on the interests of established investigators who make their
expertise available to the junior investigators and act as mentors or
senior collaborators for them. The research at the Institution must
be relevant to the current areas of interest of the research and
programmatic needs of the NICHD.  Research should be broadly-based,
not defined by a specific disease category or organ system. There
should be an adequate pool of junior investigators likely to benefit
from career development under the guidance of established
investigators.  In addition, each Center must have a scientifically
sound and equitable system for choosing which junior investigators
and which projects are to be supported.  Finally, there should be
evidence of an institutional commitment to support the Center
resources and to the development and retention of pediatric
Support for this program will be through National Institutes of
Health (NIH) Center Core Grant (P30) awards, which provide core
support for laboratories and administrative resources applicable to a
number of different research projects.  Policies that govern the
grants award programs of the PHS will prevail.  The support of grants
pursuant to the RFA is contingent upon receipt of appropriated funds
for this purpose.
Because the nature and scope of the research proposed in response to
this RFA may vary, it is anticipated that the size of an award will
also vary.  The maximum will be $400,000 for direct and indirect
costs (total) in the first year, with no increases for inflation in
subsequent years.  The number of awards will be influenced by the
amount of funds available to the NICHD, by the overall merit of
applications, and by their relevance to program goals.
It is not a requirement that any CHRC grant be funded at the
allowable budgetary maximum in any particular year.  Small size is
not a disadvantage for Center funding, if the support requested for
core resources (administration, shared core laboratory) is in
proportion to the activity in new investigator development which is
the Center's primary purpose.
Applications from institutions not previously funded for Child Health
Research Centers will compete on an equal basis with competing
continuation applications.
The estimated total costs awarded will be $2.8 million for the first
year of support.  It is anticipated that seven awards (new and
competing continuations) will be made.
A CHRC grant provides pediatric research institutions, both
developing and established, an opportunity to build a greater
capacity for nurturing pediatric investigators.  Established
investigators whose research is already funded by NIH or other
sources through competitively reviewed grants or contracts combine to
establish in their institution a center of research excellence.
Individuals with a wide range of scientific backgrounds, especially
those with basic science orientation, are encouraged to interact with
each other and with newly trained pediatricians just embarking on
their research careers.  A shared core laboratory, which provides
services to complement and extend the capabilities of the established
investigators to facilitate the career development of new
investigators, may be a major part of the Center.  The established
investigators make available their expertise, guidance, and
laboratory facilities, which with the shared core laboratory,
comprise the laboratory resources of the Center, to be utilized by
junior investigators for research projects that will enhance their
basic science knowledge and skills.  Support for conducting these
projects is provided by the Center grant.
The CHRC grant may provide funds for three purposes:
A.  Administration of the Center.
B.  Improvements in the child health-related research program of an
institution in an area of scientific excellence through the
establishment and maintenance of a shared core laboratory.
C.  Support for new projects, conducted by junior investigators,
designed to enhance their research skills and produce preliminary
data which could lead to successful competitive grant applications to
the NIH or other agencies (new project development funds), thereby
providing a bridge between formal research training and the receipt
of independent research grants.
The novel feature of these grants is the flexibility in the use of
the funds awarded for research support, so that decisions about which
new projects and which junior investigators are to be supported are
made by the grantee institution.  Both competing (renewal) and
noncompeting continuations of a CHRC grant are contingent on
demonstration of good judgment in these decisions, as indicated by
scientific progress, success in the initiation of new
competitively-supported research grants and contracts, and the
development of new pediatric investigators.
Components of a CHRC
A.  Principal Investigator
The principal investigator of the CHRC must be the chairperson of the
department of pediatrics or the chief of the pediatric service.  He
or she is responsible for development and maintenance of the Center
as an institutional resource and for its general oversight,
appointing the program director and members of the advisory committee
(see below).  He or she makes the decisions regarding appropriate
recipients of the Center funds for research and career development,
taking into consideration recommendations from the Center advisory
committee.  The principal investigator does not receive salary or
fringe benefit support from the CHRC for this responsibility.
