Department of Health and Human Services

Part 1. Overview Information

Participating Organization(s)
National Institutes of Health (NIH)
Components of Participating Organizations

Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)

Funding Opportunity Title
Shared Instrumentation for Animal Research (SIFAR) Grant Program (S10 Clinical Trial Not Allowed)
Activity Code
S10 Biomedical Research Support Shared Instrumentation Grants
Announcement Type

Reissue of PAR-19-178

Related Notices

NOT-OD-19-128 - Changes to NIH Requirements Regarding Proposed Human Fetal Tissue Research

NOT-OD-19-137 - Clarifying Competing Application Instructions and Notice of Publication of Frequently Asked Questions (FAQs) Regarding Proposed Human Fetal Tissue Research

Funding Opportunity Announcement (FOA) Number
Companion Funding Opportunity

PAR-20-114 S10 High-End Instrumentation (HEI) Grant Program (Clinical Trial Not Allowed)

PAR-20-113 S10 Shared Instrumentation Grant (SIG) Program (Clinical Trial Not Allowed)

Catalog of Federal Domestic Assistance (CFDA) Number(s)


Funding Opportunity Purpose

The Shared Instrumentation for Animal Research (SIFAR) Grant Program encourages applications from groups of NIH-funded investigators to purchase or upgrade scientific instruments necessary to carry out animal experiments in all areas of biomedical research supported by the NIH. Applicants may request clusters of commercially available instruments configured as specialized integrated systems or as series of instruments to support a thematic well-defined area of research using animals or related materials. Priority will be given to uniquely configured systems to support innovative and potentially transformative investigations.

This FOA supports requests for state-of-the art commercially available technologies needed for NIH-funded research using any vertebrate and invertebrate animal species.

This funding opportunity announcement (FOA) does not support requests for single instruments. At least one item of the requested instrumentation must cost at least $50,000, after all applicable discounts. No instrument in a cluster can cost less than $20,000, after all applicable discounts. There is no maximum price requirement; however, the maximum award is $750,000.

Key Dates

Posted Date

February 18, 2020

Open Date (Earliest Submission Date)
May 01, 2020
Letter of Intent Due Date(s)

Not applicable

Application Due Date(s)

June 1, 2020

All applications are due by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on the listed date(s).

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s)

Not applicable

Scientific Merit Review

September - November, 2020

Advisory Council Review

January 2021

Earliest Start Date

February, 2021

Expiration Date
June 02, 2020
Due Dates for E.O. 12372
Not Applicable
Required Application Instructions
It is critical that applicants follow the instructions in the Research (R) Instructions in the SF424 (R&R) Application Guide,except where instructed to do otherwise (in this FOA or in a Notice from NIH Guide for Grants and Contracts ).

Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review.

Table of Contents

Part 2. Full Text of Announcement

Section I. Funding Opportunity Description

The Shared Instrumentation for Animal Research (SIFAR) Grant Program invites groups of NIH-funded investigators engaged in biomedical research using animals to seek support for high-cost, state-of-the art, commercially available scientific instruments. All requested instruments must be used on a shared basis and enhance research that uses animals or related materials such as animal tissues, cells, or germplasm.

NIH-funded investigators use many different vertebrate and invertebrate animals in biomedical research, including worms, flies, fish, and rodents. This Funding Opportunity Announcement (FOA) supports instrumentation requests related to all animal species needed for NIH-supported biomedical research. NIH-funded investigators rely on a broad spectrum of technologies including nuclear magnetic resonance (NMR) spectrometers, mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell-sorters, and biomedical imagers. This FOA supports requests for all available technologies to enhance research using animals or related biological materials, such as tissue, cells, or germplasm, for the ultimate benefit of human health.

Applicants may request clusters of instruments configured as specialized integrated systems or as a series of instruments to support a specific thematic area of biomedical research using animals. An integrated instrumentation system is one in which components, when used in conjunction with one other, perform a function that no single component can provide. A series of instruments may support a specialized workflow or provide synergetic functionalities to advance a thematic area of research. Any instrument, requested as a part of a cluster or a series, must be commercially available.

For example, applicants may request integrated systems to support animal research in any field of biomedical research, such as neurophysiology, cardiac physiology, immunology, developmental biology, or neurobehavioral sciences. Similarly relevant are series of instruments for high-throughput experiments in research areas such as genomics, phenotyping, or metabolomics. Clusters of instruments may improve surgical approaches by incorporating robotics and real-time decision-making procedures based on imaging or molecular characterizations of tissue. A combination of microfluidics-related technologies with high-throughput and high-content screening may advance phenotyping procedures. Likewise, a combination of optical imaging, flow-cytometry, and mass spectrometry may improve and speed up molecular profiling. Also appropriate are integrated systems for cognitive-behavioral studies or advanced monitoring set-ups for comprehensive physiological and metabolic assessment.

Of special interest are unique instrumentation systems that augment experimental capabilities through complementary functions of the individual items. Such systems can enable multi-step protocols and broader approaches by incorporating best practices drawn from different experimental specialties, for example, by combining different modalities to achieve multi-scale capabilities such as linking gene expressions to cell-, organ-, and organism- level pathologies.

It is expected that instruments within a series will be used in conjunction with each other. For example, the placement of instruments in a thematic core facility would focus on investigations in a common scientific field such as cardiovascular or neurological studies. Similarly, instruments placed in a barrier facility would enable longitudinal studies and other investigations requiring special settings such as gnotobiotic environment.

To ensure the effective and collaborative use of all requested instruments, they should be placed in a common or adjacent physical location for ease of access and to promote synergetic operation of the items within the cluster/series.

