Research (OER)
9000 Rockville Pike
Bethesda, Maryland 20892
and Human Services (HHS)
Full Text DE-94-005
INSTITUTIONAL DENTIST SCIENTIST AWARD
NIH GUIDE, Volume 23, Number 18, May 13, 1994
RFA: DE-94-005
P.T. 34
Keywords:
Oral Diseases
Biomedical Research, Multidiscipl
National Institute of Dental Research
Letter of Intent Receipt Date: December 1, 1994
Application Receipt Date: January 18, 1995
PURPOSE
The National Institute of Dental Research (NIDR) invites applications
proposing new and competing renewal Institutional Dentist Scientist
Award programs in basic biomedical, behavioral, and clinical oral
health research.
The ultimate purpose of these programs is the development of
outstanding clinician research scientists. Programs must provide
doctoral-level (Ph.D.) training in basic science and advanced
clinical knowledge and skills development in either a recognized
clinical specialty or other equivalent dental clinical discipline and
a supervised research experience designed to facilitate transition to
an active research career. It is anticipated that most graduates
will undertake two or more years of post-Ph.D. research development
to complete their preparation for an independent research career.
Programs must be relevant to the goals of the NIDR including:
research on the causes, epidemiology, prevention, diagnosis and
treatment of dental caries, periodontal and soft tissue diseases,
oral cancer, oral manifestations of AIDS, and craniofacial anomalies;
orofacial pain; temporomandibular disorders; structure and function
of teeth, jaws, oral mucosa, bone, connective tissue, salivary
glands; behavioral, social, economic, and cultural factors related to
oral diseases and disorders; biomaterials; fluoride and nutrition;
and research on older Americans, gender differences, minorities,
those with medical problems and handicaps, and individuals and groups
at high-risk for oral health problems.
Several changes have been introduced in the policies and provisions
governing these awards. Current policies and provisions will remain
in effect for all programs through June 30, 1995, and will continue
to apply to appointees accepted into programs prior to that date
until completion of their five years career development. The new
policies and provisions will apply to all new appointments made on or
after July 1, 1995 and to all new and competitive renewal awards made
after July 1, 1996.
HEALTHY PEOPLE 2000
The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas. This Request
for Applications (RFA), Institutional Dentist Scientist Award
Program, is related to the priority area of oral health. Potential
applicants may obtain a copy of "Healthy People 2000" (Full Report:
Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report:
Stock No. 017-001-00473-1) through the Superintendent of Documents,
Government Printing Office, Washington, DC 20402-9325 (telephone
202/783-3238).
ELIGIBILITY REQUIREMENTS
Applications may be submitted by domestic, public and private dental
schools, or institutions with a dental school affiliation. Only one
award will be made to an institution.
MECHANISM OF SUPPORT
This RFA will use the National Institutes of Health (NIH)
Institutional Dentist Scientist Award (K16). Responsibility for the
planning, direction, and execution of the proposed program will be
solely that of the program director (PD) on behalf of the applicant
institution. The project period for applications submitted in
response to this RFA must be five years. Awards may be renewable
upon the submission of a successful competing application, depending
on programmatic needs and the availability of funds. The earliest
award date is July 1, 1996.
FUNDS AVAILABLE
The NIDR expects to make at least six new or competing renewal
awards, in response to this RFA, at a total first year cost of
approximately five million dollars. This level of support is
dependent on the receipt of a sufficient number of applications of
high scientific and educational merit. Although this program is
provided for in the financial plans of the NIDR, awards pursuant to
this RFA are contingent upon the availability of funds for this
purpose.
RESEARCH OBJECTIVES
Background
Many studies have shown the need for post-D.D.S. career development,
including exposure to basic biomedical and behavioral sciences and
advanced clinical knowledge and skills development, for dentists who
wish to pursue a career in oral health research. The NIDR has
supported postdoctoral training of basic scientists and clinicians
under the National Research Service Awards (NRSA) for many years.
However, the declining numbers of clinician scientists called for
additional opportunities tailored to the needs of promising clinician
scientists. The Institutional Dentist Scientist Award program was
initiated approximately nine years ago to help fill this need.
