DRUG ABUSE PREVENTION AND COMMUNICATIONS RESEARCH Release Date: February 20, 1998 RFA: DA-98-006 P.T. National Institute on Drug Abuse Letter of Intent Receipt Date: April 7, 1998 Application Receipt Date: May 7, 1998 PURPOSE This Request for Applications (RFA) encourages research to explore the role of mass media and communications in drug abuse prevention. It would serve to inform the National Youth Anti-Drug Media Campaign sponsored by the Office of National Drug Control Policy (ONDCP). ONDCP has initiated a major national media campaign as part of its long-term strategy to reduce drug use in the United States. The media campaign seeks to reduce drug use by changing attitudes about the dangers and acceptability of drug use. NATIONAL DRUG CONTROL STRATEGY The Federal government is committed to reducing drug use and availability. To put this commitment into action, ONDCP has developed the 1997 National Drug Control Strategy. A copy of The National Drug Control Strategy for 1997 may be requested from the ONDCP Clearinghouse at 1-800-666-3332; FAX 301-251-5212; or Email: askncjrs@aspensys.com. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This RFA, Drug Abuse Prevention and Communications Research, is related to the priority areas of alcohol and other drugs. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic and foreign, for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, research institutions, units of state and of local governments, and eligible agencies of the Federal government. Applications from minority individuals, women and persons with disabilities are encouraged. Foreign institutions are not eligible for small grants (R03). MECHANISM OF SUPPORT Support mechanisms for the RFA are research project grants (R01) and small grants (R03). Consultation with National Institute on Drug Abuse (NIDA) program staff is encouraged prior to application and is required for applications with Direct Costs over $500,000 in any year. Please refer to the guidelines for the specific eligibility requirements for the small grant program (R03). FUNDS AVAILABLE The NIDA, with funds from ONDCP, has set aside $2 million total costs for the first year of funding. This level of support is dependent on the receipt of a sufficient number and diversity of applications of high scientific merit. Five to six awards are anticipated for project periods not to exceed 5 years. Because the nature and scope of the research being encouraged in response to this RFA may vary, it is anticipated that the size of individual awards will vary also. Awards are subject to a limit of $750,000 in total costs (direct plus indirect costs) for each year. Budget requests should be carefully justified and be commensurate to the complexity of the project. Although this program is provided for in the financial plans of the NIDA, awards pursuant to this RFA are contingent upon the availability of funds for this purpose. RESEARCH OBJECTIVES Interpersonal and media messages can have a significant influence on attitudes, expectancies, intentions, and behaviors which affect individual decisions about illicit drug use. Although some knowledge has been developed regarding message salience and acceptance, there has been little systematic study of communication practices to prevent drug abuse. Prior research indicates that health messages with a positive goal are more readily accepted and maintained than messages with a negative goal. The theories and research-based knowledge about the attributes of communications have been applied to drug abuse prevention research and programming in a very limited way. Thus, research targeting the full spectrum of settings, from communications research in the laboratory to studies examining the elements and impact of mass media and applied studies using prevention communications in the community, is needed. Laboratory research on the cognitive and affective aspects of communication that enhance understanding and acceptance of messages is needed to form the basis from which prevention programming and media messages can be developed. Current research suggests that the use of strategies such as indirect influence techniques, conditioning in low-thought situations, and strengthening of existing attitudes show promise for drug prevention programming. However, it is not known if these strategies are universally effective. Studies that elucidate various communication components such as audiovisual perceptions, motivations, and salience would provide helpful background information for designing and targeting messages. The role of effective communication as a determinant of intervention success also has not been addressed. Incorporation of communications components into new intervention trials would clarify the components of a successful intervention. Research on effective message construction and delivery in group settings may lead to more cost effective programs. Mass media, as communications vehicles, play an important role in reaching the American public with a multitude of messages and images that provide news, information, ideas, entertainment, and products that can affect every part of American life. Because the media have the ability to both reflect and shape attitudes and behaviors, drug abuse prevention programmers often look to the media to reach critical audiences with important messages. Research in the 1970s and early 1980s, however, showed that mass media campaigns designed to prevent drug use by themselves often failed to do so for a variety of reasons. More reasonable expectations about the effectiveness of media for the delivery of public health messages and recent developments in communications research are stimulating renewed interest. For example, some researchers have examined the relationship between drug abuse stories in the natural media (i.e., the media