Department of Health and Human Services

Part 1. Overview Information
Participating Organization(s)

National Institutes of Health (NIH)

Components of Participating Organizations

Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP)
National Center for Research Resources (NCRR) (IC Removed per NOT-OD-12-075)

Funding Opportunity Title

Limited Competition: National Primate Research Centers (P51)

Activity Code

P51 Primate Research Center Grants

Announcement Type


Related Notices

  • May 16, 2014 - This PAR has been reissued as PAR-14-226.
  • October 24, 2013 - See Notice NOT-OD-14-008. The purpose of this notice is to expire this PAR.
  • September 28, 2012 See Notice NOT-OD-12-161. NIH Announces Plans to Transition to Electronic Submission of Multi-Project Applications
  • August 15, 2012 - Applications submitted in response to PAR-11-136 will be accepted on the non-standard due date of February 25, 2013, replacing the January 25, 2013 date for the September 2013 Council round. See Notice NOT-OD-12-135.
  • March 6, 2012 - See Notice NOT-OD-12-075. Notice of Change in Participation of NIH Institutes and Centers.
  • May 11, 2011 - See Notice NOT-RR-11-006 This Notice clarifies the fact that letters of support are not necessary or expected and will not be accepted for P51 grant applications submitted.

Funding Opportunity Announcement (FOA) Number


Companion FOA


Number of Applications

See Section III. 3. Additional Information on Eligibility.

Catalog of Federal Domestic Assistance (CFDA) Number(s)


FOA Purpose

This FOA issued by the National Center for Research Resources (NCRR), National Institutes of Health (NIH), encourages grant applications that support the activities of the National Primate Research Centers (NPRCs). Nonhuman primates (NHPs) are most closely related to humans, both physiologically and genetically. Therefore, NHPs are critical animal models for translational research aimed at understanding human biology, both in normal and diseased states. Proper husbandry and management of NHPs requires specialized physical and intellectual resources, which are most effectively and economically provided in centralized primate centers, the resources of which are made available to investigators on a national basis. The NPRCs provide these resources that complement and help enable the missions of the NIH Institutes and Centers, the grantees of which utilize NHPs to study specific diseases.

Key Dates
Posted Date

March 9, 2011

Letter of Intent Due Date

Not Applicable

Application Due Date(s)

Standard dates applly

AIDS Application Due Date(s)

Not applicabler

Scientific Merit Review

Standard dates apply

Advisory Council Review

Standard dates apply

Earliest Start Date(s)

Standard dates apply

Expiration Date

(Now Expired October 25, 2013 per NOT-OD-14-008), Originally May 8, 2014

Due Dates for E.O. 12372

Not Applicable

Required Application Instructions

It is critical that applicants follow the instructions in the PHS398 Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. While some links are provided, applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Looking ahead: NIH is committed to transitioning all grant programs to electronic submission using the SF424 Research and Related (R&R) format and is currently investigating solutions that will accommodate NIH’s multi-project programs. NIH will announce plans to transition the remaining programs in the NIH Guide to Grants and Contracts and on NIH s Applying Electronically website.

Table of Contents

Part 1. Overview Information
Part 2. Full Text of Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission Information
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information

Part 2. Full Text of Announcement

Section I. Funding Opportunity Description


The National Center for Research Resources (NCRR) of the National Institutes of Health (NIH) funds a National Primate Research Center (NPRC) program, the goal of which is to facilitate the effective use of NHPs by scientists engaged in biomedical research. The NPRC program complements and enables the missions of the other NIH Institutes and Centers, the grantees of which utilize NHPs to study specific diseases. NCRR’s Division of Comparative Medicine (DCM) currently funds eight NPRCs, which are centralized facilities in various parts of the country, and are available to investigators on a national basis. Individual NPRCs can have specific areas of emphasis, but each is expected to provide a variety of services both individually and through inter-NPRC collaborations to a wide range of investigators. Applicants to this FOA are limited to existing NPRCs. Investigators who want to use the resources available at the NPRCs should consult