Requests for single instruments are not appropriate for this FOA and, if submitted to this FOA, they will not be considered for funding. Single instrument requests are supported by the Shared Instrumentation Grant (SIG) Program or the High-End Instrumentation (HEI) Grant Program. Concurrent submissions to the SIFAR, SIG, and HEI Programs can be made only under conditions described in Section III.

All requests must be justified by the needs of NIH-funded projects and must demonstrate how the instruments will enhance the conduct of animal research and strengthen scientific outcomes. Priority will be given to specialized clusters of instruments and uniquely configured systems to support innovative and potentially transformative animal research.

In summary, this FOA seeks requests to purchase state-of-the-art commercially available instruments that are to be used on a shared basis and are needed by NIH-funded investigators engaged in biomedical research using animals or related biological materials such as animal tissues, cells, or germplasm.

Instruments must be used for research purposes only. Foreign-made equipment is allowable.

The SIFAR Program will not support requests for:

  • A single instrument;
  • A series/cluster of instruments that does not include at least one instrument whose individual cost is at least $50,000;
  • Any instrument in a cluster/series with a base cost of less than $20,000;
  • Software, unless it is integrated in the operation of the instrument(s) and/or necessary for the generation of high-quality output experimental data from the instrument(s);
  • Stand-alone workstations for data processing, software licenses, and duplicate software items;
  • Purely instructional equipment, institutional administrative management systems, clinical management systems;
  • Instruments to be used for clinical (billable) care;
  • General purpose equipment (such as standard machine shop equipment), instruments to furnish a research facility (such as autoclaves, hoods, equipment to upgrade animal facilities), and equipment for routine sustaining infrastructure (such as standard computer networks or data storage systems).
  • Disposable devices, office furniture, and supplies;
  • Alteration or renovation of space to house the instruments.

Applicants are advised to discuss with the SIFAR Scientific/Research Contact (See Section VII) any questions regarding eligibility, Program requirements, and appropriate configurations of integrated instrument systems or series of instruments to support a particular thematic workflow.

To promote cost effectiveness, to encourage optimal sharing among individual investigators, research groups, and academic departments, and to foster a collaborative multidisciplinary environment, the requested instruments should be integrated in a core facility, whenever practical.

Each applicant institution must propose a Program Director/Principal Investigator (PD/PI) who can assume administrative and scientific oversight responsibility for the requested instrumentation. See Section III for qualifications for the PD/PI. The PD/PI also will be responsible for:

  • Requesting no-cost extensions of the project period, if needed;
  • Preparing (and working with the Institution to submit) a Final Research Performance Progress Report (FRPPR) at the end of the project period that describes the purchased instrument(s), lists all users and publications resulting from use of the instrument(s), and outlines the value of the instrument to the investigators and to the institution as a whole. See Section VI.3.
  • Submitting Annual Usage Reports (AURs) to the NIH for a period of four years after the project end date. See Section VI.3.

An Advisory Committee must be named to assist the PD/PI in administering the grant and overseeing the usage of the instruments. For details on the composition of the Advisory Committee see Section IV.2 under "Administration." The PD/PI and the Advisory Committee are responsible for the development of guidelines for:

  • Maximum utilization of the instrument(s), including time allocation;
  • A detailed plan for the day-to-day management and safe operation of the instrument(s);
  • A plan to ensure that access to the instruments is limited to users whose projects have received approval from Institutional Review Board, Institutional Animal Care and Use Committee or a biosafety committee, as applicable;
  • A financial plan for the long-term operation and maintenance of the instrument(s) during the post award period;
  • A relocation of the instrument(s) within or outside the institution or changes of ownership, if such changes are necessary
  • Recommending a new PD/PI, if such a need arises.
The PD/PI and the Advisory Committee should convene meetings and issue annual reports on the instrument status, including their recommendations for the instrument operations. See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information

Funding Instrument

Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed

The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this FOA.

Clinical Trial?
Not Allowed: Only accepting applications that do not propose clinical trials

Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

ORIP intends to commit an estimated total of $6M in FY 2021 to fund about 8-12 awards.

Award Budget

Applications will be accepted for commercially available instruments only. At least one item of the requested instrumentation must cost at least $50,000, after all applicable discounts. No instrument in a cluster can cost less than $20,000, after all applicable discounts. There is no upper limit on the cost of each instrument, but the maximum award is $750,000 of direct costs. Since the cost of the various instruments will vary, it is anticipated that the amount of the award will also vary. S10 awards do not allow indirect costs.

It is expected that applicants will employ the best economical approaches, including securing academic discounts, if applicable, to formulate a cost-effective budget while meeting the users scientific needs. See Section IV. 6. Funding Restrictions for additional details

Award Project Period

Awards are made for one year only.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this FOA.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Higher Education Institutions

  • Public/State Controlled Institutions of Higher Education
  • Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

  • Hispanic-serving Institutions
  • Historically Black Colleges and Universities (HBCUs)
  • Tribally Controlled Colleges and Universities (TCCUs)
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education

  • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
Foreign Institutions

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Required Registrations

Applicant organizations

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

  • Dun and Bradstreet Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.
  • System for Award Management (SAM) Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
  • eRA Commons - Applicants must have an active DUNS number to register in eRA Commons.Organizations can register with the eRA Commons as they are working through their SAM or registration, but all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
  • Applicants must have an active DUNS number and SAM registration in order to complete the registration.

