Release Date:  August 23, 1999

PA NUMBER:  PAR-99-154

National Heart, Lung, and Blood Institute


The overall goals of the National Heart, Lung, and Blood Institute (NHLBI)
Career Transition Award (K22) program are to enable outstanding individuals 
to obtain a research training experience in the NHLBI Division of Intramural
Research and to facilitate their successful transition to an extramural
environment as independent researchers.  The award will provide up to three
years of support for research training in an NHLBI intramural laboratory
followed by two years of support for an independent research project in an
extramural institution.  It is anticipated that awardees will subsequently
obtain research project grants such as the R01 to support the continuation of
their work.


The Public Health Service (PHS) is committed to achieving the health 
promotion and disease prevention objectives of "Healthy People 2010," a PHS 
led national activity for setting priority areas. This Program Announcement 
(PA), Title of PA, is related to one or more of the priority areas. Potential 
applicants may obtain a copy of "Healthy People 2010" at 
http://www.health.gov/healthypeople/ .


The candidate must have a research or a health-professional doctorate or its
equivalent, and must have some research experience, during which the 
potential for highly productive basic or clinical research was demonstrated.  
During the intramural phase of the award,  the candidate will spend full time 
on research. During the subsequent two-year extramural phase, the candidate 
must spend a minimum of 75 percent of full-time professional effort 
conducting research and research career development activities.

Minorities, women, and persons with disabilities are encouraged to apply. 
Candidates must be U.S. citizens or noncitizen nationals, or must have been
lawfully admitted for permanent residence and possess an Alien Registration
Receipt Card (I-151 or I-551) or some other verification of legal admission 
as a permanent resident.  Individuals on temporary or student visas are not

The required research experience may have been completed in an intramural NIH 
laboratory or at an extramural institution.  To obtain support for the 
extramural phase, candidates must have a formal tenure- track (or equivalent) 
offer in an extramural institution.

Former principal investigators on NIH research project (R01), FIRST Awards
(R29), SBIR/STTR awards, sub-projects of program project (P01) or center
grants (P50), K08 awards, or the equivalent, are not eligible.  Former
principal investigators of an NIH Small Grant (R03) or Exploratory/ 
Development Grants (R21) remain eligible.  A candidate for the NHLBI Career 
Transition Award may not concurrently apply for any other PHS award that 
duplicates the provisions of this award nor have another application pending 


Awards in response to this PA will use the K22 mechanism.  Planning, 
direction, and execution of the candidate's individual research and training
program will be the responsibility of the candidate and his/her mentor.  The
total period of support is four or five years (two or three years intramural,
plus two years extramural).  Awards are not renewable. Total direct costs for
the intramural phase are based on the candidate's experience, not to exceed
$150,000 per year, including salary; those for the extramural phase cannot
exceed $150,000 plus fringe benefits per year in direct costs or $300,000 for
the two-year period.  (For information about specific allowable costs, please


It is anticipated that applications for the NHLBI Career Transition Award 
will be solicited annually through the reissuance of this PA.  Each annual
solicitation will indicate the number of positions that will be sponsored in
that year.  For Fiscal Year 2000, the NHLBI anticipates making five awards.


The NHLBI intramural research environment has provided a unique opportunity
for the training of new scientists who have subsequently entered the
extramural biomedical research community and have become leaders in their
fields of investigation.  The goal of the NHLBI K22 program is to provide
highly qualified new investigators with an opportunity to receive research 
and research training experience in the NHLBI Division of Intramural Research 
and then to provide them with bridge funding to facilitate the transition of 
their research programs to extramural institutions.

To achieve these objectives, the NHLBI Career Transition Award will support
two phases of research:  an intramural phase and an extramural phase, for a
total of four to five years of combined support.  Transition from the
intramural phase of support to the extramural phase is not automatic. 
Approval of the transition will be based on the success of the awardees'
research program as determined by an NHLBI progress review, which will take
place no later than the end of the second year of the Intramural Support
Phase, and the evaluation of a research plan to be carried out at the
extramural institution.  The extramural institution must demonstrate a
commitment to the candidate by providing protected research time and space
needed to perform the proposed research.  Matching funds from the extramural
institution for equipment and supplies (and if necessary, salary) are
encouraged.  Awardees approved to proceed with the second phase of support
will receive notification of approval in writing from the NHLBI.  An
application from the extramural institution on behalf of the candidate will 
be required for the NHLBI to process the second phase of the K22.


The NHLBI provides leadership for a national program in diseases of the 
heart, blood vessels, blood, and lungs, and in the use of blood and the 
management of blood resources.  It plans, conducts, fosters, and supports an 
integrated and coordinated program of research, investigations, clinical 
trials, and demonstration and education projects relating to the causes, 
prevention, methods of diagnosis, and treatment (including emergency medical 
treatment) of cardiovascular and cardiopulmonary diseases.