The overall objective of the NPRC program is to provide support for scientists who use NHPs in their research. This is accomplished by funding NPRCs that provide the animals, facilities, and expertise needed to enable research using NHPs. More specifically, support is provided to:


An NPRC receives funding from the NCRR through a base grant using the NIH P51 activity code (hereafter referred to as the P51 base grant). The P51 base grant provides the nucleus of support for the NPRC. By accepting the grant award, the grantee institution agrees to make the facilities and resources available to selected affiliate and visiting scientists from other institutions, as well as to its own scientists. The P51 base grant is not intended to provide the total funding for the NPRC. Funding of NPRC operations should be augmented by other sources such as program income, peer reviewed research grants, contracts, or cooperative agreements and other sources, as appropriate.

P51 base grant awards are made under authorization of Title 111, Part A, Section 301 of the Public Health Service Act (Public Law 78-410, as amended, 42-USC-241) and administered under PHS Grants Policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74. The P51 base grants are subject to the policies and procedures set forth in the most current version of the NIH Grants Policy Statement, hereafter referred to as the Grants Policy Statement. However, there are special circumstances related to the administration and operation of the NPRCs that require additional guidelines as set forth in this document. These guidelines are intended to supplement the existing Grants Policy Statement and to provide guidance for unique management aspects of the program.

An NPRC is a distinct organizational and structural component affiliated with a major research institution. The grantee institution is the recipient of the P51 base grant funds and assumes legal responsibility and accountability for use and disposition of these funds in accordance with PHS policy. The grantee institution is responsible for the scientific programs being conducted at, with or through the NPRC. The grantee institution is responsible for the academic environment of the NPRC by providing access to joint appointments in appropriate departments and by encouraging cooperative activities and interchange between the NPRC and the grantee institution’s other scientific and technical staff.

The P51 base grant supports the specialized facilities, scientific and technical personnel, and NHP species needed for the conduct of biomedical and behavioral research. Activities and costs supported by the P51 base grant can include, but are not limited to:


The specific content of the grant application will depend on the organizational structure of the NPRC. In general, an NPRC is comprised of major functional sections, which may include individual components. Individual NPRCs have latitude in regard to functional organization, which may depend, in part, on the requirements of the grantee institution and on the specific activities of the NPRC.

A component is defined as a functional group within an NPRC that has an internal organizational chart and reporting structure, as well as specific resources and responsibilities that make an essential contribution to the research activities and day-to-day operations of the NPRC. These components are described in the renewal application for the NPRC and are peer-reviewed.

Specific points regarding some of the NPRC functions are as follows:

A. Doctoral Level Personnel

The Program Director / Principal Investigator (PD/PI) is designated by the grantee institution and has ultimate responsibility for the conduct of NPRC operations. The NIH communicates with the PD/PI on broad institutional issues relating to the NPRC. The PD/PI should hold a position in the grantee institution that crosses organizational lines, for example, as the Vice President for Research or Dean of the graduate school, medical school or health sciences center. The PD/PI must occupy a senior level position in the grantee institution to assure administrative continuity of the NPRC’s programs and to avoid dependence on individual departments within the grantee institution. The PD/PI of an NPRC is required to commit at least 0.12 person-month effort (based on a 12 month calendar year appointment) to the P51 base grant. However, he/she derives no salary from the P51 base grant. Multiple PD/PIs are not permitted on the P51 base grant.

The Center Director is a senior scientist appointed by the PD/PI and the grantee institution and approved by NCRR. The Center Director is responsible for the day-to-day management and scientific direction of the NPRC. The Center Director should be an established scientist with a doctoral degree in one of the health science disciplines and a recipient of peer-reviewed biomedical research support. The Center Director is responsible to the PD/PI and derives a significant portion of his or her salary for providing scientific leadership and administrative oversight of the NPRC. Support for a Center Director from the P51 base grant is normally between 3 and 9 person-months (based on a 12 month calendar year appointment) for administrative responsibilities.