B.  Administrative Staff
The day-to-day administration of the Center grant may be made the
responsibility of a senior faculty member, called the program
director, supported for up to 10 percent time and effort for this
activity.  The program director must be a physician who is
knowledgeable about pediatric research and has a record of success at
laboratory or clinical investigation and preferably a demonstrated
skill in career development.  The principal investigator may also
serve as program director, with appropriate support.  The program
director may be assisted by a part-time Center-supported secretary.
Administrative staff funds may also be used for a well-qualified
recruitment officer, supported up to 20 percent time and effort, to
enhance participation in the program by women and members of minority
groups that are underrepresented in pediatric research (see below).
C.  Advisory Committee
The advisory committee is a group of Center scientists, selected from
the pediatric department and other departments or institutions as
appropriate, who have interests and expertise relevant to pediatric
research.  The advisory committee is to be chaired by the principal
investigator and must include the program director, the core
laboratory director, and some or all of the established
investigators.  It may also include the recruitment officer and any
other persons considered potentially contributory by the principal
investigator.  It is the function of the advisory committee to
evaluate applications for the use of the Center's new project
development funds and make recommendations to the principal
investigator about appropriate awardees. It evaluates ongoing
activities annually, makes recommendations about their continuation,
and recommends to the principal investigator priorities for use of
the resources of the core laboratory.  For these functions, the
committee may utilize institutional or outside consultants as
The advisory committee provides expert counsel essential to the
principal investigator for his or her administration of the Center.
It should meet regularly and its evaluation activities formalized.
Minutes of the advisory committee meetings may be reviewed as part of
a competing or non-competing continuation application.
D.  Established Investigators
At least six established investigators, supported by NIH or other
competitively-awarded grants, are required for a CHRC.  They should
be expert in the application of new advances in basic science
methodology to problems of human development and pediatric disease
that are relevant to the mission of the NICHD and within its
authority to support.  Their research interests must contribute to
areas that justify their collective designation as a Child Health
Research Center, making the CHRC attractive to recently-trained
pediatricians as a place to develop their investigative careers.  The
established investigators need not be pediatric department members;
linkage to other departments can enhance the power of the CHRC, and
is expected to be a key feature of each Center.  When a junior
investigator is to be supported by the Center through new project
development funds, at least one of the established investigators must
agree to provide his or her expertise as a mentor and collaborator
and allow the junior investigator access to his or her laboratories.
The established investigators do not receive support for their
salaries or fringe benefits from the Center grant.  Established
investigators may be added as appropriate to the roster of an ongoing
funded Center.
E.  Laboratory Resources
The laboratory resources of the CHRC comprise the research
laboratories of the established investigators, as well as a shared
core laboratory to be utilized by the established investigators and
the Center-supported junior investigators whose activities they will
supervise.  The justification for the shared core laboratory is its
provision of a cost-effective expansion or centralization of the
research resources that make the Center a magnet for beginning
investigators.  The CHRC grant may support professional supervision
of the shared core laboratory (core laboratory director, maximum 50
percent time and effort), as well as technical assistance, supplies,
and equipment purchase and maintenance.  The principal investigator,
program director, and core laboratory director are responsible for
efficient and equitable utilization of the core laboratory on the
basis of recommendations from the advisory committee.  Core
laboratory log books are subject to review by NICHD staff and outside
consultants upon request of the former.
There must be an institutional commitment to this shared core
laboratory, which may take the form of alterations and renovations to
establish it, the purchase of research equipment, the assignment of
research space, and/or the support of personnel.  Approaches to
stimulating interactions between diverse investigators who can
contribute to Center goals are particularly desirable.
The laboratories of the established investigators are not supported
directly by the Center grant.  Funds for supplies, small equipment,
and technical assistance needed for the conduct of Center-supported
research projects in these laboratories are provided through new
project development funds. Support for projects conducted in the core
laboratory by recipients of new project development funds may come
either from those funds, the core laboratory budget, or both.