This award prepares individuals for careers as highly skilled
investigators and potential leaders in the full scope of oral health
research. It enables individuals to undertake five years of
intensive preparation in a course of study that involves three
distinct phases that include basic and clinical science components
integrated with a supervised research experience. The basic science
component includes both didactic and laboratory experiences and
typically is comparable to a doctoral-level program leading to a
Ph.D. The research program can employ either a basic or clinical
science approach to studying an oral health problem. The program
also requires an advanced clinical knowledge and skills development
component of a caliber that the individual would be eligible to
receive specialty certification at the completion of the five year
program. Throughout the course of the entire program, the
individuals are closely supervised by mentors who have basic science
and clinical specialty research experience.
The first RFA appeared in June 1984 and the second in April 1988.
The first group of programs are in their ninth year and the second
group are in their fourth year. The current project period will end
on June 30, 1995. However, the programs will be supported by
administrative supplements through June 30, 1996. Approximately 85
individuals are being supported, with approximately 20 appointees
graduating from the program and a similar number entering the program
each year.
Program Characteristics
Opportunities will be provided for dentists pursuing advanced
clinical knowledge and skills development and a Ph.D., or equivalent
degree, in a basic biomedical or behavioral science. The program
will have the following characteristics:
A. The Environment: Applicant institutions must have
well-established research, research career development, and clinical
programs, and adequate numbers of highly qualified faculty in both
clinical and basic science departments. The environment must
stimulate interactions among basic scientists and clinical
investigators. Collaboration with other institutions and
organizations, such as other components of the NIH, the Department of
Veterans Affairs, not-for-profit and private organizations, is
encouraged.
B. Program: The institutional award is intended to provide support
for up to five consecutive twelve month appointments to each
individual Dentist Scientist Appointee (DSA) selected by the program
director (PD). There are to be three distinct but overlapping and
integrated components to the program offered to each DSA: advanced
basic science development, advanced clinical knowledge and skills
development, and a supervised research experience. No component can
be offered in isolation from the others.
The basic science development component must develop knowledge and
research skills in scientific areas relevant to oral health. It must
include both didactic and laboratory experiences in a basic science.
It must consist of a doctoral (Ph.D.) level program that is
consistent with the applicant institution's degree requirements and
with the objectives of the Dentist Scientist Award Program. The
clinical development component must ensure that the DSA acquires
requisite advanced clinical knowledge and skills in either a
recognized clinical specialty or other equivalent dental clinical
discipline. The research experience component uses a basic science
or clinical science approach to problems in oral health research.
Typically, it is what is required for a doctoral degree and it must
facilitate transition to an active research career.
The areas of clinical development are not limited to the eight dental
specialties currently recognized by the American Dental Association.
If specialty certification is possible in the clinical discipline
proposed, the program of study is to be arranged so that conferring
of the clinical specialty certificate does not occur until completion
of the entire program by the DSA. The application must indicate the
clinical disciplines and degree certifications to be offered to the
DSAs. After an award is made, this offering may not be changed
without the approval of the NIDR.
A minimum of 80 percent of the DSA's effort must be devoted to this
program. The remaining 20 percent effort may be devoted to other
clinical and teaching pursuits only if they are consonant with the
objectives of the Dentist Scientist Award Program.
The PD and applicant institution are encouraged to develop innovative
multidisciplinary programs that maximize the research and educational
resources of the institution and any collaborating institutions.
Applicant institutions must be able to provide programs individually
tailored to meet the unique research and clinical development needs
of each DSA and ensure that DSAs complete the program with requisite
competencies.
C. Program Director: The PD must possess the scientific expertise,
leadership, and administrative capabilities required to coordinate
and supervise a multidisciplinary research and clinical career
development program of this scope. The PD must have the commitment
and capability to provide guidance to DSAs in their research career
development. The PD is responsible for the selection of the DSAs,
and the applicant must have developed a recruitment plan, which
addresses the efforts to recruit women, minorities, and individuals
from non-research intensive dental schools. Plans must be provided
for the appointment of an advisory body to act as an overview
committee and to assist in DSA selection.
The PD will be expected to participate in at least one annual meeting
with the staff of the NIDR. This meeting likely will be held in
conjunction with the annual meeting of the American Association for
Dental Research.