Core scientists direct research programs and/or provide scientific expertise, veterinary expertise or leadership in specific subject areas. Core scientists may have full- or part-time permanent appointments at the NPRC. Core scientists are considered part of the intellectual infrastructure of the NPRC and provide expertise regarding NHPs for the conduct of research projects, including investigations by affiliate and visiting scientists.

Core scientists are appointed by the Center Director in accord with the host institution’s academic and personnel policies and are directly responsible to the Center Director for performance of duties that contribute to the aims of the NPRC. Joint appointments of core scientists in academic departments are encouraged to foster mutually beneficial relationships between the NPRC and other components of the grantee institution. Core scientists can potentially represent many different disciplines, depending on the needs of the NPRC.

Except as discussed below, no more than 40 percent of a core scientist’s salary can be supported by the P51 base grant. Salary support, in addition to that provided by the P51 base grant, may be derived through a joint appointment within the grantee institution. The specific level of outside funding versus P51 base grant funding for a core scientist will depend on the responsibilities of the core scientist.

Core scientists may, with appropriate justification and depending on availability of funds, receive up to 100 percent salary support from the P51 base grant. Such full-time support must be justified on the basis of short-term, interim funding or continuity of specialized functions and responsibilities critical to the NPRC’s overall operation. The grantee institution must specifically justify support of any core scientist at greater than 40 percent salary each year in the non-competing renewal application. Core scientists who receive their full salary from the base grant may devote up to 1.2 person-months, based on a 12 month calendar year appointment o scholarly activities in an academic department, usually in the grantee institution.

Regardless of the source of funding, core scientists must devote at least 1.2 person-months, based on a 12 month calendar year appointment to service that is directly related to supporting the scientific programs and activities of the NPRC. In addition, a core scientist must devote at least 6 person-months, based on a 12 month calendar year appointment to NHP-related research.

Affiliate scientists are investigators from outside the NPRC who conduct research on NHPs and collaborate with NPRC staff in the conduct of this research. Scientists from within the grantee institution, but who do not have appointments at the NPRC, are considered affiliate scientists, as are investigators from outside the grantee institution.

Affiliate scientists obtain approval from the Center Director to use the resources of the NPRC prior to submission of a grant application. Contingent on the awarding of funds, they are assured of a working relationship with NPRC staff and have access to the facilities and resources of the NPRC for regular or intermittent periods necessary to complete a project. Affiliate scientists do not derive salary support from the P51 base grant.

Scientists who visit or consult with the NPRC to learn a procedure or obtain advice, but who otherwise do not use NPRC resources, are not considered affiliate scientists. Likewise, investigators who obtain services, resources such as animals, or materials such as tissue samples on a fee for service basis, but who otherwise do not collaborate with NPRC personnel, are not considered affiliate scientists.

Visiting scientists are established investigators in residence at the NPRC for a limited period by virtue of an appointment approved by the Center Director. A visiting scientist is directly responsible to the Center Director. The studies of visiting scientists must be enhanced by access to an NPRC s resources, and the NPRC is expected to benefit from access to a visiting scientist’s expertise and knowledge. Visiting scientists typically provide their own salary support, with facilities and resource support provided by the NPRC.

In addition to affiliate and visiting scientists, other investigators may collaborate directly with NPRC core scientists on specific research projects, using varying amounts of NPRC resources. These collaborative scientists are usually identified as co-authors on papers or co-investigators on grant proposals with NPRC core scientists, if not otherwise designated as affiliate or visiting scientists.

B. Advisory Committees

The NPRCs are guided in their governance by two or more Advisory Committees, described below. The roles of these Advisory Committees is to provide a balanced perspective of external advice and review to more fully inform internal executive management and decision-making.

