Full Text PAR-96-046
NIH GUIDE, Volume 25, Number 13, April 26, 1996
PA NUMBER:  PAR-96-046
P.T. 34

  Disease Prevention+ 
  Diagnosis, Medical 
  Treatment, Medical+ 

National Cancer Institute
The goal of the National Cancer Institute's (NCI) Howard Temin Award
is to bridge the transition from a mentored research environment to
an independent research career for scientists who have demonstrated
unusually high potential during their initial stages of training and
development.  This special award is aimed at fostering the research
careers of outstanding, junior, basic, clinical, and behavioral
scientists who are committed to developing research programs highly
relevant to the understanding of human biology and human disease as
it relates to the etiology, pathogenesis, prevention, diagnosis, and
treatment of cancer.  The NCI recognizes the need to maintain
diversity in the research backgrounds of individuals who receive this
award, and will work toward maintaining a representative balance of
scientists in basic, clinical, and population research. The major
objective of the award is to sustain and advance the early research
careers of the most promising M.D.s and Ph.D.s while they consolidate
and focus their independent research programs, and obtain their own
research grant support.
The Public health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of ~Healthy People 2000",
a PHS-led national activity for setting priority areas.  This program
announcement, the Howard Temin Extended Support Award, is related to
the priority area of human resource development.  Potential
applicants may obtain a copy of "Healthy People 2000" (Full Report:
Stock No. 017-001-00474-0 or Summary Report:  Stock No. 017-001-
00473-1) from the Superintendent of Documents, Government Printing
Office, Washington, DC 20402-9325 (telephone 202-512-1800).
All applicants are encouraged to contact the NCI regarding their
eligibility for this award (see Inquiries Section).  In general, the
candidate must have a research or a health professional doctorate or
its equivalent and must have demonstrated highly productive research
activity and the potential for establishing an independent research
program in the period after the doctorate.  Candidates must have
completed at least three years of postdoctoral research before the
initiation of a successful award.  However, individuals who have been
principal investigators on either PHS research grants or non-PHS peer
reviewed grants that are over $70,000 direct costs per year, are not
eligible to apply for this award.
The candidate must identify a mentor with extensive research
experience and appropriate support for the initial phase (up to three
years) of this award.  Support beyond three years is contingent on
the candidate moving to an unmentored, independent research
environment.  All candidates must provide three letters of
recommendations from established scientists.
The candidate must make a commitment to spend a minimum of 75 percent
of full-time professional effort conducting cancer-related research
and research career development activities during the period of the
award.  However, salary will be paid at 100 percent up to the stated
ceiling of the salary component Candidates may be currently pursuing
cancer research or be interested in moving into the cancer research
field.  All current NCI Career awardees in their last two years of
support who meet the eligibility criteria are encouraged to apply.
Applications may be submitted on behalf of candidates by domestic,
non-Federal organizations, public and private, such as medical,
dental, or nursing schools or other institutions of higher education.
Minorities and women are encouraged to apply.  Candidates must be
U.S. citizens or noncitizen nationals, or must have been lawfully
admitted for permanent residence and possess an Alien Registration
Receipt Card (I-151 or I-551) or some other verification of legal
admission as a permanent resident.  Noncitizen nationals, although
not U.S. citizens, owe permanent allegiance to the U.S.  They are
usually born in lands that are not states, but are under U.S.
sovereignty, jurisdiction, or administration.  Individuals on
temporary or student visas are not eligible.
Awards in response to this program announcement will use the Research
Scientist Development Award (K01). Planning, direction, and execution
of the program will be the responsibility of the candidate and
her/his mentor on behalf of the applicant institution.  The project
period will be for up to five years of support depending upon the
number of years of prior research experience and the need for
additional experiences to achieve independence.  Awards are not
A.  Environment:  The institution must have a well-established
research and/or clinical career development program(s) and qualified
faculty to serve as mentors.  The candidate, mentor and institution
must be able to describe a multi-disciplinary career development
program that will maximize the use of relevant research and
educational resources.
B.  Program:  The award provides up to five consecutive 12 month
appointments.  At least 75 percent of the recipients's full-time
professional effort must be devoted to the program and the remainder
devoted to other research-related and/or teaching pursuits consistent
with the objectives of the award.  The candidate must develop
knowledge in the basic and/or clinical or behavioral sciences and
research skills relevant to his or her career goals.  The candidate
may find it appropriate to include relevant didactic and laboratory
or field research experiences.
