Release Date:  May 1, 1998

PA NUMBER:  PAR-98-062


National Human Genome Research Institute


The National Human Genome Research Institute (NHGRI) is soliciting applications
from U.S. educational institutions for Institutional Mentored Research Scientist
Development Awards (K12).  These awards are intended to foster the career
development of individuals with expertise in scientific disciplines that would
further technological developments critical to the success of the Human Genome
Program and the understanding of the genetic basis of diseases.  Eligibility is
limited to individuals with degrees in computer sciences, mathematics, chemistry,
engineering, physics and closely related scientific disciplines, such as
bioinformatics, computational biology, statistics, biomathematics,
bioengineering.  Under this Institutional Mentored Research Scientist Development
Award, up to three scientists may be selected and appointed to this program by
the grantee institutions.  In other respects, the research experiences of the
candidates selected for support under this award should resemble those supported
by the individual Mentored Research Scientist Development Award (see PAR-98-061)

Applications for this award should propose a development plan which has both
intrinsic research importance and will also serve as a suitable vehicle for
learning the methodology, theories, and conceptualizations necessary for well
trained independent, interdisciplinary researchers.  Appointees are expected to
enter a structured, phased developmental program, including a designated period
of didactic training followed by a period of supervised research experience. It
is expected that at the end of the career development period, individuals will
transition successfully into positions as independent investigators.


The Public Health Service is committed to achieving the health promotion and
disease prevention objectives of "Healthy People 2000," a PHS-led national
activity for setting priority areas.  This program announcement, Institutional
Mentored Research Scientist Development Award in Genomics Research and Analysis,
is related to the priority area of human resource development.  Potential
applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No.
017-001-00474-0 or Summary Report:  Stock No. 017-001-00473-1) from the
Superintendent of Documents, Government Printing Office, Washington, DC
20402-9325 (telephone 202/512-1800).


Applications will be accepted from domestic, non-Federal organizations of higher
education that have strong, well-established research and training programs in
both areas of interest: (1) genomics or genetics and (2) a subset of the these
disciplines: mathematics; chemistry; physics; computer science; engineering; and
closely related disciplines, such as bioinformatics, computational biology,
statistics, biomathematics, bioengineering. The applicant institution must have
adequate numbers of highly trained faculty in scientific areas of interest and
the capability to provide guidance to individuals who wish to work at the
interface of biology and the physical/computing/engineering sciences in the
development of research independence.  The environment should be one which will
stimulate and increase the interactions between biologists and physical, computer
and engineering scientists.

Institutions with a K12 Award may recruit and select candidates into their
programs on a local or national basis.  In all aspects, the K12 Awards are
intended to provide support for the development of research scientists in the
same manner and under the same conditions as the Individual Mentored Research
Scientist Development Award (K01) (PAR-98-061).

Appointment of minorities, women and individuals with disabilities under this
program is encouraged.  Candidates appointed under this program award must be
U.S. citizens or noncitizen nationals, or have been lawfully admitted for
permanent residence and possess an Alien Registration Receipt Card (I-151 or
I-551) or some other verification of legal admission as a permanent resident. 
Noncitizen nationals, although not U.S. citizens, owe permanent allegiance to the
U.S.  They are usually born in lands that are not states, but are under U.S.
sovereignty, jurisdiction, or administration.  Individuals on temporary or
student visas are not eligible.

Candidates who are or have been former principal investigators on NIH research
projects (R01), FIRST Awards (R29), sub-projects of program project (P01) or
center grants (P50), or the equivalent, are not eligible for appointment under
this program.  Candidates may not concurrently hold any other PHS award that
duplicates the provisions of this award.  Appointees to the K12 program are
encouraged to apply for independent research grant support during the period of
support under this award.