environment of news, advertising, and entertainment programming including movies, magazines, and television) and actual drug abuse trends and found that as media attention declines, drug use increases among youth. Furthermore, media coverage appears to be related to the public s attitude about the seriousness of the drug problem and to anti-drug attitudes among youth. Despite the considerable progress made in drug abuse prevention research in recent years, there have been few studies that have combined the most effective research-based prevention interventions with sophisticated communication approaches that could inform interventions, particularly the ONDCP media campaign. It is important, therefore, for NIDA to encourage the expansion of research on communications approaches to drug abuse prevention. Such research will increase understanding the most effective use of the mass media for reaching all audiences: individual to individual, individual to group, and mass communications. Specific areas of research that should be addressed include message development, especially content, and structure and message delivery. The key issue is to establish principles of effective communication approaches to discourage the initiation and progression of drug using behaviors, to encourage discontinuation of drug use, and to address relapse once these behaviors have been initiated. Small-scale laboratory studies, research within particular interventions and targeted communities, and large-scale studies of the impact of the media are all needed. Although this announcement focuses on children and adolescents, research is also needed on parents and other adults who influence drug-related knowledge, attitudes, and behaviors. Examples of issues that would come under this RFA are: o Elucidation of the relationship between emotional and cognitive functioning to better understand the shaping of messages so as to assure appropriate responses to specific stimuli, such as triggering appropriate refusal behaviors when confronted with the decision to use or not use drugs. These studies can range from laboratory to full community-wide interventions. o Assessment of communications messages, including terms of drug use expectancies, and strategies that are appropriate to target audiences at different developmental stages (such as 10-year-old children versus children who are aged 12-14) or with specific cultural needs (such as new Latino/Hispanic immigrants). o Studies on social cognition that characterize how youth process informative material under varying conditions, to include being under the influence of drugs. Behavioral, physiological, and other measures of attention and arousal would be appropriate. o Specification of the relationship between knowledge about drugs and the harmful effects of drugs, attitudes or perceptions of risk and personal susceptibility, and drug using/refusal behaviors with particular emphasis on barriers that interfere with these relationships. o Assessment of media strategies that establish community norms against the use of drugs and community support for drug abuse prevention programming, and examination of the extent to which norms become individual values. o Analysis and assessment of the impact of the presentation of drug use in existing media, both print and electronic, as well as advertisements and entertainment, on attitudes, norms, and behaviors of children aged 9-18. o Assessment of the role and impact of the World Wide Web communications networks to disseminate science-based drug prevention information and to distribute pro-drug messages and misinformation to youth and adults. o Development of new epidemiologic models which include factors associated with changes in drug use trends, such as availability of drugs, attitudes, risk perceptions, price, as well as other economic factors. The ONDCP will make available to researchers any media materials and paid media buying resources associated with the National Youth Anti-Drug media campaign. Researchers who wish to incorporate these components into their research should contact Alan Levitt, 202-395-6794. Applications should include documentation describing the use of these materials and the arrangements that have been made with Mr. Levitt. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This new policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research, which were published in the Federal Register on March 28, 1994 (FR 59 14508-14513) and in the NIH Guide for Grants and Contracts on March 18, 1994, Volume 23, Number 11. Investigators may obtain copies from these sources or from the program staff or contact person listed below. Program staff may also provide additional relevant information concerning the policy. National Advisory Council On Drug Abuse Recommended Guidelines For The Administration Of Drugs To Human Subjects The National Advisory Council on Drug Abuse recognizes the importance of research involving the administration of drugs to human subjects and has developed guidelines relevant to such research. Potential applicants are encouraged to obtain and review these recommendations before submitting an application that will administer compounds to human subjects. The guidelines are available on NIDA s Home Page at http://www.nida.nih.gov under the What's New, or they may be obtained by calling 301-443-2755. LETTER OF INTENT Prospective applicants are asked to submit, by April 7, 1998, a letter of intent that includes a descriptive title of the overall proposed research; the name, address, telephone number, and institution of the Principal Investigator; the names of other key investigators and their respective institutions; and the number and title of the RFA in response to which the letter of intent is submitted. Although the letter of intent is not required, is not binding, and is not a