Full Text PAR-96-046 THE HOWARD TEMIN AWARD NIH GUIDE, Volume 25, Number 13, April 26, 1996 PA NUMBER: PAR-96-046 P.T. 34 Keywords: Cancer/Carcinogenesis Etiology 0755033 Disease Prevention+ Diagnosis, Medical Treatment, Medical+ National Cancer Institute PURPOSE The goal of the National Cancer Institute's (NCI) Howard Temin Award is to bridge the transition from a mentored research environment to an independent research career for scientists who have demonstrated unusually high potential during their initial stages of training and development. This special award is aimed at fostering the research careers of outstanding, junior, basic, clinical, and behavioral scientists who are committed to developing research programs highly relevant to the understanding of human biology and human disease as it relates to the etiology, pathogenesis, prevention, diagnosis, and treatment of cancer. The NCI recognizes the need to maintain diversity in the research backgrounds of individuals who receive this award, and will work toward maintaining a representative balance of scientists in basic, clinical, and population research. The major objective of the award is to sustain and advance the early research careers of the most promising M.D.s and Ph.D.s while they consolidate and focus their independent research programs, and obtain their own research grant support. HEALTHY PEOPLE 2000 The Public health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of ~Healthy People 2000", a PHS-led national activity for setting priority areas. This program announcement, the Howard Temin Extended Support Award, is related to the priority area of human resource development. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No. 017-001- 00473-1) from the Superintendent of Documents, Government Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800). ELIGIBILITY REQUIREMENTS All applicants are encouraged to contact the NCI regarding their eligibility for this award (see Inquiries Section). In general, the candidate must have a research or a health professional doctorate or its equivalent and must have demonstrated highly productive research activity and the potential for establishing an independent research program in the period after the doctorate. Candidates must have completed at least three years of postdoctoral research before the initiation of a successful award. However, individuals who have been principal investigators on either PHS research grants or non-PHS peer reviewed grants that are over $70,000 direct costs per year, are not eligible to apply for this award. The candidate must identify a mentor with extensive research experience and appropriate support for the initial phase (up to three years) of this award. Support beyond three years is contingent on the candidate moving to an unmentored, independent research environment. All candidates must provide three letters of recommendations from established scientists. The candidate must make a commitment to spend a minimum of 75 percent of full-time professional effort conducting cancer-related research and research career development activities during the period of the award. However, salary will be paid at 100 percent up to the stated ceiling of the salary component Candidates may be currently pursuing cancer research or be interested in moving into the cancer research field. All current NCI Career awardees in their last two years of support who meet the eligibility criteria are encouraged to apply. Applications may be submitted on behalf of candidates by domestic, non-Federal organizations, public and private, such as medical, dental, or nursing schools or other institutions of higher education. Minorities and women are encouraged to apply. Candidates must be U.S. citizens or noncitizen nationals, or must have been lawfully admitted for permanent residence and possess an Alien Registration Receipt Card (I-151 or I-551) or some other verification of legal admission as a permanent resident. Noncitizen nationals, although not U.S. citizens, owe permanent allegiance to the U.S. They are usually born in lands that are not states, but are under U.S. sovereignty, jurisdiction, or administration. Individuals on temporary or student visas are not eligible. MECHANISM OF SUPPORT Awards in response to this program announcement will use the Research Scientist Development Award (K01). Planning, direction, and execution of the program will be the responsibility of the candidate and her/his mentor on behalf of the applicant institution. The project period will be for up to five years of support depending upon the number of years of prior research experience and the need for additional experiences to achieve independence. Awards are not renewable. RESEARCH TRAINING OBJECTIVES A. Environment: The institution must have a well-established research and/or clinical career development program(s) and qualified faculty to serve as mentors. The candidate, mentor and institution must be able to describe a multi-disciplinary career development program that will maximize the use of relevant research and educational resources. B. Program: The award provides up to five consecutive 12 month appointments. At least 75 percent of the recipients's full-time professional effort must be devoted to the program and the remainder devoted to other research-related and/or teaching pursuits consistent with the