NIH Guide, Volume 22, Number 14, April 9, 1993


P.T. 34, FF


  Biomedical Research Training 

  Blood Diseases 

  Cardiovascular Diseases 

  Pulmonary Diseases 

National Heart, Lung, and Blood Institute

Application Receipt Date:   August 27, 1993


The National Heart, Lung, and Blood Institute (NHLBI) announces a

program directed at developing the research capabilities of faculty

investigators at minority schools in areas relevant to cardiovascular,

pulmonary, and hematologic* diseases and resources.  The purpose of the

award is to encourage the enhancement of research skills in the areas

of interest to the NHLBI by faculty members at minority institutions

and to increase the number of minority individuals involved in research


* Within the NHLBI, the term "hematologic" covers research on

thrombosis and hemostasis, immunohematology, blood cell disorders,

hematopoiesis, thalassemia, sickle cell disease, transfusion medicine

including blood component and derivative therapy, blood substitutes and

blood resource management, aspects of AIDS-products in AIDS prevention

and treatment, and AIDS-related bone marrow and hematologic disorders.

Other Institutes of the NIH are responsible for research on disorders

of white cells, including the leukemias and other blood malignancies,

and basic immunology related to the lymphoid system.  Therefore the

NHLBI cannot provide support for such studies.


The Public Health Service (PHS) is committed to achieving the health

promotion and disease prevention objectives of "Healthy People 2000",

a PHS-led national activity for setting priority areas.  This program

announcement, the Minority School Faculty Development Award, is related

to the priority area of heart disease and stroke.  Potential applicants

may obtain a copy of "Healthy People 2000" (Full Report:  Stock No.

017-001-00474-0) or "Healthy People 2000" (Summary Report:  Stock No.

017-001-00473-1) through the Superintendent of Documents, Government

Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238).


Awards in this program will be made to domestic minority institutions

on behalf of awardees, each of whom will work with a mentor at a nearby

(within 100 miles) research center, who is recognized as an

accomplished investigator in the research area proposed and who will

provide guidance for the awardee's development and research plan.  A

minority school is defined as a domestic medical or non-medical

college, university or equivalent school in which students of minority

ethnic groups including Blacks, Hispanics, American Indians, and Asian

or Pacific Islanders comprise a majority or significant proportion of

the school enrollment.  The commitment of the institution to the

faculty candidate's research and development must clearly be presented

in the application.  This should include statements from the Dean and

departmental chair indicating that the candidate will be provided with

sufficient release time from other duties to accomplish the research

goals stated in the application.

Candidates for this award are minority school faculty members who (1)

are citizens of the United States, non-citizen nationals or permanent

residents at the time of application, (2) have a doctoral degree or

equivalent in a biomedical or behavioral science, (3) wish to receive

specialized training in cardiovascular, pulmonary, or hematologic

research, and (4) have the background and potential to benefit from the

training.  Each candidate must identify and complete arrangements with

a nearby mentor (within approximately 100 miles) who is recognized as

an accomplished investigator in the research area proposed and who will

provide guidance for the awardee's development and research plan.

Plans for the intensive training during the summer period (2 - 3

months) as well as during the academic years should be developed with

the mentor.


The mechanism of support is the career development award (K14).  Awards

will be made to the minority institution on behalf of the awardee.

Each award will have a duration of five years and is non-renewable.

These awards may not be transferred to another institution or faculty

member.  Funding beyond the first year of the grant is contingent upon

satisfactory progress during the preceding year.  If funds are to be

transferred to the mentor's institution for any purpose, arrangements

for the transfer or conduct of activities must be formalized in a

contract or written agreement with the mentor's institution.

The awardee may receive salary support up to a maximum of $50,000 plus

fringe benefits per year for five years.  All funds must be used to

support the awardee.  Awardees must commit 100 percent of effort during

summer and/or off quarter periods and at least 25 percent of effort

during the academic year.  In addition to the salary request for the

candidate, support for up to 10 percent of the mentor's salary during

the summer experience may also be requested.  Up to $20,000 per year

will be provided for research support.  Details regarding the

apportionment of these funds between the minority institution and the

research center must be worked out with the mentor at the research

center and agreed to by representatives of both institutions.  Indirect

costs will be awarded on 8 percent of total direct costs exclusive of

equipment.  The indirect cost rate on subcontract costs for the

mentor's institution may not exceed 8 percent of total costs.


The Minority School Faculty Development Award is intended to:

1.  Encourage the development of faculty investigators at minority

schools in areas relevant to cardiovascular, pulmonary and hematologic

diseases and transfusion medicine.

2.  Stimulate cardiovascular, pulmonary, and hematologic disease

research, prevention, control and education by offering minority school

faculty members the opportunity to enhance their research capabilities

in these areas.