F.  New Project Development Funds
The principal investigator, after considering recommendations from
the advisory committee, is to use Center funds to make annual awards
to junior faculty members for the pursuit of research projects that
will utilize the Center laboratory resources and established
investigator expertise.  The projects may be clinical or
non-clinical, as long as they relate to the goal of the Center.  Each
junior investigator must be under the mentorship of an established
investigator who will provide supervision of the research to be
The maximum award to any individual for a project in this category is
$50,000 per year.  These funds may be used to defray the costs of
materials, supplies, technical assistance, and miscellaneous expenses
generated by these projects in the laboratories of the established
investigators who serve as preceptors and collaborators of the
awardees;  for supplies needed for work in the core laboratory that
are beyond the capacity of that laboratory's budget; for small items
of equipment; for travel; and for a portion of the salaries and
fringe benefits of the junior investigators.  These funds may not be
used for patient care costs such as inpatient bed days or outpatient
visits, except for clinical laboratory analyses essential for the
The recipient of new project development funds should be a physician
who has completed pediatric training, who has not previously been the
principal investigator of a competitively awarded NIH research grant
or contract* (except for an NICHD-supported R03 grant), and who is no
more than three years beyond fellowship training at the time the
first new project development fund award is made.  The awards are
renewable at the discretion of the principal investigator, contingent
upon presentation of evidence of satisfactory progress to the
advisory committee and the NICHD in the Center annual progress
report.  Each recipient should make a commitment of time and effort
to research that is appropriate for the magnitude of the award.
Institutions with CHRC grants are encouraged to develop novel
mechanisms for recruiting qualified pediatricians to become
grant-supported investigators in the Center.  Such mechanisms could
include, for example, part-time appointments for persons with
families and special efforts to recruit members of minority groups.
*Note:  This restriction does not apply to NIH CIDA (K08) awards or
any of its precursors (CIA, PSA), which are career development awards
and not research grants.  Recipients of new project development funds
are especially encouraged to apply for CIDA awards, which may be held
prior to or concurrently with (subject to the relevant CIDA salary
restriction) new project development funds.
Allowable Budgetary Items and Supportable Activities
Allowable costs in NIH grants are governed by the Public Health
Service Grants Policy Statement and the NIH Guide for Grants and
Contracts.  Under these rules the principal investigator may exercise
flexibility in meeting unexpected Center requirements by rebudgeting
or requesting approval to rebudget among categories within the total
direct cost budget of the Center (as shown on the Notice of Grant
Award), within the ceilings set in these guidelines.
CHRC grants are for five years, at a maximum level of $400,000
(direct plus indirect cost) annually, and are renewable.  Competing
continuation (renewals) are limited by Congressional action to one
five-year period.  No institution will be funded for a CHRC for more
than ten years in any twelve-year period. That is, institutions that
have been funded for a new CHRC and one competing continuation may
not reapply until after a lapse of two years.  An institution not
funded for a competing continuation application may make a new
application when a new RFA is issued.
Items fundable under a CHRC grant include:
A.  Administration
1.  Salaries and support for a Center program director (maximum 10
percent time and effort), a part-time secretary, and a recruiting
officer (maximum 20 percent time and effort).
2.  Administrative support services, including supplies, duplicating
equipment, telephone, or maintenance contracts for equipment if not
covered by institutional overhead charges.
3.  Travel of principal investigator and Center program director to
an annual scientific meeting of Centers.
B.  Shared Core Laboratory (maximum $200,000 annually)
1.  Salaries and support for shared core laboratory staff.
2.  Supplies and animals.
3.  Scientific equipment (purchase and maintenance).
4.  Computer facilities.
C.  New Project Development Funds
Up to $50,000 annually can be used to provide support for projects of
individual junior investigators that are pursued in their own
laboratories, in the shared core laboratory, and/or in the
laboratories of the established investigators.  For each person
supported in this category, the maximum expenditure for equipment is
$7,000 annually and for travel $2,000 annually. The grant application
should indicate the number of awards proposed for each year, and
provide evidence that this number of worthwhile projects is likely to
be forthcoming.  No investigator may receive more than one such award
per year.  The number of new project development awards to be
supported  must be commensurate with the institution's capacity to
develop and recruit appropriate candidates.  To encourage use of
these funds only for the most deserving candidates, requests will be
considered for the carry-over of unexpended new project development
funds into subsequent budget periods.
