Full Text AG-94-005 CENTERS ON THE DEMOGRAPHY OF AGING NIH GUIDE, Volume 23, Number 2, January 14, 1994 RFA: AG-94-005 P.T. 04 Keywords: Aging/Gerontology Demography Health Care Economics National Institute on Aging Letter of Intent Receipt Date: February 1, 1994 Application Receipt Date: March 31, 1994 PURPOSE The National Institute on Aging (NIA) invites applications for Exploratory Center Grants in the area of the demography and economics of health and aging. The Demography and Population Epidemiology Cluster within the Behavioral and Social Research Program supports research and training in the dynamics of population aging using a variety of demographic and economic approaches. Congress has urged the further development of research on the demographic aspects of population aging. These center grants will support the infrastructure necessary for research, new program development in selected areas, the development of innovative networks of researchers, and enhanced sharing of specialized databases including rapid application of research results from these databases. Scientific initiatives in the demography and economics of health and aging increasingly require integration and collaboration with each other and also with allied scientific fields such as genetics, biology, clinical medicine, and epidemiology. Collaboration across institutions is often required. Advances in computing technology have made new methodologies such as macro and microsimulation and the multivariate analysis of complex longitudinal data more practical and efficient. Progress in research on population aging can be accelerated and significantly enhanced by the widespread collaboration of investigators at multiple institutions and by the creation of innovative networks of researchers. Moreover, the NIA has supported the development of major data collection efforts in areas such as long term care (LTC), retirement and economic status, and health and functional change in the very old. However, use of these and other datasets require considerable investments of time and funding prior to conducting any sophisticated research. Efficiency is increased, and costs of individual research projects can be reduced, when several researchers at the same institution can make use of centralized datafiles staffed by knowledgeable data managers. Finally, there is a growing demand from the federal government and the policy community for timely and appropriately synthesized research findings from these datasets. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Request for Applications (RFA), Centers on the Demography of Aging, is related to several priority areas including chronic disabling conditions. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238). ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the Federal government. Applications from minority individuals and women are encouraged. Foreign institutions may not apply, but may be involved through contractual/consortium arrangements. A P20 core grant assumes substantial pre-existing research activity on population aging at the institution. A minimum of one peer-reviewed and externally funded, currently active research project directly within the area of demography or economics of health and aging is required. Sub-projects on P01 grants may be counted as individual projects. MECHANISM OF SUPPORT The support mechanism for this program is the exploratory center grant (P20). The exploratory center grant (P20) is an institutional award that supports a variety of research-related activities organized around one or more common themes or areas of interest. The exploratory center grant for this RFA minimally consists of (1) an administrative and research support core, which will provide coordination, research planning, logistical, and centralized data and technical support, and (2) a program development core providing for small scale pilot studies related to program development or methodological innovation. In addition, an application may elect to include (3) an external innovative network core, and (4) an external research support and dissemination core. The P20 is awarded competitively for no more than five years, and is expected to lead to a competing application for a P30 or P50 Center Grant award. The exploratory center grant is a resource designed to encourage the development and maintenance of a significant and enduring high quality research program on population aging. Except for pilot projects included in program development, no funds are provided for the direct support of research projects. The P20 grant also helps to integrate existing projects in a specialized research area, often with a central theme, and to encourage the scientific development of the research area. By making research resources more accessible, this support is designed to enhance the productivity of other NIA-funded population aging research and training grants. While the exploratory center grant is primarily designed to support a research center at a specific institution, some centers may also wish to assume a national or international role in making research resources available to the larger scientific community, and galvanizing scientists at several institutions through the development of networks. The Center support may therefore be used to create or assemble new databases and methodologies for the larger research community. These centers may also develop and maintain innovative national and international research networks on population aging. Resources may also be used to disseminate research findings more widely and in a more effective and timely manner to the scientific, federal, and policy communities. Consortium arrangements are permissible, provided that the applicant institution meets the eligibility requirements. In addition to these functions, it is anticipated that one of the centers funded under this RFA will also serve as a coordinating center in order to encourage collaboration and networking among the NIA Demographic Centers. FUNDS AVAILABLE The NIA anticipates that an estimated $1,500,000 in total costs per year for five years will be committed to fund applications in response to this RFA. Although this program is provided for in the financial plans of the NIA, awards are contingent on the availability of funds for this purpose. The NIA expects to make between four and eight awards. Direct costs of the awards are expected to vary between $75,000 and $250,000 depending upon the scale of activity that can be reasonably supported by the institution in terms of the current level of funded research on population aging. No request may exceed $350,000 total costs in the first year, with a four percent per annum inflation increase allowable in subsequent years. However, in addition to the $350,000 limit, up to $25,000 in direct costs (plus any indirect costs) may be separately requested for the functions of a