The PD will be required to submit to the NIDR a detailed description
of each DSA's planned supervised research experience as soon as
feasible but no later than the midpoint of each DSA's program.
Annually, the PD and advisory committee will assess the progress of
each DSA and submit a detailed report on the progress of each DSA to
the NIDR. Support for the DSA for the subsequent year in the program
will be dependant on satisfactory performance.
D. Mentors: Each DSA must have a mentor, who is an accomplished
investigator active in the proposed area, to guide the DSA's
development and research project. Usually, such a mentor will be the
doctoral thesis advisor. The mentor must be committed to continue
this involvement through the individual's total period of development
under the award. A co-mentor, representing the clinical component,
also may be named. Where feasible, women and minority mentors should
be involved as role models.
E. Dentist Scientist Appointees: DSAs must meet the following
criteria: they must have completed a dental degree (D.D.S., D.M.D.,
or equivalent) and must be, at the time of appointment, citizens or
noncitizen nationals of the United States, or have been lawfully
admitted to the United States for permanent residence and have in
their possession an Alien Registration Receipt Card (I-151 or I-551).
Noncitizen nationals are persons who, although not citizens of the
United States, owe permanent allegiance to the United States. They
are generally persons born in lands which are not states but which
are under United States sovereignty, jurisdiction, or administration
(e.g., American Samoa). Individuals on temporary or student visas
are not eligible.
Dentists who have completed a Ph.D., Sc.D., or equivalent research
degree are not eligible for appointment. The NIDR will consider a
written request from a PD for an exception on behalf of such an
individual, if such a degree was awarded in an area unrelated to oral
health.
Individuals who have completed advanced clinical knowledge and skills
development in a recognized dental specialty or who have undergone
two or more years of formal postdoctoral clinical development in a
non-specialty recognized clinical field are not eligible. Such
individuals should apply for an individual Dentist Scientist Award
(K15). However, applicants who have undergone clinical development
in either an Advanced Program in General Dentistry or a General
Practice Residency Program are eligible for appointment. Under
special circumstances where an applicant already has significant
clinical experience but wishes to pursue career development in
another clinical area, the NIDR will consider a written request from
a PD on behalf of the applicant.
An individual who has been a principal investigator on an NIH-
research grant, such as a research project grant (R01), FIRST award
(R29), sub-project on a program project (P01) or center grant (P50),
or the equivalent, is not eligible for appointment to this award.
F. Duration, Effort, and Allowable Costs: The applicant must
request support for two DSAs to enter the program in each year,
giving a total of ten during the five year project period. In the
case of competitive renewal applications, these positions are in
addition to those required to allow completion of five years support
for appointees already on the program. In planning DSA appointments
beyond the first year of the award, the PD and the DSAs should be
aware that continued NIDR support beyond the five-year project period
is dependent upon the availability of appropriated funds and success
in competition for renewed support. In the event that a competitive
renewal application for the next five-year project period is
unsuccessful, it is the intention of the NIDR to provide salary, and
Research Development Support funds, until each DSA in that program
has completed the five-year program. However, the applicant
institution must have plans in place to provide such support in the
event that funding from the NIDR is not available.
1. Appointments of new DSAs must occur within three months of the
start of a new budget period, usually between July 1 and September
30. Unfilled positions resulting from either failure to make
appointments within the prescribed period or due to termination of an
appointee prior to completion of a five-year program, will be
eliminated from the program. The associated funds will not be
available for carry over and will be deleted from future years. A
"Statement of Appointment" form (PHS 2271, rev. 3/92) must be
completed and sent to the NIDR whenever an individual is appointed or
reappointed to the program.
2. Salary - The NIDR will provide salary up to the amounts listed
below, starting at $26,500 for 0 years relevant experience, with four
percent annual increases thereafter, up to a maximum of $39,226.
However, the salary must not exceed the established salary provided
by the institution from its own funds to other staff or faculty
members of equivalent qualifications, rank, and responsibility in the
department concerned. Fringe benefits will be provided.