Items not fundable under a CHRC grant include:
1.  Direct support of the laboratories, salaries, fringe benefits,
travel, and research projects of the established investigators,
except for reimbursement for costs from new project development funds
within the Center.
2.  Salary and support for central institutional administrative
personnel usually paid from institutional overhead charges, such as
budget officers, grant assistants, and building maintenance
3.  Salary and support for administrative activities such as public
relations or health and educational services.
4.  Travel of principal investigator, program director, core
laboratory director, or established investigators to scientific
5.  Costs of clinical care, such as patient bed days or outpatient
visit charges.
6.  Alterations and renovations.
Application Format
A.  Text
Applicants should follow the instructions for applications included
in the "National Institute of Child Health and Human Development
Research Center Programs P30 Center Core Grant Guidelines," except
where these are at variance with these specific guidelines for CHRC
grants.  Since P30 Guidelines were not designed prospectively to be
used for CHRC-type applications, considerable flexibility in format
will be permitted.  Applicants should take care, however, that
adequate information is provided for evaluation with respect to the
eleven review criteria described below.  Prospective applicants are
urged to discuss their plans with Institute staff.
Specific research projects proposed for support need not be described
in the application.  However, a brief description of examples of
junior investigators who might be supported through this award, their
training background, research areas in which they are interested, and
established investigators who could supervise them is desirable,
since it might provide evidence that enough worthy projects will be
available to justify the requested budget.
B.  Budget
Each application submitted in response to this RFA should include the
following separate budget pages (Form Page 4, PHS 398 (rev. 5/95)),
plus appropriate budget justification pages:
1.  A composite budget, the sum of the other budgets, in categories,
for the first year.  New project development funds should be listed
under Other Expenses.
2.  A budget for the administrative core, including personnel or
supplies, travel for the principal investigator and program director
to the Centers' meeting, and any other expenses requested, for the
first year.
3.  A budget for the shared core laboratory including personnel,
equipment, supplies, and other expenses, for the first year (maximum
$200,000 annually).
4.  A budget for new project development funds for the first year,
providing under Other Expenses the total dollars and minimum number
of positions requested, according to the following format:
New Project Development Awards:  4 @ $50,000
                              or 5 @ $40,000
The new project development funds budget need not be allocated into
categories, since these will vary with the situations of the
recipients. However, it should be specified to what extent these
funds will be used for salaries.  The number of such awards planned
should be appropriate for the size of the institution, the number and
skills of the established investigators, and the magnitude of the
request for Center administration and core laboratory resources.
5.  A categorical budget page (Form Page 5, PHS 398 - rev. 5/95) for
the composite and for each separate core budget.  Planned new project
development awards should be shown in the Other category.
Non-competing continuations
Annual progress reports of a CHRC grant will be reviewed by NICHD
staff and outside consultants in order to confirm that the Center is
continuing to meet its goal of recruiting promising new pediatric
investigators and stimulating and facilitating their career
development.  In addition, each Center will be asked to send some of
its recent recipients of research support as well as the principal
investigator and/or program director to an annual meeting.  One
purpose of this meeting will be to allow these junior investigators
to present their Center-supported research to their peers as well as
to other critics. Center principal investigators and program
directors are expected to make a special effort to attend these
meetings to demonstrate their support of the program and the junior
investigators.  In addition, they will have an opportunity at these
meetings to exchange ideas about common problems and make suggestions
to NICHD staff about possible modifications in the program.
The NICHD is engaged in a longitudinal tracking procedure to follow
the careers of persons supported by new project development funds.
