Full Text PAR-96-031
NIH GUIDE, Volume 25, Number 7, March 8, 1996
PA NUMBER:  PAR-96-031
P.T. 34

  Biomedical Research, Multidiscipl 
  Digestive Diseases & Disorders 
  Metabolic Diseases 

National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Allergy and Infectious Diseases
The National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK) and the National Institute of Allergy and Infectious Diseases
(NIAID) of the National Institutes of Health announce a pilot program
to promote collaborative biomedical research efforts in both clinical
and basic science research that addresses the mission of the NIDDK.
The grant mechanism used is the small grant (R03), which provides
limited funds (maximum of $50,000 direct costs per year) for
short-term (up to two years) research projects.  The small grant
awards (R03) responsive to this Program Announcement support either
clinical or basic science collaborative research efforts related to
the mission of the NIDDK that are performed outside the United
States, taking advantage of established NIAID-supported International
Centers.  Investigators are encouraged to establish formal
collaboration(s) with the Director or participating scientists of a
NIAID International Center(s) and submit an application for small
grant support to initiate small research projects or pilot
investigations that would have specific aims consistent with the
mission of the NIDDK and the research scope of the NIAID
International Center.
The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas.  This PA,
NIDDK-NIAID International Collaboration:  Small Grants Awards, is
related to the priority area of chronic disabling conditions.
Potential applicants may obtain a copy of "Healthy People 2000" (Full
Report:  Stock No. 017-001-00474-0 or Summary Report:  Stock No.
017-001-00473-1) through the Superintendent of Documents, Government
Printing Office, Washington, DC 20402-9325 (telephone 202-512-1800).
Applications may be submitted by domestic and foreign for-profit and
non-profit organizations, public and private, such as universities,
colleges, hospitals, laboratories, units of State and local
governments, and eligible agencies of the Federal government.
Applications may be from one institution or as consortia with
NIAID-supported International centers.
Support for this Program Announcement will be through the NIH small
grants (R03) mechanism.  The small grants research program provides
limited funds (maximum of $50,000 direct costs per year) for short
term (up to two years) research projects.  These grants are
non-renewable, but continuation of projects developed under this
program can be supported by the investigator-initiated research
project grant (R01) mechanism.  Applicants will be responsible for
the planning, direction, and execution of the proposed project.
Applications submitted in response to this PA will compete for funds
with other R03 and regular research project grant applications
assigned to the NIDDK.
Applications from institutions that have a General Clinical Research
Center (GCRC) funded by the NIH National Center for Research
Resources may wish to identify the GCRC as a resource for conducting
the proposed research.  If so, a letter of agreement from either the
GCRC program director or principal investigator should be included
with the application.
The award of grants in response to this PA is also contingent upon
the availability of funds.  Awards will be administered under PHS
grants policy as stated in the PHS Grants Policy Statement (rev.
The mission of the NIDDK is to provide broad fundamental and clinical
research support for a spectrum of chronic and disabling diseases
including: diabetes mellitus, digestive diseases, kidney and urologic
diseases, hematological diseases, metabolic and endocrine diseases,
nutritional disorders and obesity.  Noting that collaborative
international research provides special opportunities for furthering
the mission of the NIH through unusual resources, populations and
environmental conditions, the NIDDK invites applications for small
grants to augment collaborative international research.
The major areas of interest and potential that have been identified
relevant to this new program are the following:
o  autoimmune liver diseases and hepatitis
o  gastric ulcer disease and Helicobacter pylori
o  parasitic diseases which have an impact on liver
o  mucosal immunity
o  pediatric liver disease
o  influence of altered nutritional status on health and disease
o  parasitic diseases with kidney/urinary tract sequelae
o  hemolytic uremic syndrome
o  infectious diseases of the kidney
o  benign prostatic hypertrophy in minority populations
o  therapies for hematologic disorders such as iron chelating agents
o  diabetic kidney disease
o  hypertensive kidney disease
Small grant applications for support of research on these and related
topics can be submitted in collaboration with existing
NIAID-supported International Centers.  A current list of those
centers and full information about their specific research areas can
be obtained from the NIAID staff contact listed in the INQUIRIES
section.  Currently, the countries and general foci of research
represented in the NIAID International Centers Program are:
BRAZIL:  Leishmaniasis, Malaria, Schistosomiasis Chagas' Disease,
Immunoparasitology, Diarrheal Diseases, Hydatid Diseases,
CAMEROON:  Malaria
CHILE:  Cholera & Enteric Diseases
MEXICO:  Tuberculosis
PERU:  Enteric Pathogens, Neurocysticercosis
EGYPT:  Lymphatic Filariasis
ISRAEL:  Diarrheal Diseases, Leishmaniasis, Hydatid Diseases
KENYA:  Schistosomiasis, Filariasis, Hydatid disease
NEPAL:  Geohelminths
SOUTH AFRICA:  Amoebiasis
THAILAND:  Malaria
LEBANON:  Leishmaniasis
UGANDA:  Tuberculosis
MOROCCO:  Leishmaniasis
JORDAN:  Leishmaniasis
TUNISIA:  Hydatid Diseases
It is the policy of the NIH that women and members of minority groups
and their subpopulations must be included in all NIH supported
biomedical and behavioral research projects involving human subjects,
unless a clear and compelling rationale and justification is provided
that inclusion is inappropriate with respect to the health of the
subjects or the purpose of the research.  This new policy results