Awards in response to this program announcement will use the Mentored Clinical
Scientist Development Program Award (K12) mechanism.  The program awards will
normally be for a five year period and are renewable.  Up to three positions may
be requested.  Individuals may be appointed for three to five years; appointments
are not renewable.  The duration of the appointment depends upon the number of
years of prior research experience and the need for additional experiences to
achieve independence.  Planning, direction, and execution of the program will be
the responsibility of the principal investigator, the appointee and her/his



The NIH Human Genome Program has been initiated as a 15-year project which has
very specific goals: completion of a high-density genetic linkage map of the
human genome; construction of a high-resolution physical map comprised of large
overlapping contigs; development of a "sequence-tagged site" map; development of
technology to reduce the expense of DNA sequencing significantly below current
cost; development of new technologies for interpreting the genome; development
of computer tools to manage and provide access to mapping and sequencing data; 
examination of the ethical, legal, and social implications of the Human Genome
Program; and research training.

Several of the biological goals have been completed or adequate resources are in
place for completion.  These include: dense genetic maps of the human and mouse
genomes using microsatellite markers; a human physical map containing 30,000
uniquely ordered sequence tagged sites (STS) markers; the complete DNA sequence
of E. coli and S. cerevisiae (and several other bacterial genomes); and the
anticipated DNA sequence of C. elegans by 1998.  There goals could have not been
met without the development and implement of efficient, cost-effective, robust
technologies that are required for large-scale projects.

Although the genome project itself is predicated on the new and powerful methods
that have become available in the past decade, further technology development
will be essential to facilitate the sequencing goals of the Human Genome Program
and to interpret all the data resulting from the mapping and sequencing projects. 
The planning of the course of the Human Genome Program has assumed that new
ideas, instrumentation, and approaches will be developed to further reduce the
cost and increase the efficiency of DNA sequencing and to improve the management
of data emanating from large-scale mapping and sequencing projects.  The
development and successful introduction of new technologies require both an
understanding of biology and the fundamentals of the technology to be applied,
so that the solutions derived are appropriate and implementable.  The NHGRI
believes that advances in genomic research will depend, in part, upon a cadre of
scientists and scholars who have been trained intensely in more than one
discipline and have the capabilities to develop innovative, appropriate, and
cost-effective solutions for the problems of large-scale mapping, sequencing, and
interpretation of the genome.  To stimulate the training of scientists who are
facile in more than one scientific discipline, the NHGRI has emphasized
interdisciplinary training as one of its goals.  In addition to interdisciplinary
training of young scientists, there is also the opportunity to recruit scientists
who have the appropriate training and experiences to design and conduct such
interdisciplinary or cross-disciplinary research as it relates to the
construction of various types of maps, improved or new sequencing technologies,
development of new and improve existing technologies to help interpret the
genome, and informatics needs in support of such projects.


The purpose of this Institutional Mentored Research Scientist Development Award
is to provide eligible institutions the opportunity to develop and implement a
program to recruit scientists interested in and capable of interdisciplinary
research in areas critical to the advancement of the research goals of the Human
Genome Program.  The K12 award offers opportunities for training in the
biological sciences to individuals with doctoral degrees in scientific
disciplines that have the potential to further the technological developments
essential to the success of the Human Genome Program, such as mathematics,
engineering, computer sciences, chemistry and physics, and related scientific
disciplines in order to enable such individuals to pursue a career in genomics

Individual appointees' programs are often divided into two distinct phases--a
basic science component and an intensive research experience under the general
guidance of a qualified mentor. The basic science component must develop
knowledge and research skills in scientific areas relevant to the career
development goals of the candidate and must include relevant didactic and
laboratory experiences.  In all cases, the types of developmental experiences
provided should be consistent with the candidate's prior experience and needs. 
During the period of the appointment, individuals will participate in career
development activities and research projects under the supervision of mentors who
have distinguished themselves in the area of genomics research.  At the
conclusion of their career development and research experience, appointees are
expected to pursue an independent career in genomics research.

The award aims to develop a close and extended working relationship between the
awardee and one or more highly qualified scientists working in genomics research
or a closely relevant field.  The relationship should optimize the opportunity
for interdisciplinary communication and collaboration.  As a result of the
experience, the awardee should develop the capacity to apply the knowledge and
research methods of her (his) discipline to relevant problems in genomics
research.  For the sponsoring institution, the relationship should stimulate
awareness among scientists of the potential for interdisciplinary or cross-
disciplinary research in genomics research.