coordinating center. If any NIA Center award from this RFA is made to an institution with an NICHD-funded Population Center also receiving supplementary NIA funds, then it is anticipated that the NIA supplementary support will be replaced by direct NIA funding. RESEARCH OBJECTIVES Each proposed Center should focus on one or more scientific themes or areas directly relevant to population aging. Important initiatives and priorities within population aging include: o forecasting life and active life expectancies, health, medical services and long term care usage, especially for the very old; o medical demography of chronic diseases including the dementias and the integration of medical demography with epidemiology, population genetics, early life determinants of health in old age, nutrition, and health services research; o the cost and impact of aging-related illnesses and disabilities (especially in the last years of life), and cost-benefit analyses in terms of added health expectancy; o demographic or economic evaluations of the impact of DHHS or other public policies (such as changes in retirement-benefit eligibility ages, or the proposed health care reform) on the health and wellbeing of the older population, including the development of relevant macro- and microsimulation models; o demographic analyses of the aging of disadvantaged components of the population, including the Black and Hispanic populations; o the macro and micro dynamics of inter-generational exchanges associated with population aging; o demographic and survey methods for studying elderly populations; o the determinants of retirement and consequences for health and wellbeing; comparative research on retirement and income support policies in other countries; the dynamic interaction of health and financial status in old age; Applicants may address several areas or themes. These areas are not intended to be prescriptive. Applicants may redefine these areas, merging and combining topics according to their own perspectives of the future course of the population sciences related to aging. Comparative international research may be included, provided the research is clearly relevant to population aging within the United States. Wherever possible special attention should be given to the demographic and economic aspects of the health and wellbeing of special older populations such as the oldest old, Blacks and Hispanics, and older women. Applicants are also encouraged to compete for the coordinating Center function. The coordinating Center will serve to encourage collaboration and net-working among the NIA Demography Centers, arrange annual meetings and produce bibliographic or other special reports. Funds of up to $25,000 in direct costs (plus indirect costs) may be separately requested for these functions above the $350,000 total cost limit. Cores In addition to (A) an administrative and research support core and (B) a program development core, both of which are required, each proposed Center may also request funding for (C) an external innovative network core and/or (D) an external research resources support and dissemination core. Applications are not required to include requests for cores C and D. The following limitations apply to the maximum amount that may be requested for average annual direct costs over five years, excluding the indirect costs associated with consortiums: core A, up to $160,000; core B, up to $80,000; core C, up to $35,000, and core D, up to $100,000. Given these constraints plus the limitation on total annual costs, no institution will be able to submit an application for all four cores for the full amounts. Therefore each institution should decide on an optimal mix of topical foci and cores, and within cores, of specific core functions and levels of effort. Further, in order to maximize flexibility, the dollar limit for each core is set in terms of average annual costs over the life of the requested center rather than simple annual costs. However, the $350,000 total cost limit (plus an allowable four percent escalation for inflation and exclusion of funds requested for coordinating center functions) cannot be exceeded in any year. A. Administrative and Research Support Core (MANDATORY) The Administrative and research support core manages the activities of the Center and provides shared resources such as datasets. The application must name a Center Director who will provide the overall scientific management and coordination of the Center. The Center Director must be an experienced researcher with appropriate experience in research on population aging. It is recommended that an Advisory Committee be established to assist the Director in making the scientific and administrative decisions relating to the Center, including the allocation of funds for pilot studies. While it is recommended that this Committee include one or more members outside of the applicant institution, any such members should not be contacted or named in the application until after initial and secondary review in order to facilitate review by not limiting the potential pool of reviewers. The objective of this core is to accomplish the following: 1. Plan, coordinate, review and manage the Center's activities, including the funding of pilot studies. 2. The purchase and provision of facilities or services such as centralized data libraries including the purchase of hardware such as workstations and high capacity storage devices (hardware or equipment purchases may not exceed 10 percent of requested funding) and datafiles, and development of user-friendly datafiles and salary for data managers; cost effective data processing for the Institution's research and training on population aging. Facilities and services should have the potential for general use at the institution, and must not be for the sole use of any single project. Any overlap with activities funded or proposed through NICHD center grants must be clearly specified. Salary support may be requested for the scientific director, core technical staff, consultants, and advisors. Travel funds should be requested to attend an annual NIA-sponsored meeting of scientific center directors, and may be requested for researchers to attend other scientific meetings, for training of technical and scientific staff, for new program development, and for travel related to outreach and network functions. B. Program Development Core (MANDATORY) Each Center grant application must include a program development core. The objective of this support is to allow the institution to develop sufficient preliminary information to permit the submission of applications for peer-reviewed research or career development projects. This core must include at least one small-scale project that will lead to new program development. The new pilot or development projects should address research topics listed above. Funds may be requested for: 1. Small-scale