The purpose of this procedure is to evaluate the effectiveness of the
CHRC Program in meeting its explicit goals.  In accepting a CHRC
award, grantee institutions commit themselves to an earnest effort to
provide information requested by NICHD Staff for this purpose for the
period of the award and for five years thereafter.  In general, the
information required about each individual will include an address,
academic status, time in research activities, and funds for research
support.  This commitment will apply to individuals who have left the
grantee institution as well as to those who remain on faculty there.
It is the policy of the NIH that women and members of minority groups
and their subpopulations must be included in all NIH supported
biomedical and behavioral research projects involving human subjects,
unless a clear and compelling rationale and justification is provided
that inclusion is inappropriate with respect to the health of the
subjects or the purpose of the research.  This new policy results
from the NIH Revitalization Act of 1993 (Section 492B of Public Law
103-43) and supersedes and strengthens the previous policies
(Concerning the Inclusion of Women in Study Populations, and
Concerning the Inclusion of Minorities in Study Populations) which
have been in effect since 1990.  The new policy contains some new
provisions that are substantially different from the 1990 policies.
All investigators proposing research involving human subjects should
read the "NIH Guidelines For Inclusion of Women and Minorities as
Subjects in Clinical Research", which have been published in the
Federal Register of March 28, 1994 (FR 59 14508-14513), and reprinted
in the NIH GUIDE FOR GRANTS AND CONTRACTS of March 18, 1994, Volume
23, Number 11.
Investigators may obtain copies from these sources or from the
program staff or contact person listed below.  Program staff may also
provide additional relevant information concerning the policy.
Prospective applicants are asked to submit, by August 15, 1996, a
letter of intent that includes a descriptive title of the proposed
Center, the name, address, and telephone number of the Principal
Investigator, the identities of other key personnel (established
investigators excepted) and participating institutions, and the
number and title of this RFA.
Although a letter of intent is not required, is not binding, and does
not enter into the review of subsequent applications, the information
that it contains allows NICHD staff to estimate the potential review
workload, and to avoid possible conflicts of interest in the review.
The letter of intent is to be sent to Dr. Ephraim Levin at the
address listed under INQUIRIES.
The research grant application form PHS 398 (rev. 5/95) is to be used
in applying for these grants.  Applications kits are available at
most institutional offices of sponsored research and may be obtained
from the Grants Information Office, Office of Extramural Outreach and
Information Resources, National Institutes of Health, 6701 Rockledge
Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267,
email:  girg@drgpo.drg.nih.gov.
The RFA label available in the application form PHS 398 must be
affixed to the
bottom of the face page.  Failure to use this label could result in
processing of the application such that it may not reach the review
in time for review.  In addition the RFA title (CHILD HEALTH RESEARCH
and number (HD-96-003) must be typed on line 2 of the face page of
Institutions that have previously submitted an unsuccessful CHRC
application should treat an application in response to this present
RFA as a new application, not a revision of the previous one.
Submit a signed, typewritten original of the application, including
the Checklist, and three signed, exact photocopies, in one package
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)
At the time of submission, two additional copies of the application
must also be sent to:
Susan Streufert, Ph.D.
Division of Scientific Review
National Institute of Child Health and Human Development
6100 Executive Boulevard, Room 5E01 - MSC 7510
Bethesda, MD  20892-7510
Applications prepared in response to this RFA must be received by
November 15, 1996.  If an application is received after that date, it
will be returned to the applicant without review.
Upon receipt, applications will be reviewed for completeness by DRG
and responsiveness by the NICHD.  Incomplete or non-responsive
applications will be returned to the applicant without further
consideration.  Applications that are complete and responsive to the
RFA will be evaluated for scientific and technical merit by an
appropriate peer review group convened by the NICHD in accordance
with the review criteria stated below.  As part of the initial merit
review, all applications will receive a written critique and undergo
a process in which only those applications deemed to have the highest
scientific merit, generally the top half of applications under
review, will be discussed, assigned a priority score, and receive a
second level review by the NICHD Advisory Council.