The proposed Program Director should possess the scientific expertise, leadership
and administrative capabilities required to coordinate and supervise an
interdisciplinary program at the interface of genomics or genetics research and
another discipline and be willing to develop a career development program of the
scope described in the program announcement.  The Program Director should also
be experienced in the design and management of programs for developing
investigators, and should be able to demonstrate a superior record of 
preparation of scientists for independent research careers.  In addition, a
committee with representatives from the appropriate science departments should
be established to advise the Program Director.


The mentor must have extensive research experience in genomics research or in 
developing genomic approaches for genetics research or functional analyses. The
mentor will sponsor and oversee the proposed training and research program, and
will ensure that the appointee receives the proper experience for a future career
of interdisciplinary genomic research.  The mentor is expected to be a
collaborator on the appointee's research project.  However, the appointee may
conduct collaborative research with other experienced genome researchers, subject
to the approval of the advisor.  Where feasible, women, minorities and
individuals with disabilities should be involved as role models.


Appointees must hold a Ph.D. or equivalent professional degree in a scientific
discipline other than biology, such as engineering, mathematics, computer
sciences, physics, chemistry or a closely related scientific discipline such as
bioinformatics, computational biology, statistics, biomathematics,
bioengineering, and show evidence of expertise in their discipline (e.g., by
scholarly publications or comparable accomplishments in other settings). In
exceptional cases, individuals who do not have doctoral degrees, but have
significant research experience, may be eligible.  The candidates must
demonstrate a commitment to pursue a career in genomic research following
completion of the award.  Individuals at all career levels may be appointed. 
Candidates must be willing to spend 100 percent of full-time professional effort 
conducting research, career development, teaching and/or research related
activities.  Tenure-track faculty are eligible for appointment if they can
demonstrate that they can spend a substantial portion of their professional
effort in research and career-development related activities and if the proposed
program has the potential of accomplishing the NHGRI goals of the K12 program .

Appropriate individuals who have had some postdoctoral experience in biology may
be eligible for appointment to the program, if they can demonstrate that they
need additional time in order to transition into independent investigators.  If
such individuals are appointed, their research program must include sufficient
didactic activities to ensure that they receive the appropriate exposure to
concepts in biology and their appointments should generally be limited to three
years or less.


The institution must: (1) have well-established research programs in genomics or
genetics research and several of the following disciplines: mathematics;
chemistry; physics; computer science; engineering; and closely related
disciplines, such as bioinformatics, computational biology, statistics,
biomathematics, bioengineering, (ii) have a commitment to pursuing
interdisciplinary research at the interface of these disciplines, (iii) be
interested in promoting career development programs at the interface, and (iv)
have qualified faculty to serve as mentors.  Institutions where there are highly
integrated clusters of biologists working with computer scientists,
mathematicians, engineers, physicists, chemists or scientists in closely related
disciplines working in the area of genomics research or genomic approaches to
genetics or functional analyses are particularly appropriate training
environments for appointees. The candidate, mentor and institution must be able
to maximize the use of relevant research and educational resources.


A.  Appointee's Salary.  Up to a maximum of $125,000 for full-time professional
effort salary support may be requested. The total salary requested must be based
on a full-time 12 month staff appointment.  It must be consistent both with the
established salary structure at the institution and with the salaries actually
provided by the institution from its own funds to other staff members of
equivalent qualifications, rank, and responsibilities in the department
concerned.  If full-time 12-month salaries are not currently paid to comparable
staff members, the salary proposed must be appropriately related to the existing

The institution may supplement the NIH contribution up to a level that is
consistent with the institutionþs salary scale; however, supplementation may not
be from Federal funds unless specifically authorized by the Federal program from
which such funds are derived.  In no case, may DHHS funds be used for salary
supplementation.  Institutional supplementation of salary must not require extra
duties or responsibilities that would interfere with the purpose of the K12