The Division of Intramural Research conducts clinical research on the normal
and pathophysiologic functioning of the cardiac, pulmonary, blood, and
endocrine systems and basic research on normal and abnormal cellular behavior
at the molecular level.  The research activities of the 16 laboratories and
branches range from structural organic chemistry to cardiology.  Major areas
of interest include:

Mechanisms of gene regulation; viral-mediated gene transfer and gene therapy;
the molecular basis of lipoprotein dysfunctions and the atherogenic process;
the molecular basis of diseases of the alveolar structures of the lung and 
the design of new therapeutic modalities; the cellular and molecular events
underlying ischemic heart disease and myocardial hypertrophy; biochemical
events associated with aging and certain pathologic processes; molecular,
structural, and developmental aspects of muscle and nonmuscle contractile
systems; molecular and cellular processes for the conversion of metabolic
energy into useful work; the molecular basis of transmembrane signaling; the
pathophysiology of renal function at the cellular and molecular levels; the
biochemistry of trace nutrients; enzyme kinetics, metabolic regulation, and
protein chemistry; the cellular and molecular basis of toxicities induced by
drugs and other foreign compounds; molecular immunology and cytokines;
hematopoietic stem cell biology and bone marrow transplantation;
pathophysiology of vascular diseases with emphasis on molecular genetic
interventions; cardiac imaging through ultrasound and magnetic resonance
imaging; as well as some aspects of cardiovascular devices, computational
biophysics, and mass and optical spectroscopy.  Animal medicine and surgery
support is provided to both clinical and basic science by full-time NHLBI


Intramural Support Phase:

Support during the intramural phase will include a fellowship stipend,  be 
based on the candidate's years of postdoctoral experience, commensurate with 
the NHLBI intramural salary structure.  Research expenses including 
personnel, consultants, equipment, supplies, and travel will be negotiated 
with the laboratory chief and will depend on the nature and scope of the 
research approved by peer review. Allowable costs will follow those specified 
for the Extramural Support Phase which follows.

Extramural Support Phase:

1. Salary:  The Ne NIH NHLBI will provide salary for the award recipient of 
up to $75,000 per year plus commensurate fringe benefits for a minimum of 75 
percent effort.  Although a greater effort may be proposed, the maximum 
allowable salary is $75,000.  The total salary requested must be based on a 
full-time, 12-month staff appointment.  It must be consistent both with the 
established salary structure at the institution and with salaries actually 
provided by the institution from its own funds to other staff members of 
equivalent qualifications, rank, and responsibilities in the department 
concerned.  The institution may supplement the NIH contribution up to a level 
that is consistent with the institution’s salary scale; however, 
supplementation may not be from Federal funds unless specifically authorized 
by the Federal program from which such funds are derived.  Institutional 
supplementation of salary must not require extra duties or responsibilities 
that would interfere with the purpose of the K22.  Under expanded 
authorities, institutions may rebudget funds within the total costs awarded 
to cover salaries consistent with the institution’s salary scale provided 
they don’t exceed the current legislated maximum salary.

2.  Research Support:  The NHLBI will provide up to $75,000 per year for (a) 
research expenses, such as supplies, equipment, and technical personnel; (b) 
travel to research meetings or training; and (c) statistical services, 
including personnel and computer time.  Total direct costs, including salary, 
fringe benefits and research support, may not exceed $150,000 per year.

3.  Ancillary Personnel Support:  Salary for secretarial and administrative
assistance, etc., is not allowed.

4.  Facilities and Administrative Costs (F&A):  F&A costs will be reimbursed
at eight percent of modified total direct costs.

Special Restrictions:

Acceptance into the NHLBI Career Transition Award Program does not convey any
commitment or intent of the NHLBI to consider the awardee for a tenure track
position within the NHLBI.  The NHLBI Career Transition Award is specifically
intended to help develop scientists who will pursue their careers in the
extramural biomedical research community.  However, the NHLBI K22 awardees 
are not explicitly precluded from applying for available tenure track 
positions at the NIH.  If an awardee obtains an NIH position, the NHLBI 
Career Transition Award will be terminated.

Once a K22 award is made, the awardee is expected to remain with the NHLBI
Intramural Program for at least 18 months.  Exceptions may be reviewed on a
case-by-case basis.


It is the policy of the NIH that women and members of minority groups and
their subpopulations must be included in all NIH supported biomedical and
behavioral research projects involving human subjects, unless a clear and
compelling rationale and justification is provided that inclusion is
inappropriate with respect to the health of the subjects or the purpose of 
the research. This policy results from the NIH Revitalization Act of 1993 
(Section 492B of Public Law 103-43).