Minimum requirements for these committees are described below. Within these minimum parameters, the exact composition of the committees, terms of service, and the frequency and type of meetings can vary depending on the needs of the individual NPRCs. The Center Director has the option of appointing additional advisory committees to augment these standing committees, depending on the unique needs of the NPRC, which can vary because of differences in leadership structures, NHP populations, university affiliations, community interactions and other factors that affect governance.

Each NPRC must have a National Scientific Advisory Board (NSAB), which provides guidance to the PD/PI and Center Director on all aspects of the NPRC, including scientific direction. The NSAB reports to the PD/PI of the NPRC. The NSAB must consist of at least six eminent scientists from outside the NPRC, with experience using NHPs for research. Overall, the composition of the NSAB must reflect the range of technical subjects that are pursued at the NPRC. It is permissible to have limited representation (maximum of two members) on the NSAB from other NPRCs, which may facilitate NPRC consortium activities. Individuals serving on the NSAB are appointed annually, are typically reappointed for 3-5 consecutive terms and may serve concurrently on the NSAB of, at most, one other NPRC.

The NSAB must meet at the NPRC as a full group or as specialty subgroups, at least on an annual basis, to review and provide advice regarding the development and conduct of the NPRC’s scientific programs, resource programs and general policies. Periodic teleconferences or videoconferences involving the entire NSAB or a subcommittee may be scheduled between annual meetings to address continuing or unanticipated scientific or administrative issues at the NPRC. The NSAB must have a chairperson, who is appointed by the NPRC Director, in consultation with the PD/PI. A record of the conclusions of the NSAB must be maintained in the office of the Center Director and made available for DCM program staff visits.

Each NPRC also must have a Research Advisory Committee (RAC), which provides advice to the Center Director regarding prioritization of projects and resources. Final decisions regarding prioritization are at the discretion of the Center Director. The RAC must consist of at least four members appointed by the Center Director with the concurrence of the PD/PI. Members of the RAC must be core scientists representative of the functional components within the NPRC. The RAC must meet at least monthly to discuss the research programs of the NPRC and to review all new project proposals that will use NPRC resources in regard to feasibility in the context of NPRC capabilities. In addition, the RAC must review the scientific merit of all new project proposals that have not undergone NIH peer review and that will use NPRC resources. Records summarizing the recommendations of the RAC must be maintained in the office of the Center Director and made available at review site visits and DCM program staff visits.

C. Animal Colonies

Animal colonies are key components of the function of an NPRC, and efficient and humane management of the NHP colonies is a key element for an NPRC. Each NPRC must support breeding colonies to provide for national research needs. NPRCs that have limited space for breeding colonies can fund breeding colonies at other sites. In this case, the NPRC that funds the off-site breeding colony will have the primary responsibility for decisions regarding its management. The NPRC must be able to provide animals upon request from existing pools of research animals, while maintaining an appropriate number of animals for breeding purposes. A computer-based system for tracking animals in the research and breeding colonies must be in place.

Various NHP species can be accommodated at an NPRC. Generally, demand on a national level and availability are necessary for support of a given species through the P51 base grant. The major support for infrastructure, space, and resources should be used for maintenance and husbandry of those species for which there is major national demand. Additional factors, such as conditions and practices to allow social interactions that contribute to the psychological well-being of the animals may also influence resource allocation for a given species. It is also acceptable for P51 base grant funding to be used to ensure the continued availability of species of biomedical research importance whose wild populations are considered threatened or endangered. The NPRC must have programs in place to maintain the genetic diversity of animal colonies and for environmental enrichment.

Animal colonies must meet the following criteria:

D. Scientific Components

Research is carried out in components, often referred to as Departments, Divisions or Program Areas, organized according to specific areas of scientific research. Investigations carried out by core scientists relating to their specific research grants (for example, NIH R01 grants) can be performed in the same laboratories as activities related to NPRC activities, such as collaborations with affiliate or visiting scientists. However, the P51 base grant is not intended to fund R01 type research performed by core scientists. Research projects in scientific components supported by the P51 base grant can fall under the following categories:

A scientific component can also contain entities that provide core services, either to multiple components within the NPRC or to the individual scientific component.