It is expected that the appointee will devote full-time to career development and
research activities.  However, up to 15 percent of the appointee's time may be
used for activities, such as teaching, research-related activities or advising
on research, which make use of the awardee's own discipline as a special
contribution of the NHGRI career development program to relevant
interdisciplinary research programs of the sponsoring institution.  In the case
of tenure-track faculty, the appointee must be willing to spend a substantial
amount of her/his professional effort in research and career development
activities related to genomics research and analysis and the goals of the K12

B.  Research Development Support.  In addition to the appointee's salary, up to
a maximum of $20,000 in each year of the award may be requested to partially
defray the research expenses of each appointee:  e.g. instrument development,
computer time, data collection, analysis costs, domestic travel, publication
costs, and other appropriate expenses which are essential to the proposed
research program.  Requests for research support must be well-justified in the

C.  Tuition.  If essential to the awardee's individual development program, funds
for tuition for training courses may be requested during the first year or two
of the appointment on a course-by-course basis.

D.  Ancillary Personnel Support.  Salary for mentors, secretarial and
administrative support, etc., is not allowed.

E.  Indirect Cost.  Indirect cost will be reimbursed at eight percent of modified
total direct costs, or at the actual indirect cost rate, whichever is less.

F.  Evaluation.  In carrying out its stewardship of human resources related
programs, the NIH may request information essential to an assessment of the
effectiveness of this program.  Accordingly, recipients may be contacted after
the completion of this award for periodic updates on various aspects of their
employment history, publications, support from research grants and contracts,
honors and awards, professional activities, and other information helpful in
evaluating the impact of the program.

G.  Other Income:  Fees resulting from professional consultation or other
comparable activities required by the research and research-related activities
of this award may not be retained by the career award recipient.  Such fees must
be assigned to the grantee institution for disposition by any of the following

The funds may be expended by the grantee institution in accordance with the NIH
policy on supplementation of career award salaries and to provide fringe benefits
in proportion to such supplementation. Such salary supplementation and fringe
benefit payments must be within the established policies of the grantee

The funds may be used for health-related research purposes.

The funds may be paid to miscellaneous receipts of the U.S. Treasury. Checks must
be made payable to the Department of Health and Human Services, NIH and forwarded
to the Director, Division of Financial Management, NIH, Bethesda, Maryland 20892. 
Checks must identify the relevant award account and reason for the payment.

Appointees may retain royalties and fees for activities such as scholarly
writing, service on advisory groups, or honoraria from other institutions for
lectures or seminars, provided these activities remain incidental and provided
that the retention of such pay is consistent with the policies and practices of
the grantee institution.

Usually, funds budgeted in an NIH supported research or research training grant
for the salaries or fringe benefits of individuals, but freed as a result of a
career award, may not be rebudgeted.  The awarding component will give
consideration to approval for the use of released funds only under unusual
circumstances.  Any proposed retention of funds released as a result of a career
award must receive prior written approval of the NIH awarding component.

H.  Special Leave:  Leave to another institution, including a foreign laboratory,
may be permitted if directly related to the purpose of the award.  Only local,
institutional approval is required if such leave does not exceed three months. 
For longer periods, prior written approval of NHGRI is required.  To obtain prior
approval, the appointee must submit a letter to the NHGRI describing the plan,
countersigned by his or her department head and the appropriate institutional
official.  A copy of a letter or other evidence from the institution where the
leave is to be taken must be submitted to assure that satisfactory arrangements
have been made. Support from the career award will continue during such leave.

Leave without award support may not exceed 12 months.  Such leave requires the
prior written approval of the NHGRI and will be granted only in unusual
situations.  Support from other sources is permissible during the period of
leave.  Such leave does not reduce the total number of months of program support
for which an individual is eligible.  Parental leave will be granted consistent
with the policies of the NIH and the grantee institution.

I.  Termination or Change of Institution.  When a grantee institution plans to
terminate an award, the NIH funding component must be notified in writing at the
earliest possible time so that appropriate instructions can be given for
termination.  If the individual is moving to another eligible institution, career
award support may be continued provided:

A new career award application is submitted by the new institution;

All conditions of the award are met at the new institution including the presence
of a qualified mentor;

The period of support requested is no more than the time remaining within the
existing award period; and

The new application is submitted far enough in advance of the requested effective
date to allow the necessary time for review.