Number of Years Experience Salary (maximum
provided by the NIDR)
0 $26,500
1 $27,560
2 $28,662
3 $29,808
4 $31,000
5 $32,240
6 $33,530
7 $34,871
8 $36,266
9 $37,717
10 or more $39,226
The scale extends up to 10 years to give credit for relevant
postdoctoral experience at the time of appointment. This may include
research (including industrial); teaching; residency; clinical
practice; or other time spent in a health-related field beyond that
of the qualifying doctoral degree.
Salaries may be supplemented by an institution from non-Federal
funds. Other NIH funds may not be used to provide additional salary
support. Non-NIH Federal funds may not be used for salary
supplementation unless specifically authorized under the terms of the
program from which the supplemental funds are derived. An individual
may make use of Federal educational loan funds or Department of
Veterans' Affairs benefits when permitted by those programs. Under
no circumstance may the condition of stipend supplementation detract
from or prolong the program.
3. Plans must be provided for the support of DSAs choosing clinical
specialties, such as oral-maxillofacial surgery, that require more
than the usual two years of clinical knowledge and skills
development.
4. Research Development Support (RDS) - $15,000 per year for each
DSA will be allowed. The PD may allocate these funds among DSAs as
deemed necessary. These funds may be used for the following expenses
incurred by DSAs: (a) tuition, fees, and books directly related to
their career development; (b) research project expenses, such as
supplies, equipment and technical personnel costs; (c) travel; (d)
core support, including maintenance, for common equipment for all
DSAs; (e) biostatistical services including personnel and computer
time; (f) invited seminar speakers; (g) PD travel to the annual
meeting; (h) advisory committee. Authorization to use RDS funds for
other purposes may be requested from the NIDR.
5. Authorization may be requested from the NIDR to carry over
unobligated funds from one budget period to the next; for example,
for support of a DSA's salary and RDS for up to twelve months beyond
the standard five years to permit completion of the program. Funds
attributable to unfilled positions, whether due to failure to make
appointments within the prescribed period defined in paragraph 1
above or due to termination of appointees prior to completion of the
five year program, will not be available for carry over.
6. Procedures and reporting forms used to track the expenditure of
the funds attributable to each DSA must be provided. Annual reports
of these expenditures will be required.
7. Program Director's Support - Up to ten percent of the PD's
salary, with four percent annual increments thereafter, plus fringe
benefits, will be allowed. A PD may serve as a mentor.
8. Ancillary Personnel Support - Salary for mentors, secretarial and
administrative assistance, etc., is not allowed. The sponsoring
institution is expected to provide these services.
9. Indirect costs - reimbursement of actual indirect costs at a rate
up to, but not exceeding, eight percent of the total direct costs,
exclusive of tuition, fees, and expenditures for equipment, is
allowed.
G. Concurrent Awards: DSAs are encouraged to seek support for a
post-Ph.D. experience after completion of the K16 program, ideally at
another institution. During the final one to two years of their
program, they may apply for a post-Ph.D., NRSA individual fellowship
(F32), apply for appointment to a NIDR sponsored NRSA institutional
postdoctoral training program (T32), or arrange for other support
from the NIH or from nongovernmental sources sufficient to ensure two
or more years of post- Ph.D. career development. If such support
becomes effective prior to completion of the K16 program, it may be
used without reduction in the annual RDS from the Dentist Scientist
Award.
H. Evaluation: For purposes of evaluating the Dentist Scientist
Award, the PD, on behalf of the applicant organization, and the DSAs
must agree to inform the NIDR annually of the career of each DSA for
a period of ten years after leaving the program. This information
must include the employment history, including all professional
activities, publications, participation in research grants and/or
contracts, honors and awards, professional organizational activities,
and any other information that may be of value in evaluating the
impact of the Dentist Scientist Award program.
STUDY POPULATIONS
INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN
SUBJECTS
It is the policy of the NIH that women and members of minority groups
and their subpopulations must be included in all NIH supported
biomedical and behavioral research projects involving human subjects,
unless a clear and compelling rationale and justification is provided
that inclusion is inappropriate with respect to the health of the
subjects or the purpose of the research. This new policy results
from the NIH Revitalization Act of 1993 (Section 492B of Public Law
103-43) and supersedes and strengthens the previous policies
(Concerning the Inclusion of Women in Study Populations, and
Concerning the Inclusion of Minorities in Study Populations) which
have been in effect since 1990. The new policy contains some new
provisions that are substantially different from the 1990 policies.