projects, which may include pilot or feasibility projects. These small-scale projects are ordinarily limited to two years but may be extended with appropriate justification. The application must describe the proposed use of funds for the first two years of the proposed center. Adequate detail should be provided in order to allow for the evaluation of the scientific value and significance of the proposed activities. Provision should be made in the Administrative and research support core for the institutional review of new projects, and new projects must be submitted to NIA staff for approval before they are initiated, ordinarily as part of the annual non-competing renewal application. The description of all pilot projects, and any results must be reported in the Center's annual progress report to the NIA. 2. Optional salary support for increasing the critical mass of the scientific research staff and the development of new program areas and methodologies. Salary support is limited to tenure track junior faculty (or equivalent in research organizations), and five years per individual. The total annual salary support cannot exceed $50,000 in direct costs (salary and fringe benefits) from the Center grant, and the institution is expected to supplement any such salary costs with funds from other sources. It is expected that scientists supported through this mechanism will either compete successfully for grant support or ultimately receive full support from the institution by the end of the third year year. C. External Innovative Network Core (OPTIONAL) This optional core differs from the new program development core in that it explicitly is for the development of networks beyond the applicant institution's boundaries; hence the designation, external. Funds may be requested for: 1. The development of innovative national and international research networks on topics consistent with the Center's goals that will serve to enhance research not only at the institution, but more generally within the field, as well as in relation to other relevant disciplines. Such networks might include electronic bulletin boards, workshops, funding for pilot projects, and the development of common research resources. 2. Outreach activities that will encourage and nurture the development of minority researchers. Such activities may include, e.g., sponsoring workshops on minority populations and issues, developing networks of minority researchers, and providing mentorship opportunities. D. External Research Resources Support and Dissemination Core (OPTIONAL) This optional core differs from Core A in that its objective is the dissemination of research resources, findings and new concepts and techniques within and beyond the institution. Funds may be requested for, but are not limited to: 1. The dissemination of new methodologies and important databases to the larger scientific community. Encouragement is given for the development, support, and sharing of user-friendly databases and specific analytic methodologies resulting from grants, contracts, and cooperative agreements, both within the institution, and nationally to appropriate researchers. Such dissemination might include, e.g., research and training workshops, development of user-friendly extract files with imputed variables, newsletters, and electronic bulletin boards providing technical support. Development of innovative approaches to dissemination is also encouraged. 2. The timely dissemination of well-synthesized research results to the Federal government, scientific community, and policy making community. Strong encouragement is given for the dissemination of research results from NIA sponsored databases on the topics listed above under "Research Objectives". Such dissemination might include briefings, working paper series, and research briefs, and newsletters. 3. The dissemination and development of new research techniques and concepts to the larger demography and economics of aging and health research communities. Such dissemination might include workshops and training institutes. The value-added components to any on-going activities should be clearly specified. E. Coordinating Center Function (OPTIONAL) Applicants are encouraged to apply for the coordinating center function in order to promote collaboration and networking among the NIA Demography Centers. Funds of up to $25,000 in direct costs (plus indirect costs) may be requested to arrange annual meetings or produce bibliographic or other special reports that would be of benefit to all NIA Demography Centers. STUDY POPULATIONS SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH policy is that applicants for NIH clinical research grants and cooperative agreements will be required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information should be included in the form PHS 398 in Sections 1-4 of the Research Plan AND summarized in Section 5, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., Native Americans (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups should be provided. For the purpose of this policy, clinical research includes human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. For foreign awards, the policy on inclusion of women applies fully; since the definition of minority differs in other countries, the applicant must discuss the relevance of research involving foreign population groups to the United States' populations, including minorities. If the required information is not contained within the application, the application will be returned. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies. LETTER OF INTENT Prospective applicants are asked to submit, by February 1, 1994, a letter of intent that includes the number and title of this RFA, a descriptive title, and identification of the Principal Investigator (including address, telephone and fax number), other key personnel and participating institutions. Although a letter of intent is not required, is not binding, and does not enter into the review of subsequent applications, the information that it contains allows NIA staff to estimate the potential review workload and to avoid possible conflicts of interests in the review. The letter of intent is to be sent to Dr. Suzman at the address listed under INQUIRIES. APPLICATION PROCEDURES Applicants are advised to discuss their eligibility and project with NIA program staff (listed under INQUIRIES) as early as possible in advance of formal submission. For institutions receiving support from NICHD for Population Centers, the functions and scope of the proposed NIA Aging Center must be clearly differentiated. All applications must be complete and submitted using form PHS 398 (rev. 9/91). Application kits are available at most institutional offices of sponsored research and may be obtained from the Office of Grants Information, Division of Research Grants, National Institutes of Health, Westwood Building, Room 449, Bethesda, MD 20892, telephone (301) 710-0267. To identify the application as a response to this RFA, check "YES" in item 2a on the face page of the application and enter the title "Centers on Demography of Aging" and the RFA number. Additional materials will not be accepted after the receipt date. The RFA label available in the PHS 398 form must be affixed to the bottom of the face page of the original application. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. The Description and Key Personnel Section (PHS 398, page 2) should concisely state the overall goals of the entire Exploratory Center and clearly state the contribution of each component to the overall goals. Key personnel for the entire Exploratory Center, including any consultants and consortium collaborators, should be listed alphabetically. The text of the application should begin with an overview that presents a succinct plan for the center as a whole, with a clear description of ongoing and pending research projects in population research related to aging, the major theme(s) and rationale(s) for the exploratory center, the organization of the administrative and new program development cores and their relationship to ongoing research and training projects in the demography and economics of health and aging (including oversight activities), the extent of institutional, departmental, and interdepartmental cooperation, and a summary program budget. Issues related to institutional commitment and settings, and the mechanisms that will ensure the coherence of the project should be described. The introduction is limited to 8 pages, followed by separate sections that fully document each core component. Institutions proposing to undertake the coordinating center function may use up to an additional three pages to describe the research plan and accompanying budget for this function. Except for Core B, sections 1-4 of PHS 398 for each core component is limited to 10 pages. For Core B, the maximum length is 20 pages. Each core should be prepared as a separate section that begins on a new page of the application. Complete information, including a fully justified budget, is required for each core component. Appendix materials should be kept to a minimum as per the instructions in form PHS 398. Applications exceeding the specified page limits will be returned to the applicant without review. Applications involving human subjects must be reviewed and approved by the appropriate Institutional Review Board (IRB) prior to submission. Applications without IRB approval are incomplete and will be returned. Additional instructions for completing an NIA multicomponent application can be obtained from Dr. Suzman at the address listed under INQUIRIES. Send the completed application and three legible copies in a single package, making sure that the original application with the RFA label attached is on top, to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Send two additional copies of the application to: Michael Oxman, Ph.D. Scientific Review Office National Institute on Aging Gateway Building, Suite 2C212 7201 Wisconsin Avenue Bethesda, MD 20892 Applications must be received by the Division of Research Grants on March 31, 1994. REVIEW CONSIDERATIONS Upon receipt applications will be reviewed by NIA staff for completeness and responsiveness to the RFA. Incomplete or nonresponsive applications will be returned to the applicant without further consideration. Applications may be triaged by an NIA peer review group on the basis of relative competitiveness. The NIH will withdraw from further competition those applications judged to be non-competitive for award and notify the applicant Principal Investigator and institutional official. Those applications judged to be competitive will undergo further scientific merit review by a special study section convened by the NIA in accordance with the criteria stated below. The second level review will be provided by the National Advisory Council on Aging. In addition to the general review criteria of scientific and technical merit and the potential for meeting the goals of the RFA, the following set of criteria will be applied: o the potential for significant scientific progress in the specific areas or themes addressed by the application, and the overall strategy for developing research in the demography and economics of health and aging generally and specifically within the areas or themes; o the level and extent of funded research directly relevant to the demography and economics of health and aging; o the scientific qualifications, leadership, and research experience in aging research of the Principal Investigator and professional staff; o successful training activity in the area of population aging including the recruitment and training of junior investigators; o the scientific merit of the proposed pilot or new program development projects and the adequacy of the review procedures to assess the scientific merit of future studies; o the value to the institution's research community of the support and maintenance functions for e.g. databases and methodologies; o evidence of commitment of the institution's administration to develop and support research and training on population aging; and o the scientific value and public good that might result from any proposed external outreach and network building activities. AWARD CRITERIA The anticipated date of award is September 30, 1994. In addition to the scientific and technical merit of the application, NIA will consider how well the application meets the goals and objectives of the program as described in this RFA, including increasing the number of NIH-funded population centers, as well as the general criteria for excellence and availability of funds. Applications recommended for further consideration by the National Advisory Council on Aging will be considered for funding on the basis of overall scientific, clinical, and technical merit of the proposal as determined by peer review, appropriateness of budget estimates, program needs and balance, policy considerations, adequacy of provisions for the protection of human subjects, and availability of funds. INQUIRIES Written and telephone inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic issues to: Dr. Richard Suzman Behavioral and Social Research Program National Institute on Aging Gateway Building, Suite 533 Bethesda, MD 20892 Telephone: (301) 496-3136 FAX: (301) 402-0051 E-mail: Suzman@NIHNIAGW.BITNET Direct inquiries regarding fiscal matters to: Ms. Linda Whipp Grants and Contracts Management National Institute on Aging Gateway Building, Room 2N212 Bethesda, MD 20892 Telephone: (301) 496-1472 FAX: (301) 402-3672 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.866. Awards are made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. .
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