The NHGRI may require a review by an initial review group and/or the National
Advisory Council for Human Genome Research.  Alternatively, review may be carried
out by staff within the NIH funding component depending upon the circumstances.

The Director of the NIH may discontinue an award upon determination that the
purpose or terms of the award are not being fulfilled.  In the event an award is
terminated, the Director of the NIH shall notify the grantee institution and
career award recipient in writing of this determination, the reason thereof, the
effective date, and the right to appeal the decision.

A final progress report, invention statement, and Financial Status Report are
required upon either termination of an award or relinquishment of an award in a
change of institution situation.


It is the policy of the NIH that women and members of minority groups and their
subpopulations must be included in all NIH supported biomedical and behavioral
research projects involving human subjects, unless a clear and compelling
rationale and justification is provided that inclusion is inappropriate with
respect to the health of the subjects or the purpose of the research.  This
policy results from the NIH Revitalization Act of 1993 (Section 492B of Public
Law 103-43).

All investigators proposing research involving human subjects should read the
"NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical
Research," which have been published in the Federal Register of March 28, 1994
(FR 59 14508-14513), and in the NIH GUIDE FOR GRANTS AND CONTRACTS of March 18,
1994, Volume 23, Number 11.

Investigators may obtain copies from these sources or from the program staff or
contact person listed under INQUIRIES.  Program staff may also provide additional
relevant information concerning the policy.


It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by the
NIH, unless there are scientific and ethical reasons not to include them.  This
policy applies to all initial (Type 1) applications submitted for receipt dates
after October 1, 1998.

All investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines on the Inclusion of Children as Participants in
Research Involving Human Subjects" that was published in the NIH Guide for Grants
and Contracts, March 6, 1998, and is available at the following URL address:


Applications are to be submitted on the grant application form PHS 398 (rev.
5/95) and will be accepted on application receipt deadlines indicated in the
application kit.  Forms are available at most institutional offices of sponsored
research and from the Division of Extramural Outreach and Information Resources,
National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD
20892-7910, telephone 301/710-0267, Email:; and from the
program administrator listed under INQUIRIES.

Submit a signed, typewritten original of the application, including the
Checklist, and three signed photocopies, in one package to:

BETHESDA, MD 20892-7710
BETHESDA, MD 20817 (for express/courier service)

At the time of submission, two additional copies of the application must be sent

Office of Scientific Review
National Human Genome Research Institute
Building 38A, Room 609
Bethesda, MD 20892-6050

To identify the application as a response to this program announcement, check
"YES" on item 2 of page 1 of the application and enter PAR-98-062, NHGRI Mentored
Research Scientist Development Program Award In Genomic Research and Analysis."

The application must address the following issues:

(1) Provide information establishing the commitment of the applicant institution,
the program director, and the faculty mentors to providing developmental
experiences that lead to independence in an interdisciplinary program in genomics
or genetics research.

(2) Summarize the immediate and long-term objectives of the program, explaining
how the program and the K12 award will contribute to their attainment.

(3) Describe the career development plans for prospective candidates. 
Considering the program goals and the likely goals of prospective candidates,
describe a plan to provide the necessary basic science background and research
experiences considering the expected range of prior research training in the
applicant pool.  For example, candidates with little previous research experience
may require a phased developmental period in which the first year or two of
support under this program award are comprised largely of didactic training in
the basic sciences.  For these candidates, a second phase would be an intensive,
supervised research experience to complete the five year developmental program. 
More experienced candidates may benefit from moving immediately to a mentored
research environment and a shorter period of support under this program award. 
The application should contain a description of how the career development plan
will be tailored to the needs of the prospective candidates.

(4) Describe the pool of potential candidates including information about the
types of prior research training.  Also, describe how  the appointments will be
made to the K12 Award.  Describe the composition of the selection committee and
the criteria to be used for selection.

(5) Describe plans to recruit candidates from racial or ethnic groups that are
currently underrepresented in biomedical research.