C.  Mentor(s):  The recipient must receive appropriate mentoring
during some fraction of the first three years of the initial phase of
the award. The candidate may move to an unmentored research
environment beginning with any time within the first year, however,
the transition must take place no later than the end of the third
year.  Where feasible, women and minority mentors should be involved
as role models.
D.  Allowable Costs:
1.  Salary:  The Temin award will provide salary up to $75,000 plus
fringe benefits.  The institution may supplement the NCI contribution
up to a level that is consistent with the institution's salary scale;
however, supplementation may not be from Federal funds unless
specifically authorized by the Federal program from which such funds
are derived.  In no case, may PHS funds be used for salary
supplementation.  Institutional supplementation of salary must not
require extra duties or responsibilities that would interfere with
the purpose of this award.  Under expanded authorities, however,
institutions may rebudget funds within the total costs awarded to
cover salaries consistent with the institution~s salary scale.
The total salary requested must be based on a full-time, 12 month
staff appointment.  It must be consistent both with the established
salary structure at the institution and with salaries actually
provided by the institution from its own funds to other staff members
of equivalent qualifications, rank, and responsibilities in the
department concerned.  If full-time, 12 month salaries are not
currently paid to comparable staff members, the salary proposed must
be appropriately related to the existing salary structure.
2.  Research Development Support:  During the mentored phase of the
award, $20,000 per year will be provided for the following types of
expenses: (a) research expenses, such as supplies, equipment, and
technical personnel; (b) statistical services including personnel and
computer time; (c) tuition, fees, and books related to career
development; and (d) travel to research meetings or for training.
The amount of this support will increase to $50,000 when the
principal investigator moves to a new research environment, as
opposed to the environment provided by a mentor, which includes an
independent research position either at the same institution or at a
different institution.
3.  Ancillary Personnel Support:  Salary for mentors, secretarial and
administrative assistance, etc., is not allowed.
4.  Indirect Costs:  Indirect costs will be reimbursed at eight
percent of modified total direct costs, or at the actual indirect
cost rate, whichever is less.
E.  Termination or Change of Institution:  When a grantee institution
plans to terminate an award, the NCI must be notified in writing at
the earliest possible time so that appropriate instructions can be
given for termination (see INQUIRIES section for contacts).  If the
individual is moving to another eligible institution, career award
support may be continued provided:
1.  A new career award application is submitted by the new
2.  The period of support requested is no more than the time
remaining within the existing award period.
3.  The new application is submitted far enough in advance of the
requested effective date to allow the necessary time for review.
4.  A final progress report, invention statement, and Financial
Status Report are required upon either termination of an award or
relinquishment of an award in a change of institution situation.
It is the policy of the NIH that women and members of minority groups
and their subpopulations must be included in all NIH supported
biomedical and behavioral research projects involving human subjects,
unless a clear and compelling rationale and justification is provided
that inclusion is inappropriate with respect to the health of the
subjects or the purpose of the research.  This new policy results
from the NIH Revitalization Act of 1993 (Section 492B of Public Law
103-43) and supersedes and strengthens the previous policies
(Concerning the Inclusion of Women in Study Populations, and
Concerning the Inclusion of Minorities in Study Populations) which
have been in effect since 1990.  The new policy contains some new
provisions that are substantially different from the 1990 policies.
Investigators proposing research involving human subjects should read
the "NIH Guidelines For Inclusion of Women and Minorities as Subjects
in Clinical Research," which have been published in the Federal
Register of March 28, 1994 (FR 59 14508-14513), and reprinted in the
NIH Guide for Grants and Contracts, Volume 23, Number 11, March 18,
Investigators may obtain copies from these sources or from the
program staff or contact person listed under INQUIRIES.  Program
staff may also provide additional relevant information concerning the
Applications are to be submitted on form PHS 398 (rev. 5/95) and will
be accepted on or before the receipt deadlines indicated in the
application kit (October 1, February 1 and June 1).  Applications
kits are available at most institutional offices of sponsored
research and may be obtained from the Grants Information Office,
Office of Extramural Outreach and Information Resources, National
Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD
20892-7910, telephone 301/710-0267, email:
To identify the application as a response to this program
announcement, check "YES" on item 2 of page 1 of the application and
The completed original application and five legible copies must be
sent or delivered to:
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)
Applications will be assigned on the basis of established PHS
referral guidelines.  Applications that are complete and responsive
to the program announcement will be evaluated for scientific and
technical merit by an appropriate peer review group convened by the
NCI in accordance with the standard NIH peer review procedures.  As
part of the initial merit review, all applications will receive a
written critique and undergo a process in which only those
applications deemed to have the highest scientific merit, generally
the top half of applications under review, will be discussed,
assigned a priority score, and receive a second level review by the
National Cancer Advisory Board.