factor in the peer review of the application, the information it contains is helpful in planning for the review of applications. The letter of intent is to be sent to: Director Office of Extramural Program Review National Institute on Drug Abuse 5600 Fishers Lane, Room 10-42 Rockville, MD 20857 Telephone: (301) 443-2755 FAX: (301) 443-0538 APPLICATION PROCEDURES Applications are to be submitted on the grant application form PHS 398 (rev. 5/95). These forms are available at most institutional offices of sponsored research and may also be obtained from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC-7910, Bethesda, MD 20892, telephone 301-710-0267, Email: asknih@od.nih.gov. The RFA label available in the PHS 398 (rev. 5/95) application form must be affixed to the bottom of the face page of the application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. In addition, to ensure the identification of the application with this RFA the YES box must be marked in Item 2 of the face page of the application form and the title and number of this RFA typed in. Applications that are not received as a single package from the Principal Investigator and that do not conform to the instructions contained in PHS 398 (rev. 5/95) application kit will be judged non-responsive and will be returned to the applicant. The completed original, including the checklist, and three legible copies must be sent or delivered to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040, MSC-7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) At the time of submission, two additional copies of the application must be sent to: Director Office of Extramural Program Review National Institute on Drug Abuse 5600 Fishers Lane, Room 10-42 Rockville, MD 20857 Telephone: (301) 443-2755 Applications must be received by May 7, 1998. If an application is received after this date, it will be returned to the applicant without review. The Center for Scientific Review (CSR) will not accept any application in response to this RFA that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. The CSR will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of substantial revisions of applications already reviewed, but such applications must include an introduction addressing the previous critique. REVIEW CONSIDERATIONS Review Procedures Applications will be reviewed by the CSR for completeness and by NIDA staff to determine responsiveness to the RFA. Applications deemed not responsive to the RFA and/or incomplete will be returned. Applications that are responsive and complete will be evaluated for scientific and technical merit by an appropriate peer review group convened by the NIDA in accordance with NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and undergo a process in which they either will be scored or not recommended for further consideration. Those applications that are scored will receive a second level review by the National Advisory Council on Drug Abuse. Review Criteria The goals of NIH-supported research are to advance our understanding of biological systems, improve the control of disease, and enhance health. In the written comments, reviewers will be asked to discuss the following aspects of the application in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered in assigning the overall score, weighting them as appropriate for each application. Note that the application does not need to be strong in all categories to be judged likely to have major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward. (1) Significance: Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive this field? (2) Approach: Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics? (3) Innovation: Does the project employ novel concepts, approaches, or method? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies? (4) Investigator: Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers (if any)? (5) Environment: Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support? In addition to the above criteria, in accordance with NIH policy, all applications will also be reviewed with respect to the following: o The adequacy of plans to include both genders, minorities, and their subgroups as appropriate for the scientific goals of the research. Plans for the recruitment and retention of subjects will also be evaluated. o The reasonableness of the proposed budget and duration in relation to the proposed research. o The adequacy of the proposed protection for humans, animals, or the environment, to the extent they may be adversely affected by the project proposed in the application. AWARD CRITERIA Applications will be considered for funding based on the following factors: overall scientific and technical merit of the application as determined by peer review; significance and originality of the proposed research; appropriateness of budget estimates; program priorities; and availability of funds. Schedule Letter of Intent Receipt Date: April 7, 1998 Application Receipt Date: May 7, 1998 Scientific Review Date: August 1998 Council Meeting Date: September 1998 Earliest Award Date: September 1998 INQUIRIES Inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Susan David, M.P.H. Division of Epidemiology and Prevention Research National Institute on Drug Abuse 5600 Fishers Lane, Room 9A53 Rockville, MD 20857 Telephone: (301) 443-6543 FAX: (301) 443-2636 Email: sd69t@nih.gov Direct inquiries regarding fiscal matters to : Gary Fleming, J.D., M.S. Grants Management Branch National Institute on Drug Abuse 5600 Fishers Lane, Room 8A54 Rockville, MD 20857 Telephone: (301) 443-6710 Email: gf6s@nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.279. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and are administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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