Program Directors/Principal Investigators (PD(s)/PI(s))

All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator)
Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

The PD/PI chosen for this application should have documented (in the biographical sketch) technical expertise directly related to the type of the chosen instruments. The PD/PI does not need to have an NIH research grant or any other research support but is expected to be an expert on the requested instrument. The PD/PI may be a core director, tenured, or non-tenured faculty member of the applicant organization. The PD/PI must be affiliated with the applicant organization and must be registered on eRA Commons.

Multiple PDs/PIs are not allowed under the S10 mechanism.

2. Cost Sharing

This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

3. Additional Information on Eligibility

The NIH will not accept duplicate or highly overlapping applications under review at the same time. This means that the NIH will not accept:

  • A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.
  • A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.
  • An application that has substantial overlap with another application pending appeal of initial peer review (see NOT-OD-11-101)


Only one SIFAR application per institution as identified by the DUNS number, is allowed per the receipt date.
There is no restriction on the number of applications an institution can submit to the SIG and/or High-End Instrumentation (HEI) Programs each year, provided the applications request different types of equipment. Concurrent SIG, HEI and/or SIFAR applications for the same instrument (or the same type of instrument with added special accessories to meet the HEI budget requirement or the same instrument in a cluster of instruments to meet the SIFAR program requirements) are not allowed unless documentation from a high-level institutional official is provided, stating that this is not an unintended duplication, but part of a campus-wide instrumentation plan. Applicants are advised to discuss with the SIFAR Scientific/Research Contact (see Section VII) potential duplicates before submitting two applications for the same type of instrument.

Major User Group

At least three Major Users who have substantial need for the instrument must be identified. Each of these Major Users must be a PD/PI on a distinct active NIH research award (i.e., a grant or a cooperative agreement) in an area of basic, translational, or clinical research. The requirement is one award per investigator, with more awards per investigator allowed. An award given to multi-PDs/PIs is counted only once towards the fulfillment of this requirement. NIH training or fellowship grants (i.e., T and F mechanisms), other non-research and SBIR/STTR grants, Other Transaction (OT) awards, and contracts cannot be counted towards the fulfillment of this requirement. Once the eligibility requirement of at least three Major Users with distinct NIH-funded research projects has been met, additional users with active research awards from NIH or other sources may be added as Major or Minor Users. Investigators with funding from sources such as other Federal agencies (e.g., NSF, DoE, DoD), private foundations, or academic institutions, can be added as Major Users, provided they are engaged in basic, translational or clinical research and can demonstrate a substantial need for the instrument. Major Users can be researchers from the same department or from several departments, divisions or schools at the applicant institution, or from nearby or regional institutions. In certain circumstances, as technology dictates, Major Users may come from distant institutions, but they must demonstrate the need for the instruments and describe plans for regular access to the instrument.

To demonstrate the clear need for the entire instrumentation request, the projects supported by NIH research grants should collectively use the entire configuration at the 35 percent Accessible User Time (AUT) see Section Other Project Information in Section IV.2 for the definition of AUT and how to calculate the percentages. Projects supported by NIH research grants should together use each of the instruments at the 75 percent level of AUT.

The Major User group must meet the eligibility requirement at the time of submission. In addition, if/when the application is considered for funding, the SIFAR Program Staff will check that the Major User group eligibility requirement is also met at the time of award.


An itemized quote from the vendor with appropriate academic discounts and warranty terms is required and must be included in the application.

Section IV. Application and Submission Information

1. Requesting an Application Package

The application forms package specific to this opportunity must be accessed through ASSIST, Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Workspace are available in Part 1 of this FOA. See your administrative office for instructions if you plan to use an institutional system-to-system solution.

2. Content and Form of Application Submission

It is critical that applicants follow the instructions in the Research (R) Instructions in the SF424 (R&R) Application Guideexcept where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Page Limitations
All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed, with the following exceptions or additional requirements:

For this FOA, there is no overall page limit for the entire Instrumentation Plan. However, there are specified page limits for each section of the Instrumentation Plan as described below. All tables, graphs, figures, diagrams, and charts must be included within the page limits for these sections. The applicants should make every effort to be succinct. It is expected that the length of the Plan's narrative will depend on the type of the requested instrument and the number of users. To be successful, an application does not have to reach the page limits described here.

  • Introduction to Resubmission (if applicable): 3 pages
  • Justification of Need: 9 pages in total
  • Technical Expertise: 3 pages in total
  • Research Projects section must not exceed 30 pages in total. This section can be structured in subsections: Research Projects of Major Users and Research Projects of Minor Users. The limit is 4 pages per each Major User's project; however, three or fewer pages are strongly recommended. The Research Projects of Minor Users subsection is limited to 4 pages in total.
  • Summary Table(s): 6 pages in total
  • Administration (Organizational / Management Plan): 6 pages in total
  • Institutional Commitment: 3 pages in total
  • Overall Benefit: 3 pages in total

Note: Letters of Support and Bibliography & References Cited Section are not included in the page limitations.

Instructions for Application Submission
The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this FOA.
SF424(R&R) Cover
All instructions in the SF424 (R&R) Application Guide must be followed.

Descriptive Title: In the title enter the generic name of the instruments requested (for example, 600MHz NMR Spectrometer or DNA Sequencer).

Proposed Project: Enter start date of 02/01/2021 and end date of 01/31/2022.

Estimated Project Funding:

Total Federal Funds Requested: Enter the total Federal funds for the requested instruments.

This entry cannot exceed $750,000 which is the maximum award under the SIFAR Program. If the cost of the instrument is more than $750,000 enter $750,000 (or any lower amount of the requested Federal Funds).