objectives of the award. The candidate must develop knowledge in the basic and/or clinical or behavioral sciences and research skills relevant to his or her career goals. The candidate may find it appropriate to include relevant didactic and laboratory or field research experiences. C. Mentor(s): The recipient must receive appropriate mentoring during some fraction of the first three years of the initial phase of the award. The candidate may move to an unmentored research environment beginning with any time within the first year, however, the transition must take place no later than the end of the third year. Where feasible, women and minority mentors should be involved as role models. D. Allowable Costs: 1. Salary: The Temin award will provide salary up to $75,000 plus fringe benefits. The institution may supplement the NCI contribution up to a level that is consistent with the institution's salary scale; however, supplementation may not be from Federal funds unless specifically authorized by the Federal program from which such funds are derived. In no case, may PHS funds be used for salary supplementation. Institutional supplementation of salary must not require extra duties or responsibilities that would interfere with the purpose of this award. Under expanded authorities, however, institutions may rebudget funds within the total costs awarded to cover salaries consistent with the institution~s salary scale. The total salary requested must be based on a full-time, 12 month staff appointment. It must be consistent both with the established salary structure at the institution and with salaries actually provided by the institution from its own funds to other staff members of equivalent qualifications, rank, and responsibilities in the department concerned. If full-time, 12 month salaries are not currently paid to comparable staff members, the salary proposed must be appropriately related to the existing salary structure. 2. Research Development Support: During the mentored phase of the award, $20,000 per year will be provided for the following types of expenses: (a) research expenses, such as supplies, equipment, and technical personnel; (b) statistical services including personnel and computer time; (c) tuition, fees, and books related to career development; and (d) travel to research meetings or for training. The amount of this support will increase to $50,000 when the principal investigator moves to a new research environment, as opposed to the environment provided by a mentor, which includes an independent research position either at the same institution or at a different institution. 3. Ancillary Personnel Support: Salary for mentors, secretarial and administrative assistance, etc., is not allowed. 4. Indirect Costs: Indirect costs will be reimbursed at eight percent of modified total direct costs, or at the actual indirect cost rate, whichever is less. E. Termination or Change of Institution: When a grantee institution plans to terminate an award, the NCI must be notified in writing at the earliest possible time so that appropriate instructions can be given for termination (see INQUIRIES section for contacts). If the individual is moving to another eligible institution, career award support may be continued provided: 1. A new career award application is submitted by the new institution. 2. The period of support requested is no more than the time remaining within the existing award period. 3. The new application is submitted far enough in advance of the requested effective date to allow the necessary time for review. 4. A final progress report, invention statement, and Financial Status Report are required upon either termination of an award or relinquishment of an award in a change of institution situation. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification is provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This new policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43) and supersedes and strengthens the previous policies (Concerning the Inclusion of Women in Study Populations, and Concerning the Inclusion of Minorities in Study Populations) which have been in effect since 1990. The new policy contains some new provisions that are substantially different from the 1990 policies. Investigators proposing research involving human subjects should read the "NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical Research," which have been published in the Federal Register of March 28, 1994 (FR 59 14508-14513), and reprinted in the NIH Guide for Grants and Contracts, Volume 23, Number 11, March 18, 1994. Investigators may obtain copies from these sources or from the program staff or contact person listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. APPLICATION PROCEDURES Applications are to be submitted on form PHS 398 (rev. 5/95) and will be accepted on or before the receipt deadlines indicated in the application kit (October 1, February 1 and June 1). Applications kits are available at most institutional offices of sponsored research and may be obtained from the Grants Information Office, Office of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267, email: ASKNIH@odrockm1.od.nih.gov. To identify the application as a response to this program announcement, check "YES" on item 2 of page 1 of the application and enter NCI HOWARD TEMIN AWARD (K01). The completed