NIH policy is that applicants for NIH clinical research grants and

cooperative agreements are required to include minorities and women in

study populations so that research finds can be of benefits to all

persons at risk of the disease, disorder or condition under study;

special emphasis must be placed on the need for inclusion of minorities

and women in studies of diseases, disorders and conditions which

disproportionately affect them.  This policy is intended to apply to

males and females of all ages.  If women or minorities are excluded or

inadequately represented in clinical research, particularly in proposed

population-based studies, a clear compelling rationale must be


The composition of the proposed study population must be described in

terms of gender and racial/ethnic group.  In addition, gender and

racial/ethnic issues should be addressed in developing a research

design and sample size appropriate for the scientific objectives of the

study. This information must be included in the form PHS 398 in

sections 1-4 of the Research Plan AND summarized in Section 5, Human

Subjects.  Applicants are urged to assess carefully the feasibility of

including the broadest possible representation of minority groups.

However, NIH recognizes that it may not be feasible or appropriate in

all research projects to include representation of the full array of

United States racial/ethnic minority populations (i.e., Native American

(including American Indians or Alaskan Natives), Asian/Pacific

Islanders, Blacks, Hispanics).  The rationale for studies on single

minority population groups must be provided.

For the purpose of this policy, clinical research is defined as human

biomedical and behavioral studies of etiology, epidemiology, prevention

(and preventive strategies), diagnosis, or treatment of diseases,

disorders or conditions, including but not limited to clinical trials.

The usual NIH policies concerning research on human subjects also

apply.  Basic research or clinical studies in which human tissues

cannot be identified or linked to individuals are excluded.  However,

every effort should be made to include human tissues from women and

racial/ethnic minorities when it is important to apply the results of

the study broadly, and this should be addressed by applicants.

If the required information is not contained within the application,

the review will be deferred until the information is provided.

Peer reviewers will address specifically whether the research plan in

the application conforms to these policies. If the representation of

women or minorities in a study design is inadequate to answer the

scientific question(s) addressed AND the justification for the selected

study population is inadequate, it will be considered a scientific

weakness or deficiency in the study design and will be reflected in

assigning the priority score to the application.  All applications for

clinical research submitted to NIH are required to address these

policies.  NIH funding components will not award grants or cooperative

agreements that do not comply with these policies.


Applications must be received by August 27, 1993.  Applications are to

be submitted on the grant application form PHS 398 (rev. 9/91).

Application kits are available at most institutional offices of

sponsored research and may be obtained from the Office of Grants

Inquires, Division of Research Grants, National Institutes of Health,

Westwood Building, Room 449, Bethesda, MD 20892, telephone

301/710-0267.  The title and number of the announcement must be typed

in section 2a on the face page of the application.

The completed original application and three legible copies must be

sent or delivered to:

Division of Research Grants

National Institutes of Health

Westwood Building, Room 240

Bethesda, MD  20892**

Two additional copies of the application must be sent to:

Scientific Review Administrator

Division of Extramural Affairs

National Heart, Lung, and Blood Institute

Westwood Building, Room 550

Bethesda, MD  20892


All applications will be reviewed for scientific and technical merit by

the Research Training Review Committee of the Division of Extramural

Affairs, NHLBI, followed by a second level review by the National

Heart, Lung, and Blood Advisory Council.

The factors to be considered in the evaluation of the proposed training

program are:

o  the overall merit of the candidate's five year plan for research and

the development of research skills.

o  the background and potential of the proposed candidate for

developing into an independent biomedical investigator.

o  the candidate's commitment to a research career.

o  the ability of both the minority institution and the training center

to provide facilities, resources, and opportunities necessary for the

candidate's research development.

o  the qualifications, ability, and plans of the sponsor who will

provide the candidate with the guidance necessary for career

development in research.


Applications will compete for available funds with other approved

career development award applications assigned to the National Heart,

Lung, and Blood Institute.  The following will be considered in making

funding decisions:

o  Technical merit of the application as determined by peer review

o  Availability of funds

o  Program balance among the research areas of the announcement


Written and telephone inquires are encouraged.  Guidelines for this

program may be obtained from:

John Fakunding, Ph.D.

Division of Heart and Vascular Diseases

National Heart, Lung and Blood Institute

Federal Building, Room 3C04

Bethesda, MD  20892

Telephone:  (301) 496-1724

Helena O. Mishoe, Ph.D.

Division of Blood Diseases and Resources

National Heart, Lung and Blood Institute

Federal Building, Room 5A12

Bethesda, MD  20892

Telephone:  (301) 496-5911

Mary Reilly, M.S.

Division of Lung Diseases

National Heart, Lung, and Blood Institute

Westwood Building, Room 640A

Bethesda, MD  20892

Telephone:  (301) 594-7466

For fiscal and administrative matters, contact:

Jane Davis

Division of Extramural Affairs

National Heart, Lung, and Blood Institute

Westwood Building, Room 4A15C

Bethesda, MD  20892

Telephone:  (301) 594-7436


This program is described in the Catalog of Federal Domestic Assistance

numbers 93.837, 93.838, and 93.839.  Awards will be made under the

authority of the Public Health Service Act, Title III, Section 301

(Public Law 78-410, as amended; 42 USC 241) and administered under PHS

grants policies and Federal Regulations at 42 CFR Part 52 and 45 CFR

Part 74.  This program is not subject to the intergovernmental review

requirements of Executive Order 12372 or Health Systems Agency review.


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