Total Non-Federal Funds: If Total Federal Funds Requested (described immediately above) and Total Federal & Non-Federal Funds (described immediately below) are not the same, enter the difference in this line. Explain how the difference will be paid in the Equipment section on the SF424 (R&R) Other Project Information form (described below).

Total Federal & Non-Federal Funds: Enter the total cost of the instrument from the quote

Program Income: Enter zero Program Income as does not apply to the SIFAR Program.

NOTE: A warning will be generated during submission for any S10 with a budget in excess of $500,000. This warning can be ignored.

SF424(R&R) Project/Performance Site Locations
All instructions in the SF424 (R&R) Application Guide must be followed.
SF424(R&R) Other Project Information
All instructions in the SF424 (R&R) Application Guide must be followed.

Project Summary/Abstract: The Project Summary/Abstract should contain a succinct and accurate description of the requested instruments and an explanation of the need for the instruments to advance research projects of the Users. The application's broad, long-term objectives should be stated, concisely describing how access to the instruments will enhance the health-related goals of the research projects. This section should be informative to other persons working in the same or related fields and understandable to a scientifically or technically literate reader

NOTE: The Project Summary/Abstract must be no longer than 30 lines of text.

Project Narrative: Using no more than two or three sentences, describe the relevance of this research to public health. In this section, be succinct and use plain language that can be understood by a general, lay audience.

Bibliography & References Cited: List only publications that demonstrate the researchers' expertise in operation and usage of the requested instruments or are relevant to research projects, which will be supported by the instrument. References of the Research Projects Section may appear in this section or may be listed at the end of individual research subsections.

Facilities & Other Resources: Not Applicable. Do not include an attachment here.

Equipment:Describe the requested instruments by stating their manufacturers, model numbers, specific features/configurations, and accessories. Provide a detailed budget breakdown of each instrument and requested accessories, including tax and import duties, if applicable. Itemized quotes, with any appropriate discounts, from a vendor or vendors are required. Each quote has to have terms of warranty included. The quotes must be scanned and combined in a single attachment with the equipment description as part of this upload. As described above in SF424 Cover form, include an explanation of Total Non-Federal Funds in this section (if applicable). Applications without a quote will be deemed incomplete and will be returned to the applicants without review.

If any materials or substances which could create a potential biohazard, are to be analyzed, funds for accessory containment equipment for the instruments may be requested in the budget.

Do not describe the need for the instrumentation in this section; such narrative should be a part of the Justification of Need section of the Instrumentation Plan.

If any materials or substances which could create a potential biohazard, are to be analyzed, funds for accessory containment equipment for the instruments may be requested in the budget.

Do not describe the need for the instrumentation in this section; such narrative should be a part of the Justification of Need section of the Instrumentation Plan.

Other Attachments

I) Instrumentation Plan (in lieu of the Research Plan attachment).

The entire Instrumentation Plan (with the sections described below) must be saved as a single PDF file - named Instrumentation Plan - and attached via Other Attachments. Organize the Instrumentation Plan in the specified order (as described below), starting each section with the appropriate section heading (i.e., Justification of Need, Technical Expertise, Research Projects, etc.). Do not include links to websites for further information. Do not include animations/videos.

  • Introduction: Only in the case of a resubmission, include an Introduction describing the changes that have been made in response to comments in the previous review.
  • Justification of Need: Describe in detail the requested instruments and justify their configuration. Compare the performance of the requested models with other similar instruments available on the market. Justify the need for specific components of the requested instruments. Explain why the chosen models and their manufacturers are the most suitable for your user group. Importantly, demonstrate that each requested item is an integral component of the entire set-up, complements other items, and is carefully selected to meet specific scientific objectives. Demonstrate how the requested instruments will operate synergistically to enable specific workflows or to support specific thematic areas. Show unique features of the requested set-up. Identify innovative experimental approaches that the proposed configuration will enable and explain how they will enhance currently funded research projects. Specifically, outline how the instrumentation will advance animal research.

Provide an inventory of similar instruments existing at your institution, neighboring research institutions, or otherwise accessible; describe why each similar instrument is unavailable or inappropriate for the proposed research. If similar instruments are listed as "unavailable," add a letter to the Letters of Support section from the instrument manager explaining why the instruments are not available to your user group. If the requested instruments are to be placed in a barrier facility, explain the value of the arrangements for the advancements of animal research in your institution which would not be possible otherwise. Describe how the instruments will benefit the overall animal research scientific infrastructure at your institution.

Describe how the placement of the requested instruments will facilitate their complementary and synergetic use. Include specific documentation on the current usage and downtime of each of the existing instruments in annual hours and a realistic estimate of the projected usage for the requested instruments. You may use tables to clarify the presentation. Tables included within this section will count towards the specified page limit.

Justify the need for software. All software supported by this program must be integrated in the operation of the instrument or be necessary for generation of high-quality output data from the instrument. Depending on the needs of research projects, different configurations of such software may be needed to ensure the productive scientific use of the instrument. If such additional software modules are requested (e.g., to support mass spec metabolomics, special imaging protocols for optical microscopes, special pulse sequences for MRI, etc.) they must be essential for the advancement of research projects of least 3 Major Users. Stand-alone workstation, duplicate software items, and software licenses are not allowed.