original application and five legible copies must be sent or delivered to: DIVISION OF RESEARCH GRANTS NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) REVIEW CONSIDERATIONS Applications will be assigned on the basis of established PHS referral guidelines. Applications that are complete and responsive to the program announcement will be evaluated for scientific and technical merit by an appropriate peer review group convened by the NCI in accordance with the standard NIH peer review procedures. As part of the initial merit review, all applications will receive a written critique and undergo a process in which only those applications deemed to have the highest scientific merit, generally the top half of applications under review, will be discussed, assigned a priority score, and receive a second level review by the National Cancer Advisory Board. Review Criteria Candidate (Principal Investigator) o Commitment to an independent cancer research career in terms of effort and future plans. o Quality and breadth of prior scientific training and experience, including publications during the early stages of scientific training. o Recommendations of three well-established scientists attesting to the special potential of the individual to pursue an independent career in cancer research. Career Development Plan o Likelihood that the plan will contribute substantially to the scientific development of the candidate and the achievement of scientific independence. o Appropriateness of the career development plan in terms of the candidate's prior research and academic experience, and the stated career goals. o Clarity of the goals and scope of the plan and the need for the proposed research experience. o Quality of the proposed training in the responsible conduct of research. Research Plan o All applicants for this award will have had previous postdoctoral research experience and in some cases may have been Principal Investigators on small research grants. A sound research project that is consistent with the development plan for an independent career in cancer research and the candidate's level of research development must be provided. o Usefulness of the research plan as a vehicle for enhancing existing research skills as described in the career development plan. o The originality and quality of the research hypothesis/question, design and methodology,judged in the context of the candidate's previous training and experience. o The relevance of the research plan to the etiology, pathogenesis, prevention, diagnosis, and/or treatment of cancer. o Appropriateness of the mentor's research qualifications in the area of the proposed research. - Quality and time commitment of the mentor to supervising and guiding the candidate during the initial phase of the award. - Previous experience in fostering the development of cancer researchers. - History of research productivity and peer reviewed support. Institutional Environment and Commitment o Applicant institution's commitment to the scientific development of the investigator according to the terms of the Temin Award. o Applicant institution's assurance that the investigator will spend a minimum of 75 percent effort on the research project. o Adequacy of research facilities and training opportunities. o Quality of the environment for scientific and professional development. Budget o Appropriateness of the budget in relation to career development goals and research aims and plans. AWARD CRITERIA The NCI will notify the applicant of the National Cancer Advisory Board's (NCAB) action shortly after its meeting. Funding decisions will be made based on the recommendations of the initial peer review group and NCAB, achievement of an appropriate balance of basic, clinical, and population scientists, and the availability of funds. Approximately ten awards will be made each year. INQUIRIES Written, telephone, FAX, and E-Mail inquiries concerning this program announcement are encouraged, especially during the planning phase of the application. NCI contacts for specific areas of expertise are listed below: Direct inquiries regarding programmatic issues to: Dr. Vincent J. Cairoli Division of Cancer Treatment, Diagnosis, and Centers National Cancer Institute Executive Plaza North, Room 520 Bethesda, MD 20892-7390 Telephone: (301) 496-8580 FAX: (301) 402-4472 Email: vc14z@nih.gov Direct inquiries regarding fiscal matters to: Ms. Sara Stone Office of Administrative Management National Cancer Institute Executive Plaza South, Room 243 Bethesda, MD 20892 Telephone: (301) 496-7800 FAX: (301) 496-8601 Email: stones@gab.nci.nih.gov AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance Number 93.398, Cancer Research Manpower. Awards are made under the authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under PHS grants policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74 and 45 CFR Part 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The Public Health Service strongly encourages all grant recipients to provide a smoke-free workplace and promote the non-use of tobacco products. In addition, Public Law 103-227, The Pro-Children Act of 1994, prohibits smoking in certain facilities (or, in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided for children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people. .
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