E. Pilot Research Program

An NPRC must have a pilot research program and must fund at least one pilot research project per year. The number of pilot research projects supported by the P51 base grant can vary, depending on the availability of funds and is at the discretion of the Center Director. Pilot research must include activities related to the use of NHPs for biomedical research or for studies enhancing the welfare or husbandry of NHPs. Pilot research should be developmental or high risk and should be used to generate preliminary data or results necessary to apply for support from sources of funding such as NIH R01 grants. The following guidelines apply to the use of P51 base grant funds to support pilot research projects:

F. Resource-Related Research Projects

Resource-Related Research Projects (RRRPs) directly enhance the NPRC’s resources and ability to meet the needs of researchers using NHPs. Examples of RRRPs can include, but are not limited to, investigations aimed at improving NHP husbandry and welfare, or improving techniques for characterizing diseased and/or normal animals that are used in NHP research.

RRRPs are not a required component on the P51 base grant. However, if a RRRP is proposed or will be continued in the first year of a renewal cycle, then a description of the project must be included in the grant application. Requirements for the RRRP are as follows:

G. Improvement and Modernization (IM)

A maximum of $600,000 of IM funds may be requested for each year of the P51 base grant application. These funds can be used to upgrade the physical plant (repairs and renovation of facilities) and to replace obsolete shared resources and equipment. A single improvement project or equipment purchase cannot exceed $500,000 in total costs. IM funds cannot be used for construction. Requested items can be utilized by one or several components of the NPRC.

H. Outreach and Community Engagement

NPRCs must publicize their capabilities on a national level, for example through a website, providing information at national meetings, etc. This information should be provided to all interested investigators, not just core and affiliate scientists. Each NPRC is also strongly encouraged, but not required, to have a local community engagement program to educate the public about the importance of the research at the NPRC and the link between animal research and improvements in human health.

I. NPRC Consortium-Based Activities

The NPRCs are expected to participate in consortium-based activities that will enhance the resources of the program and promote cost savings by standardizing common activities across all of the NPRCs. An example of this type of activity includes, but is not limited to, participation in NPRC Working Groups, the goals of which are to consolidate system-wide activities. Working Groups are formed by NPRC representatives in consultation with NCRR staff. The Center Director will appoint at least one representative to each Working Group. The function and identity of Working Groups will change over time, as problems are solved and new problems and topic areas arise.

J. Prioritizing Requests for NPRC Resources

Requests for use of available NPRC resources (including animals, space, core facilities, etc.) must be prioritized from highest to lowest priority as follows, with investigators funded by:

1. NIH extramural grants (highest priority).

2. NIH intramural funding.

3. Nonprofit or not-for-profit funding.

4. For-profit funding.

If a proposed project is funded by more than one source, the highest priority source should be used for determining priorities. Within the above categories, projects must be prioritized on a first-come, first-served basis, with no preference given to scientists within the grantee institution or NPRC versus scientists from outside the grantee institution.

Section II. Award Information
Funding Instrument


Application Types Allowed


The OER Glossary and the PHS398 Application Guide provide details on these application types.

Funds Available and Anticipated Number of Awards

The number of awards is contingent upon NIH appropriations, and the submission of a sufficient number of meritorious applications.

Award Budget

Application budgets must reflect actual needs of the proposed project. Applicants requesting $500,000 or more in direct costs in any year (excluding consortium F&A) must contact NIH program staff at least 6 weeks before submitting the application and follow the Policy on the Acceptance for Review of Unsolicited Applications that Request $500,000 or More in Direct Costs as described in the PHS398 Application Guide.

Award Project Period

The scope of the proposed activities should determine the project period. The maximum period is 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

Section III. Eligibility Information

1. Eligible Applicants
Eligible Organizations

Higher Education Institutions:

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:

Nonprofits Other Than Institutions of Higher Education

Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Foreign (non-U.S.) components of U.S. Organizations are not allowed.