Define and justify the Accessible User Time (AUT) for the requested instruments. The AUT is the number of annual hours an instrument can be used for any research purpose. AUT hours may be limited by the times an instrument operator is available (if an operator is required), site or building access schedules, estimated or scheduled maintenance, start-up and standardization, and any other factors that take time away from use of the instrument. Define the AUT for each individual instrument. As stated above, AUT might be different for different technologies and local use arrangements. AUT for the same instrument may differ among different institutions. Justify the AUT explaining for the proposed instrument based on the individual situation at the applicant institution. More importantly, AUT will be limited by the type of the technology requested; some instruments can be and are typically operated 24/7 while other technologies can be used only during regular hours. Therefore, justify the AUT based on the type of the technology requested and an individual managerial plan at your institution to make clear that the AUT corresponds to expected practical full-time use of the instruments at your institution.

  • Technical Expertise: Without duplicating information in biosketches, describe the technical expertise of individuals who will set up and run the instruments . Specify who will ensure that the instruments are safely operated and appropriately maintained. State who will train new users. If any of the instruments requires complex sample preparation or consultation for experimental designs, describe the expert individuals who will serve in that capacity. Address technical support for data collection, management, and analysis. Describe the individual and combined technical expertise to show that the full advantage of the specialized multi-instrument configurations can be brought about.
  • Research Projects: Describe the benefit of the requested instrumentation to enhance research projects. Divide this section into the subsections Research Projects of Major Users and, as applicable, Research Projects of Minor Users. To demonstrate substantial need for all components of the requested instrumentation, at least 3 Major Users should use the entire instrumentation configuration at the level of at least 35% of AUT and NIH- funded investigators should use each individual instrument at the level of at least 75% of AUT please see the description of Summary Table(s) below.

Detailed eligibility requirements for Major Users are described in Section III 3.

Since the projects have been previously peer reviewed, describe their details only as necessary to explain how the requested instrumentation will advance the projects research objectives and enhance animal research. (Do not simply copy the Specific Aims section from a funded application.) Present sufficient technical details about types of samples or specific experimental protocols to be employed to allow evaluation of whether the instruments are appropriate, would be effectively utilized, and would provide advantages over other methods and other similar existing or new instruments. Similarly, if software modules are requested to enable special hardware capabilities or to enhance the quality of output data, justify how such configuration(s) will advance the research projects of at least 3 Major Users. Specify the anticipated usage in annual hours for each project.

In particular, explain how the integrated function of a cluster or the combined use of the instruments in the series will enhance the research projects. Show how all requested instrumentation items will be synergistically used and together enable improved experimental workflow and advance animal research. Preliminary data are not required, but if available, they may be used to illustrate the benefit of the requested instrument(s) to the research projects. Describe how generated data will be handled and analyzed, so that benefits of the entire experimental set-up can be evaluated. Summarize benefits that the requested instruments will provide towards answering specific scientific questions or towards the advancement of a specific research area. Describe how the availability of the instruments is expected to aid to the progress of animal research. Be succinct and clear.

In the beginning of each Major User’s Project narrative, list the PD/PI’s name and grant information (number, title, project start and end dates). Specify the anticipated usage in annual hours for each project.

Keep in mind that the sole number of users is not a compelling factor to justify scientific needs for the requested instruments. You must focus this section on detailed explanation of how the requested instruments will advance research projects and potentially provide innovative solution to experimental approaches. Research projects may be drawn from a broad array of topics in biomedical research, but all must use animals or related materials, such as animal tissues, cells or germplasm.

  • Summary Table(s): As a reminder, state AUT in annual hours for each item, as introduced in the Justification of Need Section. Then show a table summarizing Research Projects of Users. For each instrument, include a Major Users table with the following columns: User's name, grant number (for NIH awards list the grant numbers as, R01IC123456), brief title of the project, grant start and end dates, and estimated percentage of AUT hours. If there are multiple Users funded by the same grant, list a total of their estimated number of AUT hours of use of the instruments for projects supported by that grant. Follow with a Minor User table, in the same format.

Following the tables, for each instrument state

(i) a total estimated usage time by Users projects in annual hours,

(ii)the percentage of the estimated usage time devoted to Major Users NIH-funded projects, and

(iii) the percentage of the estimated usage time devoted to NIH-funded projects.

Major Users with NIH research funding should use the entire instrument configuration at the level of at least 35% of the AUT; NIH-funded users (Major and Minor) should use each instrument at the level of 75% of the AUT.

Administration (Organizational/Management Plan): Describe the organizational plan to administer the grant. Describe where the instruments will be located, how they will be utilized, how requests to use the instruments will be made, how time will be allocated among Major and Minor Users, how other projects and new users will be enlisted. Describe how users will be trained in experimental design, instrument operation and data analysis; particularly, if the requested set-up offers to support special workflows. Describe typical day-by-day management of the instrument. If the plans are to install the instruments in a setting other than a core or a shared resource facility, describe the procedures that will implement and assure broad access to the instrument and its use on a shared basis.

List the names and titles of the members of the local Advisory Committee. The membership of this Committee should be broad, to balance interests of different users, and should include members without conflicts of interest (non-users of the requested instruments) who can resolve disputes, if they arise. The membership of this Committee should include at least one senior institutional official (e.g., Provost for Research, Dean of School, Department Chair) who will represent the financial commitment of the institution. Major and other active Users of the instruments may be members, but none may Chair the Advisory Committee. The PD/PI cannot be a voting member of the Advisory Committee.

The Advisory Committee should meet on a regular basis and should prepare an annual report, which will become part of the Final Research Performance Progress Report and the Annual Usage Reports (see Section VI.3).

Provide a plan about how the Users will be instructed and reminded about citing the S10 award in their publications.

Describe a plan for managing access to the instruments if users' projects involve vertebrate animals or biohazards such as infectious materials.