All investigators proposing research involving human subjects should
read the "NIH Guidelines For Inclusion of Women and Minorities as
Subjects in Clinical Research," which have been published in the
Federal Register of March 9, 1994 (FR 59 11146- 11151), and reprinted
in the NIH GUIDE FOR GRANTS AND CONTRACTS of March 18, 1994, Volume
23, Number 11.
Investigators may obtain copies from these sources or from the
program staff or contact person listed below. Program staff may also
provide additional information concerning the policy.
LETTER OF INTENT
Prospective applicants are asked to submit, by December 1, 1994, a
letter of intent that includes a descriptive title of the proposed
Dentist Scientist Award program, the name, address, and telephone
number of the PD, the identities of other key personnel,
participating institutions, and the number and title of the RFA (RFA:
DE-94-005, Institutional Dentist Scientist Award) in response to
which the application may be submitted.
Although a letter of intent is not required, is not binding, and does
not enter into the review of subsequent applications, the information
that it contains is helpful in planning for the review of
applications. It allows NIDR staff to estimate the potential review
workload and to avoid conflicts of interest in the review.
The letter of intent is to be sent to Dr. Thomas M. Valega at the
address listed under INQUIRIES.
APPLICATION PROCEDURES
It is strongly recommended that prospective applicants contact Dr.
Valega early in the planning phase of application preparation. Such
contact may help ensure that applications are responsive to this RFA.
Applications must be submitted on form PHS 398 (Rev. 9/91).
Application forms are available at most institutional offices of
sponsored research and from the Office of Grants Information,
Division of Research Grants, National Institutes of Health, 5333
Westbard Avenue, Room 449, Bethesda, MD 20892, telephone (301)
710-0267, and from Dr. Valega at the address listed under INQUIRIES.
Applications must include a description of formal and informal
activities related to instruction in the responsible conduct of
research. Information must be provided on the rationale, subject
matter, appropriateness, format, and the frequency and duration of
instruction; and the amount and nature of faculty participation.
Progress reports in continuation applications must include the type
of instruction, topics covered and other details, such as attendance
by trainees and names of the instructors. No award will be made if
an application lacks this component.
Budget requests must be provided according to the instructions in
form PHS 398. In addition, the salary level requested for "to be
appointed" positions must be at the level of three years experience,
$29,808. The RDS requested for tuition and fees, books, travel,
etc., must be specified by category for each position. Competitive
renewal applications must request support for current appointees at
the levels specified under the existing policies, until completion of
five years support.
To identify the application as a response to this RFA, check "YES" on
item 2a of page 1 of the application and enter "RFA: DE-94-005,
Institutional Dentist Scientist Award. The RFA label available in
the application form PHS 398 must be affixed to the bottom of the
face page. Failure to use this label could result in delayed
processing of the application such that it may not reach the review
committee in time for review.
Submit a signed, typewritten original of the application, including
the Checklist, and three signed photocopies, in one package to:
Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, MD 20892-4500**
At the time of submission, two additional copies of the application
must be sent to:
H. George Hausch, Ph.D.
Extramural Program
National Institute of Dental Research
Westwood Building, Room 519
Bethesda, MD 20892
Telephone: (301) 594-7632
This RFA is for a single competition. Applications must be received
by January 18, 1995. If an application is received after that date
or is deemed non-responsive to the RFA, it will be returned without
review.
REVIEW CONSIDERATIONS
Applications will be reviewed for completeness and responsiveness to
the RFA by NIH staff. Incomplete or nonresponsive applications will
be returned to the applicant without further consideration.
Remaining applications may be subjected to triage by an initial
review group, convened by the NIDR Scientific Review Section, to
determine their merit, relative to others received in response to the
RFA. The NIDR will withdraw applications judged to be noncompetitive
and notify the applicant and institutional official. Applications
judged to be competitive will receive further review for scientific
and technical merit by the review committee.