from the NIH Revitalization Act of 1993 (Section 492B of Public Law
103-43) and supersedes and strengthens the previous policies
(Concerning the Inclusion of Women in Study Populations, and
Concerning the Inclusion of Minorities in Study Populations), which
have been in effect since 1990. The new policy contains some
provisions that are substantially different from the 1990 policies.
All investigators proposing research involving human subjects should
read the "NIH Guidelines For Inclusion of Women and Minorities as
Subjects in Clinical Research," which have been published in the
Federal Register of March 28, 1994 (FR 59 14508-14513) and reprinted
in the NIH Guide for Grants and Contracts, Volume 23, Number 11,
March 18, 1994.
Investigators also may obtain copies of the policy from the program
staff listed under INQUIRIES.  Program staff may also provide
additional relevant information concerning the policy.
The research grant application form PHS 398 (rev. 5/95) is to be used
in applying for these grants.  Applications kits are available at
most institutional offices of sponsored research and may be obtained
from the Grants Information Office, Office of Extramural Outreach and
Information Resources, National Institutes of Health, 6701 Rockledge
Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267,
email:  girg@drgpo.drg.nih.gov.
The completed original application and five legible copies must be
sent or delivered to:
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)
Applications will be assigned on the basis of established Public
Health Service referral guidelines.  Applications that are complete
and responsive to this program announcement will be evaluated for
scientific and technical merit by an appropriate peer review group
convened by the NIDDK in accordance with NIH peer review procedures.
As part of the initial merit review, all applications will receive a
written critique and undergo a process in which only those
applications deemed to have the highest scientific merit, generally
the top half of applications under review, will be discussed,
assigned a priority score, and receive a second level review by the
appropriate national advisory council or board.
Review Criteria
o  scientific, technical, or medical significance and originality of
proposed research;
o  appropriateness and adequacy of the experimental approach and
methodology proposed to carry out the research;
o  qualifications and research experience of the Principal
Investigator and staff, particularly, but not exclusively, in the
area of the proposed research;
o  availability of the resources necessary to perform the research;
o  appropriateness of the proposed budget and duration in relation to
the proposed research;
o  adequacy of plans to include both genders and minorities and their
subgroups as appropriate for the scientific goals of the research.
Plans for the recruitment and retention of subjects will also be
o  availability of special opportunities for furthering research
programs through the use of unusual talent resources, populations, or
environmental conditions in other countries that are not readily
available in the United States or that provide augmentation of
existing U.S. resources.
The initial review group will also examine the provisions for the
protection of human and animal subjects and the safety of the
research environment.
Applications will compete for available funds with all other approved
applications assigned to the National Institute of Diabetes and
Digestive and Kidney Diseases.  The following will be considered in
making funding decisions:
o  Quality of the proposed project as determined by peer review
o  Availability of funds
o  NIDDK Program priority.
Inquiries are encouraged.  The opportunity to clarify any issues or
questions from potential applicants is welcome.  Individuals
interested in this new program are encouraged to contact the relevant
Program Official below:
For inquiries related to the mission of the NIDDK:
Thomas F. Kresina, PhD
Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases
Building 45, Room 6AN-12A, MSC 6600
Bethesda, MD  20892-6600
Telephone:  (301) 594-8871
FAX:  (301) 480-8300
Email:  kresinat@ep.niddk.nih.gov
Camille A. Jones, MD., MPH
Division of Kidney, Urologic and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Building 45, Room 6AS-13K, MSC 6600
Bethesda, MD  20892-6600
Telephone:  (301) 594-7715
FAX:  (301) 480-3510
Email:  camille-jones @nih.gov
For inquiries related to the NIAID International Centers:
Dr. Michael Gottlieb
Parasitology and International Programs Branch
National Institute of Allergy and Infectious Diseases
Solar Building, Room 3A12 - MSC 7630
Bethesda, MD  20892-7630
Telephone:  (301) 496-7115
FAX:  (301) 402-0659
Email:  mg35s@nih.gov
Direct inquiries regarding fiscal and administrative matters to:
Ms. Nancy Dixon
Supervisory Grants Management Specialist
National Institute of Diabetes and Digestive and Kidney Diseases
45 Center Drive MSC 6600
Bethesda, MD  20892-6600
Telephone:  (301) 594-8854
FAX:  (301) 480-3504
Email:  dixonn@ep.niddk.nih.gov
This program is described in the Catalog of Federal Domestic
Assistance No. 93.848 and 93.849.  Awards are made under
authorization of the Public Health Service Act, Title IV, Part A
(Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and
285) and administered under PHS grants policies and Federal
Regulations 42 CFR 52 and 45 CFR Part 74.  This program is not
subject to the intergovernmental review requirements of Executive
Order 12372 or Health Systems Agency review.
The PHS strongly encourages all grant and contract recipients to
provide a smoke-free workplace and promote the non-use of all tobacco
products.  In addition, Public Law 103-227, the Pro-Children Act of
1994, prohibits smoking in certain facilities (or in some cases, any
portion of a facility) in which regular or routine education,
library, day care, health care or early childhood development
services are provided to children.  This is consistent with the PHS
mission to protect and advance the physical and mental health of the
American people.

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