Financial Plan: Submit a specific financial plan for long-term operation and maintenance of the instruments. Explain how various operational costs will be met; specifically, costs associated with routine operation and maintenance of the instruments, and costs for support personnel. The financial plan must include a table for year one of operation with approximate dollars for anticipated expenditures and anticipated income, showing how these estimates were derived. For year one specific dollar amounts are required; for years 2 5, approximate amounts are recommended.

Typically, during year one, the maintenance costs are fully covered by one-year manufacturer's warranty. In subsequent years, costs of maintenance must be considered in the financial plan. Include a description of projected changes of the financial plan over the subsequent four years

Operation: Include salary support of expert personnel that will operate the instruments and oversee routine care and procedures for standardization.

Maintenance: May include a service contract, or funds for parts and local technical personnel who will maintain the instruments (if such personnel are qualified to do so).

Supplies: Include necessary supplies for operating the instruments such as chemicals, cryogenics, and other expendable items.

Software: Include costs for updates/maintenance of software licenses needed for the proper operation of the instruments or additional software for data analysis.

Anticipated Income: Enumerate the sources of income, such as any charge back fee structure, grants, or institutional support.

  • Institutional Commitment: Describe the institutional infrastructure available to support the instrumentation, including space to house the instruments and site for sample preparation, if applicable.

Confirm the institutional support toward the maintenance and operation of the instruments. In particular, confirm that the institution will commit to provide backup of the financial plan for five years from installation of the instruments or for its effective/usable lifetime. The expected usable lifetime depends on the type of requested instruments. Describe institutional support for personnel.

  • Overall Benefit: Explain how the instruments will impact NIH-funded research and contribute to the institution's long-range biomedical research goals.

II) Letters of Support

All letters of support should be combined in a single file named Letters of Support and uploaded as a separate attachment via Other Attachments. This combined file should include, as applicable:

  • Letters from institutional officials;
  • Institutional back-up for the proposed financial plan;
  • Letters about inventory of instruments at the institution which are unavailable to the PD/PI (as noted in the Justification of Need Section).
  • The institution must also provide a table that includes information about performance of all previous S10- awarded instruments within the past five years; that is, FY 2015 - 2019. The table should have the following columns

1) S10 Grant Number;

2) Year of Award;

3) Installation Date of the Instrument

4) PD/PI's Name;

5) Generic Name of Instrument;

6) Instrument Status: (Active (instrument in use), Pending (order placed but instrument not delivered, instrument received but not installed or not calibrated for general use), Upgraded (or replaced), Not Available (sold, decommissioned, transferred)). (If the instrument is currently non-functional, provide a succinct explanation of the instrument status immediately following this table.);

7) Actual Usage Time (actual total time in hours per year the instrument was used for research; if the instrument has been installed less than a year ago, the hours can be extrapolated for an estimate of hours per full year);

8) Maintenance Agreement: (Active (Warranty in place), In-House (or Self-Insured), None (Fee for Service, Pending), Not Available (no longer supported by manufacturer);

9) Number of Research Publications Citing the S10 Award or Linked with the S10 Grant in My NCBI. (Do not count publications that do not cite the S10 grant or have not been associated with the S10 grant in My NCBI.) (If there are no publications for any of the previously awarded S10-awarded instruments provide an explanation immediately following this table.

  • Letter from Biosafety Official. If any (e.g., animal or infectious) materials, which could create a potential biohazard, are to be analyzed, a signed letter from the institutional biosafety officer stating the proposed containment plan was reviewed and adheres to documented biosafety regulations. If relevant, this letter is required in the application.
SF424(R&R) Senior/Key Person Profile
All instructions in the SF424 (R&R) Application Guide must be followed.

Include the profile of the PD/PI, Major Users, Minor Users, and technical personnel, as applicable.

This FOA requires the attachment Current & Pending Support for the PD/PI at the time of application submission. If PD/PI has no research grant or any other research support, state None in the form.

PHS 398 Cover Page Supplement

All instructions in the SF424 (R&R) Application Guide must be followed.

Appendix materials are not allowed for this FOA.
PHS Assignment Request Form
All instructions in the SF424 (R&R) Application Guide must be followed.

3. Unique Entity Identifier and System for Award Management (SAM)

See Part 1. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and

4. Submission Dates and Times

Part I. Overview Information contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday, the application deadline is automatically extended to the next business day.

Organizations must submit applications to (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH’s electronic system for grants administration. NIH and systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Policy on Late Application Submission.

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.

5. Intergovernmental Review (E.O. 12372)

This initiative is not subject to intergovernmental review.

6. Funding Restrictions

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.

Pre-award costs are allowable only as described in the NIH Grants Policy Statement.

Under the S10 mechanism, funding requests are limited to the purchase cost of the instrument only. Support for technical personnel, service contracts, extended warranties, software (except as defined in Part 2, Section I), and supplies are not allowable. Cost sharing towards purchase of the instrument is not required and any institutional funds contributed to the costs of the purchase of the instrument are voluntary. If the amount of funds requested does not cover the total cost of the instrument, the application should describe the proposed source(s) of funding for the balance of the cost of the instrument and document their availability in a letter signed by an appropriate institutional official. Note that any voluntarily committed cost will be noted in the Notice of the Award and the institution will be held to the commitment and reporting requirements.

Program does not provide facilities and administrative (F&A) costs or support for construction or alterations or renovations. Matching funds are not required. However, commitment of an appropriate level of institutional support, to ensure the associated sustaining infrastructure, is expected and should be described. Appropriate Grant will be awarded for a period of one year and are not renewable.