This FOA is limited to organizations that currently have a NPRC funded by NCRR using the P51 activity code. Applications from other organizations will be returned without peer review.

Required Registrations

Applicant organizations must complete the following registrations as described in the PHS398 Application Guide to be eligible to apply for or receive an award. Applicants must have a valid Dun and Bradstreet Universal Numbering System (DUNS) number in order to begin each of the following registrations.

All Program Directors/Principal Investigators (PD/PIs) must also work with their institutional officials to register with the eRA Commons or ensure their existing eRA Commons account is affiliated with the eRA Commons account of the applicant organization.

All registrations must be completed by the application due date. Applicant organizations are strongly encouraged to start the registration process at least four (4) weeks prior to the application due date.

Eligible Individuals (Project Director/Principal Investigator)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Project Director/Principal Investigator (PD/PI) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

Multiple PD/PIs are not allowed.

2. Cost Sharing

This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.

3. Additional Information on Eligibility

Number of Applications

Only one application per organization is permitted.

NIH will not accept any application in response to this FOA that is essentially the same as one currently pending initial peer review unless the applicant withdraws the pending application. NIH will not accept any application that is essentially the same as one already reviewed. Resubmission applications may be submitted, according to the NIH Policy on Resubmission Applications from the PHS398 Application Guide.

Section IV. Application and Submission Information

1. Address to Request Application Package

Applicants are required to prepare applications according to the current PHS 398 application forms in accordance with the PHS 398 Application Guide.

2. Content and Form of Application Submission

It is critical that applicants follow the instructions in the PHS398 Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.

Application Submission

Applications must be prepared using the PHS 398 research grant application forms and instructions for preparing a research grant application. Submit a signed, typewritten original of the application, including the checklist, and three signed photocopies in one package to:

Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710 (U.S. Postal Service Express or regular mail)
Bethesda, MD 20817 (for express/courier service; non-USPS service)

At the time of submission, two additional paper copies of the application and all copies of the appendix files must be sent to:

Martha Matocha, Ph.D.
Scientific Review Officer
National Center for Research Resources
National Institutes of Health, DHHS
6701 Democracy Blvd., Room 1070
Bethesda, MD 20892-4874
Bethesda, MD 20817 (FedEx or courier)
Tel 301-435-0813 (direct line)

Page Limitations

All page limitations described in the PHS398 Application Guide must be followed, with the following exceptions or additional requirements:

I. Overview of the NPRC

This section should provide information regarding the function of the NPRC as a whole and should only include the information that is not specific to individual components of the NPRC. This section should not duplicate the detailed information in the sections describing specific functional components.

Page Limits:

The organization of the Overview section is at the discretion of the applicant, but at a minimum must include the following:

II. Component Content Requirements - Preface Pages

The component preface information is not subject to page limits. Do not include information that belongs in the content section or your application may be will not be reviewed.. Include the following information in the preface to each component:

III. Component Content Requirements - Page Limited Sections

Page limits are set for the Research Strategy section for each component, not per major section. Major sections may include the components listed (a, b, c ) if applicable.

For all component within a Renewal or Revision Application, include a Progress Report regarding the specific component. For a Resubmission application, include a one page response to the previous summary statement for the specific component.


The components within Administration should provide services across the entire NPRC and are usually under the direct supervision of the Center Director or his/her designee. Examples of administrative components may include the following. The specific titles of these components may differ among NPRCs.

a) Administration Overview

b) Director’s Office

c) Business Office

d) Environmental Health and Safety

e) Computer Services

f) Information Technology

g) NPRC-specific Library Services

h) Bioengineering Services

i) Photography Services

j) Education and Training Programs

k) Public Affairs Office

l) Other components, as relevant to the specific NPRC

a) Administration Overview

The Research Strategy section is limited to 12 pages. For a Renewal or Revision Application, include a Progress Report regarding overall Administration. For a Resubmission application, include a one page response to the previous summary statement for overall Administration.