The following review criteria will be applied:
o Environment: The institutional commitment and ability to provide
opportunities for research career development; the quality of
clinical knowledge and skills development; the level of ongoing basic
and clinical research activity; the evidence of multidisciplinary,
collaborative activities, especially between basic and clinical
investigators and departments; the availability of facilities,
equipment, clinical resources, and research support; and the plans to
provide support for DSAs in the event that a competitive renewal
application is unsuccessful and the NIDR is unable to continue
support.
o The clinical and research development program: The structure of a
typical DSA's program; the integration of the didactic, clinical and
research components; the relationships among clinical and basic
science departments and the graduate school in the design and conduct
of programs; degree requirements; types of specialty development
offered; the availability of prescribed and optional courses or
seminars; the manner in which individual guided research activities
will be selected; procedures for monitoring DSAs' progress; the
unique and innovative aspects of the program.
o Program Director: Scientific and administrative expertise, or
potential, for managing clinical and research career development
programs and research grants; time commitment; other research
support; the composition and role of the advisory committee in
development of the program, recruitment and DSA selection, assignment
of mentors and projects, and evaluation of progress.
o Mentors: Their roles and time commitment now and for the duration
of the program; accomplishments in basic or clinical research;
current and pending research grant holdings; and experience in
graduate research and clinical career development.
o Recruitment: Plans for recruitment, including minorities, women
and others who are underrepresented in oral health research, and
individuals from non-research intensive institutions; selection
criteria; the availability of high-quality candidates; and retention
strategies.
o Career development record: For competitive renewal applications,
the performance of the program in developing clinician research
scientists, as indicated by graduates' success in obtaining
fellowships, career awards, and individual research grant support;
the rate at which former appointees establish independent productive
research careers; recognition for outstanding scientific
accomplishments; involvement in clinically oriented and laboratory
research; their ongoing productivity; and the record of the program
in filling positions.
o Recruitment and retention of women and minority appointees: After
review of the application for scientific and technical merit and
assignment of a priority score, the initial review committee will
comment on the plans for recruiting women and individuals from
underrepresented minority groups to the program. In the case of
renewal applications, this will include the accomplishments in
recruiting and retaining women and individuals from underrepresented
minority groups and in preparing them for research positions.
o Responsible Conduct of Research: The quality of scientific
integrity instruction.
Secondary review will be by the National Advisory Dental Research
Council. Among the information the Council considers will be the
report of the initial review committee on the plans for, and success
in, recruitment of women and individuals from underrepresented
minority groups.
Schedule
Applications will be processed according to the following schedule:
Letter of Intent Receipt Date: December 1, 1994
Application Receipt Date: January 18, 1995
Initial Review Group Meeting: May/June 1995
Council Meeting: September 1995
Earliest Date of Award: July 1995
AWARD CRITERIA
Funding decisions will be based on the initial review committee's and
Council's recommendations, the need for research personnel in
specific program areas, and the availability of funds. The earliest
award date will be July 1, 1996.
The NIDR appreciates the value of complementary funding from other
public and private sources, including foundations and industrial
concerns, for activities that will complement and expand those
supported by the NIDR.
INQUIRIES
Written and telephone inquiries concerning this RFA are encouraged.
The opportunity to clarify any issue or questions from potential
applicants is welcome. Direct inquiries on programmatic issues to:
Thomas M. Valega, Ph.D.
Extramural Program
National Institute of Dental Research
Westwood Building, Room 503
Bethesda, MD 20892
Telephone: (301) 594-7617
FAX: (301) 594-7616
Direct inquiries on fiscal matters to:
Ms. Theresa Ringler
Extramural Program
National Institute of Dental Research
Westwood Building, Room 510
Bethesda, MD 20892
Telephone: (301) 594-7629
AUTHORITY AND REGULATIONS
Institutional Dentist Scientist Awards are made under the authority
of Title III, Section 301 of the Public Health Service (PHS) Act as
amended (Public Law 78-410, as amended, 42 USC 241). The Code of
Federal Regulations, Title 42 Part 52, and Title 45 part 74, are
applicable to this program. This program is also described in the
Catalog of Federal Domestic Assistance No. 93.121. This program is
not subject to the intergovernmental review requirements of Executive
Order 12372 or Health Systems Agency review.
The Public Health Service (PHS) strongly encourages all grant
recipients to provide a smoke-free workplace and promote the non-use
of all tobacco products. This is consistent with the PHS mission to
protect and advance the physical and mental health of the American
people.
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