Applicants proposing purchase of an instrument that the institution is planning to lease prior to award are urged to consult with their institutional sponsored projects office and the NIH Grant Management Office regarding applicable NIH policy prior to executing the leasing agreement. If the leasing agreement was executed more than one year prior to submission of the SIG application, the applicant must provide a strong justification for the requested Federal funds. This justification must demonstrate that the leased instrument is considered state-of-the-art at the time of submission - appropriate award adjustments may be necessary. Execution of a purchase order or agreement, making a down payment or other formal commitment to purchase the equipment prior to award will automatically eliminate an applicant from eligibility for an award.

7. Other Submission Requirements and Information

Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. Paper applications will not be accepted.

Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.

For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply Application Guide. If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance. For assistance with application submission, contact the Application Submission Contacts in Section VII.

Important reminders:

All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF424(R&R) Application Package. Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH. See Section III of this FOA for information on registration requirements.

The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization’s profile in the eRA Commons and for the System for Award Management. Additional information may be found in the SF424 (R&R) Application Guide.

See more tips for avoiding common errors.

Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review, NIH. Applications that are incomplete or non-compliant will not be reviewed.

Post Submission Materials

Applicants are required to follow the instructions for post-submission materials, as described in the policy.

Any instructions provided here are in addition to the instructions in the policy. No animations/videos are allowed.

Section V. Application Review Information

1. Criteria

Only the review criteria described below will be considered in the review process. Applications submitted to the NIH in support of the NIH mission are evaluated for scientific and technical merit through the NIH peer review system.

Overall Benefit/Impact

Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).

Scored Review Criteria

Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.

Justification of Need

Is the need for the instruments clearly and adequately justified? Is the equipment essential and appropriate? Is the thematic area of animal research well-defined and well-served by the requested instruments? Are all specific features, special accessories, and software configuration of the requested instruments well justified; in particular, by their need of Major Users? Does the requested set-up offer innovative experimental solutions and does it advance animal research? Is the placement of the instrument well-justified to facilitate the complementary and synergetic use of the instruments? Is Accessible User Time (AUT) well defined and explained? Is AUT reasonable? Is the choice of the instrument justified by comparison with other commercially available instruments of similar function?

Technical Expertise

Does the institution have the technical expertise to make effective use of the requested instruments? How well-qualified are the participating investigators or other assigned personnel to operate and maintain the instruments, conduct the projects, and evaluate the research results, including analysis and interpretation of data? Are the plans for new users training well developed? Are the proposed biosafety procedures well described and appropriate?

Research Projects

Will research with the requested instruments advance the knowledge and understanding of the proposed projects? Will animal research be strengthened and enhanced? How will the research projects of individual Users be enhanced? Do Users adequately justify the requested instruments for the needs of their specific projects? Do at least three Major Users require the entire configuration for their research projects at the level of at least 35% AUT?


Is the plan for the management and maintenance of the requested instruments appropriate? Are the plans for the use of the instruments on a shared basis well-documented? Are the plans for time allocation of the instrument to different projects well developed? Are the sharing arrangements equitable? If needed, are the policies to manage projects which have animals or biohazards adequate? Is the membership of the Advisory Committee broadly based to oversee the use of the instruments for the appropriate range of biomedical investigators, to balance interests of different users, and to resolve disputes, if they arise? Is the financial plan for the instruments for five years or the expected lifetime of the instruments reasonable and secured, balancing anticipated expenditures and anticipated income? Is the expected usable lifetime of the instruments reasonable? Are adequate plans in place to document the use and scientific benefits of the instrument by citations and acknowledgments of the S10 grant in the scientific publications?

Institutional Commitment?

Does the institution commitment letter provide support in the event of a shortfall of income? Is the institutional commitment to back-up the financial plan provided for a time period consistent with the expected effective lifetime of the requested instruments? Is the management of the awarded S10 instruments adequate (based on the data in the table of Previously Awarded S10 Instruments in the institutional Letter of Support)? Does the Institution provide adequate infrastructure support for the requested instruments including space to house the instrument and site for sample preparation, if needed?

Additional Review Criteria
As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items.

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

Generally not applicable. Reviewers should bring any concerns to the attention of the Scientific Review Officer.

Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.

For Resubmissions, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.

Not applicable

Not applicable

Additional Review Considerations
As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.

Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research. Reviewers will consider whether applicants employed the best economical approaches, including securing academic discounts, to formulate the cost-effective budget while meeting users' scientific needs.

2. Review and Selection Process

Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by the Center for Scientific Review, in accordance with NIH peer review policy and procedures, using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons.

As part of the scientific peer review, all applications:
  • May undergo a selection process in which only those applications deemed to have the highest scientific and technical merit (generally the top half of applications under review) will be discussed and assigned an overall impact score.
  • Will receive a written critique.

Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications . Following initial peer review, recommended applications will receive a second level of review by the appropriate national Advisory Council or Board. The following will be considered in making funding decisions:

  • Scientific and technical merit of the proposed project as determined by scientific peer review.
  • Availability of funds.
  • Relevance of the proposed project to program priorities
  • Program balances among various types of supported instruments and geographical distribution of awards.

3. Anticipated Announcement and Award Dates

After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons.Refer to Part 1 for dates for peer review, advisory council review, and earliest start date.

Information regarding the disposition of applications is available in the NIH Grants Policy Statement.

Section VI. Award Administration Information

1. Award Notices

Applicants should ignore eRA Commons system-generated just-in-time (JIT) requests which are typically sent soon after peer review. If an application is considered for funding, ORIP SIG Program staff will send PD/PI special instructions on how to submit a JIT update, from the e-mail address Once an application is selected for funding, the grants management officer may request additional information.