All investigators proposing research involving human subjects should read the
"NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical
Research," which was published in the Federal Register of March 28, 1994 (FR
59 14508-14513), and in the NIH Guide for Grants and Contracts, Vol. 23, No.
11, March 18, 1994, available on the web at: 


It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by 
the NIH, unless there are scientific and/or ethical reasons not to include 
them.  This policy applies to all initial (Type 1) applications submitted for 
receipt dates after October 1, 1998.  All investigators proposing research 
involving human subjects should read the "NIH Policy and Guidelines" on the 
Inclusion of Children as Participants in Research Involving Human Subjects 
that was published in the NIH Guide for Grants and Contracts, March 6, 1998, 
and is available at the following URL address: 

Investigators also may obtain copies of these policies from the program staff
listed under INQUIRIES. Program staff may also provide additional relevant
information concerning the policy.


Individuals interested in applying for the NHLBI K22 Award must contact the 
Office of Education in the NHLBI Division of Intramural Research ( Ms. Nancy 
Curro at (301) 496-2116; email: curron@nih.gov).  This contact is required to 
initiate the process of selecting a mentor and completing the application.   
Preliminary information on the NHLBI Intramural Program may be found on the 
web at: http://www.nhlbi.nih.gov/nhlbi/relab/relab.htm

Following initial contact with the Office of Education of the NHLBI Division 
of Intramural Research, the applicant will submit a curriculum vitae and a 
brief pre-application describing his/her past training, research experience 
and research interests.  Senior DIR staff will review this pre-application, 
identify 3-5 potential mentors in the applicant’s area of interest and 
provide this information to the applicant. The Office of Education may then 
arrange for the applicant to visit the NIH campus and meet with these 
investigators so that a prospective mentor can be selected.  Once a mentor is 
identified, the candidate and mentor must work together to complete the 
application.  The application must include information regarding the 
candidate's long-term career plan, a research training plan, including 
descriptions of proposed formal course work, a research plan, and the 
mentor's statement of support.

Applications are to be submitted on form PHS 398 (rev. 4/98) (See additional
instructions for preparing individual research career award applications on
page IV-1) and will be accepted on the receipt deadlines indicated in the
application kit.  These forms are available at most institutional offices of
sponsored research and from the Division of Extramural Outreach and
Information Resources, National Institutes of Health, 6701 Rockledge Drive,
MSC 7910, Bethesda, MD 20892-7910, telephone 301-710-0267; Email:

Both new and revised K22 applications are due on the first appropriate 
receipt date for each cycle (February 1, June 1, and October 1).

The application must address the following issues:


o The candidate's commitment to a career in biomedical or behavioral 

o The candidate's potential to develop into a successful independent

o The candidate's immediate and long-term career objectives, explaining how
the award will contribute to their attainment.

o Letters of recommendation.  Three sealed letters of recommendation
addressing the candidate's potential for a research career must be included 
as part of the application.

o Candidates must describe plans to receive instruction in the responsible
conduct of research.  These plans must detail the proposed subject matter,
format, frequency, and duration of instruction, as well as the amount and
nature of senior staff participation.  No award will be made if an 
application lacks this component.

Research Plan

o Describe the research plan and the use of a basic or clinical approach to a
biomedical or behavioral problem.  The candidate must describe the research
plan as outlined in form PHS 398 including sections on the Specific Aims,
Background and Significance, Progress Report/Preliminary Studies, Research
Design and Methods.

Mentor's Training Plan (Intramural Phase)

o The mentor must describe the elements of research training planned for the
candidate, including any formal course-work, and specify how the candidate's
scientific independence and professional development will be promoted.


The applicant should work with the potential NHLBI mentor to devise a budget 
for the Intramural Phase. Budget information for TOTAL DIRECT COSTS and cost 
justifications should be developed in accordance with the Budget Information 
instructions in form PHS 398.  For candidates who receive approval for 
transition to the Extramural Phase a budget will be submitted at that time as 
part of the form PHS 2590 (noncompeting application) as discussed below in 

Submission Procedures

o Identify the application as a response to this PA; check "YES" on item 2 of
page 1 of the application and enter "PAR-99-154, NHLBI Career Transition

o Submit a signed, typewritten original of the application and three signed,
photocopies in one package to:

BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

At the time of submission, send an additional two copies of the application
to Dr. James Scheirer at the address listed under INQUIRIES.  It is important
to send these two copies at the same time as the original and three copies 
are sent to the Center for Scientific Review (CSR). These copies are used to
identify conflicts and help ensure the appropriate and timely review of the


Upon receipt, applications will be reviewed for completeness by the Center 
for Scientific Review (CSR) and responsiveness to the PA by the appropriate 
NHLBI staff.  Applications that are complete and responsive to the program
announcement will be evaluated for scientific and technical merit by an
appropriate peer review group, convened by the NHLBI, in accordance with the
review criteria stated below.