6) Describe to the extent possible the types of interdisciplinary research
experiences available to the candidates.

(7) Instructions in the responsible conduct of research. Applications must
include plans for instruction in the responsible conduct of research, including
the rationale, subject matter, appropriateness, format, frequency and duration
of instruction; and the amount and nature of faculty participation.  No award
will be made if an application lacks this component.

(8) Renewal applications must include a detailed account of the career outcomes
of all candidates supported by this grant including positions held, research
involvement, publications, and other evidence that this program award is meeting
the objectives of the NIH awarding component.

(9) Budget requests must be provided according to the instructions in form PHS
398.  The request for tuition and fees, books, travel, research development
expenses, etc., must be justified and specified by category.


Applications will be reviewed for completeness by the Center for Scientific
Review (CSR).  Applications that are complete will be evaluated for scientific
and technical merit by an appropriate peer review group convened in accordance
with the standard NIH peer review procedures.  As part of the initial merit
review, all applications will receive a written critique and undergo a process
in which only those applications deemed to have the highest scientific merit,
generally the top half of applications under review, will be discussed, assigned
a priority score, and receive a second level review by the National Advisory
Council for Human Genome Research.

The following review criteria will be applied:

Program Director

o  The strength of the program director's research program at the interface of
genomics or genetics and other related scientific disciplines

o  The program directorþs experience in managing research training or career
development programs and success in preparing investigators for independent
interdisciplinary research careers in genomics or genetics and related
interfacing fields such as mathematics, chemistry, physics, computer sciences,
engineering and other closely related scientific disciplines;


o  Availability of high quality potential candidates,

o  Plans for recruiting and selecting candidates (including minorities, women and
individuals with disabilities);

o  Plan to identify candidates with a commitment to research and the potential
to develop as an independent researcher; and

o  For renewal applications, the career success of candidates that have received
support and completed their appointeeship under this award.

Career Development Plan

o  Likelihood that the career development plan will contribute substantially to
the scientific development of the candidates;

o Likelihood that the career development program of the candidates will result
in preparing investigators who will contribute to the goals of the Human Genome

o  Appropriateness of the content, the phasing, and the proposed duration of the
career development plan for achieving scientific independence for the prospective

o  Consistency of the career development plan with prospective candidate's career
goals; and

o  Quality of the training in the responsible conduct of research.

Research Opportunities and Mentors

o  Availability of research opportunities appropriate to the purpose of this

o  Commitment of proposed mentors to interdisciplinary training;

o  Previous experience of the mentors in fostering the development of
researchers; and


o  Applicant institution's commitment to the scientific development of the
candidate(s) and assurances that the institution intends the program and the
supported candidate(s) to be an integral part of its research program;


o  Justification of budget requests in relation to career development goals and
research aims.


Funding decisions will be made based on the recommendations of the initial review
group and the Council, the need for research personnel in specific program areas,
and the availability of funds.


Written and telephone inquiries concerning this program announcement are
encouraged especially during the planning phase of the application.

Direct inquiries regarding programmatic issues to:

Bettie J. Graham, Ph.D.
National Human Genome Research Institute
Building 38A, Room 610
Bethesda, MD  20892
Telephone:  (301) 496-7531

Inquiries about PHS Grant Policy may be directed to:

Ms. Jean Cahill
Grants and Contracts Management Section
National Human Genome Research Institute
Building 38A, Room 613
Bethesda, MD  20892
Telephone:  (301) 402-0733


This program is described in the Catalog of Federal Domestic Assistance No.
93.121.  Awards are made under the authority of Title III, Section 301 of the
Public Health Service Act as amended (Public Law 78-410, as amended, 42 USC 241). 
The Code of Federal Regulations, Title 42 Part 52, and Title 45 part 74, are
applicable to this program.  This program is not subject to the intergovernmental
review requirements of Executive Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a smoke-
free workplace and promote the non-use of all tobacco products.  In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain
facilities (or in some cases, any portion of a facility) in which regular or
routing education, library, day care, health care or early childhood development
services are provided to children.  This is consistent with the PHS mission to
protect and advance the physical and mental health of the American people.

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