A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the grantee’s business official.

Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.

Any application awarded in response to this FOA will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website. This includes any recent legislation and policy applicable to awards that is highlighted on this website.

2. Administrative and National Policy Requirements

All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.

Recipients of federal financial assistance (FFA) from HHS must administer their programs in compliance with federal civil rights law. This means that recipients of HHS funds must ensure equal access to their programs without regard to a person’s race, color, national origin, disability, age and, in some circumstances, sex and religion. This includes ensuring your programs are accessible to persons with limited English proficiency. HHS recognizes that research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigator’s scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research.

In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Defense Authorization Act of Fiscal Year 2009 (Public Law 110-417), NIH awards will be subject to the Federal Awardee Performance and Integrity Information System (FAPIIS) requirements. FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award. An applicant, at its option, may review information in the designated integrity and performance systems accessible through FAPIIS and comment on any information about itself that a Federal agency previously entered and is currently in FAPIIS. The Federal awarding agency will consider any comments by the applicant, in addition to other information in FAPIIS, in making a judgement about the applicant’s integrity, business ethics, and record of performance under Federal awards when completing the review of risk posed by applicants as described in 45 CFR Part 75.205 Federal awarding agency review of risk posed by applicants. This provision will apply to all NIH grants and cooperative agreements except fellowships.

For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this FOA. HHS provides general guidance to recipients of FFA on meeting their legal obligation to take reasonable steps to provide meaningful access to their programs by persons with limited English proficiency. Please see The HHS Office for Civil Rights also provides guidance on complying with civil rights laws enforced by HHS. Please see Recipients of FFA also have specific legal obligations for serving qualified individuals with disabilities. Please see Please contact the HHS Office for Civil Rights for more information about obligations and prohibitions under federal civil rights laws at call 1-800-368-1019 or TDD 1-800-537-7697. Also note it is an HHS Departmental goal to ensure access to quality, culturally competent care, including long-term services and supports, for vulnerable populations. For further guidance on providing culturally and linguistically appropriate services, recipients should review the National Standards for Culturally and Linguistically Appropriate Services in Health and Health Care at

Cooperative Agreement Terms and Conditions of Award
Not Applicable

3. Reporting

When multiple years are involved, awardees will be required to submit the Research Performance Progress Report (RPPR) annually and financial statements as required in the NIH Grants Policy Statement.

At the expiration of the grant, a Final Research Performance Progress Report (Final RPPR) is required that describes the purchased instrument, and a list of all users and description of the value of the instrument to the investigators and to the institution as a whole. The following information about the award and the instrument must be included in the SIFAR Final RPPR:

1) Grant Number: 1S10OD#####-01

2) Principal Investigator: (Name, Institution, Department, Address)

3) Funding Period

4) Name of Instrument (including manufacturer and model)

5) Total Purchase Cost

6) Total SIFAR Award Amount

7) Other Sources of Funding (if appropriate)

8) Instrument Installation Date

9) List of users, their funding and hours of use

10) List of publications, if available. This publication list should be consistent with the NIH Public Access Policy.

11) A narrative describing the impact of the instrument on the research community, specific research accomplishments, and administration and operation of the instrument.

12) A report from the Advisory Committee.

The SIFAR Final RPPR must be submitted electronically through the Closeout module in eRA Commons. For facilitation of Final RPPR preparation, the SIFAR Scientific Research/Contact staff will contact grantees prior to the due date for report and provide specific instructions.

Annual Instrument Usage Report

In addition, for the period of four years after the Final RPPR, on the anniversaries of the expiration of the award, Annual Instrument Usage Reports (AURs) must be provided to the NIH. These reports will include analogous information requested in S10 Final RPPR (as listed above in Final Research Performance Progress Report section) about the usage and operation of the instrument, with an attached report from the Advisory Committee, description of research which benefited from the instrument, and a summary of research outcomes as documented by publications.

The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.

In accordance with the regulatory requirements provided at 45 CFR 75.113 and Appendix XII to 45 CFR Part 75, recipients that have currently active Federal grants, cooperative agreements, and procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 for any period of time during the period of performance of a Federal award, must report and maintain the currency of information reported in the System for Award Management (SAM) about civil, criminal, and administrative proceedings in connection with the award or performance of a Federal award that reached final disposition within the most recent five-year period. The recipient must also make semiannual disclosures regarding such proceedings. Proceedings information will be made publicly available in the designated integrity and performance system (currently FAPIIS). This is a statutory requirement under section 872 of Public Law 110-417, as amended (41 U.S.C. 2313). As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available. Full reporting requirements and procedures are found in Appendix XII to 45 CFR Part 75 Award Term and Conditions for Recipient Integrity and Performance Matters.

Section VII. Agency Contacts

We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.
Application Submission Contacts
eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threatensubmission by the due date, and post-submission issues)

Finding Help Online: method of contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)

General Grants Information (Questions regarding application instructions, application processes, and NIH grant resources) method of contact)
Telephone: 301-945-7573 Customer Support(Questions regarding registration and Workspace)
Contact Center Telephone: 800-518-4726

Scientific/Research Contact(s)

Alena Horska, PhD
Office of Research Infrastructure Programs (ORIP)
Telephone: 301-435-0772

Peer Review Contact(s)

Nuria Assa-Munt, PhD
Center for Scientific Review (CSR)
Telephone: 301-451-1323

Financial/Grants Management Contact(s)

Karen Brummett
Office of Research Infrastructure Programs (ORIP)
Telephone: 301-827-8024

Section VIII. Other Information

Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Authority and Regulations
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Part 75.

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