Review Criteria

Intramural Support Phase


o  Commitment to an independent research career;

o  Potential to develop as an outstanding scientist who will make significant
contributions to the field.

o All candidates for this award must have had previous research experience. 
Quality and breadth of prior scientific training and experience including,
where appropriate, the record of previous research support and publications.

Research Plan

o A sound research plan that is appropriate for the research training
objectives of the candidate must be provided.

o  Usefulness of the research plan as a vehicle for enhancing research skills
necessary to fulfill the objectives of the career development plan;

o  Scientific and technical merit of the research question, design, and
methodology, judged in the context of the candidate's proposed career

Career Development Plan

o  Appropriateness of the proposed training experience to the candidate's
career development, considering the candidate's goals and prior experience.

o  Adequacy of plans to obtain instruction in the responsible conduct of

o  Adequacy of plans to include both genders and minorities and their
subgroups as appropriate for the scientific goals of the research.  Plans for
the recruitment and retention of subjects will also be evaluated.


o  Research qualifications and previous experience as a research supervisor.

o  Adequacy of the nature and extent of supervision that will occur during 
the proposed award period.

o  Appropriateness of the mentor's research interests and qualifications to
the career development needs of the candidate.

o  Adequacy of the proposed mentoring plan.


o  Appropriateness of the budget for the scope of the research and training
activities proposed (see Allowable Costs).


Intramural Support Phase

Following peer review, applications will be considered by a NHLBI Selection
Committee (NSC) consisting of Senior Scientists from the NHLBI Intramural
Program convened by the Division of Extramural Affairs, NHLBI.  Based on
priority score ranking and programmatic needs, this committee will determine 
the final candidates to be selected.


Funding decisions will be made based on the recommendations of the initial
review group and secondary review by the National Heart, Lung, and Blood
Advisory Council.


The candidate must receive approval in writing from the NHLBI and must be
accepted by an extramural institution in order to activate the extramural
support phase.  The extramural institution will submit an application on
behalf of the candidate for the extramural phase of support, using form PHS
2590, the noncompeting application.  The application submitted by the awardee
and the extramural institution for activation of the extramural phase of the
program will be evaluated by NHLBI extramural staff for completeness and
responsiveness to the program.


Written and telephone inquiries concerning this PA are encouraged, especially
during the planning phase of the application.  The opportunity to clarify any
issues or address questions from potential applicants is welcome.

Address inquiries regarding intramural programmatic issues to:

Ms. Nancy Curro
Division of Intramural Research
National Heart, Lung, and Blood Institute
Building 10, Room 7N-214
Bethesda, MD  20892
Telephone:  (301) 496-2116
Email:  curron@nih.gov

Address inquiries regarding extramural programmatic issues to:

Beth Schucker, M.A.
Division of Heart and Vascular Diseases
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, Room 9206, MSC 7940
Bethesda, MD  20892- 7940
Telephone:  (301) 435-0535
FAX:  (301) 480-1454
Email:  schuckeb@nih.gov

Address inquiries regarding review issues and mail two copies of the 
completed application to:

C. James Scheirer, Ph.D.
Division of Extramural Affairs
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, Room 7220, MSC 7924
Bethesda, MD  20892-7924
Telephone:  (301) 435-0266
FAX:  (301) 480-3541
Email:  js110j@nih.gov

Address inquiries regarding fiscal issues to:

Robert Vinson, Jr.
Division of Extramural Affairs
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, Room 7148, MSC 7926
Bethesda, MD  20892-7926
Telephone:  (301) 435-0171
FAX:  (301) 480-3310
Email: rv7g@nih.gov


Intramural Support Phase

Each awardee will be evaluated for progress on an annual basis by the mentor,
Laboratory Chief, and Scientific Director.

Extramural (Transition) Support Phase

The awardee will be required to submit a form PHS 2590 non-competing
continuation application for the final years of extramural support.  The
application should provide a description of the research and career progress
of the awardee, including: 1) publications in press or submitted; 2) current
investigator-initiated research grant support; and 3) all applications
submitted for investigator-initiated research grant support.  After the
completion of this award, periodic updates on various aspects of employment
history, publications, support from research grants or contracts, honors and
awards, professional activities, and other information helpful in evaluating
the impact of the program may be solicited from awardees.


This program is described in the Catalog of Federal Domestic Assistance No.
93.837, 93.838, and 93.839.  Awards are made under authorization of the 
Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by 
Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants 
policies and Federal Regulations 42 CFR 52 and 45 CFR Part 74.  This program 
is not subject to the intergovernmental review requirements of Executive 
Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a
smoke-free workplace and promote the non-use of all tobacco products.  In
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking
in certain facilities (or in some cases, any portion of a facility) in which
regular or routine education, library, day care, health care or early
childhood development services are provided to children.  This is consistent
with the PHS mission to protect and advance the physical and mental health of
the American people.

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