Review Criteria
Candidate (Principal Investigator)
o  Commitment to an independent cancer research career in terms of
effort and future plans.
o  Quality and breadth of prior scientific training and experience,
including publications during the early stages of scientific
o  Recommendations of three well-established scientists attesting to
the special potential of the individual to pursue an independent
career in cancer research.
Career Development Plan
o  Likelihood that the plan will contribute substantially to the
scientific development of the candidate and the achievement of
scientific independence.
o  Appropriateness of the career development plan in terms of the
candidate's prior research and academic experience, and the stated
career goals.
o  Clarity of the goals and scope of the plan and the need for the
proposed research experience.
o  Quality of the proposed training in the responsible conduct of
Research Plan
o  All applicants for this award will have had previous postdoctoral
research experience and in some cases may have been Principal
Investigators on small research grants.  A sound research project
that is consistent with the development plan for an independent
career in cancer research and the candidate's level of research
development must be provided.
o  Usefulness of the research plan as a vehicle for enhancing
existing research skills as described in the career development plan.
o The originality and quality of the research hypothesis/question,
design and methodology,judged in the context of the candidate's
previous training and experience.
o  The relevance of the research plan to the etiology, pathogenesis,
prevention, diagnosis, and/or treatment of cancer.
o  Appropriateness of the mentor's research qualifications in the
area of the proposed research.
-  Quality and time commitment of the mentor to supervising and
guiding the candidate during the initial phase of the award.
-  Previous experience in fostering the development of cancer
-  History of research productivity and peer reviewed support.
Institutional Environment and Commitment
o  Applicant institution's commitment to the scientific development
of the investigator according to the terms of the Temin Award.
o  Applicant institution's assurance that the investigator will spend
a minimum of 75 percent effort on the research project.
o  Adequacy of research facilities and training opportunities.
o  Quality of the environment for scientific and professional
o  Appropriateness of the budget in relation to career development
goals and research aims and plans.
The NCI will notify the applicant of the National Cancer Advisory
Board's (NCAB) action shortly after its meeting.  Funding decisions
will be made based on the recommendations of the initial peer review
group and NCAB, achievement of an appropriate balance of basic,
clinical, and population scientists, and the availability of funds.
Approximately ten awards will be made each year.
Written, telephone, FAX, and E-Mail inquiries concerning this program
announcement are encouraged, especially during the planning phase of
the application.  NCI contacts for specific areas of expertise are
listed below:
Direct inquiries regarding programmatic issues to:
Dr. Vincent J. Cairoli
Division of Cancer Treatment, Diagnosis, and Centers
National Cancer Institute
Executive Plaza North, Room 520
Bethesda, MD  20892-7390
Telephone:  (301) 496-8580
FAX:  (301) 402-4472
Email:  vc14z@nih.gov
Direct inquiries regarding fiscal matters to:
Ms. Sara Stone
Office of Administrative Management
National Cancer Institute
Executive Plaza South, Room 243
Bethesda, MD  20892
Telephone:  (301) 496-7800
FAX:  (301) 496-8601
Email:  stones@gab.nci.nih.gov
This program is described in the Catalog of Federal Domestic
Assistance Number 93.398, Cancer Research Manpower.  Awards are made
under the authorization of the Public Health Service Act, Title IV,
Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC
241 and 285) and administered under PHS grants policies and Federal
Regulations 42 CFR Part 52 and 45 CFR Part 74 and 45 CFR Part 92.
This program is not subject to the intergovernmental review
requirements of Executive Order 12372 or Health Systems Agency
The Public Health Service strongly encourages all grant recipients to
provide a smoke-free workplace and promote the non-use of tobacco
products.  In addition, Public Law 103-227, The Pro-Children Act of
1994, prohibits smoking in certain facilities (or, in some cases, any
portion of a facility) in which regular or routine education,
library, day care, health care or early childhood development
services are provided for children.  This is consistent with the PHS
mission to protect and advance the physical and mental health of the
American people.

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