Review Criteria
A.  The review criteria for the evaluation of new and competing
continuation CHRC applications are the following:
1.  Probable impact of the Center on enhancing the capacity of the
grantee institution to develop well-qualified new pediatric
investigators, thereby advancing pediatric research at the grantee
institution, in the local medical environment, and in the nation,
especially with regard to the application of basic research
developments to clinical problems in pediatrics.
2.  Quality and productivity of the research activities of the
participating established investigators and the relevance of their
programs to the NICHD mission.
3.  Institutional commitment to the requirements of the program, such
as recruitment efforts, salaries, equipment, transfer of indirect
costs to direct costs, or other forms of cost sharing.
4.  Evidence for a pool of prospective investigators, trained locally
or recruited from elsewhere, who could benefit from receiving support
from the Center.
5.  Opportunities for recipients of new project development funds for
faculty positions at the applicant institution or elsewhere that
emphasize research.
6.  Previous success of the institution in developing new pediatric
7.  Nature and quality of the shared core laboratory:  technical
merit, scientific justification, evidence of cost-effectiveness,
procedures for quality control and allocation of resources,
qualifications of the core laboratory director and technical staff,
and probable utility to the investigators.
8.  For renewal (competing continuation) applications, or subsequent
new applications from an institution with a previously-funded Center,
success of the Center-funded junior investigators in producing
research publications and in obtaining independent,
competitively-funded support for pediatric research.
9. Efforts to develop novel mechanisms for recruiting candidates for
new project development awards from groups under-represented in
pediatric research.
10.  Procedures established for evaluating candidates for new project
development funds and providing internal quality control of ongoing
Note:  Page limitations on research grant applications do not apply
to CHRC applications.  Applicants should ensure that all material
directly applicable to the above criteria are included in the body of
the application, not in an Appendix.
Scientific merit and technical proficiency, based on the demonstrated
and projected capabilities described in the application will be the
predominant criteria for determining funding priorities.
Letter of Intent Receipt Date:  August 15, 1996
Application Receipt Date:       November 13, 1996
Review by Advisory Council:     June 1997
Anticipated Date of Award:      December 1, 1997
Competing continuation applications that are identified for funding
will be awarded interim support for the period from September 1
through November 30, 1997.
Written and telephone inquiries concerning this RFA are encouraged.
The opportunity to clarify any issues or questions for potential
applicants is welcomed.
Direct inquiries regarding programmatic issues and address the letter
of intent to:
Ephraim Y. Levin, M.D.
Center for Research for Mothers and Children
National Institute of Child Health and Human Development
6100 Executive Boulevard, Room 4B11 - MSC 7510
Bethesda, MD  20892-7510
Telephone:  (301) 496-5593
FAX:  (301) 402-2085
Direct inquiries regarding fiscal matters to:
Ms. Mary Ellen Colvin
Grants Management Branch
National Institute of Child Health and Human Development
6100 Executive Boulevard, Room 8A17 - MSC 7510
Bethesda, MD  20892-7510
Telephone:  (301) 496-1303
FAX:  (301) 402-0915
This program is described in the Catalog of Federal Domestic
Assistance No. 93.865, Research for Mothers and Children.  Awards are
made under the authority of the Public Health Service Act, Title IV,
Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC
241 and 285) and administered under PHS grants policies and Federal
Regulations 42 CFR Part 52 and 45 CFR Part 74.  This program is not
subject to the intergovernmental review requirements of Executive
Order 12372 or Health Systems Agency review.
The PHS strongly encourages all grant and contract recipients to
provide a smoke-free workplace and promote the non-use of all tobacco
products.  In addition, Public Law 103-227, the Pro-Children Act of
1994, prohibits smoking in certain facilities (or in some cases, any
portion of a facility) in which regular or routine education,
library, day care, health care or early childhood development
services are provided to children.  This is consistent with the PHS
mission to protect and advance the physical and mental health of the
American people.

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